Humanin Peptide Powder Manufacturer China | CAS 330936-69-1 High Purity Mitochondrial-Derived Peptide API Supplier

Core Selling Points

✅ ≥98% HPLC Purity Research‑Grade Peptide Material

✅ LC‑MS Full Cyclic Octapeptide Sequence & Disulfide Bond Verification

✅ Batch‑Specific COA, HPLC & MS Test Reports Available

✅ Optimized Fmoc SPPS Cyclization Workflow, In‑house Independent QC Laboratory

✅ Global Export Documentation & Cross‑border Cold‑chain Logistics Support

✅ Custom Peptide Purification & Salt‑form Adjustment Service

What Is Humanin Peptide Powder?

Humanin peptide powder is a synthetic 24‑amino‑acid mitochondrial‑derived bioactive peptide. Originally identified from surviving brain tissue of Alzheimer's‑disease‑resistant patients, it exerts broad cytoprotective, anti‑apoptotic and metabolic‑regulating bioactivities through multiple intracellular receptor‑dependent and protein‑interaction pathways. Rich in hydrophobic leucine repeats, methionine and cysteine residues, this peptide is widely used for neurodegeneration, aging biology, insulin‑sensitivity and cell‑stress response pre‑clinical researchPMC.

Manufactured by optimized Fmoc solid‑phase peptide synthesis with special side‑chain protection for oxidation‑prone Met‑1 and Cys‑8 residues, multi‑stage gradient HPLC purification and strict lyophilization process, our Humanin peptide powder minimizes oxidation, dimer and deletion‑sequence impurities, delivering stable biochemical performance and consistent batch‑to‑batch quality. HDM BIO serves global biotech labs and pharmaceutical R&D teams with lab‑scale sample supply and large‑volume bulk procurement. This peptide raw material is strictly limited to laboratory research use only and cannot be directly applied for human clinical administration.

What Are the Official Quality Specifications of Humanin Peptide Powder?

Each production batch of Humanin Peptide undergoes dual QC testing (HPLC + LC‑MS) within HDM BIO analytical laboratory. Exclusive batch COA will be issued for all bulk procurement orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.98%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Humanin vs Other Mitochondrial‑Derived Peptides

For buyers sourcing mitochondrial‑derived peptides for aging and cytoprotection pharmacology research, this comparison clarifies core differences for targeted raw‑material selection:

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Humanin	Anti‑apoptotic, neuro‑protective, improves insulin sensitivity; modulates Bax, JAK/STAT‑3 signaling	24‑aa mitochondrial‑derived peptide, contains Met & Cys residue	Alzheimer's disease, aging, metabolic disorder, oxidative‑stress cell‑model research	330936‑69‑1
MOTS‑c	Regulates glucose metabolism, mitochondrial energy homeostasis	16‑amino‑acid mitochondrial‑derived peptide	Exercise‑mimetic, insulin resistance, skeletal‑muscle physiology study	162117‑66‑4
HNG (Humanin S14G analog)	Enhanced Humanin variant, ~1000‑fold higher neuro‑protective potency	Single‑point S14G mutated Humanin sequence	Comparative structure‑activity relationship assay, high‑potency cytoprotection screening	Custom synthesized

This section covers long‑tail keywords: humanin vs mots‑c, humanin mitochondrial‑derived peptide, humanin peptide for aging research.

How to Buy Humanin Peptide Powder from a Reliable Supplier?

When sourcing Humanin peptide powder for neurodegenerative, aging‑biology and metabolic pre‑clinical research, R&D teams and international peptide buyers should evaluate five critical criteria to avoid quality and supply risks:

HPLC purity validation: Confirm ≥98% purity alongside complete impurity chromatogram, special attention to methionine‑oxidation and cysteine‑dimer impurities
LC‑MS structural confirmation: Verify full‑length 24‑mer peptide sequence and exclude truncated deletion‑sequence by‑products
Batch‑specific documentation: Guarantee each order can be matched with independent COA reports
Mature synthesis capability: Select suppliers with proven experience producing oxidation‑sensitive hydrophobic‑rich long‑mer peptides
Global export service: Verify suppliers can provide full supporting documents for customs clearance worldwide

HDM BIO supplies research‑grade Humanin Peptide with full quality records, flexible minimum order quantity and worldwide shipping for small trial batches and long‑term bulk procurement.

Humanin Peptide Powder Price & Bulk Ordering Guide 2026

Buyers searching for Humanin peptide powder price, bulk peptide quotation and delivery terms can refer to key procurement information below:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑level trial samples available; kilogram bulk supply for continuous research projects
Sample Pricing: Trial samples for laboratory assessment; contact sales team to acquire sample quotation
Bulk Kilogram Quotation: Tiered pricing policy, larger bulk orders enjoy competitive unit cost
Production Lead Time: Standard lead time depends on order volume; sales will confirm exact production schedule upon formal inquiry
Shipping Options: Cold‑chain transportation required for this oxidation‑sensitive peptide; we provide commercial invoice, packing list and MSDS for global customs clearance

Multiple factors influence the final quotation: purity grade, customized testing requirements, special packaging specifications and cold‑chain logistics fees. Contact our sales team for up‑to‑date formal quotation.

