Estradiol Cypionate API for Preclinical R&D | Long-Acting Sustained-Release Estrogen Raw Material | Pharmaceutical-Grade Estradiol Cypionate for Oral & Injectable Formulation Development
Core Highlights
Long-acting sustained-release estrogen raw material | Stable high-purity profile | GMP-compliant pharmaceutical-grade estrogen API | Strict impurity control | Batch-to-batch consistency and traceability
Product Overview
Estradiol Cypionate API for preclinical research and long-acting estrogen formulation development is a synthetic cypionate ester derivative of estradiol, and is a widely used pharmaceutical-grade sustained-release estrogen raw material suitable for HRT studies, oral and oil-based injectable R&D, and endocrine regulation experiments.
This pharmaceutical-grade Estradiol Cypionate Powder is manufactured using advanced chemical synthesis and purification technologies, featuring a stable molecular structure and sustained-release characteristics. It is widely applied in preclinical R&D, long-acting formulation development, endocrine research, and pharmaceutical intermediate production. We strictly follow GMP pharmaceutical raw material manufacturing standards, with rigorous control of heavy metals, residual solvents, and related substances. The product demonstrates excellent batch consistency and can meet the procurement demands of overseas research institutions, pharmaceutical companies, and fine chemical traders seeking high-quality long-acting estrogen API raw materials.
COA
| Item | Specification | Result | |
| Characteristics | This product is a white or almost white crystalline powder | White powder | |
| Identification | A:IR B:HPLC | Conform | |
| Solubility | Insoluble in water, soluble in alcohol, in acetone, in chloroform and in dioxane ;sparingly soluble in vegetable oils. | Conform | |
| Melting range | 149~153℃ | 150.3~151.8℃ | |
| Specific optical rotation | +39~+44° | +40.8° | |
| Loss on drying | ≤1.0% | 0.05% | |
| Residuc on ignition | ≤0.10% | 0.07% | |
| Assay | 97.0~103.0% | 99.69% | |
| Residual solvents Methanol Methylene chloride |
≤3000ppm ≤600ppm |
262 ppm Not detected |
|
| Particle size | 100%≤20μm | 100%≤20μm | |
| Conclusion | The product complies with the requirements of USP Standard. | ||
Mechanism of Action
Estradiol Cypionate Powder, as a long-acting estrogen prodrug for preclinical R&D, is hydrolyzed in vivo to release active 17β-estradiol, providing sustained estrogen availability for HRT studies, endocrine research, and formulation development. After entering the body, it is hydrolyzed by esterases to release active estradiol.
Estradiol specifically binds to estrogen receptors (ERα and ERβ), thereby regulating cell proliferation, differentiation, and metabolic activity through modulation of gene transcription and protein expression.
The cypionate group significantly enhances lipophilicity and prolongs the in vivo half-life, enabling long-acting release. It provides sustained estrogen release while minimizing plasma hormone fluctuations in preclinical studies associated with short-acting estrogens. This makes it suitable for long-acting hormone regulation applications, and its mechanism of action is consistent with internationally recognized endocrinology principles.
Product Applications
Applications of Estradiol Cypionate Powder for Preclinical R&D and Long-Acting Formulation Development:
1. Raw material for long-acting oral and oil-based injectable formulations in preclinical studies
2. HRT-related drug research, formulation screening, and stability testing
3. Research materials for endocrinology, reproductive medicine, and pharmacology studies
4. Pharmaceutical intermediate for sustained-release estrogen injections and endocrine-regulation formulations
5. Overseas pharmaceutical trade, bulk fine chemical procurement, and customized R&D supply
Detailed Efficacy
Based on the physiological mechanism of estrogen activity, Estradiol Cypionate Powder releases estradiol after hydrolysis in vivo and may exert the following physiological regulatory effects. All descriptions are scientifically supported by endocrinology principles without exaggerated claims:
1. Supports estrogen supplementation and preclinical endocrine R&D: Helps improve endocrine imbalance associated with low estrogen levels and provides stable long-acting estrogen support for formulation studies.
