Sincalide Acetate Powder CAS 25126‑32‑3 | High Purity CCK‑8 Octapeptide Cholecystokinin Receptor Agonist Supplier China

Core Selling Points

✅ ≥98% HPLC Purity Salmon Calcitonin Powder with Batch‑Specific COA Available

✅ Verified by HPLC, LC‑MS and Structural Analysis for Peptide Identity Confirmation

✅ China Peptide Manufacturer with Fmoc‑SPPS Production & GMP‑Compliant Quality System

✅ Specialized in Complex 32‑Mer Disulfide‑Bonded Salmon Calcitonin Peptide Synthesis and Purification

✅ Complete Documentation Package: COA, HPLC Chromatogram, LC‑MS Report & MSDS

✅ Flexible Supply from Research Samples to Bulk Peptide Orders Worldwide

What Is Sincalide Acetate Powder?

Sincalide Acetate powder, also widely known as CCK‑8 peptide, is a synthetic sulfated‑tyrosine‑containing octapeptide corresponding to the biologically active C‑terminal fragment of human cholecystokinin (CCK) hormone. It acts as a potent CCK‑A / CCK‑B receptor agonist, triggering gallbladder contraction, pancreatic enzyme secretion and participating in central appetite‑regulating neuroendocrine signaling. It is extensively used in gastrointestinal hormone mechanism research, CCK receptor pharmacology, pancreatic‑gallbladder pre‑clinical models and peptide structure‑activity‑relationship investigation.

Manufactured via optimized Fmoc solid‑phase peptide synthesis under our GMP‑aligned quality system, our Sincalide Acetate powder strictly controls methionine oxidation, tyrosine desulfation impurity, deletion truncates and C‑terminal de‑amidated variants, securing stable biological receptor‑binding activity and consistent batch‑to‑batch performance. HDM BIO serves global biochemistry laboratories, pharmaceutical R&D institutions and biological‑reagent manufacturers, covering milligram‑level research samples up to kilogram‑scale worldwide bulk procurement. This peptide raw material is restricted exclusively to laboratory research use and must not be directly used for human clinical administration.

What Are the Official Quality Specifications of Sincalide Acetate Powder?

Every production batch of Sincalide Acetate undergoes multi‑level QC testing including HPLC, LC‑MS and structural analysis within HDM BIO in‑house analytical laboratory. Batch‑specific COA will be issued for all purchase orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.57%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Sincalide Acetate vs Other CCK‑Related Regulatory Peptides

For buyers sourcing gastrointestinal‑neuroendocrine peptide raw materials for CCK‑receptor pharmacology research, the comparison table clarifies core differences for targeted raw‑material selection：

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Sincalide Acetate	CCK‑A / CCK‑B full agonist, stimulate gallbladder & pancreatic secretion	8‑mer octapeptide, sulfated‑Tyr, dual‑Met residues, C‑terminal amidation	Gastrointestinal hormone assay, CCK receptor binding, gall‑bladder contraction pre‑clinical model	25126‑32‑3
Desulfated Sincalide (CCK‑8‑ns)	Preferential CCK‑B receptor agonist	Octapeptide without tyrosine sulfate group	Central nervous system CCK‑B receptor research	Custom
CCK‑4	Selective CCK‑B short agonist	4‑mer C‑terminal fragment peptide	Anxiety‑related neuroendocrine screening	51743‑74‑9

This section covers long‑tail keywords: sincalide acetate CCK‑8 raw peptide, sulfated tyrosine octapeptide research material, cholecystokinin receptor agonist peptide.

How to Buy Sincalide Acetate Powder from a Trustworthy Supplier?

When sourcing Sincalide Acetate powder for gastrointestinal endocrinology and CCK‑receptor pre‑clinical research, R&D teams and international purchasers need to assess five core criteria to avoid supply‑quality risks:

HPLC purity validation: Confirm ≥98% HPLC purity with batch‑specific COA and full impurity chromatogram; pay special attention to tyrosine desulfation by‑product and dual‑methionine oxidative variants which will sharply reduce receptor‑binding bioactivity
Multi‑method structural confirmation: Peptide identity validated by HPLC, LC‑MS and structural analysis to confirm full‑length octapeptide, intact tyrosine‑sulfate modification and complete C‑terminal amidation
Complete batch documentation package: Guarantee each order obtains batch‑specific COA, HPLC chromatogram, LC‑MS report and MSDS to satisfy global import customs clearance and lab audit requirements
Qualified manufacturing system: Select China peptide manufacturer with mature Fmoc‑SPPS workflow and GMP‑aligned quality system, proven track record on sulfated‑tyrosine modification and dual‑methionine‑containing amidated peptide synthesis
Global flexible supply: Confirm vendor can deliver both small‑scale research samples and large‑volume worldwide bulk peptide orders

HDM BIO provides research‑grade Sincalide Acetate with full traceable quality records, flexible MOQ for lab trial batches and long‑term worldwide bulk procurement.

