Doreptide API Powder Supplier China | GMP PLG Analog Peptide Manufacturer CAS 90104-48-6

Core Selling Points

✅ GMP-Aligned PLG Analog Peptide Manufacturing

✅ ≥98% HPLC Purity & Stable Structural Stability Guaranteed

✅ Batch-Specific COA, HPLC & LC-MS Reports for Every Lot

✅ Global Bulk Export & Full Customs Clearance Documentation

✅ Custom Peptide Synthesis & OEM Lyophilization Service

What Is Doreptide API?

Doreptide Powder is a synthetic small peptide API intermediate and optimized structural analog of endogenous PLG (Pro-Leu-Gly-NH₂) neuropeptide, widely used in central nervous system pharmacology research and peptide structure-activity relationship exploration.

Doreptide has been investigated as a PLG analog research peptide in dopaminergic signaling studies and CNS pharmacology models, including exploratory research related to L-dopa-associated pathways. Produced under strict GMP-aligned production protocols, our Doreptide API adopts precise short-chain amino acid coupling technology and multi-stage HPLC impurity removal process, ensuring accurate peptide sequence, stable molecular structure and consistent batch experimental activity. As a reliable China-based neuropeptide bulk supplier, HDM BIO provides one-stop customized synthesis, bulk wholesale and professional technical support for global R&D institutions.

What Are the Official Quality Specifications of Doreptide API Powder?

Every batch of Doreptide API undergoes independent dual quality testing (HPLC purity detection + LC-MS structural verification) in HDM BIO's professional QC laboratory. Each bulk order is equipped with a unique batch COA to fully meet research-grade peptide API quality standards.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.66%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

What Is the Mechanism of Doreptide in CNS Peptide Research?

As a synthetic PLG analog peptide API, Doreptide serves as a core experimental tool for central nervous system dopaminergic pathway research. It is applied to explore signal regulation activities within dopaminergic networks and supports experimental modeling for studies involving L-dopa related pathways.

Different from common endogenous neuropeptides, Doreptide features optimized structural stability, making it an ideal research model for PLG analog structure-activity relationship analysis and CNS basic pharmacology research.

Disclaimer: This peptide API is for laboratory research and pharmaceutical R&D use only, not a finished drug, prohibited for direct clinical administration to humans or animals.

How Does Doreptide vs Other Mainstream Neuroactive CNS Peptides?

HDM BIO builds a complete CNS neuropeptide API product cluster. The following comparison clarifies the core differences between Doreptide and other common neuroactive peptides, helping researchers select targeted experimental reagents for different research directions:

Peptide Product	Core Research Target	CAS Number	Core Feature	Primary Application Scenario
Doreptide	Dopaminergic pathway / PLG analog research	90104-48-6	Optimized stable PLG analog for signaling mechanism study	CNS dopaminergic pathway & peptide structure-activity research
Dynorphin A (1-13)	Kappa opioid receptor (KOR)	72957-38-1	Endogenous KOR agonist neuropeptide with stable binding activity	Neuroscience pain mechanism & neuroendocrine regulation research
Substance P	NK1 tachykinin receptor	33507-63-0	Classic pain signaling neuropeptide mediating neuroinflammation	Neural nociception pathway & inflammatory pain research
Neurotensin	NTS neurotensin receptor	39379-15-0	Multifunctional neuroendocrine regulatory peptide	Neuroendocrine signal transduction & behavioral pharmacology research
Neuropeptide Y	NPY receptor family	81705-39-1	Highly conserved CNS regulatory neuropeptide	Neural metabolism, mood and neuroimmune regulation research
β-Endorphin	Mu opioid receptor (MOR)	60617-12-1	Long-acting endogenous opioid neuropeptide	Central analgesia and neuroendocrine pharmacological research

What Is the Doreptide Synthesis & Manufacturing Process?

