Acetylsalicylic Acid API CAS 50-78-2 | ≥98% Aspirin NSAID Manufacturer China

Key Selling Points

✓ Classic Salicylate NSAID - The Reference Standard for All NSAIDs

✓ Irreversible COX-1/COX-2 Acetylation (Unique Among NSAIDs)

✓ Antipyretic + Analgesic + Anti-Inflammatory + Antiplatelet

✓ Water-Soluble Sodium Salt Form Available for Drinking Water

✓ Swine, Calf & Poultry Fever/Pain/Inflammation Reference

✓ Low-Cost, High-Availability API with Mature Supply Chain

What Is Acetylsalicylic Acid Powder?

Acetylsalicylic Acid Powder, commonly known as aspirin (ASA), is the original and most widely studied salicylate-class non-steroidal anti-inflammatory drug. It serves as the reference standard to which all other NSAIDs are compared, and is used in veterinary medicine as an antipyretic, analgesic and anti-inflammatory agent.

In veterinary practice, acetylsalicylic acid is most commonly administered as its sodium salt (sodium acetylsalicylate) in drinking water or feed for pigs, calves and chickens at doses of 5–300 mg/kg body weight per day for periods not exceeding 10 days. Commercial veterinary products are typically formulated as 50–75% water-soluble powders. Its low cost, wide availability and well-characterized pharmacology make it a staple raw material for veterinary formulation development.

How Does Acetylsalicylic Acid Powder Work?

Acetylsalicylic Acid Powder exerts its effects through irreversible acetylation of the cyclooxygenase enzymes COX-1 and COX-2, which catalyze the conversion of arachidonic acid to prostaglandins, thromboxanes and prostacyclin. This irreversible inhibition distinguishes aspirin from most other NSAIDs, which bind COX reversibly. By suppressing prostaglandin synthesis, it produces antipyretic effects (lowering the hypothalamic thermoregulatory set point), analgesic effects (reducing peripheral pain sensitization) and anti-inflammatory effects.

Additionally, Acetylsalicylic Acid Powder irreversibly inhibits platelet COX-1, reducing thromboxane A₂ production and exerting an antiplatelet effect that is unique among commonly used veterinary NSAIDs. Its active metabolite salicylic acid also contributes to anti-inflammatory activity through additional mechanisms including NF-κB pathway modulation.

What Are the Applications of Acetylsalicylic Acid Powder?

Swine Fever & MMA Syndrome: Used in formulation research for fever, metritis-mastitis-agalactia (MMA) syndrome, respiratory and gastrointestinal diseases in pigs.
Calf & Young Cattle: Evaluated for hyperthermia, inflammatory conditions and mild-to-moderate pain in calves under 3 months of age.
Poultry Heat Stress & Infectious Fever: Studied for heat stress, post-vaccinal reactions, viral and acute bacterial diseases, and respiratory conditions in broilers and breeders.
Musculoskeletal & Postoperative Pain: Used for rheumatoid arthritis, osteoarthritis, muscle pain, postoperative pain, tendinitis, myositis and neuritis in large animals.
Antiplatelet Research: Serves as a reference compound for platelet aggregation and thromboxane pathway studies in cardiovascular research.

What Is the Difference Between Acetylsalicylic Acid and Sodium Acetylsalicylate?

Feature	Acetylsalicylic Acid	Sodium Acetylsalicylate
CAS	50-78-2	26635-79-0
Form	Free acid	Sodium salt
Molecular Weight	180.16	202.14
Water Solubility	Slightly soluble (~3 mg/mL)	Freely soluble
Typical Use	Oral tablets / feed additive	Drinking-water medication
pH	Acidic	Neutral to slightly alkaline
Veterinary Formulation	50–75% soluble powder (often as sodium salt)	Direct soluble powder

How Does Acetylsalicylic Acid Compare With Other Veterinary NSAIDs?

Feature	Acetylsalicylic Acid	Carbasalate Calcium	Flunixin Meglumine	Metamizole Sodium
CAS	50-78-2	5749-67-7	42461-84-7	68-89-3
Class	Salicylate	Salicylate (aspirin complex)	Nicotinic acid	Pyrazolone
COX Inhibition	Irreversible	Irreversible (via aspirin)	Reversible	Reversible
Antipyretic	Moderate	Moderate	Strong	Strong
Analgesic	Moderate	Moderate	Strong	Strong
Anti-Inflammatory	Moderate	Moderate	Strong	Moderate
Antiplatelet	Yes (unique)	Yes	No	No
Spasmolytic	No	No	No	Yes
Water Solubility	Poor	Good (complex)	Good (salt)	Good
Cost	Low	Low-Medium	Medium	Medium

How Is Acetylsalicylic Acid Powder Manufactured?