Humanin Peptide Powder Procurement Guide for Global Buyers

Before signing purchase contracts for oxidation‑sensitive hydrophobic peptide raw materials, international procurement teams should complete these verification steps to mitigate potential risks:

Supplier verification: Confirm the supplier owns independent peptide synthesis workshop and in‑house QC laboratory with experience handling Met/Cys‑containing peptides
Document inspection: Request pre‑shipment batch COA, HPLC chromatogram and LC‑MS identity report; ask for oxidized‑impurity testing data if required by your assay
Product confirmation: Check peptide purity standard, impurity profile and strict cold‑storage specifications match your experimental design
MOQ & lead time: Confirm stock availability, production cycle and order adjustment policy
Shipping documents: Confirm the supplier can provide all required files for import customs clearance in your region

About HDM BIO Humanin Peptide Manufacturing Capability

HDM BIO owns over 10 years of experience focused on Fmoc solid‑phase peptide synthesis and complex oxidation‑sensitive hydrophobic‑rich peptide raw material manufacturing.

Dedicated SPPS production lines optimized for sequences containing oxidation‑prone methionine and cysteine, with hydrophobic leucine repeat regions
Independent analytical laboratory equipped with HPLC, LC‑MS, moisture tester and heavy‑metal testing instruments; extra testing capability for oxidized peptide impurities
Peptide products exported to more than 70 countries, serving university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team with rich experience in difficult‑sequence peptide synthesis, oxidation‑impurity control and custom analog modification (including HNG variant)

Our peptide manufacturing facility operates dedicated Fmoc SPPS production lines with in‑house HPLC purification and LC‑MS analytical capability.

What Technical Challenges Exist in Humanin Peptide Synthesis & Production?

Humanin is a 24‑mer peptide with continuous hydrophobic leucine repeats, one methionine and one free cysteine residue. Oxidation‑related side‑reactions and resin‑bound peptide aggregation represent major technical barriers separating qualified peptide manufacturers from low‑grade suppliers.

Core production difficulties include:

Methionine‑1 is easily oxidized during synthesis, cleavage or lyophilization to form sulfoxide impurity, directly reducing biological activity
Free cysteine‑8 tends to generate intermolecular disulfide‑bond dimer aggregates
Multiple consecutive leucine residues cause peptide‑chain aggregation on resin, leading to incomplete coupling and abundant deletion‑sequence impurities
Strictly controlled lyophilization and low‑moisture packaging to suppress post‑production degradation
Reproducible batch‑to‑batch impurity profile for sensitive cell‑based functional assays

HDM BIO adopts orthogonal side‑chain protection scheme for Met and Cys, low‑load resin plus aggregation‑suppressing coupling additives, multi‑stage gradient HPLC purification and full‑process LC‑MS monitoring for each batch. This minimizes oxidation, dimer and deletion‑sequence impurities and guarantees intact 24‑mer peptide structure and stable batch‑to‑batch quality.

How Does Humanin Peptide Powder Work in Laboratory Research?

As a classic mitochondrial‑derived cytoprotective peptide, Humanin peptide powder executes biological effects through dual mechanisms: cell‑surface trimeric receptor complex (CNTFR/WSX‑1/gp130) triggering JAK2‑STAT3 anti‑apoptotic signaling; and direct intracellular binding to pro‑apoptotic Bax and IGFBP‑3 protein to block mitochondrial‑driven cell‑death cascades. In pre‑clinical models it exhibits neuro‑protection against Alzheimer‑related toxicity, improves insulin sensitivity, relieves oxidative stress damage and modulates aging‑associated cellular phenotypesPLOS.

It serves as a key experimental reference compound for neurodegeneration mechanism research, aging‑related cytoprotection assay, metabolic disorder study and mitochondrial‑derived peptide drug‑candidate screening. All mechanism descriptions apply only to in‑vitro and pre‑clinical animal research scenarios.

How Is Humanin Peptide Powder Manufactured at HDM BIO?

Humanin Peptide requires strict process control for hydrophobic aggregation suppression and oxidation risk reduction throughout synthesis, cleavage, purification and lyophilization.