HDM BIO adopts fully standardized, traceable GMP-aligned production workflows for Doreptide API. As a short-chain PLG analog, Doreptide synthesis brings unique production advantages compared to longer polypeptide sequences: Short-chain peptide synthesis advantages:

High amino acid coupling efficiency

Lower impurity complexity during synthesis

Simpler purification control strategy

Superior batch-to-batch molecular consistency

Production Workflow

Raw Material Inspection → Fmoc SPPS Sequential Coupling → Resin Cleavage & Global Deprotection → Multi-stage HPLC Purification → Lyophilization → QC Testing → Batch COA Issuance → Sealed Light-Proof Pharmaceutical Packaging

QC Inspection Workflow

Incoming Raw Material QC → In-process Production Monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification → Moisture & Heavy Metal Testing → Residual Solvent Detection → Final Batch Release Approval

Core Process Highlights

Precise amino acid coupling control eliminates deletion impurities and ensures correct peptide sequence, molecular integrity and reproducible experimental activity. All production processes are completed in GMP-aligned peptide production facilities with full raw material traceability. Multi-stage high-precision HPLC purification thoroughly removes synthesis byproducts and residual impurities. Vacuum-sealed light-proof packaging effectively maintains Doreptide structural stability during long-distance transportation and low-temperature storage.

Where Can I Buy Doreptide API Powder in Bulk?

HDM BIO supplies Doreptide API powder in bulk quantities for research institutions, pharmaceutical R&D companies and peptide distributors worldwide. We support flexible order scales from gram lab samples up to kilogram bulk orders. Available services include batch exclusive COA documentation, LC-MS molecular verification, custom peptide synthesis and complete worldwide shipping support with full export documentation. Contact our team to get the latest bulk quotation and production lead time.

Why Choose Doreptide API From HDM BIO?

10+ years of professional CNS neuropeptide & PLG analog peptide manufacturing experience in China
Mature short-chain peptide Fmoc SPPS synthesis technology with strict impurity control
GMP-aligned clean workshop, ISO & HACCP dual certified quality management system
Full batch traceability management for every Doreptide API production lot
Strict HPLC+LC-MS dual testing to guarantee consistent API-level quality
Flexible supply mode covering R&D samples, pilot batches and large bulk orders
Global export service covering 70+ countries with complete customs certification documents
Professional peptide technical team provides CNS pharmacology research technical support

How to Choose a Reliable Doreptide API Supplier in China?

Global pharmaceutical R&D teams and laboratory procurement institutions need to verify the following core qualifications and product indicators when sourcing bulk Doreptide API, to avoid unstable experimental data and supply risks:

Complete HPLC full purity report and related substances impurity profile data
LC-MS molecular structural identity confirmation and full peptide sequence verification
Batch-exclusive COA and complete production process traceability records
Professional synthesis capability for short-chain PLG analog peptides
GMP-aligned production workshop and standardized quality management system
Stable bulk supply capacity for long-term CNS research projects
Complete international export documentation and one-stop customs clearance support
Professional technical team supporting neuropeptide experimental application guidance

What Factors Affect Doreptide API Bulk Price?

The bulk procurement price of Doreptide API is affected by multiple customized procurement factors, different from ordinary laboratory reagents. Core influencing factors include product purity grade, additional analytical testing items, total order batch quantity, personalized packaging and labeling specifications, complete certification documents and international logistics destinations.

HDM BIO provides full-scenario flexible supply and tiered preferential bulk pricing: gram-scale exploratory experiment samples, medium-batch continuous research supply and large-scale commercial bulk wholesale. We also support custom modified peptide synthesis services. Contact our sales team to obtain the latest real-time Doreptide API bulk quotation and production delivery cycle.

How to Store & Handle Doreptide API for Optimal Stability?