Sincalide Acetate Powder Price & Bulk Ordering Guide 2026

If you are searching for Sincalide Acetate powder price, bulk quotation and delivery terms, please refer to key procurement information as follows:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑scale research samples available; kilogram‑level worldwide bulk supply for sustained research projects
Sample Access: Trial research samples for lab evaluation; contact sales team to get formal sample quotation
Bulk Kilogram Pricing: Tiered pricing structure; larger bulk volume brings competitive unit price
Production Lead Time: Special handling required for sulfated‑tyrosine, dual‑methionine oxidation‑prone octapeptide; sales will confirm exact production schedule upon formal inquiry
Shipping Options: Sealed cold‑recommended shipping worldwide; avoid prolonged room‑temperature exposure; we supply complete documentation package (batch‑specific COA, HPLC chromatogram, LC‑MS report, MSDS, commercial invoice, packing list) for global customs clearance

Sincalide Acetate Powder Procurement Guide for Global Buyers

Before placing purchase orders for sulfated‑tyrosine‑containing CCK‑8 octapeptide raw materials, international procurement teams should finish these verification steps to mitigate potential risks:

Supplier qualification check: Confirm the manufacturer owns independent peptide‑synthesis workshop and QC lab with GMP‑aligned quality system, hands‑on experience on tyrosine sulfate modification protection, dual‑methionine oxidation suppression and C‑terminal amidation process
Document inspection: Request pre‑shipment complete documentation package including batch‑specific COA, HPLC chromatogram, LC‑MS report and MSDS; require multi‑method peptide identity confirmation, sulfation‑integrity verification and related‑substance impurity profile including desulfated‑Tyr and Met‑oxidation impurities
Product confirmation: Confirm purity standard, sulfation retention rate, impurity profile and cold‑storage requirement match your experimental design; aqueous reconstituted solution accelerates methionine oxidation and tyrosine desulfation
MOQ & lead‑time confirmation: Verify research sample / bulk peptide worldwide availability, special modified‑peptide production cycle and order‑adjustment policy
Shipping‑document confirmation: Make sure supplier can provide complete paperwork set to satisfy import requirements of your target region

About HDM BIO Sincalide Acetate Manufacturing Capability

HDM BIO possesses more than 10‑year expertise in Fmoc‑SPPS peptide synthesis under GMP‑aligned quality system, specialized in complex post‑translationally modified sulfated‑tyrosine endocrine‑hormone peptide manufacturing.

Dedicated Fmoc‑SPPS production lines; adopt stable sulfated‑tyrosine building‑block protection strategy; full‑process inert‑atmosphere antioxidant protection for two methionine residues; controlled C‑terminal amidation setup for high amidation yield
Independent analytical laboratory equipped with HPLC, LC‑MS and structural analysis instruments; specialized workflow for peptide identity confirmation, sulfate‑group integrity validation and dual‑Met oxidative‑impurity quantification
Peptide products exported worldwide to over 70 countries, supporting university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team experienced in CCK‑family peptide‑series synthesis, sulfate‑modification preservation and related analog custom modification

What Technical Challenges Exist in Sincalide Acetate Synthesis & Production?

Sincalide Acetate is a complex modified octapeptide carrying acid‑labile tyrosine‑O‑sulfate group plus two oxidation‑sensitive methionine residues and C‑terminal argininamide. Controlling tyrosine desulfation degradation, dual‑site methionine oxidative by‑products, amino‑acid deletion impurities and high‑yield C‑terminal amidation constitute core technical bottlenecks separating qualified peptide manufacturers from low‑grade suppliers.