Acetylsalicylic Acid Powder is manufactured by acetylation of salicylic acid with acetic anhydride under acid catalysis, followed by crystallization, purification and drying.

Raw Material QC → Salicylic Acid → Acetylation (Acetic Anhydride) → Crystallization → Recrystallization Purification → Drying → Final QC → Packaging

HDM BIO controls key acetylation, crystallization and drying parameters to maintain consistent purity, particle size and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White or off-white powder	Consistent
Assay (HPLC)	≥98%	99.2%
Identity (IR)	Conforms to reference standard	Confirmed
Melting Point	~135°C (decomposition)	134.8°C
Salicylic Acid (Free)	≤0.1%	0.05%
Related Substances	Within specification	Pass
Loss on Drying	≤0.5%	0.2%
Residue on Ignition	≤0.1%	Compliant
Heavy Metals	≤10 ppm	Compliant
Chloride	≤0.01%	Compliant
Sulfate	≤0.02%	Compliant

What Quality Control Tests Are Performed for Acetylsalicylic Acid Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity, free salicylic acid content and physical properties.

Raw Material QC → In-Process Control → HPLC Assay → IR Identity Verification → Melting Point Determination → Free Salicylic Acid Test → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Residue on Ignition → Chloride/Sulfate Tests → Final Batch Release

Key evaluations include identification via infrared (IR) spectroscopy, HPLC active content assay, free salicylic acid limit test (critical degradation product), melting point determination, related substances analysis, loss on drying, heavy metal limits, residue on ignition and chloride/sulfate tests. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Acetylsalicylic Acid Powder Bulk Price?

Acetylsalicylic Acid Powder bulk pricing is driven by several key factors:

Starting Material Costs: Salicylic acid and acetic anhydride availability and pricing directly influence manufacturing expenses.
Purity & Grade: Higher assay percentages and strict free salicylic acid control cost more to produce.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price.
Order Volume: Large-scale industrial or wholesale contracts receive steeper per-kilogram discounts than small-batch specialty orders.
Logistics & Geography: Shipping distance, moisture-barrier packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Acetylsalicylic Acid Powder Supplier?

High-purity (≥98% / typical 99%+) classic salicylate NSAID reference standard
Irreversible COX inhibition with unique antiplatelet profile
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Acetylsalicylic Acid Powder

Q1: What is Acetylsalicylic Acid Powder?

A: The classic salicylate NSAID commonly known as aspirin (ASA), supplied as veterinary raw material for antipyretic, analgesic and anti-inflammatory formulation development.

Q2: What is the CAS number?

A: 50-78-2.

Q3: Is acetylsalicylic acid the same as aspirin?

A: Yes. Acetylsalicylic acid is the chemical name; aspirin (ASA) is the common/brand-derived name.

Q4: How does it work?

A: It irreversibly acetylates COX-1 and COX-2 enzymes, reducing prostaglandin, thromboxane and prostacyclin synthesis. This produces antipyretic, analgesic, anti-inflammatory and unique antiplatelet effects.

Q5: What animals is aspirin used for in veterinary medicine?

A: Primarily pigs, calves and chickens (as sodium salt in drinking water/feed), and large animals for musculoskeletal and postoperative pain. Dosing typically does not exceed 10 days.

Q6: What documents are provided with each batch?

A: Batch-specific COA, HPLC report, IR identity records, free salicylic acid data, MSDS/SDS and relevant export documentation are available according to order requirements.

Q7: What purity do you supply?

A: Standard ≥98% HPLC; typical batch result 99.2%. Higher grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Acetylsalicylic Acid Powder with batch COA and global export support.

Q9: How much does Acetylsalicylic Acid Powder cost?

A: Bulk pricing depends on salicylic acid/acetic anhydride starting material costs, purity grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q10: Is this product for human clinical use?

A: It is supplied as veterinary raw material and is not intended for direct clinical administration. Finished products manufactured from the material must comply with applicable local regulatory requirements.