Penicillin G Sodium API Manufacturer China | ≥98% Beta-Lactam Antibiotic Powder CAS 69-57-8

Key Selling Points

✓ Natural Penicillin G Sodium Salt - Gold-Standard Narrow-Spectrum β-Lactam

✓ Less Painful IM Injection vs Potassium Salt - Preferred for Intramuscular Administration

✓ High Potency ~1650 U/mg - Time-Dependent Bactericidal PBP Inhibition

✓ Classic Treponema & Streptococcus Agent - Syphilis, Leptospirosis, Strep Throat, Erysipelas

✓ Anaerobic & Gram-Positive Coverage - Clostridium, Actinomyces, Pasteurella, Anthrax

✓ Well-Established Veterinary API - Bovine/Swine/Poultry Respiratory, Mastitis, Tetanus

What Is Sodium Penicillin Powder?

Sodium Penicillin Powder (benzylpenicillin sodium, penicillin G sodium) is the sodium salt of natural penicillin G (C₁₆H₁₇N₂NaO₄S, MW 356.37), the first clinically used antibiotic and a gold-standard narrow-spectrum β-lactam. Unlike the potassium salt, it causes less pain on IM injection but carries a sodium load (~64.5 mg Na/g) relevant for cardiac/renal patients.

Active against Gram-positive organisms (streptococci, pneumococci, non-penicillinase-producing staphylococci, enterococci, Listeria, Clostridium, Actinomyces, Bacillus anthracis), selected Gram-negatives (Neisseria, Pasteurella), spirochetes (Treponema, Leptospira) and anaerobes. Acid-labile (not oral) and β-lactamase-susceptible. Human uses: syphilis (first-line), streptococcal pharyngitis/erysipelas, pneumococcal pneumonia, meningococcal infection, leptospirosis, diphtheria, tetanus, gas gangrene, anthrax, actinomycosis. Veterinary uses: bovine/swine/poultry respiratory infections (Pasteurella, Streptococcus), mastitis, tetanus, leptospirosis, swine erysipelas, fowl cholera. Penicillin hypersensitivity is the most serious risk (rash to anaphylaxis, cross-allergenicity across all β-lactams); high doses may cause neurotoxicity (seizures) and sodium overload.

How Does Sodium Penicillin Powder Work?

Sodium Penicillin Powder exerts bactericidal activity through β-lactam inhibition of penicillin-binding proteins (PBPs), blocking the final transpeptidation step in cell wall peptidoglycan synthesis, weakening the wall and causing osmotic lysis in actively dividing bacteria.

Because Sodium Penicillin Powder is time-dependent (efficacy correlates with time above MIC), frequent dosing optimizes activity. The benzyl side chain gives narrow spectrum - primarily Gram-positive - with no Gram-negative porin penetration (unlike aminopenicillins). It does not resist β-lactamase, which hydrolyzes the ring to inactive penicilloic acid (primary resistance, esp. S. aureus). Excretion primarily renal (~60–80% unchanged); dose adjustment in severe renal impairment. Not active against Mycoplasma, Chlamydia, Legionella or β-lactamase producers. The sodium counter-ion is pharmacologically inert but contributes to sodium load at high doses.

What Are the Applications of Sodium Penicillin Powder?

Human Treponemal & Streptococcal Infections: First-line for syphilis (Treponema pallidum); streptococcal pharyngitis, erysipelas, cellulitis, scarlet fever; pneumococcal pneumonia.
Human Serious Infections: Meningococcal meningitis/sepsis, leptospirosis, diphtheria, tetanus, gas gangrene (Clostridium perfringens), anthrax, actinomycosis, infective endocarditis.
Veterinary Respiratory Infections: Bovine respiratory disease (Pasteurella multocida, Mannheimia), swine pneumonia, fowl cholera (Pasteurella multocida).
Veterinary Other: Mastitis (streptococci, sensitive staphylococci), tetanus, leptospirosis, swine erysipelas (Erysipelothrix rhusiopathiae), anthrax in livestock.
Pharmaceutical API: Raw material for injectable penicillin G sodium formulations (IM/IV), often combined with procaine benzylpenicillin for depot effect.

