Estradiol Enanthate API｜Ultra-Long-Acting Estrogen Raw Material
Key Highlights
Estradiol Enanthate API | Sustained and Stable Release | High Purity & Stability | Excellent Lipophilicity | Compatible with Long-Acting Injectable Formulation Development | Fully Batch-Traceable
Product Overview
Estradiol Enanthate API for preclinical R&D and long-acting injectable formulation development is a long-acting estrogen pharmaceutical raw material and an enanthate ester derivative of estradiol designed for HRT and endocrine research applications. Its long-chain ester structure enhances lipophilicity and prolongs in vivo metabolism, making it ideal for ultra-long-acting hormone replacement therapy (HRT) formulations, endocrine research, and preclinical R&D.
Manufactured under GMP-compliant pharmaceutical standards, this high-purity Estradiol Enanthate API ensures consistently low impurity levels and full batch traceability. This product, also commonly supplied as Estradiol Enanthate Powder, is intended exclusively for human pharmaceutical research, formulation development, and scientific experimentation.
COA
| Item | Specification | Result | |
| Characteristics | White crystalline powder | Conform | |
| Identification | A: IR B: UV C: TLC | Conform | |
| Solubility | Practically insoluble in waterSoluble in alcohol, acetone, dioxane, chloroform; Sparingly soluble in vegetable oils. | Conform | |
| Specific optical rotation | +38° ~+43° | +40.3° | |
| Melting point | 94.0℃~114.0℃ | 98.5-99.9℃ | |
| Heptanoic acid | ≤0.50% | 0.07% | |
| Total related substances | ≤2.0% | 0.49% | |
| Any individual impurity | ≤0.7% | 0.22% | |
| Loss on drying | ≤0.1% | 0.01% | |
| Residue on ignition | ≤0.1% | 0.08% | |
| Resi78dual solvents Methanol Acetic ether |
≤3000ppm ≤5000ppm |
20ppm Not detected |
|
| Assay | 97%~103% | 100.05% | |
| Micron | 100%≤20μm | 100%≤20μm | |
| Conclusion | The product complies with the requirements of USP Standard. | ||
Mechanism of Action
Estradiol Enanthate API for sustained-release preclinical research is a prodrug ester that slowly releases 17β-estradiol, providing ultra-long-acting estrogen availability for formulation development and endocrine experiments. The active estradiol binds to estrogen receptors ERα and ERβ, regulating gene expression and exerting physiological effects on multiple systems:
● Supports reproductive system function in preclinical studies
● Maintains bone density and metabolism in research models
● Regulates lipid metabolism and vascular function for preclinical R&D
● Supports skin tissue integrity in long-term studies
● Prevents plasma concentration spikes, ensuring stable hormone levels for sustained-release formulations
Applications of Estradiol Enanthate API
The Estradiol Enanthate Powder is suitable as a human pharmaceutical intermediate and research raw material, including:
● Core raw material for ultra-long-acting estrogen oil-based injectables in preclinical studies.
● Development of sustained-release HRT formulations and endocrine research projects.
● Reproductive medicine, endocrinology, and pharmacology research in academic and industrial laboratories.
● Overseas pharmaceutical raw material import/export and pilot-scale R&D procurement.
● Support for small-scale trials, pilot production, and formulation development studies.
Benefits of Estradiol Enanthate API
The Estradiol Enanthate Powder acts as a prodrug, gradually releasing biologically active estradiol and providing mild, long-lasting endocrine regulation. Research-backed benefits include:
● Long-acting estrogen supplementation for preclinical R&D: Regulates sex hormone levels and supports HRT and endocrine research to improve hormonal balance
● Reproductive system support: Maintains normal reproductive physiology; ideal for HRT and long-acting formulation research
● Bone health support in research models: Regulates bone metabolism, slows calcium loss, maintains bone density, and reduces osteoporosis risk
● Cardiovascular support: Modulates lipid metabolism and maintains vascular endothelial homeostasis
● Skin metabolism regulation: Supports normal skin tissue function and elasticity
● Endocrine axis stability: Supports hypothalamic-pituitary-gonadal axis regulation for new drug development
Why Choose Estradiol Enanthate API?
● Ultra-long-acting release: Long-chain enanthate ester ensures slower metabolism and longer duration than other esters.
● High purity & stability: HPLC purity ≥99.0%, low impurities, compliant with international standards.
● Formulation-friendly: Ideal for oil-based injectable systems.
● Flexible supply: Suitable for both small-scale and bulk procurement.
Quality Assurance
● High-purity starting materials and GMP-compliant cleanroom synthesis.
● Full batch testing: HPLC, melting point, moisture, heavy metals, related substances.
● Strict limitation to human pharmaceutical research and production.
● Sample testing ensures trial and bulk material consistency.
● Complete export documentation for global compliance.
FAQ
Q1: Can Estradiol Enanthate API be used directly in humans?
A: No. Estradiol Enanthate Powder is a pharmaceutical raw material and must be processed into formulations by certified pharmaceutical companies. Personal use is prohibited.
Q2: How does Estradiol Enanthate API compare with estradiol cypionate and valerate?
A: Long-acting duration increases as follows: estradiol valerate < estradiol cypionate < Estradiol Enanthate API. Estradiol Enanthate API has the longest sustained release and slowest metabolism.
Q3: Which dosage forms are suitable for Estradiol Enanthate API?
A: Primarily long-acting oil-based injectables and sustained-release endocrine regulatory formulations.
factory
Certificates
Shipping & Packing
Procurement & Support
High-purity Estradiol Enanthate API / Ultra-Long-Acting Estrogen Raw Material is available worldwide for preclinical R&D, formulation development, and pharmaceutical research.
● Sample testing
● Bulk procurement
● Custom packaging
● Rapid delivery and full technical support
Contact for COA, quotations, and supply plans:
Whatsapp & Mobile: +8619991242181
Email:sales@hdmbio.com
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