2 .Long-acting estrogen support in preclinical research: Maintains normal physiological function of reproductive system, bone, skin, and cardiovascular tissues in sustained-release studies.
3. Assists in regulating lipid metabolism and maintaining healthy lipid profiles, supporting vascular endothelial health.
4. Bone metabolism regulation for preclinical R&D: Reduces calcium loss, maintains bone density, and supports long-term endocrine experiments.
5. Endocrine axis stabilization in formulation studies: Supports HRT and long-acting hormone regulation R&D.
Core Advantages
1. Long-Acting Sustained-Release PropertiesThe ester bond structure slows metabolic release, providing a longer duration of action and more stable plasma concentrations, thereby reducing fluctuations caused by frequent administration.
2. Controlled Purity and ImpuritiesHPLC purity remains stable at ≥99.0%, while related substances, residual solvents, and heavy metals are strictly controlled to meet overseas pharmaceutical raw material requirements.
3. Excellent Batch ConsistencyStandardized synthesis technology combined with full-process quality control minimizes physicochemical property and purity variations between batches, making it suitable for large-scale pharmaceutical formulation manufacturing.
4. Comprehensive Compliance SupportThis product is intended for human pharmaceutical research and manufacturing applications. Complete documentation facilitates overseas customs clearance and qualification review.
5. Customized Supply ServicesSupports small-scale sample orders and bulk supply. Packaging and testing reports can be customized according to overseas customer procurement preferences.
Quality Assurance
1. Manufactured using pharmaceutical-grade starting materials in GMP-compliant cleanroom facilities under standardized production management
2. Each batch undergoes comprehensive testing, including HPLC analysis, melting point, moisture content, heavy metals, and related substances, with official COA quality inspection reports issued
3. All the documentations, production process descriptions, and batch traceability records are available to satisfy overseas customs and purchaser qualification reviews
4. Sample testing is supported, and bulk product quality remains consistent with sample quality to ensure procurement stability
FAQ
Q1: Can this product be directly used by humans?
A: This long-acting Estradiol Cypionate Powder is a pharmaceutical raw material and should not be directly consumed orally or injected. It must be processed into formulations by pharmaceutical companies or research institutions under compliant manufacturing procedures. Direct use by individuals is not recommended.
Q2: How does Estradiol Cypionate differ from regular estradiol in duration of action?
A: This sustained-release Estradiol Cypionate Powderestrogen raw material is a long-acting sustained-release estrogen prodrug with a longer in vivo half-life and more stable plasma concentrations. Its duration of action is significantly longer than short-acting estradiol and does not require frequent administration.
Q3: What types of formulations is this raw material suitable for?
A: It is mainly suitable for the development of long-acting oil-based injections, sustained-release hormone formulations, and endocrine-regulation pharmaceutical formulations, with mature and stable application scenarios.
Q4: What is the difference between Estradiol Cypionate and Estradiol Valerate?
A: Estradiol Cypionate has higher lipophilicity and slower metabolic release, resulting in a more pronounced long-acting sustained-release effect, making it more suitable for ultra-long-cycle hormone-regulation formulation development.
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Shipping & Packing
Contact Us for Procurement | Professional Support & Fast Delivery
Estradiol Cypionate Powder for preclinical R&D and long-acting estrogen formulation development is available worldwide for HRT studies, pharmaceutical formulation development, and endocrine-regulation research, providing stable and compliant raw materials together with one-stop procurement solutions for overseas pharmaceutical companies, research institutions, and fine chemical traders.Both sample orders and bulk purchases can be processed efficiently with fast shipping and comprehensive after-sales technical support.
For detailed quality reports, sample quotations, or customized packaging solutions, feel free to contact us.
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Email:sales@hdmbio.com
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