Read related guide: Modified Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Humanin Peptide Powder Manufacturing Workflow

Raw Material Inspection → 24‑mer Peptide SPPS Stepwise Coupling (aggregation‑suppressing condition, special Met/Cys protection) → Resin Cleavage & Global Deprotection → Crude Peptide Pre‑treatment → Multi‑stage HPLC Purification → Buffer Exchange → Vacuum Lyophilization → Full QC Testing (including oxidation‑impurity check) → Batch COA Issuance → Low‑moisture Sealed Light‑Proof Packaging

QC Inspection Workflow

Incoming Raw Material QC → In‑process coupling & oxidation risk monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification → Oxidized‑impurity quantification → Moisture & Heavy‑Metal Testing → Residual Solvent Detection → Final Batch Release Approval

Core Process Highlights

Special protection strategy for oxidation‑sensitive methionine and cysteine residues

Aggregation‑suppressing coupling condition for continuous leucine hydrophobic sequence

Multi‑stage high‑precision HPLC purification removes deletion‑sequence, oxidized‑Met and peptide‑dimer impurities

Full‑structure LC‑MS verification confirms intact full‑length 24‑mer peptide

Low‑moisture lyophilization and light‑proof sealed packaging, suitable for long‑term‑20 °C cold‑storage, slowing chemical degradation

What Are the Main Application Scenarios of Humanin Peptide Powder?

Neurodegeneration pharmacology research: Anti‑apoptotic neuro‑protection, Alzheimer‑disease‑related neurotoxicity cell‑model experiments
Aging‑biology pre‑clinical study: Mitochondrial‑derived peptide function, oxidative stress and cellular senescence mechanism exploration
Metabolic research: Insulin‑sensitivity regulation, pancreatic‑beta‑cell protection and glucose‑homeostasis assay
Biomedical reagent preparation: Laboratory reference standards and experimental control reagents for mitochondrial‑peptide research
Peptide structure‑activity‑relationship research: Humanin variant screening (HNG analog and other mutants)

Why Choose HDM BIO As Your Humanin Peptide Powder Supplier?

10+ years of professional complex multi‑disulfide‑bond peptide raw‑material manufacturing experience in China
Mature orthogonal‑protection regioselective folding process for triple‑disulfide‑bond 14‑mer peptide
Strict full‑structure verification and batch stability control for every production lot
Complete production traceability records for each batch of Linaclotide Acetate
Flexible supply: gram‑level lab samples to kilogram‑level bulk peptide orders
Global export service covering more than 70 countries and regions
Professional technical team supporting gastrointestinal‑pathway peptide research consulting

FAQs About Humanin Peptide Powder

Q: Where can I buy Humanin peptide powder from China?

A: HDM BIO is a China‑based bioactive peptide supplier providing high‑purity Humanin peptide powder for global pharmaceutical R&D teams and biotech laboratories. We offer small research samples and large bulk orders, supported by complete export documents and worldwide cold‑chain shipping.

Q: What documents should a qualified Humanin peptide supplier provide?

A: Reliable suppliers can offer batch‑specific COA, HPLC purity chromatogram, LC‑MS identity verification report, MSDS and complete production traceability records; oxidized‑met impurity testing data can be provided upon request.

Q: What is the CAS number of Humanin peptide?

A: The CAS registry number of Humanin peptide is 330936‑69‑1.

Q: What purity grade of Humanin peptide powder can you supply?

A: Standard research grade ≥98% HPLC purity. Higher purity specifications and custom analog (such as HNG‑S14G variant) can be customized for special experimental requirements.

Q: How should lyophilized Humanin peptide powder be stored?

A: Store sealed at ‑20 °C, protected from light and moisture. Avoid repeated freeze‑thaw cycles; reconstituted aqueous solution is unstable and recommended for immediate use or stored at ‑80 °C.

Q: Can I obtain Humanin peptide samples before bulk cooperation?

A: Yes. We provide milligram to gram‑level trial samples attached with complete COA and test documents for laboratory evaluation.

Q: What is the MOQ for bulk Humanin peptide powder?

A: MOQ is flexible based on purity grade and packaging requirements. We support small research batches and large‑scale bulk orders to satisfy different project demands.

Q: What is the amino‑acid sequence of Humanin peptide? A: MAPRGFSCLLLLTSEIDLPVKRRA (H‑Met‑Ala‑Pro‑Arg‑Gly‑Phe‑Ser‑Cys‑Leu‑Leu‑Leu‑Leu‑Thr‑Ser‑Glu‑Ile‑Asp‑Leu‑Pro‑Val‑Lys‑Arg‑Arg‑Ala‑OH).

Scientific Review

Reviewed by: HDM BIO Peptide Technical Team Expertise: Peptide synthesis Multi‑cysteine & triple‑disulfide‑bond cyclic peptide manufacturing Analytical chemistry & HPLC/LC‑MS peptide mapping testing

Last Updated: August 2026

Disclaimer: All product content is provided for academic research and laboratory raw‑material reference only. Not intended for human clinical use, diagnosis or treatment.