Glucuronolactone API Manufacturer China | ≥98% Hepatoprotective Pharmaceutical Raw Material CAS 32449-92-6

Key Selling Points

✓ Endogenous Glucuronic Acid Precursor - Enhances Hepatic Phase II Detoxification (Glucuronidation)

✓ β-Glucuronidase Inhibitor - Blocks Enterohepatic Recirculation, Ensures Toxin Excretion

✓ Well-Established Hepatoprotector - OTC-A Liver Support for Hepatitis, Cirrhosis, Drug/Food Poisoning

✓ Veterinary Liver & Gut Health - Laying Hen Performance, Piglet Weaning Stress, Mycotoxin Detox

✓ High Water Solubility & Oral Bioavailability - Convenient Drinking Water & Feed Administration

✓ Energy Drink Ingredient - Synergistic with Caffeine & Taurine, Wide Food/Pharma/Veterinary Applications

What Is Glucurolactone Powder?

Glucurolactone Powder (D-Glucurone, glucuronolactone) is the γ-lactone of D-glucuronic acid (C₆H₈O₆, MW 176.12), a naturally occurring metabolite and well-established hepatoprotective/detoxificant. After oral administration it is converted to glucuronic acid, the key substrate for hepatic phase II glucuronidation conjugation.

It is used in human medicine as OTC-A liver support for acute/chronic hepatitis, cirrhosis and as an adjunct in food/drug poisoning; it is also a common energy drink ingredient (with caffeine and taurine). In veterinary practice it is widely used for liver protection and mycotoxin detox in livestock, improved laying performance and eggshell quality in hens, and intestinal barrier/oxidative stress support in weaned piglets. It also inhibits β-glucuronidase, preventing intestinal bacteria from hydrolyzing glucuronide conjugates back to free toxins (enterohepatic recirculation), ensuring excretion. Generally well tolerated; high doses may cause transient renal irritation (osmotic load) and mild GI discomfort.

How Does Glucurolactone Powder Work?

Glucurolactone Powder acts primarily as an endogenous precursor of glucuronic acid, which conjugates with liver toxins, drug metabolites, bilirubin and steroid hormones via UDP-glucuronosyltransferase (UGT) phase II enzymes, forming non-toxic, water-soluble glucuronide conjugates excreted in bile or urine.

Because Glucurolactone Powder also inhibits β-glucuronidase - the intestinal bacterial enzyme that hydrolyzes glucuronide conjugates back to free, reabsorbable toxins - it blocks enterohepatic recirculation and enhances net toxin elimination. It is also a precursor of D-glucaric acid. Hepatoprotective effects include reduced hepatic lipid accumulation (downregulation of FASN, ACSL, PPAR-γ fatty acid synthesis genes) and, in the gut, activation of the Nrf2-Akt-FOXO1 pathway to reduce oxidative stress and inflammation, with modulation of microbiota (increased Lactobacillus reuteri). Excretion is renal/biliary; high doses may cause transient renal tubular vacuolation due to osmotic load.

What Are the Applications of Glucurolactone Powder?

Human Liver Support: Adjunct treatment of acute/chronic hepatitis, cirrhosis and food/drug intoxication; OTC-A hepatoprotector.
Veterinary Hepatoprotection: Mycotoxin (ochratoxin A, aflatoxin) detox and drug-induced liver injury in poultry, pigs and aquaculture.
Laying Hen Performance: Improved egg production, eggshell quality and liver health; reduced hepatic lipid accumulation (fatty liver hemorrhagic syndrome prevention).
Piglet Weaning Support: Intestinal barrier protection, redox balance and microbiota modulation during weaning stress.
Food & Beverage: Energy drink ingredient, often combined with caffeine and taurine.

What Is the Difference Between Glucurolactone and Sodium Glucuronate?

Feature	Glucurolactone	Sodium Glucuronate
CAS	32449-92-6	14984-34-0
Form	γ-Lactone (cyclic)	Open-chain sodium salt
Molecular Weight	176.12	214.11
Oral Bioavailability	Good (lactone readily absorbed)	Lower (salt less bioavailable)
β-Glucuronidase Inhibition	Yes	Minimal
Stability	More stable	Less stable (hygroscopic)
Typical Use	Oral liver support, energy drinks	IV/topical, cosmetic
Cost	Lower	Higher

How Does Glucurolactone Compare With Other Hepatoprotectors?

Feature	Glucurolactone	Silymarin	Glycyrrhizin	Bicyclol
CAS	32449-92-6	65666-07-1	1405-86-3	118159-42-5
Class	Glucuronic acid precursor	Flavonolignan	Triterpene saponin	Synthetic biphenyl
Mechanism	Glucuronidation + β-glucuronidase inhibition	Antioxidant, CYP modulation	Anti-inflammatory, membrane stabilization	Antioxidant, ALT/AST reduction
Detoxification	Strong (phase II)	Moderate	Moderate	Low
Veterinary Use	Poultry, pigs, aquaculture	Limited (pet)	Poultry, pigs	Limited
Oral Availability	Good	Moderate	Good	Good
Cost	Low	High	Moderate	High

How Is Glucurolactone Powder Manufactured?

Glucurolactone Powder is manufactured by oxidation of starch or glucose to glucuronic acid, followed by intramolecular esterification (lactonization) to form the γ-lactone, then purification and crystallization.