What Is the Difference Between Penicillin G Sodium and Penicillin G Potassium?

Feature	Penicillin G Sodium	Penicillin G Potassium
CAS	69-57-8	113-98-4
Molecular Formula	C₁₆H₁₇N₂NaO₄S	C₁₆H₁₇KN₂O₄S
Molecular Weight	356.37	372.48
Counter-Ion	Sodium	Potassium
IM Injection Pain	Less painful	More painful (often with procaine)
Sodium Load	High (~64.5 mg/g)	None
Potassium Load	None	Present
Cardiac/Renal Caution	Sodium-sensitive patients	Hyperkalemia patients
Antibacterial Spectrum	Identical	Identical
Mechanism	Identical	Identical
Typical Use	IV/IM (less pain)	IM (often procaine combination)

How Does Penicillin G Compare With Other Natural Penicillins?

Feature	Penicillin G (Sodium)	Penicillin V	Procaine Penicillin	Benzathine Penicillin
CAS (salt)	69-57-8	87-08-1	54-35-3	1538-09-6
Route	IV/IM	Oral	IM (depot)	IM (long-acting depot)
Acid Stability	No (destroyed)	Yes (oral)	No (IM only)	No (IM only)
Duration	Short (4–6 hr)	Short (oral)	Intermediate (12–24 hr)	Long (2–4 weeks)
Typical Use	Serious infections, IV	Strep throat, mild infections	Syphilis, IM depot	Syphilis prophylaxis, rheumatic fever
Pain on IM	Moderate	N/A	High (procaine)	High (benzathine)
Spectrum	Identical (narrow Gram+)	Identical	Identical	Identical

How Is Sodium Penicillin Powder Manufactured?

Sodium Penicillin Powder is manufactured by fermentation of Penicillium chrysogenum to produce penicillin G, followed by extraction, purification and sodium salt formation.

Raw Material QC → Penicillium chrysogenum Fermentation → Penicillin G Extraction (Solvent) → Purification (Chromatography) → Sodium Salt Formation (Sodium Hydroxide / Sodium 2-ethylhexanoate) → Crystallization / Lyophilization → Drying → Milling → Sterile Filtration (injectable grade) → Final QC → Aseptic Packaging

HDM BIO controls key fermentation, extraction, salt formation and crystallization parameters to maintain consistent potency, purity and β-lactam ring integrity.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Potency	≥1600 U/mg	1650 U/mg
Identity (IR / HPLC)	Conforms to reference standard	Confirmed
pH (60 g/L)	5.0–7.5	6.2
Water Content (Karl Fischer)	≤1.0%	0.5%
Specific Optical Rotation	+285° to +310°	+298°
Related Substances	Within specification	Pass
Penicilloic Acid	≤1.0%	Compliant
Heavy Metals	≤10 ppm	Compliant
Residual Solvents	Within specification	Pass
Sterility (injectable grade)	Sterile	Compliant
Bacterial Endotoxins (injectable grade)	≤0.01 EU/U	Compliant

What Quality Control Tests Are Performed for Sodium Penicillin Powder?

Each batch undergoes multi-step quality control before release to verify identity, potency, purity and sterility (injectable grade).

Raw Material QC → In-Process Control → Potency Assay (Microbiological / HPLC) → IR Identity Verification → pH Determination → Karl Fischer Water Content → Specific Optical Rotation → Related Substances (HPLC, incl. penicilloic acid) → Heavy Metals → Residual Solvents → Sterility Test (injectable grade) → Bacterial Endotoxin Test (LAL, injectable grade) → Final Batch Release

Key evaluations include potency assay (≥1600 U/mg), IR identity, pH, Karl Fischer water content, specific optical rotation, related substances with specific penicilloic acid limit, heavy metals, residual solvents, and for injectable grade: sterility and bacterial endotoxin (LAL) testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Sodium Penicillin Powder Bulk Price?

