Diminazene Aceturate CAS 536-71-0 | High Purity Veterinary Pharmaceutical Ingredient Manufacturer & Bulk Supplier China

Key Selling Points

✓ Aromatic Diamidine Antiprotozoal - DNA Minor Groove Binder (A-T Rich Regions)

✓ First-Line for African Animal Trypanosomiasis - T. congolense / T. vivax / T. brucei

✓ Dual Efficacy Against Babesiosis & Theileriosis - B. bovis, B. canis, T. annulata

✓ Irreversible Kinetoplast DNA Binding - Blocks Replication & Transcription

✓ Classic Reference Trypanocide - Berenil, Used in Cattle/Sheep/Goats/Horses/Dogs

✓ Often Formulated with Antipyrine / Vitamin B12 - Commercial Injection Standards

What Is Diminazene Aceturate Powder?

Diminazene Aceturate Powder is the diaceturate salt of diminazene, an aromatic diamidine antiprotozoal compound widely used in veterinary medicine. It is structurally related to pentamidine and is one of the commonly used veterinary trypanocidal agents.

Diminazene Aceturate is mainly used in veterinary pharmaceutical development for the study and treatment of protozoal diseases, including African animal trypanosomiasis, babesiosis and theileriosis in livestock and companion animals.

Due to its antiprotozoal activity, it is widely researched for applications involving Trypanosoma, Babesia and Theileria species. The compound is typically supplied as a yellow to orange powder and formulated into injectable veterinary preparations.

How Does Diminazene Aceturate Powder Work?

Diminazene Aceturate Powder exerts its antiprotozoal activity mainly by binding to the minor groove of parasite DNA, especially adenine-thymine (A-T) rich regions. This interaction disrupts DNA replication and mRNA transcription, preventing parasite growth and reproduction.

By targeting kinetoplast DNA and nuclear DNA of protozoa, Diminazene Aceturate Powder interferes with nucleic acid metabolism and energy production pathways, leading to the elimination of susceptible Trypanosoma and Babesia species.

Its strong DNA-binding activity also contributes to potential toxicity in mammals, especially with overdose or repeated administration. Due to its narrow therapeutic window, accurate dosing and proper veterinary use are essential. Resistance in some field strains has also been reported, requiring responsible application and monitoring.

What Are the Applications of Diminazene Aceturate Powder?

Bovine Trypanosomiasis (Nagana): First-line treatment of Trypanosoma congolense, T. vivax and T. brucei infections in cattle - the most economically important livestock disease in sub-Saharan Africa.
Equine Trypanosomiasis (Surra): Treatment of Trypanosoma evansi infections in horses, camels and other equids.
Babesiosis (Piroplasmosis): Treatment of Babesia bovis and B. bigemina in cattle, B. ovis and B. motasi in sheep/goats, and B. canis in dogs.
Theileriosis: Adjunct treatment of Theileria annulata (tropical theileriosis) in cattle.
Small Ruminant & Canine Protozoal Infections: Used in sheep, goats and dogs for susceptible blood protozoa, subject to species-specific dosing and safety considerations.

What Is the Difference Between Diminazene Aceturate and Isometamidium Chloride?

Feature	Diminazene Aceturate	Isometamidium Chloride
CAS	536-71-0	34301-55-8
Drug Class	Aromatic diamidine	Phenanthridinium trypanocide
Primary Use	Therapeutic treatment	Prophylaxis + treatment
Duration of Action	Short (therapeutic)	Long (prophylactic, up to 2-4 months)
Administration	Deep IM injection	IM injection
Mechanism	DNA minor groove binding (A-T rich)	DNA intercalation + kinetoplast targeting
Resistance	Increasing reports	Increasing reports
Typical Species	Cattle, sheep, goats, horses, dogs	Cattle (primarily)
Toxicity Profile	Narrow therapeutic index, neurotoxicity in dogs	Narrow therapeutic index, local tissue reaction

How Does Diminazene Compare With Other Veterinary Antiprotozoals?

Feature	Diminazene	Imidocarb	Pentamidine	Suramin
CAS	536-71-0	27885-92-3	100-33-4	129-46-4
Class	Diamidine	Carbanilide	Diamidine	Sulfonated naphthylamine
Trypanosomes	Yes	No	Yes	Yes
Babesia	Yes	Yes (best)	No	No
Theileria	Partial	No	No	No
Primary Route	IM	IM/SC	IM/IV	IV
Prophylactic Use	No	Yes	No	No
Narrow TI	Yes	Moderate	Yes	Yes

How Is Diminazene Aceturate Powder Manufactured?

