Elamipretide Powder CAS 736992-21-5 | SS-31 Peptide Supplier China | GMP Research Peptide Manufacturer

Core Selling Points

✅ ≥98% HPLC Purity Research‑Grade Peptide Material

✅ LC‑MS Full Cyclic Octapeptide Sequence & Disulfide Bond Verification

✅ Batch‑Specific COA, HPLC & MS Test Reports Available

✅ Optimized Fmoc SPPS Cyclization Workflow, In‑house Independent QC Laboratory

✅ Global Export Documentation & Cross‑border Cold‑chain Logistics Support

✅ Custom Peptide Purification & Salt‑form Adjustment Service

What Is Elamipretide Powder?

Elamipretide powder, also known as SS‑31 or MTP‑131, is a synthetic aromatic‑cationic Szeto‑Schiller tetrapeptide containing D‑arginine and non‑canonical 2,6‑dimethyl‑L‑tyrosine (Dmt) residue. It selectively accumulates within inner mitochondrial membrane independent of mitochondrial membrane potential, binds tightly to cardiolipin, stabilizes cristae architecture, preserves electron‑transport‑chain supercomplex assembly and suppresses mitochondrial reactive oxygen species generation. Widely deployed for mitochondrial disorder, ischemia‑reperfusion injury, cardiac protection, renal injury and aging‑related oxidative‑stress pre‑clinical assays.

Manufactured by optimized Fmoc solid‑phase peptide synthesis with special coupling protocol for bulky Dmt building block, multi‑stage gradient HPLC purification and controlled lyophilization process, our Elamipretide powder minimizes deletion‑sequence by‑products and oxidative degradation impurities, delivering stable biochemical performance and consistent batch‑to‑batch quality. HDM BIO serves global biotech labs and pharmaceutical R&D teams with lab‑scale sample supply and large‑volume bulk procurement. This peptide raw material is strictly limited to laboratory research use only and cannot be directly applied for human clinical administration.

What Are the Official Quality Specifications of Elamipretide Powder?

Each production batch of Elamipretide undergoes dual QC testing (HPLC + LC‑MS) within HDM BIO analytical laboratory. Exclusive batch COA will be issued for all bulk procurement orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.58%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Elamipretide vs Other Mitochondria‑Targeting Peptides

For buyers sourcing mitochondrial‑acting bioactive peptides for oxidative‑stress and bioenergetics pharmacology research, this comparison clarifies core differences for targeted raw‑material selection:

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Elamipretide (SS‑31)	Binds inner‑mitochondrial‑membrane cardiolipin; stabilizes respiratory supercomplex, reduces ROS at source, non‑membrane‑potential‑dependent mitochondrial enrichment	Tetrapeptide with D‑Arg and non‑natural Dmt modified residue; aromatic‑cationic Szeto‑Schiller peptide	Ischemia‑reperfusion injury, cardiac‑renal protection, Barth syndrome, mitochondrial myopathy, aging‑related bioenergetic decline research	736992‑21‑5
Humanin	Mitochondrial‑derived peptide; anti‑apoptotic via cell‑surface receptor & intracellular Bax inhibition, modulates insulin sensitivity	24‑mer endogenous‑origin peptide containing Met & free Cys residue	Neurodegeneration, cellular senescence, metabolic disorder assay	330936‑69‑1
MOTS‑c	Mitochondrial‑encoded short peptide; activates AMPK signaling, regulates glucose homeostasis	16‑amino‑acid mitochondrial‑derived peptide	Exercise‑mimetic study, insulin‑resistance, skeletal‑muscle metabolic research	162117‑66‑4

This section covers long‑tail keywords: elamipretide SS‑31 peptide, elamipretide vs humanin, cardiolipin binding peptide raw material.

How to Buy Elamipretide Powder from a Reliable Supplier?

