Linaclotide Acetate Powder CAS 851199‑60‑5 | High Purity GC‑C Agonist Peptide Supplier China

Core Selling Points

✅ ≥98% HPLC Purity Research‑Grade Peptide Material

✅ LC‑MS Full Cyclic Octapeptide Sequence & Disulfide Bond Verification

✅ Batch‑Specific COA, HPLC & MS Test Reports Available

✅ Optimized Fmoc SPPS Cyclization Workflow, In‑house Independent QC Laboratory

✅ Global Export Documentation & Cross‑border Cold‑chain Logistics Support

✅ Custom Peptide Purification & Salt‑form Adjustment Service

What Is Linaclotide Acetate Powder?

Linaclotide Acetate powder is a synthetic 14‑amino‑acid cyclic peptide acetate salt, stabilized by three intramolecular disulfide bonds, acting as a potent guanylate cyclase‑C (GC‑C) receptor agonistPMC. It triggers intracellular cGMP elevation within intestinal epithelial cells, widely adopted for gastrointestinal physiology research, constipation‑related mechanism studies, and irritable bowel syndrome pre‑clinical assay developmentPMC.

Manufactured by optimized Fmoc solid‑phase peptide synthesis, regioselective oxidative folding and multi‑stage gradient HPLC salt‑switch purification, our Linaclotide Acetate powder maintains correct triple disulfide‑bond connectivity, compact bioactive conformation and consistent batch‑to‑batch biochemical performance. HDM BIO serves global biotech labs and pharmaceutical R&D teams with lab‑scale sample supply and large‑volume bulk procurement. This peptide raw material is strictly limited to laboratory research use only and cannot be directly applied for human clinical administration.

What Are the Official Quality Specifications of Linaclotide Acetate Powder?

Each production batch of Linaclotide Acetate undergoes dual QC testing (HPLC + LC‑MS) within HDM BIO analytical laboratory. Exclusive batch COA will be issued for all bulk procurement orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.88%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Linaclotide Acetate vs Other GC‑C Targeting Peptides

For buyers sourcing cysteine‑rich cyclic peptides for gastrointestinal pharmacology research, this comparison clarifies core differences for targeted raw‑material selection:

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Linaclotide Acetate	Potent GC‑C agonist, elevates intestinal cGMP level	14‑mer peptide with three disulfide bonds	Constipation, IBS‑C, gastrointestinal secretion research	851199‑60‑5
Guanylin	Endogenous GC‑C peptide agonist	15‑amino‑acid, two disulfide bonds	Intestinal physiology endogenous ligand comparative assay	147686‑86‑2
Uroguanylin	Endogenous GC‑C receptor activator	16‑amino‑acid, two disulfide bonds	Gut epithelial signaling pathway study	147686‑85‑1

This section covers long‑tail keywords: linaclotide vs guanylin, linaclotide acetate GC‑C peptide, gastrointestinal cyclic peptide raw material.

How to Buy Linaclotide Acetate Powder from a Reliable Supplier?

When sourcing Linaclotide Acetate powder for gastrointestinal pharmacology and gut‑disease pre‑clinical research, R&D teams and international peptide buyers should evaluate five critical criteria to avoid quality and supply risks:

HPLC purity validation: Confirm ≥98% purity alongside complete impurity chromatogram
LC‑MS structural confirmation: Verify full‑length 14‑mer sequence and correct triple disulfide‑bond regioselective connectivity
Batch‑specific documentation: Guarantee each order can be matched with independent COA reports
Mature synthesis capability: Select suppliers with proven experience producing peptides requiring controlled triple disulfide oxidative folding
Global export service: Verify suppliers can provide full supporting documents for customs clearance worldwide

HDM BIO supplies research‑grade Linaclotide Acetate with full quality records, flexible minimum order quantity and worldwide shipping for small trial batches and long‑term bulk procurement.