Diminazene Aceturate Powder is manufactured through chemical synthesis involving diazotization and coupling reactions to form the triazene-linked bis-benzamidine structure, followed by aceturate salt formation and purification.

Raw Material QC → p-Aminobenzamidine Synthesis → Diazotization → Triazene Coupling → Diminazene Base Formation → Aceturate Salt Formation → Purification (Recrystallization) → Drying → Milling → Final QC → Packaging

HDM BIO controls key diazotization, coupling, salt formation and crystallization parameters to maintain consistent purity and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	Yellow to orange powder	Consistent
Assay (HPLC)	≥98.0%	99.0%
Identity (IR / UV)	Conforms to reference standard	Confirmed
Melting Point	~217°C (decomposition)	215°C
Loss on Drying	≤0.5%	0.2%
Residue on Ignition	≤0.2%	Compliant
Heavy Metals	≤10 ppm	Compliant
Arsenic	≤2 ppm	Compliant
Related Substances	Within specification	Pass
Residual Solvents	Within specification	Pass
pH (1% solution)	5.0–7.0	6.0

What Quality Control Tests Are Performed for Diminazene Aceturate Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity and physical properties.

Raw Material QC → In-Process Control → HPLC Assay → IR / UV Identity Verification → Melting Point Determination → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Arsenic → Residue on Ignition → pH Test → Residual Solvents → Final Batch Release

Key evaluations include identification via infrared (IR) and ultraviolet (UV) spectroscopy, HPLC active content assay, melting point determination, related substances analysis, loss on drying, heavy metal and arsenic limits, residue on ignition, pH and residual solvent testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Diminazene Aceturate Powder Bulk Price?

Diminazene Aceturate Powder bulk pricing is driven by several key factors:

Synthesis Costs: Multi-step chemical synthesis including diazotization, triazene coupling and aceturate salt formation directly influence manufacturing expenses.
Purity & Grade: Higher purity (≥99%) and pharmaceutical-grade batches command premiums over standard veterinary grade.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price.
Order Volume: Large-scale veterinary pharmaceutical contracts receive steeper per-kilogram discounts than small-batch orders.
Logistics & Geography: Light-protected packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Diminazene Aceturate Powder Supplier?

High-purity (≥98% / typical 99%) aromatic diamidine antiprotozoal with proven trypanocidal and babesiocidal efficacy
First-line agent for African animal trypanosomiasis - the most economically important livestock disease in sub-Saharan Africa
Dual efficacy against trypanosomiasis, babesiosis and theileriosis
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Diminazene Aceturate Powder

Q1: What is Diminazene Aceturate Powder?

A: The diaceturate salt of diminazene, an aromatic diamidine antiprotozoal agent (Berenil), used for trypanosomiasis, babesiosis and theileriosis in livestock and companion animals.

Q2: What is the CAS number?

A: 536-71-0 (diminazene base; the aceturate salt is commonly referenced under the same CAS in veterinary API specifications).

Q3: How does diminazene aceturate work?

A: It irreversibly binds the minor groove of parasite DNA (A-T rich regions), inhibiting DNA replication and transcription; kinetoplast DNA is a primary target. It also interferes with aerobic glycolysis.

Q4: What animals is diminazene used for?

A: Cattle, sheep, goats, horses and dogs for trypanosomiasis, babesiosis and theileriosis. Typical dosage: horses 3–4 mg/kg, cattle/sheep/goats 3–5 mg/kg by deep IM injection.

Q5: Is diminazene aceturate safe?

A: It has a narrow therapeutic index. Adverse effects include restlessness, frequent urination, muscle tremors, salivation and sweating; overdosage can be fatal. Multiple doses in dogs may cause neurotoxicity. Use under veterinary supervision.

Q6: What documents are provided with each batch? A

: Batch-specific COA, HPLC report, IR/UV identity records, melting point data, MSDS/SDS and relevant export documentation.

Q7: What purity do you supply?

A: Standard ≥98% HPLC; typical batch result 99%. Higher grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Diminazene Aceturate Powder with batch COA and global export support.

Q9: How much does Diminazene Aceturate Powder cost?

A: Bulk pricing depends on synthesis costs, purity/grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q10: Can diminazene be given intravenously?

A: No. Diminazene aceturate Powder is administered by deep intramuscular injection only. IV administration may cause severe hypotension and shock.