17α-Estradiol Powder CAS 57-91-0 | High-Purity ≥99% Steroid Estrogen for Preclinical R&D & Pharmaceutical Formulation Development
Core Highlights
High-Purity ≥99% (HPLC) | 17α-Stereoisomer Estrogen | Research & Pharmaceutical Grade | Stable Physicochemical Properties | USP/EP Compliant | Complete Documentation & Global Stable Supply
Product Overview
17α-Estradiol(α-stereoisomer of estradiol) is a high-purity steroid estrogen for preclinical research, R&D, and pharmaceutical formulation development. It exhibits unique stereochemistry, stable physicochemical properties, and strictly controlled impurities, making it ideal for endocrine mechanism studies, cell-based experiments, analytical calibration, and laboratory research.
This high-purity raw material is supplied as a white crystalline powder, odorless, with stable physicochemical properties and strictly controlled impurities. It is widely used in pharmaceutical research, endocrine mechanism studies, life science experiments, analytical calibration, and formulation development.
Produced using multi-step purification and advanced synthesis, this high-purity 17α-Estradiol powder ensures batch-to-batch consistency and excellent solubility in alcohols and ketones, suitable for formulation screening, preclinical studies, and bulk laboratory procurement.Available for global bulk purchase.
COA
| Item | Specification | Result | |
| Appearance | White or off‑white crystalline powder. | Conform | |
| Identification | A: IR | Conform | |
| Solubility | Soluble in ethyl alcohol, acetone; slightly soluble in ether and chloroform; insoluble in water | Conform | |
| Melting range | 223.0 ~ 229.0℃ | 223.1 ~ 224.4℃ | |
| Specific rotation | +51.0° ~ +56.0° | +53.2° | |
| Relate substance Any individual impurity Total impurities |
≤0.2% ≤1.0% |
0.13% 0.28% |
|
| Loss on drying | ≤3.0% | 0.52% | |
| Residual solvents Ethyl acetate Ethyl alcohol |
≤5000 PPm ≤5000 PPm |
820 ppm 160 ppm |
|
| Assay | 97-103%(C18H24O2) | 99.80% | |
| Conclusion | The product complies with the requirements of USP Standard. | ||
Mechanism of Action
17α-Estradiol Powder for preclinical R&D selectively binds estrogen receptor subtypes, modulating gene expression, hormone signaling, and metabolic regulation. Its unique stereochemistry differentiates it from 17β-Estradiol, making it suitable for endocrine mechanism research, drug lead validation, and steroid optimization experiments.Mechanism Highlights:
● Supports estrogen supplementation and endocrine mechanism R&D
● Regulates cell proliferation, differentiation, and metabolic processes in preclinical models
● Facilitates steroid pharmacology, receptor selectivity studies, and drug target validation
Product Applications
1. Scientific & Laboratory Research17α-Estradiol is a premium research-grade estrogen material. Compared with 17β-Estradiol, it has weak estrogenic activity but outstanding anti-aging and neuroprotective effects, widely used in aging, neurobiology, oxidative stress and metabolic mechanism research.
2. Anti-Aging & Neuroprotection DevelopmentIt is used for the research and development of anti-aging and neuroprotective pharmaceuticals. It can relieve neuroinflammation, protect nerve cells and improve age-related cognitive impairment, serving as a key raw material for anti-aging formulation development.
3. Metabolic & Endocrine ResearchThis API is commonly applied in endocrine and metabolic research, including glucose and lipid metabolism regulation. It supports the study of estrogen subtypes' effects on human metabolism and related metabolic diseases.
4. Pharmaceutical Intermediate & FormulationWith high purity and stable properties, 17α-Estradiol acts as a professional steroid intermediate for the synthesis and production of special estrogen pharmaceutical preparations.
Detailed Efficacy
● Preclinical endocrine mechanism research: 17α stereochemistry allows selective study of estrogen receptor subtypes, hormone signaling pathways, and metabolic regulation.
● Preclinical SAR studies comparing 17α- vs 17β-Estradiol: Can be compared with 17β-Estradiol for molecular stereochemistry and bioactivity analysis, supporting drug lead screening.
● Cell-based pharmacology and drug target verification studies: Regulates proliferation and differentiation in cell models, suitable for pharmacological studies and drug target verification.
● Laboratory calibration and analytical standard R&D: High-purity and consistent, ideal for hormone detection, chromatography, and laboratory quality control.
● Preclinical formulation and process optimization studies: Stable physicochemical properties support formulation stability testing, excipient compatibility, and process optimization.
Core Advantages
● High-purity 17α-Estradiol for preclinical R&D and pharmaceutical applications: HPLC purity ≥99%, with strictly controlled residual solvents, heavy metals, and impurities; ideal for precise laboratory experiments and formulation development.
● Stable 17α Stereochemistry: Resistant to oxidation and moisture, ensuring reproducibility in preclinical and pharmaceutical studies.
● Broad Solubility Compatibility: Soluble in alcohols and ketones; adaptable to formulation R&D, chromatographic detection, and laboratory research applications.
● Flexible Supply & Global Delivery: Supports 10g sample orders, small-medium batches, and ton-level long-term contracts; fast processing with international logistics.
● Professional Technical Support.
Quality Assurance
● Multi-Step Strict QC: HPLC purity, related substances, and physicochemical verification for each batch; fully traceable.
● GMP-Compliant Production: Manufactured following GMP and ISO9001 standards; fully adherent to USP/EP guidelines.
● Complete Documentation: COA, HPLC spectra, MSDS, TDS; supports third-party verification and regulatory compliance.
● Full Traceability: Raw material procurement, synthesis, purification, and finished product shipping are monitored to ensure batch consistency.
FAQ
Q1: What are the typical applications of 17α-Estradiol powder?
A: Research in endocrine mechanisms, new drug development, analytical calibration, and academic studies.
Q2: What is 17α-Estradiol powder used for?
A: It is widely used for endocrine mechanism research, new drug development, analytical calibration, and academic experiments. It can also serve as a reference standard for formulation screening and structure-activity relationship studies.
Q3: Can 17α-Estradiol powder be used directly in pharmaceutical formulations?
A: Yes, it can be used as a raw material in laboratory R&D and preclinical studies, supporting formulation development, stability testing, and analytical standard preparation.
factory
Certificates
Shipping & Packing
Order Now | Stable Global Supply
Order 17α-Estradiol powder for preclinical R&D, pharmaceutical formulation development, and laboratory research with bulk purchase options, competitive pricing, and fast delivery to worldwide markets. Free samples, COA documentation, and technical support are available from a reliable supplier.
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