High-Purity Dihexa Powder | GMP-Compliant Research Compound for Cognitive & Neuroplasticity Research | Global Wholesale Supplier

Core Benefits

High-purity blood-brain barrier–penetrating peptide featuring excellent stability and bioactivity▕ GMP compliant manufacturing▕ flexible worldwide supply

Product Overview

Dihexa Powder (PNB-0408), derived from Angiotensin IV, is a chemically optimized peptide designed for neuroplasticity and cognitive research. Despite its name "dipeptide," it is a modified oligomer peptide with three backbone structures. N-terminal hexanoylation and C-terminal aminohexanamide modifications enhance stability and improve BBB permeability, solving the common limitations of traditional neuropeptides (poor CNS penetration, low bioavailability).

Mechanistically, Dihexa Powder binds hepatocyte growth factor (HGF) with high affinity, allosterically enhancing c-Met receptor activation. This facilitates synaptic formation, neuronal survival, and neuroinflammation control, supported by preclinical studies. The product strictly follows GMP standard.

COA

Appearance	White to off White powder	Consistent
Purity (HPLC)	≥98.0%	99.11%
MS	Consistent	Consistent
Conclusion	The product complies with the requirements

Mechanism of Action

▲Target Binding: Dihexa Powder penetrates the BBB and binds HGF with high affinity, modulating c-Met signaling allosterically.

▲Signal Activation: HGF/c-Met activation triggers downstream pathways, promoting synaptogenesis and neuronal survival while reducing inflammation.

▲Sustained Effect: Structural modification enhances stability and resistance to enzymatic degradation, ensuring consistent research outcomes.

Product Applications

● Neuroplasticity research: Synapse formation, dendritic spine density, neuronal connectivity studies.

● Cognitive function research: Animal models of cognitive impairment, mechanistic studies, intervention screening.

● Neuroprotection: Neurodegeneration models, neuronal survival assays, intervention studies.

● Neuroinflammation regulation: Glial cell activation, cytokine modulation studies.

● Peptide formulation development: Oral, injectable, and blood-brain-barrier-targeting formulations.

Detailed Efficacy

Dihexa Powder is a potent synthetic neurotrophic peptide engineered for targeted brain health support, with proven scientific backing for cognitive optimization and neural protection.

● Enhance Memory & Focus: Activates BDNF‑related pathways, boosts hippocampal synaptic plasticity to improve learning speed, working memory and mental clarity, relieving brain fog and cognitive fatigue.

● Protect & Repair Neurons: Fights oxidative stress and neuroinflammation, prevents neuronal loss, accelerates synaptic reconstruction and damaged brain circuit recovery.

● Regulate Mood & Anti‑Stress: Modulates central stress responses, eases anxiety and mental exhaustion, improves emotional stability and mental resilience.

● Delay Brain Aging: Sustains long‑term neural vitality, slows age‑related cognitive decline and neural atrophy for lasting brain youthfulness.

Core Advantages

▲ Blood-Brain-Barrier Penetration: Optimized structure enables efficient CNS delivery without carriers.

▲ Mechanism Clarity & Research Value: High-affinity HGF binding, allosteric c-Met enhancement, supports synaptogenesis, neuronal survival, neuroinflammation control.

▲ Stability & Bioavailability: Structural modifications increase half-life and oral bioavailability , suitable for oral, IP injection, and in vitro applications.

▲ High Purity & Reliable Data: Third-party verified, consistent batch-to-batch reproducibility.

Quality Assurance

● High‑Grade Purity Verification: Strict impurity control of residual solvents, heavy metals and microbial limits, meeting research‑grade and pharmaceutical‑intermediate‑grade requirements.

● Third‑Party Independent Testing: Authorized third‑party laboratory validates molecular identity, purity and stability; complete test reports support experimental reproducibility and regulatory review.

● GMP Compliant Production: Manufactured under standardized GMP‑aligned workshops, following the strict quality guidelines, with traceable production records covering synthesis, purification and packaging.

● Complete Documentation Support: Full set of official documents including COA, MSDS, HPLC chromatogram, NMR spectrum, impurity profile and batch records for cross‑border customs clearance and academic research use.

● Stable Batch Consistency: Optimized synthesis process and structural modification technology guarantee uniform bioavailability and long‑term storage stability, avoiding efficacy fluctuation between batches.

FAQ

Q1: How soluble and stable is Dihexa Powder?
A1: Highly soluble in DMSO (100mg/ml) and MeOH. Stable as powder at –20℃ for 2 years; DMSO stock –80℃ (1 year) / –20℃ (1 month). Avoid repeated freeze-thaw cycles.

Q2: Can I trust batch-to-batch consistency?
A2: Yes. Each batch undergoes multi-stage RP-HPLC purification, HPLC purity verification, and third-party testing for reproducible bioactivity.

Q3: Does it penetrate the blood-brain barrier without a carrier?
A3: Yes. Optimized molecular structure ensures efficient BBB penetration, eliminating the need for additional delivery carriers.