Neomycin Sulfate API CAS 1405-10-3 | ≥98% Aminoglycoside Veterinary Antibiotic Manufacturer China

Key Selling Points

✓ Aminoglycoside Antibiotic from Streptomyces fradiae

✓ Irreversible 30S Ribosomal Binding (16S rRNA A-Site)

✓ Oral Non-Absorbable - Gut-Level Antibacterial Action

✓ Active Against Gram-Negative Aerobes (E. coli, Salmonella)

✓ ≥630 μg/mg Potency, White to Light Yellow Powder

✓ Livestock & Poultry Gastrointestinal Infection Research

What Is Neomycin Sulfate Powder?

Neomycin Sulfate Powder is the water-soluble trisulfate salt of neomycin, an aminoglycoside antibiotic produced by fermentation of Streptomyces fradiae. It is widely used in veterinary medicine for the prevention and treatment of gastrointestinal infections in livestock and poultry, with activity against gram-negative aerobic bacteria including E. coli, Salmonella and Campylobacter species.

A defining pharmacological feature is its very low oral absorption, which concentrates the drug in the intestinal lumen and makes it particularly suitable for gut-level antibacterial action. Anaerobic bacteria are intrinsically resistant to neomycin, and it exhibits partial or complete cross-resistance with other aminoglycosides.

How Does Neomycin Sulfate Powder Work?

Neomycin Sulfate Powder exerts its bactericidal effect by irreversibly binding to the 16S rRNA at the aminoacyl-tRNA (A) site of the bacterial 30S ribosomal subunit. This binding causes a conformational change in the ribosome, leading to misreading of the mRNA genetic code, incorporation of incorrect amino acids and synthesis of abnormal proteins. At higher concentrations, aminoglycosides also damage the bacterial cell membrane, increasing permeability and causing leakage of essential cellular materials, ultimately resulting in bacterial cell death.

Its activity against both dividing and resting-phase bacteria, combined with its gut-localized pharmacokinetics, makes Neomycin Sulfate Powder a valuable reference compound for veterinary gastrointestinal infection research and formulation development.

What Are the Applications of Neomycin Sulfate Powder?

Poultry Gastrointestinal Infections: Used in formulation research for E. coli infections in chickens, turkeys, ducks, geese, quail and partridges, including neonatal chick and poult enteritis.
Swine Enteric Disease: Evaluated for post-weaning diarrhea and gastrointestinal infections caused by E. coli and Salmonella in piglets and growing pigs.
Calf & Young Ruminant Diarrhea: Studied for E. coli and Campylobacter-associated enteritis in calves, lambs and goat kids.
Topical & Otic Research: Investigated for skin and ear infection formulations targeting susceptible gram-negative bacteria.
Gut Sterilization Research: Used in laboratory models for selective intestinal decontamination due to its non-absorbable oral profile.

What Is the Difference Between Neomycin and Neomycin Sulfate?

Feature	Neomycin	Neomycin Sulfate
CAS	1404-04-2	1405-10-3
Form	Free base	Trisulfate salt
Molecular Formula	C₂₃H₄₆N₆O₁₃	C₂₃H₄₆N₆O₁₃·3H₂SO₄
Molecular Weight	614.64	908.88
Solubility	Slightly soluble in water	Soluble in water
Typical Use	Research standard	Oral powder / soluble powder

How Does Neomycin Sulfate Compare With Other Aminoglycosides?

Feature	Neomycin Sulfate	Streptomycin Sulfate	Gentamicin Sulfate
CAS	1405-10-3	3810-74-0	1405-41-0
Origin	Streptomyces fradiae	Streptomyces griseus	Micromonospora purpurea
Structural Class	4,5-disubstituted 2-DOS	Atypical (no 2-DOS)	4,6-disubstituted 2-DOS
Spectrum	Gram-negative aerobes	Gram-negatives + Mycobacterium	Broader gram-negative
Oral Absorption	Very low (gut-localized)	Low	Low
Nephrotoxicity	Highest among aminoglycosides	Lower	Moderate
Primary Use	GI infections / topical	Systemic / TB	Systemic infections

How Is Neomycin Sulfate Powder Manufactured?