Key production challenges:

‑ Tyrosine sulfate moiety is chemically labile under acidic cleavage and purification conditions; inappropriate pH will trigger desulfated‑Tyr inactive impurity which closely co‑elutes with main‑peak in conventional HPLC

‑ Two independent methionine residues in one sequence are highly susceptible to oxidation during cleavage, purification and lyophilization; multiple oxidized‑Met variants are difficult to fully separate

‑ Risk of incomplete C‑terminal amidation generating inactive acid‑form impurity ‑ Sulfated‑tyrosine brings strong polarity shift, increasing difficulty in preparative

‑HPLC gradient optimization for good impurity separation

‑ Single HPLC test is insufficient for quality judgement; multi‑validation via HPLC, LC‑MS and structural analysis is mandatory to guarantee intact sulfate‑modification, full‑length octapeptide and low oxidation level for CCK‑receptor functional biology assays

How Does Sincalide Acetate Powder Work in Laboratory Research?

As synthetic C‑terminal bioactive fragment of cholecystokinin hormone, Sincalide Acetate powder binds to CCK‑A and CCK‑B receptors, mediates gallbladder smooth‑muscle contraction, stimulates pancreatic digestive‑enzyme release, and participates in central nervous‑system appetite‑related neuroendocrine signaling. It serves as core experimental reagent for CCK‑receptor signaling profiling, gastrointestinal organ bath assays, gall‑bladder‑pancreas pre‑clinical animal‑model studies and sincalide‑ligand structure‑activity‑relationship exploration. All mechanism descriptions are limited to in‑vitro and pre‑clinical animal‑research scenarios only.

How Is Sincalide Acetate Powder Manufactured at HDM BIO?

Sincalide Acetate requires strict full‑process control for sulfated‑tyrosine modification preservation, dual‑methionine anti‑oxidation protection, C‑terminal amidation and pH‑buffered purification across synthesis, cleavage, purification and lyophilization, operated within our GMP‑aligned quality system.

Read related guide: Disulfide‑Containing Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Sincalide Acetate Powder Manufacturing Workflow

Raw‑material QC of Fmoc‑amino‑acid building blocks (pre‑protected sulfated‑Tyr derivative inspection) → Octapeptide SPPS step‑wise coupling with optimized protocol on Rink‑amide resin → Resin cleavage & global deprotection with mild‑pH scavenger additive to suppress tyrosine desulfation, plus antioxidant for methionine protection → Crude peptide pretreatment under inert atmosphere & pH‑buffered solution → Multi‑stage preparative‑HPLC purification (remove desulfated‑Tyr, multi‑site Met‑oxidized by‑products & deletion‑peptide impurities) → Buffer‑exchange for acetate‑salt formation under non‑acidic condition → Vacuum lyophilization under low‑oxygen environment → Full multi‑method QC testing (HPLC, LC‑MS, structural analysis for identity & sulfate‑modification & amidation‑completeness verification, dual‑Met‑oxidation impurity profiling) → Batch‑specific COA issuance → Light‑proof, low‑moisture sealed packaging

QC Inspection Workflow

Incoming raw‑material QC → In‑process sulfation‑loss & methionine‑oxidation risk monitoring → HPLC purity testing → LC‑MS molecular‑weight, full‑sequence & amidation‑completeness verification → Supplementary structural analysis for sulfated‑tyrosine integrity confirmation → Desulfated‑Tyr & multi‑site‑methionine‑oxidized impurity quantitative analysis → Moisture & heavy‑metal testing → Residual‑solvent detection → Final batch‑release approval under GMP‑aligned quality system

Core Process Highlights

‑ Specialized building‑block protection & mild‑pH cleavage system to preserve labile tyrosine‑O‑sulfate modification ‑ Full‑workflow inert‑atmosphere & scavenger protection to minimize dual‑methionine oxidative degradation ‑ Controlled C‑terminal arginine amidation to secure high ratio of active amidated target peptide ‑ Multi‑step high‑resolution HPLC to separate structurally‑similar desulfated‑Tyr variants and multiple methionine‑oxidation by‑products ‑ Multi‑level identity confirmation: HPLC, LC‑MS plus structural analysis verifying full‑length intact octapeptide, intact sulfate‑modification and complete C‑terminal amidation ‑ Lyophilized solid stable stored at −20 °C under inert sealing; aqueous solution highly susceptible to desulfation and Met oxidation, aliquot and store at −80 °C immediately after reconstitution, avoid repeated freeze‑thaw cycles.

What Are the Main Application Scenarios of Sincalide Acetate Powder?

