Sulfachlorpyrazine Sodium API CAS 102-65-8 | ≥98% Veterinary Anticoccidial Agent Supplier China

Key Selling Points

✓ Sulfonamide Antibacterial + Anticoccidial - DHPS Competitive Inhibitor (PABA Antagonist)

✓ First-Line for Poultry Coccidiosis - Eimeria tenella & E. necatrix (Cecal & Intestinal)

✓ Also Effective Against Fowl Cholera & Salmonellosis - Pasteurella + E. coli Coverage

✓ Highly Water-Soluble Sodium Salt - Ideal for Drinking Water Administration (ESB3)

✓ Coccidiostatic Action - Inhibits Parasite Replication, Allows Host Immune Development

✓ Synergistic With TMP/DVD - Potentiated Sulfonamide Formulation Option

What Is Sulfachlorpyrazine Sodium Powder?

Sulfachlorpyrazine Sodium Powder is the sodium salt of sulfachlorpyrazine (sulfaclozine), a water-soluble sulfonamide antibacterial and anticoccidial agent widely used in veterinary medicine.

It is mainly used in poultry production for coccidiosis research and veterinary formulation development, especially against Eimeria species in chickens and other poultry. Due to its high water solubility, it is commonly formulated as soluble powder for drinking-water applications.

Sulfachlorpyrazine Sodium also exhibits antibacterial activity against susceptible bacteria, including Pasteurella multocida, Salmonella species and Escherichia coli. It is often combined with potentiating agents such as trimethoprim for enhanced antimicrobial activity.

How Does Sulfachlorpyrazine Sodium Powder Work?

Sulfachlorpyrazine Sodium Powder works through the classical sulfonamide mechanism by competitively inhibiting dihydropteroate synthase (DHPS), a key enzyme involved in microbial folic acid biosynthesis.

By mimicking para-aminobenzoic acid (PABA), it blocks folate production required for the synthesis of nucleic acids and microbial cell growth. This mechanism provides selective activity against bacteria and coccidian parasites that rely on de novo folate synthesis.

In coccidia, Sulfachlorpyrazine Sodium acts mainly as a coccidiostatic agent, inhibiting parasite development and reducing oocyst production. When combined with diaminopyrimidine compounds such as trimethoprim (TMP) or diaveridine (DVD), it creates a sequential folate-pathway blockade with enhanced antibacterial and anticoccidial activity.

What Are the Applications of Sulfachlorpyrazine Sodium Powder?

Poultry Coccidiosis: Prevention and treatment of cecal coccidiosis (Eimeria tenella) and intestinal coccidiosis (E. necatrix, E. maxima, E. acervulina) in chickens, turkeys and pigeons.
Fowl Cholera: Treatment of Pasteurella multocida infections in poultry, including acute septicemic and chronic forms.
Salmonellosis & Colibacillosis: Adjunct treatment of fowl typhoid (Salmonella gallinarum), paratyphoid (Salmonella spp.) and E. coli infections in poultry.
Rabbit Coccidiosis: Prevention and treatment of intestinal and hepatic coccidiosis in rabbits.
Potentiated Formulations: API for soluble-powder combinations with TMP or DVD for enhanced antibacterial and anticoccidial spectrum.

What Is the Difference Between Sulfachlorpyrazine Sodium and Sulfadimidine Sodium?

Feature	Sulfachlorpyrazine Sodium	Sulfadimidine Sodium
CAS	102-65-8	1981-58-4
Molecular Formula	C₁₀H₈ClN₄NaO₂S	C₁₂H₁₃N₄NaO₂S
Molecular Weight	306.70	300.31
Heterocycle	Chloropyrazine	Dimethylpyrimidine
Primary Use	Coccidiosis + bacterial	Bacterial (broad)
Anticoccidial Activity	Strong (first-line)	Weak-moderate
Water Solubility	High (freely soluble)	High
Typical Species	Poultry, rabbit	All species
ESB3 Association	Yes (originator)	No

How Does Sulfachlorpyrazine Compare With Other Poultry Coccidiostats?

Feature	Sulfachlorpyrazine	Amprolium	Toltrazuril	Diclazuril
CAS	102-65-8	121-25-5	69004-03-1	101831-37-2
Class	Sulfonamide	Thiamine analog	Triazinone	Benzeneacetonitrile
Mechanism	DHPS / folate	Thiamine uptake	Nuclear division	Cell wall
Action	Coccidiostatic	Coccidiostatic	Coccidiocidal	Coccidiocidal
Eimeria tenella	Excellent	Good	Excellent	Excellent
Bacterial Activity	Yes (Pasteurella, E. coli)	No	No	No
Water Soluble	Yes	Yes	Poor	Poor
Resistance Risk	Moderate	High	Moderate	Low

How Is Sulfachlorpyrazine Sodium Powder Manufactured?