Storage Condition: Seal tightly and store at -20℃ in a dry, dark and low-temperature environment
Handling Note: Avoid repeated freeze-thaw cycles; weigh and prepare peptide solutions in a dust-free dry environment to prevent structural inactivation
Shelf Life: 2 years under standard sealed low-temperature storage conditions
Safety Specification: For pharmaceutical R&D and laboratory research only, not for direct human or animal clinical administration

What is the Main Application Scenarios of Doreptide API?

CNS Peptide Research: PLG analog peptide structure-activity relationship and dopaminergic signaling exploration
Neuropharmacology Experiments: Mechanism research focused on L-dopa related signaling pathways
Pharmaceutical R&D Intermediate: Pre-clinical raw material for central nervous system drug discovery
Biomedical Reagent Preparation: High-purity laboratory reference standards and experimental detection reagents
Basic Neurobiology Research: Neuropeptide stability and physiological function evaluation

What is the FAQ of Doreptide API?

Q: Where can I buy Doreptide API powder from China?

A: Global research institutions and pharmaceutical R&D teams can purchase high-purity Doreptide API powder directly from HDM BIO, a professional China-based GMP neuropeptide manufacturer. We provide one-stop bulk supply, complete quality documents and global delivery services.

Q: Is Doreptide available for bulk supply?

A: Yes. We support full-scale bulk supply of Doreptide API, including gram-level trial samples, medium pilot batches and kilogram-level commercial bulk orders, with flexible MOQ and exclusive tiered bulk pricing.

Q: Can HDM BIO provide Doreptide custom synthesis service?

A: Yes. Besides standard Doreptide API products, we support customized PLG analog peptide modification, sequence optimization and personalized synthesis services to meet special experimental and R&D needs.

Q: What documents are available for Doreptide API?

A: Every batch of Doreptide API is equipped with batch-specific COA, HPLC purity report, LC-MS structural verification data and MSDS safety sheet. We can also provide GMP, ISO and HACCP factory certification documents for global procurement clearance.

Q: Is Doreptide the same as PLG?

A: No. Doreptide is a synthetic PLG analog peptide designed for research applications, while PLG refers to the endogenous tripeptide sequence Pro-Leu-Gly-NH₂. Doreptide features modified chemical structure for improved stability in laboratory studies.

Q: What purity can you supply for Doreptide?

A: Our standard Doreptide API purity reaches ≥98% HPLC. Higher customized purity specifications can be produced according to customer testing requirements.

Q: What is Doreptide used for in research?

A: Doreptide Powder is a high-activity PLG analog neuropeptide API, mainly used for dopaminergic signaling research, CNS pharmacology experiments and peptide structure-activity relationship study.

Q: What is the CAS number of Doreptide?

A: The official unified CAS registration number of Doreptide is 90104-48-6.

Q: How to store Doreptide powder to maintain activity?

A: Store sealed tightly at -20℃, protected from light and moisture. Avoid repeated freeze-thaw cycles to maintain peptide molecular stability and experimental activity.

Scientific Content Review

Reviewed by: HDM BIO Peptide Chemistry Expert Team

Expertise:

Fmoc solid phase peptide synthesis technology
CNS neuropeptide synthesis & structural optimization
PLG analog peptide development and structure-activity research
High-precision HPLC purification and impurity separation technology
Research-grade peptide API quality system control

Review Scope: Molecular identity verification, short-chain peptide synthesis process validation, QC specification compliance, CNS research application suitability

Last Updated: July 2026

Manufacturer: HDM BIO

Location: China

Quality Standards: GMP-aligned manufacturing environment, ISO & HACCP certified quality management Intended Use: For pharmaceutical R&D, laboratory research and API intermediate manufacturing use only. Not for direct clinical administration to humans or animals.

Important Regulatory Notice

Doreptide is a research-grade CNS neuropeptide API intermediate, supplied exclusively for scientific research, pharmaceutical intermediate development and laboratory reagent preparation. All page content is for B2B procurement reference only. Purchasers shall comply with local regional chemical and pharmaceutical regulatory policies.