Linaclotide Acetate Powder Price & Bulk Ordering Guide 2026

Buyers searching for Linaclotide Acetate powder price, bulk peptide quotation and delivery terms can refer to key procurement information below:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑level trial samples available; kilogram bulk supply for continuous research projects
Sample Pricing: Trial samples for laboratory assessment; contact sales team to acquire sample quotation
Bulk Kilogram Quotation: Tiered pricing policy, larger bulk orders enjoy competitive unit cost
Production Lead Time: Standard lead time depends on order volume; sales will confirm exact production schedule upon formal inquiry
Shipping Options: Cold‑chain transportation to maintain multi‑disulfide peptide stability; we provide commercial invoice, packing list and MSDS for global customs clearance

Multiple factors influence the final quotation: purity grade, customized testing requirements, special packaging specifications and cold‑chain logistics fees. Contact our sales team for up‑to‑date formal quotation.

Linaclotide Acetate Powder Procurement Guide for Global Buyers

Before signing purchase contracts for multi‑disulfide‑bond cyclic peptide raw materials, international procurement teams should complete these verification steps to mitigate potential risks:

Supplier verification: Confirm the supplier owns independent peptide synthesis workshop and in‑house QC laboratory
Document inspection: Request pre‑shipment batch COA, HPLC chromatogram and LC‑MS identity report
Product confirmation: Check peptide purity standard, disulfide‑bond mapping report and storage specifications match your experimental design
MOQ & lead time: Confirm stock availability, production cycle and order adjustment policy
Shipping documents: Confirm the supplier can provide all required files for import customs clearance in your region

About HDM BIO Linaclotide Acetate Manufacturing Capability

HDM BIO owns over 10 years of experience focused on Fmoc solid‑phase peptide synthesis and complex cysteine‑rich multi‑disulfide‑bond peptide raw material manufacturing.

Dedicated SPPS production lines optimized for peptides requiring regioselective triple oxidative folding
Independent analytical laboratory equipped with HPLC, LC‑MS, moisture tester and heavy‑metal testing instruments
Peptide products exported to more than 70 countries, serving university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team with rich experience in multi‑cysteine peptide selective oxidation, purification and salt‑form conversion

Our peptide manufacturing facility operates dedicated Fmoc SPPS production lines with in‑house HPLC purification and LC‑MS analytical capability.

What Technical Challenges Exist in Linaclotide Acetate Synthesis & Production?

Linaclotide Acetate is a 14‑residue peptide containing three pairs of disulfide bonds; regioselective oxidative folding is the core technical bottleneck separating qualified peptide manufacturers from low‑grade suppliersPMC.

Core production difficulties include:

Avoiding incorrect disulfide‑bond pairing and generating large quantities of mis‑folded isomer impurities
Preventing intermolecular dimerization and oligomer formation during multi‑step oxidation
Efficient separation of structurally similar mis‑folded variants via multi‑stage chromatography
Controlling peptide degradation during folding and acetate salt‑switch procedure
Reproducible batch‑to‑batch disulfide‑bond configuration and biochemical activity

HDM BIO adopts orthogonal cysteine‑protecting‑group strategy, controlled regioselective oxidative folding protocols, multi‑stage gradient HPLC purification and full‑process LC‑MS monitoring for each batch. This minimizes mis‑paired disulfide impurities and guarantees intact 14‑mer peptide structure and stable batch‑to‑batch quality.

How Does Linaclotide Acetate Powder Work in Laboratory Research?

As a selective guanylate cyclase‑C receptor agonist, Linaclotide Acetate powder binds to GC‑C receptors expressed on intestinal epithelial cells, elevating intracellular cGMP concentration, promoting water and electrolyte secretion into intestinal lumen, accelerating gut transit and modulating visceral pain signaling in pre‑clinical modelsPMC.

It serves as a key experimental reference compound for gastrointestinal secretion research, chronic constipation and IBS‑C mechanism assays, and GC‑C targeted drug‑candidate screening. All mechanism descriptions apply only to in‑vitro and pre‑clinical animal research scenarios.

How Is Lanreotide Powder Manufactured at HDM BIO?

Linaclotide Acetate requires strict process control over amino‑acid coupling, regioselective multi‑disulfide‑bond folding and acetate salt conversion.