When sourcing Elamipretide powder for mitochondrial bioenergetics, ischemia‑reperfusion and mitochondrial‑disease pre‑clinical research, R&D teams and international peptide buyers should evaluate five critical criteria to avoid quality and supply risks:

HPLC purity validation: Confirm ≥98% purity alongside complete impurity chromatogram, pay close attention to deletion‑sequence impurities originated from low‑reactivity Dmt residue coupling
LC‑MS structural confirmation: Verify full‑length tetrapeptide including D‑arginine and 2,6‑dimethyl‑tyrosine modified‑residue identity
Batch‑specific documentation: Guarantee each order can be matched with independent COA reports
Mature synthesis capability: Select suppliers with proven experience producing peptides utilizing expensive, low‑availability non‑canonical amino‑acid building blocks
Global export service: Verify suppliers can provide full supporting documents for customs clearance worldwide

HDM BIO supplies research‑grade Elamipretide with full quality records, flexible minimum order quantity and worldwide shipping for small trial batches and long‑term bulk procurement.

Elamipretide Powder Price & Bulk Ordering Guide 2026

Buyers searching for Elamipretide powder price, bulk peptide quotation and delivery terms can refer to key procurement information below:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑level trial samples available; kilogram bulk supply for continuous research projects
Sample Pricing: Trial samples for laboratory assessment; contact sales team to acquire sample quotation
Bulk Kilogram Quotation: Tiered pricing policy, larger bulk orders enjoy competitive unit cost
Production Lead Time: Standard lead time depends on order volume; special lead‑time applies due to custom non‑canonical amino‑acid raw‑material preparation; sales will confirm exact production schedule upon formal inquiry
Shipping Options: Cold‑chain transportation recommended; avoid prolonged room‑temperature exposure; we provide commercial invoice, packing list and MSDS for global customs clearance

Multiple factors influence the final quotation: purity grade, customized testing requirements, special packaging specifications and cold‑chain logistics fees. Contact our sales team for up‑to‑date formal quotation.

Elamipretide Powder Procurement Guide for Global Buyers

Before signing purchase contracts for modified‑amino‑acid‑containing specialty peptide raw materials, international procurement teams should complete these verification steps to mitigate potential risks:

Supplier verification: Confirm the supplier owns independent peptide synthesis workshop and in‑house QC laboratory with hands‑on experience on Szeto‑Schiller‑class modified‑residue peptide production
Document inspection: Request pre‑shipment batch COA, HPLC chromatogram and LC‑MS identity report; confirm modified‑residue mass‑signature match
Product confirmation: Check peptide purity standard, impurity profile and strict cold‑storage specifications match your experimental design; aqueous reconstituted solution is light‑ and oxidation‑sensitive
MOQ & lead time: Confirm stock availability, special raw‑material lead‑time and order adjustment policy
Shipping documents: Confirm the supplier can provide all required files for import customs clearance in your region

About HDM BIO Elamipretide Manufacturing Capability

HDM BIO owns over 10 years of experience focused on Fmoc solid‑phase peptide synthesis and complex specialty peptide raw material manufacturing involving D‑configuration amino‑acids and non‑canonical modified tyrosine building blocks.

Dedicated SPPS production lines equipped for extended‑time coupling protocols required by sterically‑hindered bulky 2,6‑dimethyl‑L‑tyrosine residue
Independent analytical laboratory equipped with HPLC, LC‑MS, moisture tester and heavy‑metal testing instruments; specialized mass‑spectrometry workflow for modified‑residue peptide identity validation
Peptide products exported to more than 70 countries, serving university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team with rich experience in Szeto‑Schiller peptide series synthesis, impurity control and custom analog modification development

Our peptide manufacturing facility operates dedicated Fmoc SPPS production lines with in‑house HPLC purification and LC‑MS analytical capability.

What Technical Challenges Exist in Elamipretide Synthesis & Production?

Elamipretide tetrapeptide incorporates D‑arginine and sterically bulky non‑natural 2,6‑dimethyl‑L‑tyrosine (Dmt). Low coupling efficiency of Dmt building‑block and costly custom‑sourced modified amino‑acid represent core technical bottlenecks separating qualified peptide manufacturers from low‑grade suppliers.