Gastrointestinal endocrinology research: CCK‑A / CCK‑B receptor binding assay, gallbladder contraction organ‑bath test, pancreatic enzyme‑secretion pharmacology, sincalide analog structure‑activity‑relationship exploration
Digestive‑system pre‑clinical research: Gall‑bladder‑pancreas function evaluation, cholecystokinin‑related gastrointestinal disorder animal‑model intervention
Neuroendocrine & appetite regulation research: Central CCK‑B receptor signaling, satiety‑regulating neuro‑peptide mechanism investigation
Peptide formulation development: Lyophilized‑formulation feasibility research, sulfated‑peptide delivery‑system development
Biomedical reagent preparation: Laboratory reference standards and experimental‑control reagents for CCK‑family peptide research
Post‑translation‑modified‑peptide‑process‑development research: Sulfated‑tyrosine & dual‑methionine‑containing amidated peptide synthesis & impurity‑control benchmark compound

Why Choose HDM BIO As Your Sincalide Acetate Powder Supplier?

10+‑year China‑based peptide‑manufacturing experience with Fmoc‑SPPS production and GMP‑compliant quality system
Specialized capability for complex 29‑mer C‑terminal‑amidated sermorelin acetate peptide synthesis and purification, effectively reduce sequence‑deletion, methionine‑oxidized by‑products and de‑amidated impurities
Every batch supported by multi‑validation: HPLC, LC‑MS and structural analysis, delivered with batch‑specific complete documentation package ‑ Complete batch‑wise production‑traceability documents for Sermorelin Acetate Powder
Flexible worldwide supply capacity: research samples to kilogram‑scale bulk peptide orders ‑ Global‑export service covering more than 70 countries worldwide
Professional technical team supporting GHRH‑family peptide research and custom‑analog synthesis consulting

FAQs About Sincalide Acetate Powder

Q: Where can I buy Sincalide Acetate powder from China?

A: HDM BIO is a Chinese peptide manufacturer with Fmoc‑SPPS production and GMP‑aligned quality system, specialized in complex sulfated‑tyrosine‑containing CCK‑8 octapeptide. We deliver high‑purity Sincalide Acetate powder for global pharmaceutical R&D teams and bioreagent laboratories, flexible worldwide supply from research samples to bulk peptide orders.

Q: What documents should a qualified Sincalide Acetate supplier provide?

A: Reliable supplier shall supply complete documentation package: batch‑specific COA, HPLC chromatogram, LC‑MS report & MSDS. Peptide identity is verified by HPLC, LC‑MS and structural analysis; desulfated‑Tyr, multi‑site‑methionine‑oxidized and de‑amidated impurity‑testing data are available upon request.

Q: What is the CAS number of Sincalide Acetate Powder?

A: The CAS registry number of Sincalide Acetate Powder is 25126‑32‑3.

Q: What purity grade of Sincalide Acetate powder can you deliver?

A: Standard research‑grade ≥98% HPLC purity. Every batch comes with batch‑specific COA and multi‑method identity validation including sulfate‑modification integrity check. Higher‑purity specifications and CCK‑series custom‑peptide‑analog synthesis are available for special experimental requirements.

Q: How should lyophilized Sincalide Acetate powder be stored?

A: Store sealed under inert atmosphere at −20 °C, keep away from light and moisture. Strictly avoid repeated freeze‑thaw cycles. Aqueous reconstituted solution is highly susceptible to tyrosine desulfation and dual‑methionine oxidation; prepare single‑use aliquots and store at −80 °C, long‑term storage under 2‑8 °C is not recommended.

Q: Can I get Sincalide Acetate research samples before bulk purchase?

A: Yes. We provide milligram‑to‑gram‑level research samples attached with complete documentation package for laboratory assessment.

Q: What is the MOQ for bulk Sincalide Acetate powder worldwide orders?

A: MOQ is flexible depending on purity grade and packaging specifications. We support small‑scale research samples and large‑volume worldwide bulk peptide orders for different‑project requirements.

Q: What is the amino‑acid sequence of Sincalide Acetate Powder?

A: H‑Asp‑Tyr(SO₃H)‑Met‑Gly‑Trp‑Met‑Asp‑Phe‑NH₂,C‑terminal amidated, tyrosine sulfated.

Scientific Review

Reviewed by:

HDM BIO Peptide Technical Team

Expertise:

Fmoc‑SPPS peptide synthesis Complex long‑chain aggregation‑prone disulfide‑bonded amylin‑family peptide manufacturing Multi‑method peptide characterization: HPLC, LC‑MS and structural analysis

Last Updated: August 2026

Disclaimer: All product content serves academic research and laboratory raw‑material reference only. Not for human clinical use, diagnosis or treatment.