Benzylpenicillin Potassium CAS 113-98-4 | High Purity Pharmaceutical Antibiotic API Manufacturer & Bulk Supplier China

Key Selling Points

✓ Original Natural Penicillin - First Discovered β-Lactam Antibiotic

✓ Narrow-Spectrum Gram-Positive Coverage - Streptococci, Pneumococci, Clostridia

✓ β-Lactam Cell Wall Synthesis Inhibition - Bactericidal Against Dividing Bacteria

✓ Water-Soluble Potassium Salt - IM/IV Injectable Formulation Ready

✓ Anaerobic Activity + Synergy With Aminoglycosides

✓ Classic Reference Antibiotic - Widely Used in Veterinary Practice

What Is Potassium Penicillin Powder?

Potassium Penicillin Powder is the potassium salt of benzylpenicillin (penicillin G), a natural β-lactam antibiotic produced by fermentation. It is a narrow-spectrum penicillin mainly active against susceptible Gram-positive bacteria and some Gram-negative organisms.

In veterinary medicine, Potassium Penicillin Powder is widely used as a raw material for formulations targeting susceptible bacterial infections, including streptococcal infections, respiratory infections, mastitis, erysipelas and other bacterial diseases in livestock and companion animals. Due to its poor acid stability, penicillin G is not suitable for oral administration and is typically formulated for injection use.

As a β-lactam antibiotic, it is susceptible to β-lactamase degradation, which limits activity against resistant bacterial strains. Hypersensitivity reactions are the primary safety concern, and appropriate quality control and regulatory compliance are required for pharmaceutical applications.

How Does Potassium Penicillin Powder Work?

Potassium Penicillin Powder works by targeting bacterial cell wall synthesis. Its β-lactam ring binds to penicillin-binding proteins (PBPs), especially transpeptidases responsible for peptidoglycan cross-linking, blocking proper cell wall formation.

This disruption weakens the bacterial cell wall and causes osmotic lysis, resulting in bactericidal activity against actively dividing susceptible bacteria. Due to its mechanism, penicillin G is mainly effective against rapidly growing Gram-positive bacteria and some susceptible Gram-negative organisms.

Its activity can be reduced by β-lactamase-producing bacteria, which hydrolyze the β-lactam ring and cause resistance. Therefore, It is primarily used for susceptible bacterial strains in pharmaceutical and veterinary formulation development.

What Are the Applications of Potassium Penicillin Powder?

Equine Infections: First-line treatment for streptococcal infections (Streptococcus equi - strangles), tetanus, anthrax, pleuropneumonia and other susceptible Gram-positive respiratory and systemic infections.
Bovine Infections: Used for mastitis (intramammary and systemic), pneumonia, septicemia, tetanus, anthrax and clostridial diseases in cattle.
Swine Infections: Treatment of erysipelas (Erysipelothrix rhusiopathiae), streptococcal infections, pneumonia and leptospirosis in pigs.
Canine & Feline Infections: Used for susceptible streptococcal and staphylococcal infections, tetanus, leptospirosis, Lyme disease (Borrelia burgdorferi) and anaerobic infections.
Small Ruminants & Poultry: Used for mastitis, septicemia and clostridial diseases in sheep and goats; less commonly used in poultry due to injection-only administration.

What Is the Difference Between Penicillin G Potassium and Penicillin G Sodium?

Feature	Penicillin G Potassium	Penicillin G Sodium
CAS	113-98-4	69-57-8
Molecular Formula	C₁₆H₁₇KN₂O₄S	C₁₆H₁₇N₂NaO₄S
Molecular Weight	372.48	356.37
Cation	Potassium (K⁺)	Sodium (Na⁺)
Potassium Load	Higher (1.7 mEq K per million IU)	None
Sodium Load	None	Higher
IV Bolus Use	Caution in renal impairment / hyperkalemia	Preferred for large IV doses
Clinical Equivalence	Equivalent antibacterial activity	Equivalent antibacterial activity
Typical Veterinary Use	Most common IM/IV form	Used when sodium load preferred

How Does Penicillin G Compare With Other Veterinary Penicillins?

Feature	Penicillin G	Ampicillin	Amoxicillin	Cloxacillin
CAS (potassium/sodium)	113-98-4	69-53-4	26787-78-0	7081-44-9
Spectrum	Narrow (Gram+)	Broad (Gram+ & Gram-)	Broad (Gram+ & Gram-)	Narrow (penicillinase-resistant)
Acid-Stable	No (injection only)	Yes (oral)	Yes (oral)	Yes (oral)
β-Lactamase Resistant	No	No	No	Yes
Anaerobic Activity	Yes	Moderate	Moderate	Weak
Typical Veterinary Use	Horse, cattle, pig, dog/cat	All species, oral	All species, oral	Mastitis, staph infections

How Is Potassium Penicillin Powder Manufactured?