Core production difficulties include:

Bulky 2,6‑dimethyl‑tyrosine exhibits severe steric hindrance during coupling, easily generating single‑amino‑acid deletion impurities
D‑Arg epimerization risk under certain coupling and cleavage conditions, requiring strictly controlled reaction parameters
Non‑canonical Dmt building‑block is not commercially stock item, relying on custom raw‑material preparation, affecting overall production cycle
Dmt aromatic ring is susceptible to oxidative degradation during purification and lyophilization, which will abolish cardiolipin‑binding bioactivity even when mass remains unchanged
Difficult chromatographic separation between target peptide and structurally similar deletion‑sequence analogs, requiring multi‑step preparative‑HPLC workflow

HDM BIO adopts extended‑time activation‑optimized coupling procedure, epimerization‑suppressing base system, multi‑stage gradient HPLC purification and full‑process LC‑MS monitoring for each batch. This minimizes deletion‑sequence, epimer and oxidative‑degradation impurities and guarantees intact Elamipretide tetrapeptide structure and stable batch‑to‑batch quality.

How Does Elamipretide Powder Work in Laboratory Research?

As representative Szeto‑Schiller mitochondria‑targeted peptide, Elamipretide powder penetrates cell membrane and concentrates ~1000‑fold within inner mitochondrial membrane without requiring negative mitochondrial potential as driving force. It directly binds cardiolipin, prevents cardiolipin peroxidation, maintains cristae morphology, stabilizes electron‑transport‑chain supercomplex assembly, curtails electron leakage and cuts mitochondrial ROS generation at source, further inhibits cytochrome‑c release and mitochondrial‑driven apoptotic cascadesPMC.

It serves as a key experimental reference compound for myocardial ischemia‑reperfusion injury, acute kidney‑injury, inherited mitochondrial disorder, age‑dependent bioenergetic decline and mitochondria‑targeted drug‑candidate screening. All mechanism descriptions apply only to in‑vitro and pre‑clinical animal research scenarios.

How Is Elamipretide Powder Manufactured at HDM BIO?

Elamipretide requires strict process control for sterically‑hindered modified‑residue coupling, epimerization suppression and anti‑oxidation protection throughout synthesis, cleavage, purification and lyophilization.

Read related guide: Modified Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Elamipretide Powder Manufacturing Workflow

Raw Material Inspection (custom Dmt & D‑Arg building‑block QC) → Tetrapeptide SPPS Stepwise Coupling (extended coupling cycle for bulky Dmt residue, epimer‑suppressing condition) → Resin Cleavage & Global Deprotection → Crude Peptide Pre‑treatment → Multi‑stage HPLC Purification → Buffer Exchange → Vacuum Lyophilization → Full QC Testing (LC‑MS modified‑residue identity check, impurity profiling) → Batch COA Issuance → Light‑proof Sealed Packaging

QC Inspection Workflow

Incoming Raw Material QC → In‑process coupling & epimerization risk monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification (confirm D‑Arg‑Dmt containing molecular signature) → Moisture & Heavy‑Metal Testing → Residual Solvent Detection → Final Batch Release Approval

Core Process Highlights

Optimized extended‑duration coupling workflow solving steric hindrance issue of 2,6‑dimethyl‑tyrosine residue

Epimer‑suppressing reagent system to avoid D‑arginine configuration inversion

Multi‑stage high‑precision HPLC purification to separate hard‑to‑distinguish deletion‑sequence peptide impurities

Full‑structure LC‑MS verification confirming correct tetrapeptide sequence including non‑canonical Dmt and D‑Arg residues

Light‑proof sealed lyophilized packaging; lyophilized solid stable at −20 °C; aqueous solution is light‑ and oxidation‑sensitive, recommended for aliquot and −80 °C storage after reconstitution

What Are the Main Application Scenarios of Elamipretide Powder?

