Bulk 2-Methoxyestradiol Powder | Factory Price & Stable Supply
Key Highlights
Endogenous Estradiol Metabolite｜High-Purity Powder｜Anti-Angiogenic｜Research-Grade Steroid API｜For Cell Experiments / Preclinical Drug Development｜Batch Traceable
Product Overview
2-Methoxyestradiol Powder for research-grade preclinical and cell-based R&D (2-Methoxyestradiol API) is an endogenous estradiol metabolite and a small steroidal molecule with no classical estrogen activity, designed for tumor, anti-angiogenic, and pharmacology research. It possesses unique pharmacological properties and is widely used in preclinical tumor, anti-angiogenic, apoptosis, and anti-inflammatory studies, supporting early-stage drug discovery, formulation screening, and cell-based experiments.
2-Methoxyestradiol API is synthesized via refined processes to produce a white, fine crystalline powder. It exhibits stable purity and controlled impurities, adheres to research-grade quality standards, and is provided to global biopharmaceutical R&D institutions, university laboratories, and pharmaceutical companies. and It is suitable for research and formulation development procurement.
COA
| Item | Specification | Result | |
| Characteristics | White or almost white crystalline powder | Conform | |
| Identification | A:IR B:HPLC | Conform | |
| Melting range | 185~190℃ | 189.2~189.7℃ | |
| Water | ≤0.20% | 0.19% | |
| Residue on ignition | ≤0.10% | 0.08% | |
| Heavy metal | ≤20ppm | Conform | |
| Residual solvents Methanol Ethanol Ethyl acetate |
≤3000ppm ≤5000ppm ≤5000ppm |
1738.08 ppm not detected not detected |
|
| Assay | ≥99.0% | 99.15% | |
| Purity | ≥99.0% | 99.51% | |
| Conclusion | The product complies with the requirements of USP Standard. | ||
Mechanism of Action
2-Methoxyestradiol Powder for preclinical research is an endogenous estradiol metabolite formed via catechol O-methyltransferase metabolism. ￭ Structural modification prevents binding to classical estrogen receptors, making it suitable for research-grade tumor, anti-angiogenic, and pharmacology studies. Its primary actions occur via non-receptor pathways:
￭ Binds microtubules, inhibiting cell division in preclinical and in vitro studies, inhibiting assembly and disrupting cell division
￭ Downregulates VEGF, suppressing angiogenesis in research models
￭ Regulates apoptosis via Bcl-2 and Caspase proteins, inducing apoptosis in abnormal cells
￭ Inhibits NF-κB and inflammation pathways for pharmacology research, regulating immune and oxidative stress responses
Applications of 2-Methoxyestradiol API
The 2-Methoxyestradiol Powder is a research-grade steroid API intended exclusively for cell experiments, pharmacology, drug discovery, and academic projects:
￭ Early-stage tumor pharmacology, anti-angiogenic screening, and formulation development for preclinical studies
￭ Cell apoptosis, microtubule dynamics, and inflammation pathway research in vitro
￭ Endocrinology, oncology, and pharmacology research in academic and industrial laboratories
￭ Preclinical compound screening and pilot-scale trials for biopharma R&D
￭ Intermediate for synthesis of fine chemicals and steroid derivatives
Benefits of 2-Methoxyestradiol API
Extensive cell experiments and pharmacological studies confirm that 2-Methoxyestradiol Powder does not exhibit classical estrogen activity. Its biological effects are mediated via multiple pathways:
￭ Anti-angiogenic effect for preclinical R&D: Inhibits abnormal endothelial cell proliferation and blocks new vessel formation in tumor and pathological tissue models
￭ Induces apoptosis in research models: Regulates the cell cycle and suppresses abnormal cell proliferation, invasion, and migration in preclinical and in vitro studies
￭ Anti-inflammatory modulation: Regulates inflammation-related pathways and supports immune microenvironment studies
￭ Microtubule inhibition: Suppresses microtubule polymerization, disrupting cytoskeleton stability and cell division
￭ Oxidative stress regulation: Reduces oxidative damage, providing molecular targets for metabolic and tumor research
￭ Minimal endocrine interference: Does not affect normal hormonal balance, suitable for long-term cell and animal studies
Core Advantages of 2-Methoxyestradiol API
￭ No estrogen activity: Avoids estrogen-related side effects and reduces experimental interference.
￭ Stable and controllable purity: HPLC ≥99.0%, low impurities, consistent across batches, high reproducibility.
￭ Research-friendly API for preclinical and cell-based studies: Fine powder with excellent solubility, ideal for in vitro screening, cell culture assays, and small-scale animal dosing experiments.
￭ Complete R&D compliance documentation: COA, MSDS, HPLC chromatograms available for preclinical research and international procurement.
￭ Flexible supply: Milligram-scale samples and gram-scale bulk supply available.
Quality Assurance
￭ Synthesized from high-purity starting materials under GMP-compliant cleanroom conditions, fully traceable.
￭ Supports sample testing to ensure trial-bulk consistency.
￭ Full export documentation provided, compatible with global customs and regulatory standards.
FAQ
Q1: What is 2-Methoxyestradiol?
A1: 2-Methoxyestradiol Powder is an endogenous estradiol metabolite (CAS 362-07-2, C₁₉H₂₆O₃, MW 302.41) used in anti-tumor, anti-angiogenic, and pharmacological research.
Q2: Can it be used directly for clinical treatment?
A2: No. It is a research-grade API for cell experiments, pharmacology, and preclinical drug development only. Not for human use.
Q3: How does it differ from regular estradiol?
A3: High-purity 2-Methoxyestradiol has no estrogen activity, mainly for anti-angiogenic and tumor research. Regular estradiol is used for hormone supplementation.
Q4: Should it be filtered after dissolution?
A4: For cell or animal experiments, 0.22μm filtration is recommended.
factory
Certificates
Shipping & Packing
Procurement & Support
High-purity 2-Methoxyestradiol Powder / API for preclinical R&D and cell experiments is available worldwide for academic, pharmaceutical, and biopharma research.
￭ Sample testing
￭ Bulk procurement
￭ Custom packaging
￭ Rapid delivery and full technical support
Contact for COA, quotations, and supply plans:
Whatsapp & Mobile: +8619991242181
Email:sales@hdmbio.com
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