Potassium Penicillin Powder is manufactured through submerged fermentation of Penicillium chrysogenum, followed by extraction, purification, potassium salt formation and sterile/non-sterile processing.

Raw Material QC → Submerged Fermentation (Penicillium chrysogenum) → Filtration & Extraction → Purification (Solvent Extraction / Chromatography) → Potassium Salt Formation → Crystallization → Drying → Milling → Sieving → Final QC → Packaging

HDM BIO controls key fermentation, extraction, salt formation and crystallization parameters to maintain consistent potency, purity and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Potency (bioassay)	≥1598 IU/mg	1620 IU/mg
Assay (HPLC)	≥98%	99.0%
Identity (IR)	Conforms to reference standard	Confirmed
Specific Rotation	+270° to +300°	+285°
pH (6% solution)	5.5–7.5	6.5
Loss on Drying	≤1.0%	0.4%
Residue on Ignition	≤0.5%	Compliant
Heavy Metals	≤10 ppm	Compliant
Related Substances	Within specification	Pass
Endotoxin (sterile grade)	Within specification	Pass

What Quality Control Tests Are Performed for Potassium Penicillin Powder?

Each batch undergoes multi-step quality control before release to verify identity, potency, purity and safety.

Raw Material QC → In-Process Control → HPLC Assay → IR Identity Verification → Microbiological Potency Assay (IU/mg) → Specific Rotation → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Residue on Ignition → pH Test → Endotoxin (sterile grade) → Residual Solvents → Final Batch Release

Key evaluations include identification via infrared (IR) spectroscopy, HPLC active content assay, microbiological potency assay (IU/mg), specific rotation, related substances analysis, loss on drying, heavy metal limits, residue on ignition, pH, endotoxin (for sterile grade) and residual solvent testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Potassium Penicillin Powder Bulk Price?

Potassium Penicillin Powder bulk pricing is driven by several key factors:

Fermentation Costs: Submerged fermentation of Penicillium chrysogenum, including raw materials, energy and downstream extraction, directly influences manufacturing expenses.
Purity & Grade: Higher potency (≥1598 IU/mg), sterile grade and endotoxin-controlled batches command premiums over non-sterile industrial grade.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price.
Order Volume: Large-scale pharmaceutical contracts receive steeper per-kilogram discounts than small-batch specialty orders.
Logistics & Geography: Cold-chain shipping, light-protection packaging and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Potassium Penicillin Powder Supplier?

High-purity (≥98% / ≥1598 IU/mg) natural β-lactam antibiotic with proven potency
Narrow-spectrum Gram-positive coverage - first-line agent for streptococcal, clostridial and anaerobic infections
Water-soluble potassium salt suitable for IM/IV injectable formulations
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC, potency assay)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Potassium Penicillin Powder

Q1: What is Potassium Penicillin Powder?

A: The potassium salt of benzylpenicillin (penicillin G), the original natural β-lactam antibiotic, used for susceptible Gram-positive bacterial infections in veterinary practice.

Q2: What is the CAS number?

A: 113-98-4 (potassium salt); penicillin G sodium is 69-57-8.

Q3: How does penicillin G work?

A: Its β-lactam ring irreversibly binds bacterial DD-transpeptidases (PBPs), inhibiting peptidoglycan cross-linking and cell wall synthesis, causing osmotic lysis of dividing bacteria.

Q4: Is penicillin G effective against Gram-negative bacteria?

A: It has a narrow spectrum - primarily Gram-positive and anaerobic organisms. Only a few Gram-negative species (Neisseria meningitidis, N. gonorrhoeae) are susceptible at usual concentrations.

Q5: Can penicillin G be given orally?

A: No. Penicillin G is acid-labile and destroyed by stomach acid, so it must be administered by intramuscular or intravenous injection.

Q6: What documents are provided with each batch?

A: Batch-specific COA, HPLC report, IR identity records, microbiological potency assay (IU/mg), specific rotation data, MSDS/SDS and relevant export documentation.

Q7: What purity do you supply?

A: Standard ≥98% HPLC / ≥1598 IU/mg potency. Sterile and higher grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Potassium Penicillin Powder with batch COA and global export support.

Q9: How much does Potassium Penicillin Powder cost?

A: Bulk pricing depends on fermentation costs, purity/grade, regulatory compliance, order volume and cold-chain logistics. Contact HDM BIO for a current quotation.

Q10: Is penicillin G safe?

A: Penicillin G carries a significant risk of hypersensitivity reactions, including anaphylaxis. It is supplied as veterinary/pharmaceutical raw material only; appropriate screening and emergency preparedness are essential before clinical use. Not for direct clinical administration.