Sodium Penicillin Powder bulk pricing is driven by several key factors:

Fermentation Costs: Penicillium chrysogenum fermentation scale, yield and downstream extraction/purification costs directly influence manufacturing expenses.
Potency & Grade: Injectable grade (sterile, endotoxin-controlled, ≥1600 U/mg) commands a significant premium over oral/technical grade.
Sterility & Endotoxin Specification: Aseptic processing and LAL-tested batches for injection carry higher production costs.
Regulatory Compliance & Certification: GMP-standard API with DMF/CEP and consistent COA demand a higher price.
Order Volume: Large-scale pharmaceutical contracts (tonnage) receive steeper per-kilogram discounts.
Logistics & Geography: Cold-chain (2–8°C) / light-protected / moisture-proof packaging and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Sodium Penicillin Powder Supplier?

High-potency (≥1600 U/mg, typical 1650) natural penicillin G sodium for injectable formulations
Less painful IM injection vs potassium salt; verified β-lactam integrity and low penicilloic acid
Gold-standard narrow-spectrum β-lactam with classic treponemal/streptococcal/anaerobic coverage
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC, sterility, LAL)
Flexible supply: kilogram samples to ton-level bulk API orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Sodium Penicillin Powder

Q1: What is Sodium Penicillin Powder?

A: Sodium penicillin (benzylpenicillin sodium, penicillin G sodium) is the sodium salt of natural penicillin G, a narrow-spectrum β-lactam antibiotic. It is the first clinically used antibiotic and remains first-line for syphilis, streptococcal infections and other susceptible Gram-positive/anaerobic/spirochetal infections.

Q2: What is the CAS number?

A: 69-57-8.

Q3: How does penicillin G sodium work?

A: It inhibits penicillin-binding proteins (PBPs), blocking the final transpeptidation step in bacterial cell wall peptidoglycan synthesis, causing osmotic lysis. It is bactericidal and time-dependent. It is acid-labile (not oral) and β-lactamase-susceptible.

Q4: What is the difference between penicillin G sodium and potassium?

A: Antibacterial spectrum and mechanism are identical. The sodium salt causes less IM injection pain but carries a sodium load (~64.5 mg Na/g), relevant for cardiac/renal patients. The potassium salt is more painful on IM injection (often combined with procaine) and carries a potassium load.

Q5: What is penicillin G sodium used for?

A: Human: syphilis (first-line), streptococcal pharyngitis/erysipelas/cellulitis, pneumococcal pneumonia, meningococcal infection, leptospirosis, diphtheria, tetanus, gas gangrene, anthrax, actinomycosis. Veterinary: bovine/swine/poultry respiratory infections (Pasteurella, Streptococcus), mastitis, tetanus, leptospirosis, swine erysipelas, fowl cholera.

Q6: What documents are provided with each batch?

A: Batch-specific COA, potency assay (microbiological/HPLC), IR identity, pH, Karl Fischer water content, optical rotation, related substances (incl. penicilloic acid), heavy metals, residual solvents, and for injectable grade: sterility and LAL endotoxin results, MSDS/SDS.

Q7: What potency do you supply?

A: Standard ≥1600 U/mg; typical batch result 1650 U/mg. Injectable grade with sterility and endotoxin specification available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Sodium Penicillin Powder with batch COA and global export support.

Q9: How much does Sodium Penicillin Powder cost?

A: Bulk pricing depends on fermentation costs, potency/grade (oral vs injectable), sterility/endotoxin specification, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q10: Are there any safety concerns?

A: Penicillin hypersensitivity is the most serious risk (rash, urticaria, angioedema, anaphylaxis; cross-allergenicity across all β-lactams). Personnel with known allergy should avoid contact. High doses may cause neurotoxicity (seizures, especially in renal impairment) and sodium overload (cardiac/renal patients). IM injection pain (sodium salt less than potassium). Cold-chain storage (2–8°C) required. Not for direct clinical administration.