Estradiol Valerate API for Preclinical R&D | Pharmaceutical-Grade Estradiol Valerate for Oral & Injectable Formulation Development | High-Purity & GMP-Compliant Supply
Core Highlights
●Long-acting estrogen raw material
●Excellent lipophilicity&Stable high purity
●Pharmaceutical formulation-grade estrogen API
●Strict impurity control
●Suitable for oral and injectable formulation development applications
Product Overview
Estradiol Valerate API for preclinical research and long-acting estrogen formulation development is a valerate ester derivative of estradiol, and is a widely used pharmaceutical-grade synthetic estrogen raw material suitable for HRT, oral formulations, and oil-based injectable R&D.
Manufactured using mature fine chemical synthesis technology, this pharmaceutical-grade Estradiol Valerate Powder features excellent lipophilicity and provides a sustained release of active estradiol after entering the body, ensuring a stable hormone release profile without drastic fluctuations. It is suitable for sustained-release oral and injectable formulation development, preclinical R&D, and pharmaceutical intermediate production.
This product is manufactured in strict compliance with GMP pharmaceutical manufacturing standards, with refined control over purity, related substances, residual solvents, heavy metals, and other quality indicators. Batch consistency remains stable, and the product is mainly supplied to overseas pharmaceutical companies, biopharmaceutical research institutions, and fine chemical traders.
COA
| Item | Specification | Result | |
| Characteristics | White crystalline powder; Odorless. | Conform | |
| Solubility | Soluble in castor oil,in methanol, in benzyl benzoate and in dioxane; sparingly soluble in sesame oil and in peanut oil; practically insoluble in water. | Conform | |
| Identification | A: Infrared detection shows that the retention time of the main peak is consistent with that of the working control product. B: The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay. |
Conform | |
| Specific rotation | +41~+47° | +43.8° | |
| Water Determination | ≤0.1% | 0.03% | |
| Free acid content | Expressed as valeric acid, ≤0.5%. | 0.07% | |
| Organic Impurities RRT0.1 Estradiol RRT0.9 Estradiol‑9‑ene valerate RRT1.3 4‑Methylestradiol valerate RRT1.7 Estradiol divalerate Any individual unspecified impurity Total impurities |
≤0.2% ≤0.2% ≤0.4% ≤0.15% ≤0.10% |
0.09% |
|
| Residue on ignition | ≤0.2% | 0.05% | |
| Residual Solvents Methanol Dichloromethane |
≤0.20% ≤0.20% |
220ppm Not detected |
|
| Assay | 98.0~102.0% | 100.20% | |
| Micron | 100%≤20μm | 100%≤20μm | |
| Conclusion | The product complies with the requirements of USP Standard. | ||
Mechanism of Action
Estradiol Valerate Powder, as a prodrug for preclinical research, slowly releases active 17β-estradiol, providing long-acting estrogen availability for HRT, endocrine research, and formulation development studies. The valerate side chain significantly enhances lipophilicity and prolongs the duration of action in vivo.After entering the body, it is hydrolyzed by esterases in the blood and tissues, removing the valerate group and releasing biologically active estradiol. Active estradiol specifically binds to estrogen receptors ERα and ERβ, thereby regulating cell proliferation, differentiation, and metabolism through modulation of downstream gene expression.It exerts estrogenic physiological effects on multiple tissues and organs, including:
● Supports reproductive system function in preclinical studies
● Maintains bone density and metabolism in research models
● Regulates lipid metabolism and vascular function for preclinical R&D
● Supports skin tissue integrity and collagen metabolism in long-term studies
● Prevents rapid hormonal fluctuations, enabling sustained-release formulation developmentIts ester structure helps minimize the rapid hormonal fluctuations associated with short-acting estradiol, enabling stable and sustained endocrine regulation effects.