Raw Material QC → Starch/Glucose Oxidation → Glucuronic Acid Formation → Intramolecular Lactonization (γ-Lactone) → Crude Glucurolactone → Purification (Recrystallization from Water/Ethanol) → Drying → Milling → Final QC → Packaging

HDM BIO controls key oxidation, lactonization and crystallization parameters to maintain consistent purity, optical rotation and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Assay (Titration)	≥99.0%	99.5%
Identity (IR / Optical Rotation)	Conforms to reference standard	Confirmed
Melting Point	170–176°C	173°C
Specific Optical Rotation	+18.0° to +20.0°	+19.0°
Loss on Drying	≤0.5%	0.2%
Residue on Ignition	≤0.1%	Compliant
Heavy Metals	≤10 ppm	Compliant
Arsenic	≤2 ppm	Compliant
Related Substances	Within specification	Pass
Residual Solvents	Within specification	Pass
pH (5% solution)	3.0–4.5	3.8

What Quality Control Tests Are Performed for Glucurolactone Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity, optical activity and impurity profiles.

Raw Material QC → In-Process Control → Titration Assay → IR Identity Verification → Melting Point Determination → Specific Optical Rotation → Loss on Drying → Heavy Metals → Arsenic → Residue on Ignition → Related Substances (HPLC) → Residual Solvents → pH Determination → Final Batch Release

Key evaluations include assay by titration (≥99.0%), IR identity, melting point, specific optical rotation (+18° to +20°), loss on drying, heavy metal and arsenic limits, residue on ignition, related substances by HPLC, residual solvents and pH. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Glucurolactone Powder Bulk Price?

Amoxicillin Sodium Powder bulk pricing is driven by several key factors:

Raw Material Costs: 6-APA (6-aminopenicillanic acid) and D-p-hydroxyphenylglycine feedstock prices directly influence manufacturing expenses.
Purity & Grade: Injectable grade (sterile, endotoxin-controlled) commands a significant premium over oral/technical grade.
Sterility & Endotoxin Specification: Aseptic processing and LAL-tested batches for injection carry higher production costs.
Regulatory Compliance & Certification: GMP-standard API with DMF/CEP and consistent COA demand a higher price.
Order Volume: Large-scale pharmaceutical contracts (tonnage) receive steeper per-kilogram discounts.
Logistics & Geography: Cool storage / light-protected / moisture-proof packaging and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Glucurolactone Powder Supplier?

High-purity (≥98% / typical 99.5%) glucuronic acid precursor for hepatic detoxification
Verified optical rotation and lactone integrity; β-glucuronidase inhibition activity
Well-established OTC-A hepatoprotector with wide human, veterinary and food applications
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: kilogram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders; light-protected packaging.
Custom Packaging: OEM labeling available; veterinary premix / food grade packaging on request.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed at room temperature in a dry, light-protected environment. Shelf life: 24 months.
Handling: For pharmaceutical/veterinary/food raw material use only. Handle with appropriate PPE (gloves, mask, eye protection), avoid inhalation/dust exposure. High doses may cause transient renal irritation (osmotic load) and mild GI discomfort. Not for direct clinical administration.

Frequently Asked Questions About Glucurolactone Powder

Q1: What is Glucurolactone Powder?

A: Glucurolactone (D-Glucurone, glucuronolactone) is the γ-lactone of D-glucuronic acid, a hepatoprotective and detoxificant. After oral administration it converts to glucuronic acid, enhancing hepatic phase II glucuronidation detoxification and inhibiting β-glucuronidase to prevent toxin enterohepatic recirculation.

Q2: What is the CAS number?

A: 32449-92-6.

Q3: How does glucurolactone work?

A: It serves as a precursor of glucuronic acid, which conjugates with liver toxins, drug metabolites and bilirubin via UGT phase II enzymes to form non-toxic, excretable glucuronides. It also inhibits β-glucuronidase, preventing intestinal bacteria from hydrolyzing glucuronides back to free toxins, blocking enterohepatic recirculation.

Q4: What is glucurolactone used for?

A: Human: OTC-A liver support for hepatitis, cirrhosis and food/drug poisoning; energy drink ingredient. Veterinary: mycotoxin detox and liver protection in poultry/pigs/aquaculture, improved laying hen performance and eggshell quality, and piglet weaning intestinal/oxidative stress support.

Q5: What documents are provided with each batch?

A: Batch-specific COA, titration assay report, IR identity records, melting point, specific optical rotation, loss on drying, heavy metals, arsenic, residue on ignition, related substances (HPLC), residual solvents, pH, MSDS/SDS.

Q6: What purity do you supply?

A: Standard ≥98.0% by titration; typical batch result 99.5%. Pharmaceutical, veterinary and food grades available on request.

Q7: Where can I buy it from China?

A: HDM BIO supplies bulk Glucurolactone Powder with batch COA and global export support.

Q8: How much does Glucurolactone Powder cost?

A: Bulk pricing depends on raw material costs, purity/grade, application grade (pharma/veterinary/food), regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q9: Are there any safety concerns?

A: Glucurolactone is generally well tolerated (OTC-A). High doses may cause transient renal irritation (tubular vacuolation due to osmotic load) and mild GI discomfort. Not for direct clinical administration.

Q10: Is glucurolactone the same as glucuronic acid?

A: No. Glucurolactone is the cyclic γ-lactone form of glucuronic acid, with better oral bioavailability and stability. In the body it hydrolyzes to glucuronic acid, the active detoxification substrate.