Sulfachlorpyrazine Sodium Powder is manufactured through chemical synthesis involving acetylation of sulfanilamide, coupling with a chloropyrazine intermediate, deprotection and sodium salt formation.

Raw Material QC → Sulfanilamide Acetylation → 2-Amino-6-chloropyrazine Intermediate → Condensation / Coupling → Deprotection (Deacetylation) → Crude Sulfachlorpyrazine → Sodium Salt Formation (NaOH) → Purification (Recrystallization) → Drying → Milling → Final QC → Packaging

HDM BIO controls key coupling, deprotection, salt formation and crystallization parameters to maintain consistent purity and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to pale yellow powder	Consistent
Assay (HPLC)	≥98.0%	99.0%
Identity (IR / UV)	Conforms to reference standard	Confirmed
Melting Point	~210–215°C (dec.)	212°C
Loss on Drying	≤0.5%	0.2%
Residue on Ignition	≤0.2%	Compliant
Heavy Metals	≤10 ppm	Compliant
Arsenic	≤2 ppm	Compliant
pH (1% solution)	7.5–9.5	8.5
Related Substances	Within specification	Pass
Residual Solvents	Within specification	Pass

What Quality Control Tests Are Performed for Sulfachlorpyrazine Sodium Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity and physical properties.

Raw Material QC → In-Process Control → HPLC Assay → IR / UV Identity Verification → Melting Point Determination → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Arsenic → Residue on Ignition → pH Test → Residual Solvents → Final Batch Release

Key evaluations include identification via infrared (IR) and ultraviolet (UV) spectroscopy, HPLC active content assay, melting point determination, related substances analysis, loss on drying, heavy metal and arsenic limits, residue on ignition, pH and residual solvent testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Sulfachlorpyrazine Sodium Powder Bulk Price?

Sulfachlorpyrazine Sodium Powder bulk pricing is driven by several key factors:

Synthesis Costs: Multi-step chemical synthesis including sulfanilamide acetylation, chloropyrazine coupling and deprotection directly influences manufacturing expenses.
Purity & Grade: Higher purity (≥99%) and pharmaceutical-grade batches command premiums over standard veterinary grade.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price.
Order Volume: Large-scale veterinary pharmaceutical contracts receive steeper per-kilogram discounts than small-batch orders.
Logistics & Geography: Light-protected packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Sulfachlorpyrazine Sodium Powder Supplier?

High-purity (≥98% / typical 99%) sulfonamide with proven anticoccidial and antibacterial efficacy
First-line agent for poultry coccidiosis (Eimeria tenella) and fowl cholera
Highly water-soluble sodium salt - ideal for drinking-water administration (ESB3 standard)
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: kilogram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Sulfachlorpyrazine Sodium Powder

Q1: What is Sulfachlorpyrazine Sodium Powder?

A: The sodium salt of sulfachlorpyrazine (sulfaclozine), a sulfonamide antibacterial and anticoccidial agent (ESB3), used primarily for poultry coccidiosis and bacterial infections.

Q2: What is the CAS number?

A: 102-65-8 (sulfachlorpyrazine base); the sodium salt is CAS 23307-72-4.

Q3: How does sulfachlorpyrazine work?

A: It competitively inhibits dihydropteroate synthase (DHPS), blocking PABA utilization and folic acid synthesis in bacteria and coccidia, which must synthesize folate de novo.

Q4: What is sulfachlorpyrazine used for?

A: Primarily poultry coccidiosis (Eimeria tenella, E. necatrix), plus fowl cholera (Pasteurella), salmonellosis and E. coli infections. Also used for rabbit coccidiosis.

Q5: Is sulfachlorpyrazine coccidiocidal or coccidiostatic?

A: It is primarily coccidiostatic - it inhibits coccidial replication rather than killing the parasite, allowing the host to develop natural immunity.

Q6: What documents are provided with each batch?

A: Batch-specific COA, HPLC report, IR/UV identity records, melting point data, MSDS/SDS and relevant export documentation.

Q7: What purity do you supply?

A: Standard ≥98% HPLC; typical batch result 99%. Higher grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Sulfachlorpyrazine Sodium Powder with batch COA and global export support.

Q9: How much does Sulfachlorpyrazine Sodium Powder cost?

A: Bulk pricing depends on synthesis costs, purity/grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q10: Are there any safety concerns?

A: As a sulfonamide, it may cause crystalluria and renal effects with prolonged use or inadequate water intake. Hematological effects are possible. Ensure continuous water access and observe withdrawal periods. Not for direct clinical administration.