Product Applications
Applications of Estradiol Valerate Powder for Preclinical R&D and Long-Acting Formulation Development:
● Core raw material for oral estrogen tablets and long-acting injectable formulations in preclinical studies
● HRT-related new drug research, formulation screening, and stability testing
● Research in reproductive medicine, endocrinology, and pharmacology at universities and biopharma labs
● Overseas pharmaceutical trade, bulk fine chemical procurement, and customized R&D supply
● Materials for clinical trials and pilot-scale research projects for biopharmaceutical companies
Detailed Efficacy
Based on the physiological regulatory mechanism of estrogen activity, Estradiol Valerate Powder releases active estradiol through in vivo metabolism, providing mild and long-acting endocrine regulation. All efficacy descriptions are objective, rigorous, and supported by endocrinology research conclusions:
● Supports estrogen supplementation and preclinical endocrine research: Helps improve endocrine imbalance associated with estrogen deficiency and regulates hormone balance in sustained-release studies
● Supports the normal physiological condition of the female reproductive system and helps maintain stable endometrial and ovarian function
● Bone health support in preclinical R&D: Regulates bone metabolism, slows bone loss, maintains normal bone density, and supports long-term endocrine study models
● Skin metabolism regulation for preclinical studies: Supports collagen synthesis, lipid metabolism, and stable skin physiology in formulation experiments
● Cardiovascular support in research models: Modulates lipid metabolism and vascular function for preclinical R&D and HRT formulation studies
● Suitable for hormone replacement therapy-related research, providing stable raw material support for endocrine-regulation pharmaceutical formulation development
Core Advantages
● Mild and long-acting estrogen release for formulation R&D: The valerate ester group enhances lipophilicity, slows metabolic degradation in vivo, and supports sustained-release pharmaceutical formulation development, allowing stable hormone release with an extended duration of action, making it suitable for long-acting formulation development
● Stable and controllable purity: HPLC purity consistently remains ≥99.0%, while impurity types and contents are strictly controlled to meet stringent overseas pharmaceutical raw material standards
● Formulation-friendly API for oral and injectable R&D: Outstanding lipophilicity ensures suitability for oral tablets, oil-based injectables, and long-acting estrogen research applications
● Batch-consistent Estradiol Valerate API for preclinical and industrial R&D: Standardized synthesis and QC minimize physicochemical variations, ensuring reproducible long-acting formulation development
● Flexible supply solutions: Supports small-scale sample procurement and large-volume spot supply, meeting the different requirements of laboratory research and industrial-scale production
Quality Assurance
● Manufactured using high-purity starting materials in standardized clean workshops with fully traceable production processes
● Each batch undergoes comprehensive testing, including HPLC analysis, melting point, moisture, heavy metals, and related substances, with official COA reports provided
●Application scenarios are strictly limited to human pharmaceutical research and manufacturing fields to avoid risks associated with non-compliant use
●Customer sample testing is supported, and bulk product quality remains consistent with sample quality to ensure procurement stability
●Complete export documentation is available to comply with customs clearance requirements in most countries worldwide
FAQ
Q1: Can this pharmaceutical-grade Estradiol Valerate API powder be directly used by humans?
A: This pharmaceutical-grade Estradiol Valerate Powder is a pharmaceutical ingredient and must not be directly taken orally, injected, or applied. It must be processed into compliant formulations by pharmaceutical manufacturers before use.
Q2: Is the purity stable between batches, and are impurities controllable?
A: Manufactured using mature synthesis technology, the HPLC purity remains stable at ≥99.0%, while related substances and heavy metals are strictly controlled.
Q3: What are the core differences between Estradiol Valerate and regular estradiol?
A: Estradiol Valerate is a prodrug with stronger lipophilicity, more stable in vivo release characteristics, and a moderate duration of action.
Q4: What dosage forms is this raw material suitable for?
A: It is mainly suitable for oral tablets, long-acting oil-based injections, sustained-release formulations, and other estrogen pharmaceutical developments.
factory
Certificates
Shipping & Packing
Contact Us for Procurement | Efficient Supply & Professional After-Sales Support
High-purity Estradiol Valerate Powder for preclinical R&D and long-acting estrogen formulation development is available worldwide for HRT studies, pharmaceutical formulation development, and endocrine research, providing stable, compliant, and traceable raw material solutions for global pharmaceutical companies, research institutions, and chemical traders.
Sample testing, bulk procurement, and customized supply solutions are available, with efficient shipping and comprehensive after-sales technical support.
For quality inspection reports, sample quotations, or detailed supply solutions, feel free to contact us:
Whatsapp & Mobile: +8619991242181
Email:sales@hdmbio.com
Hot Tags: estradiol valerate powder, China estradiol valerate powder manufacturers, suppliers, factory