Neomycin Sulfate Powder is manufactured by fermentation of Streptomyces fradiae to produce the neomycin free base (a complex of neomycin B and C), followed by extraction, purification and trisulfate salt formation with sulfuric acid.

Raw Material QC → Fermentation (Streptomyces fradiae) → Extraction → Purification → Trisulfate Salt Formation → Crystallization → Drying → Final QC → Packaging

HDM BIO controls key fermentation, extraction, salt-formation and drying parameters to maintain consistent purity, potency and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White or off-white powder	Consistent
Potency	≥630 μg/mg	660 μg/mg
Assay (HPLC)	≥98%	99.0%
Identity (IR)	Conforms to reference standard	Confirmed
Sulfate Content	27.0–33.0%	30.1%
Related Substances	Within specification	Pass
Loss on Drying	≤8.0%	3.5%
Residue on Ignition	≤1.0%	Compliant
Heavy Metals	≤10 ppm	Compliant
pH (1% solution)	5.0–7.5	6.2

What Quality Control Tests Are Performed for Neomycin Sulfate Powder?

Each batch undergoes multi-step quality control before release to verify identity, potency, purity and physical properties.

Raw Material QC → In-Process Control → Microbiological Potency Assay → HPLC Assay → IR Identity Verification → Sulfate Content → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Residue on Ignition → pH Test → Final Batch Release

Key evaluations include microbiological potency assay (≥630 μg/mg), HPLC active content assay, infrared (IR) identification, sulfate content determination, related substances analysis, loss on drying, heavy metal limits, residue on ignition and pH verification. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Neomycin Sulfate Powder Bulk Price?

Neomycin Sulfate Powder bulk pricing is driven by several key factors:

Fermentation Costs: Streptomyces fradiae culture, fermentation substrates and downstream extraction costs directly influence manufacturing expenses.
Potency & Purity Grade: Higher potency (μg/mg) and purity grades with strict impurity control cost more to produce.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price than non-certified alternatives.
Order Volume: Large-scale industrial or wholesale contracts receive steeper per-kilogram discounts than small-batch specialty orders.
Logistics & Geography: Shipping distance, moisture-barrier packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Neomycin Sulfate Powder Supplier?

High-purity (≥98% / typical 99%+) aminoglycoside with controlled potency (≥630 μg/mg)
Gut-localized oral non-absorbable profile for gastrointestinal infection research
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Neomycin Sulfate Powder

Q1: What is Neomycin Sulfate Powder?

A: The water-soluble trisulfate salt of neomycin, an aminoglycoside antibiotic produced by Streptomyces fradiae fermentation, supplied as veterinary raw material for gastrointestinal infection formulations.

Q2: What is the CAS number?

A: 1405-10-3 (sulfate salt); neomycin free base is 1404-04-2.

Q3: Is Neomycin Sulfate absorbed orally?

A: No. Neomycin is poorly absorbed from the gastrointestinal tract, which concentrates its antibacterial action in the intestinal lumen and makes it suitable for gut-level infections.

Q4: How does it work?

A: It irreversibly binds to the 30S ribosomal subunit (16S rRNA A-site), causing mRNA misreading and abnormal protein synthesis, ultimately leading to bacterial cell death.

Q5: What bacteria is Neomycin Sulfate effective against?

A: It is active against gram-negative aerobic bacteria including E. coli, Salmonella and Campylobacter. Anaerobic bacteria are intrinsically resistant.

Q6: What documents are provided with each batch?

A: Batch-specific COA, HPLC report, microbiological potency assay, IR identity records, sulfate content data, MSDS/SDS and relevant export documentation are available according to order requirements.

Q7: What potency do you supply?

A: Standard ≥630 μg per mg; typical batch result 660 μg/mg. Higher potency grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Neomycin Sulfate Powder with batch COA and global export support.

Q9: How much does Neomycin Sulfate Powder cost?

A: Bulk pricing depends on fermentation costs, potency/purity grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q10: Is this product for human clinical use?

A: It is supplied as veterinary raw material and is not intended for direct clinical administration. Finished products manufactured from the material must comply with applicable local regulatory requirements.