Tetracaine Powder CAS 94-24-6 ▏≥99% Purity Local Anesthetic API for Pharmaceutical R&D
Core Benefits:
● Long-acting ester local anesthetic API with stable onset and prolonged effect;
● Suitable for topical and infiltration anesthesia formulation development.
● High purity, strict impurity control, consistent batch quality, and complete GMP-compliant documentation,
● Supporting global pharmaceutical R&D, pharmacology studies, and academic research procurement.
Product Overview
Tetracaine Powder for research-grade, injectable and topical formulation development (CAS: 94-24-6) is a classical long-acting ester local anesthetic API with a stable chemical structure and high lipophilicity. Its anesthetic effect is long-lasting and suitable for ENT, dermatology, and minimally invasive treatment applications.
Tetracaine Powder is supplied to global pharmaceutical companies, CROs, academic laboratories, and cross-border pharmaceutical trade. Using precise chemical synthesis, purification, and recrystallization processes, it meets ICH API quality standards. Tetracaine Powder is suitable for preclinical and formulation research, pilot studies, pharmacology, toxicology, and pharmacokinetics, providing a stable, traceable raw material for ENT, dermatology, and minimally invasive treatment local anesthetic drug development.
COA
| Item | Specification | Result | |
| Description | White or light yellow powder | White powder | |
| Identification | A. Dissolve 100 mg in 10 mL of dilute hydrochloric acid(1 in 120),and add 1 mL of potassium thiocyanate solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: it melts between 130 and 132. | Complies | |
| B: By UV, To match with working standard | Complies | ||
| Chromatographic purity | Conform to standard | Complies | |
| Loss on drying | ≤0.5% | 0.16% | |
| Residue on ignition | ≤0.1% | 0.03% | |
| Melting range | 41℃~46℃ | 42℃~43℃ | |
| Residual Solvents | ethyl alcohol≤0.5% acetone≤0.5% methylbenzene≤0.089% isopropyl ether≤0.5% |
N.D. N.D. 0.014% 0.017% |
|
| Assay(*) | 98.0%~102.0% (on the dried) | 99.80% | |
| Conclusion | The Sample Complies With Specification of USP43 | ||
Mechanism of Action
Tetracaine Powder for research-grade injectable and topical R&D reversibly blocks sodium channels on nerve cell membranes. Normal nerve conduction relies on sodium influx to generate action potentials. Tetracaine Powder binds to sodium channels, inhibiting sodium flow and preventing action potential propagation, producing long-acting local anesthesia and analgesia. Its high lipophilicity enables penetration of mucosal barriers, providing prolonged anesthetic effect. Metabolized primarily by plasma cholinesterase, it avoids accumulation and is suitable for preclinical and clinical topical formulation development.
Product Applications
Tetracaine Powder for injectable and topical formulation development in ENT, dermatology, and minimally invasive treatment R&D. Suitable for:
1. Development of research-grade topical anesthetic gels, ointments, sprays, and infiltration formulations.
2. Toxicology, pharmacology, and pharmacokinetics research related to sodium channel blockade and long-acting local anesthesia.
3. R&D of innovative or generic long-acting local anesthetic APIs.
4. Pharmaceutical intermediates for cross-border trade, supporting regulatory-compliant global projects.
5. Academic research on neural pharmacology and local anesthetic mechanisms.
Benefits of Tetracaine Powder
1. Potent Local Anesthetic Effect: Rapidly blocks nerve impulse transmission, with fast onset and prolonged effect. Effectively relieves local pain, suitable for ENT, dermatology, minimally invasive treatment, and research applications.
2. Broad Anesthetic Range: Effective for mucosal surface anesthesia and suitable for infiltration and conduction anesthesia; supports clinical procedures, minor surgeries, and research experiments.
3. Stable Bioavailability: Powder form dissolves well and allows flexible formulation; enhances local tissue absorption and minimizes efficacy fluctuations.
4. Chemical and Physical Stability: Resistant to decomposition and oxidation; remains active under proper storage for long-term research and scalable production.
Core Advantages
1. Mature Pharmacological Application for preclinical and clinical local anesthetic R&D: Classical long-acting ester local anesthetic with clear target and well-documented clinical data; aligns with global anesthetic drug development needs.
2. Stable Physicochemical Properties: Standardized crystallization ensures low batch-to-batch variability in purity, impurities, and crystal form, reducing experimental deviations.
3. Flexible Supply: Multiple packaging options; supports sample, small, and mid-scale orders.
4. Reliable Cross-Border Delivery: Full export compliance ensures smooth international shipping and customs clearance.
5. Long-Term Supply Stability: Scalable production ensures sufficient inventory and uninterrupted supply.
Quality Assurance
1. Full-Process GMP Control: From raw materials, synthesis, functional group modification to final packaging, each batch undergoes HPLC, moisture, impurity, and appearance testing.
2. Strict Impurity Management: Organic impurities, residual solvents, and heavy metals comply with ICH limits.
3. Complete Batch Traceability: Each batch is uniquely numbered and traceable across production, testing, and shipping.
4. Professional Storage: Low temperature, light-protected, moisture-proof storage maintains stability.
5. After-Sales Support: Raw material application consulting, specification interpretation, and technical guidance.
FAQ
Q1: Can Tetracaine Powder be directly used for commercial formulations?
A: It is a research-grade API suitable for early-stage, pilot, and pharmacology studies. Commercial use requires regulatory-compliant API grade and documentation.
Q2: Can purity or crystal form specifications be customized?
A: Yes, specifications can be tailored to project needs, supporting differentiated formulation development.
Q3: Is the crystal form stable and hygroscopic?
A: The product is crystalline; sealed, dry storage maintains stability. Moisture is strictly controlled ≤0.5%, ensuring formulation stability.
Q4: Is Tetracaine Powder water-soluble? Suitable formulation types?
A: Native Tetracaine has moderate solubility; hydrochloride salt form improves solubility. Suitable for sprays, gels, ointments, and topical solutions.
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Contact & Orders
Tetracaine Powder for research-grade, injectable and topical formulation development supports stable physicochemical properties, rigorous quality control, complete documentation, and flexible supply, enabling efficient global ENT, dermatology, and minimally invasive treatment pharmaceutical R&D. Contact us for pricing, sample requests, COA files, or custom supply solutions.
Contact:
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Email: sales@hdmbio.com
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