Read related guide: Modified Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Linaclotide Acetate Manufacturing Workflow

Raw Material Inspection → 14‑mer Peptide SPPS Stepwise Coupling → Resin Cleavage & Global Deprotection → Regioselective Triple Disulfide‑Bond Oxidative Folding → Multi‑stage HPLC Purification → Acetate Salt‑form Conversion → Vacuum Lyophilization → Full QC Testing → Batch COA Issuance → Sealed Light‑Proof Packaging

QC Inspection Workflow

Incoming Raw Material QC → In‑process coupling & oxidative folding monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification → Disulfide‑bond peptide mapping → Moisture & Heavy‑Metal Testing → Residual Solvent Detection → Final Batch Release Approval

Core Process Highlights

Orthogonal cysteine protection scheme to improve disulfide‑bond pairing selectivity

Controlled oxidative folding to reduce mis‑folded isomers and peptide dimer by‑products

Multi‑stage high‑precision HPLC purification removes structurally similar folding variants

Full‑structure LC‑MS & peptide‑mapping verification confirms correct triple‑disulfide connectivity

Vacuum lyophilization and light‑proof sealed packaging preserve multi‑disulfide peptide stability during transport and low‑temperature storage

What Are the Main Application Scenarios of Linaclotide Acetate Powder?

Gastrointestinal pharmacology research: GC‑C receptor signaling, intestinal fluid‑secretion and gut‑motility mechanism experiments
Constipation & IBS‑C pre‑clinical study: Visceral hypersensitivity and irritable bowel syndrome model research
Novel gastrointestinal drug screening: Evaluation of GC‑C‑targeted peptide small‑molecule candidate compounds
Biomedical reagent preparation: Laboratory reference standards and experimental control reagents
Peptide formulation research: Oral luminal‑acting peptide delivery system development

Why Choose HDM BIO As Your Linaclotide Acetate Powder Supplier?

10+ years of professional complex multi‑disulfide‑bond peptide raw‑material manufacturing experience in China
Mature orthogonal‑protection regioselective folding process for triple‑disulfide‑bond 14‑mer peptide
Strict full‑structure verification and batch stability control for every production lot
Complete production traceability records for each batch of Linaclotide Acetate
Flexible supply: gram‑level lab samples to kilogram‑level bulk peptide orders
Global export service covering more than 70 countries and regions
Professional technical team supporting gastrointestinal‑pathway peptide research consulting

FAQs About Linaclotide Acetate Powder

Q: Where can I buy Linaclotide Acetate powder from China?

A: HDM BIO is a China‑based complex cyclic peptide supplier providing high‑purity Linaclotide Acetate powder for global pharmaceutical R&D teams and biotech laboratories. We offer small research samples and large bulk orders, supported by complete export documents and worldwide shipping.

Q: What documents should a qualified Linaclotide Acetate supplier provide?

A: Reliable suppliers can offer batch‑specific COA, HPLC purity chromatogram, LC‑MS identity report, disulfide‑bond mapping data, MSDS and complete production traceability records for quality audit and customs clearance.

Q: What is the CAS number of Linaclotide Acetate?

A: The CAS registry number of Linaclotide Acetate is 851199‑60‑5.

Q: What purity grade of Linaclotide Acetate powder can you supply?

A: Standard research grade ≥98% HPLC purity. Higher purity specifications can be customized for special experimental requirements.

Q: How should lyophilized Linaclotide Acetate powder be stored?

A: Store sealed at ‑20 °C, protected from light and moisture. Avoid repeated freeze‑thaw cycles to maintain multi‑disulfide peptide structural stability.

Q: Can I obtain Linaclotide Acetate samples before bulk cooperation?

A: Yes. We provide milligram to gram‑level trial samples attached with complete COA and test documents for laboratory evaluation.

Q: What is the MOQ for bulk Linaclotide Acetate powder?

A: MOQ is flexible based on purity grade and packaging requirements. We support small research batches and large‑scale bulk orders to satisfy different project demands.

Q: What is the amino‑acid sequence of Linaclotide?

A: Cys‑Cys‑Glu‑Tyr‑Cys‑Cys‑Asn‑Pro‑Ala‑Cys‑Thr‑Gly‑Cys‑Tyr‑OH; three disulfide bonds: Cys1‑Cys6, Cys2‑Cys10, Cys5‑Cys13Wikipedia

Scientific Review

Reviewed by: HDM BIO Peptide Technical Team Expertise: Peptide synthesis Multi‑cysteine & triple‑disulfide‑bond cyclic peptide manufacturing Analytical chemistry & HPLC/LC‑MS peptide mapping testing

Last Updated: August 2026

Disclaimer: All product content is provided for academic research and laboratory raw‑material reference only. Not intended for human clinical use, diagnosis or treatment.