Cardiovascular pharmacology research: Myocardial ischemia‑reperfusion injury, heart‑failure mitochondrial bioenergetics, cardiomyocyte oxidative‑stress protection experiments
Mitochondrial disease pre‑clinical study: Barth syndrome, mitochondrial myopathy and inherited mitochondrial‑dysfunction disease model research
Organ injury research: Renal ischemia‑reperfusion, organ preservation and anti‑oxidative‑stress assay
Aging‑biology research: Age‑related mitochondrial functional decline, senescent‑cell mitochondrial damage mechanism exploration
Biomedical reagent preparation: Laboratory reference standards and experimental control reagents for Szeto‑Schiller mitochondria‑targeted peptide study
Peptide structure‑activity‑relationship research: SS‑series peptide analog screening and cardiolipin‑binding structure optimization

Why Choose HDM BIO As Your Elamipretide Powder Supplier?

10+ years of professional specialty peptide manufacturing experience in China, good command of peptides containing D‑amino‑acid and non‑canonical bulky modified tyrosine residues
Mature extended‑coupling SPPS workflow for sterically‑hindered Dmt‑containing Szeto‑Schiller peptide, effective reduction of deletion‑sequence impurities
Strict full‑structure verification and batch‑to‑batch impurity‑profile control for every production lot
Complete production traceability records for each batch of Elamipretide
Flexible supply: milligram lab samples to kilogram‑level bulk peptide orders
Global export service covering more than 70 countries and regions
Professional technical team supporting mitochondria‑targeted peptide research & Szeto‑Schiller custom analog synthesis consulting

FAQs About Elamipretide Powder

Q: Where can I buy Elamipretide powder from China?

A: HDM BIO is a China‑based specialty modified‑residue peptide supplier providing high‑purity Elamipretide powder for global pharmaceutical R&D teams and biotech laboratories. We offer small research samples and large bulk orders, supported by complete export documents and worldwide cold‑chain shipping.

Q: What documents should a qualified Elamipretide supplier provide?

A: Reliable suppliers can offer batch‑specific COA, HPLC purity chromatogram, LC‑MS identity verification report, MSDS and complete production traceability records.

Q: What is the CAS number of Elamipretide?

A: The CAS registry number of Elamipretide is 736992‑21‑5.

Q: What purity grade of Elamipretide powder can you supply?

A: Standard research grade ≥98% HPLC purity. Higher purity specifications and Szeto‑Schiller series custom analog can be synthesized for special experimental requirements.

Q: How should lyophilized Elamipretide powder be stored?

A: Store sealed at ‑20 °C, protected from light and moisture. Avoid repeated freeze‑thaw cycles. Reconstituted aqueous solution is susceptible to light‑triggered oxidation; prepare single‑use aliquots and store at −80 °C, avoid long‑term storage at 2‑8 °C.

Q: Can I obtain Elamipretide samples before bulk cooperation?

A: Yes. We provide milligram to gram‑level trial samples attached with complete COA and test documents for laboratory evaluation.

Q: What is the MOQ for bulk Elamipretide powder?

A: MOQ is flexible based on purity grade and packaging requirements. We support small research batches and large‑scale bulk orders to satisfy different project demands.

Q: What is the amino‑acid sequence of Elamipretide?

A: D‑Arg‑2,6‑dimethyl‑Tyr‑Lys‑Phe‑NH₂ (D‑Arg‑Dmt‑Lys‑Phe‑NH₂)

Scientific Review

Reviewed by: HDM BIO Peptide Technical Team Expertise: Peptide synthesis D‑amino‑acid & non‑canonical modified‑residue specialty peptide manufacturing Analytical chemistry & HPLC/LC‑MS modified‑peptide identity testing

Last Updated: August 2026

Disclaimer: All product content is provided for academic research and laboratory raw‑material reference only. Not intended for human clinical use, diagnosis or treatment.