Trimethoprim Lactate API Manufacturer China | ≥98% DHFR Inhibitor Antibiotic Powder CAS 23256-42-0

Key Selling Points

✓ Water-Soluble Trimethoprim Salt - 20 mg/mL in Water (vs Free Base Slightly Soluble)

✓ Ideal for Injectable & Oral Solution Formulations - Veterinary Liquid Dosage Forms

✓ Selective Bacterial DHFR Inhibitor - Same Antibacterial Activity as Free Trimethoprim

✓ Gold-Standard Sulfonamide Synergist - Sequential Folate Blockade (Bactericidal)

✓ Veterinary Injection Partner - Sulfadiazine/TMP (e.g., Diatrim 200/40 mg/mL)

✓ Broad Gram-Positive & Gram-Negative Spectrum - Livestock & Companion Animal Infections

What Is Trimethoprim Lactate Powder?

Trimethoprim Lactate Powder is the water-soluble lactate salt of trimethoprim (TMP), a synthetic diaminopyrimidine antibacterial - chemically 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine combined with lactic acid (C₁₇H₂₄N₄O₆, MW 380.40).

Its key advantage over free trimethoprim is dramatically improved water solubility (~20 mg/mL vs slightly soluble), making it the preferred form for veterinary injectable solutions and oral liquids. It is widely formulated with sulfonamides - most commonly sulfadiazine sodium (e.g., Diatrim 200/40 mg/mL injection for cattle, pigs, dogs and cats) - and also with sulfadimethoxine and sulfamethoxazole. Antibacterial activity is identical to free TMP: selective DHFR inhibition (~50,000-fold bacterial vs mammalian affinity), bacteriostatic alone, bactericidal with sulfonamides via sequential folate blockade. Used for respiratory, GI and urinary infections in livestock and companion animals caused by susceptible organisms. High/prolonged doses may cause folate deficiency (manageable with folinic acid); most serious co-trimoxazole adverse effects are sulfonamide-related.

How Does Trimethoprim Lactate Powder Work?

Trimethoprim Lactate Powder exerts the same antibacterial effect as free trimethoprim: selective, reversible inhibition of bacterial dihydrofolate reductase (DHFR), blocking conversion of DHF to THF - the active folate coenzyme for purine, thymidine and amino acid synthesis. The lactate counter-ion is pharmacologically inert and serves only to improve aqueous solubility.

Because Trimethoprim Lactate Powder releases TMP that binds bacterial DHFR far more tightly than mammalian DHFR, it depletes THF selectively in microorganisms, arresting DNA replication. Alone bacteriostatic. Its defining feature is synergy with sulfonamides: sulfonamides inhibit DHPS at the preceding folate step, while TMP blocks DHFR at the next - a sequential blockade converting bacteriostasis to bactericidal activity, broadening spectrum and slowing resistance. Optimal tissue ratio ~1:20 (TMP:sulfonamide), achieved with a 1:5 oral fixed dose. Active against Gram-positive (Staphylococcus, Streptococcus, Listeria) and Gram-negative (E. coli, Klebsiella, Proteus, Salmonella, Pasteurella) organisms. Renal excretion; dose adjustment in significant renal impairment. The high water solubility enables high-concentration injectable formulations (up to 40 mg/mL TMP) and palatable oral solutions for veterinary use.

What Are the Applications of Trimethoprim Lactate Powder?

Veterinary Injectable Solutions: The primary application - high water solubility enables concentrated injectable formulations (e.g., sulfadiazine 200 mg/mL + TMP 40 mg/mL) for cattle, pigs, dogs and cats.
Veterinary Oral Solutions & Suspensions: Water-soluble form for palatable oral liquids, including equine oral suspensions (e.g., EQUISUL-SDT sulfadiazine/TMP).
Respiratory Tract Infections: Bovine respiratory disease (Pasteurella, Mannheimia), swine pleuropneumonia (Actinobacillus, Streptococcus suis), poultry and companion animal respiratory infections.
Gastrointestinal & Urinary Infections: Colibacillosis, salmonellosis, pasteurellosis and susceptible urinary tract infections in livestock and pets.
Potentiated Sulfonamide Combinations: Formulated with sulfadiazine, sulfadimethoxine, sulfamethoxazole and other sulfonamides for broad-spectrum bactericidal activity.

What Is the Difference Between Trimethoprim Lactate and Trimethoprim (Free Base)?

Feature	Trimethoprim Lactate	Trimethoprim (Free Base)
CAS	23256-42-0	738-70-5
Molecular Formula	C₁₇H₂₄N₄O₆	C₁₄H₁₈N₄O₃
Molecular Weight	380.40	290.32
Water Solubility	~20 mg/mL (soluble)	Slightly soluble
Primary Dosage Form	Injectable solutions, oral liquids	Tablets, capsules, powders
Melting Point	170–172°C	199–203°C
Antibacterial Activity	Identical (lactate is inert counter-ion)	Identical
Veterinary Use	Injection & oral solution preferred	Oral tablets/powders
Typical Concentration	Up to 40 mg/mL TMP in injection	Standard oral dose

How Does Trimethoprim Lactate Compare With Other Water-Soluble Antibacterial Salts?

Feature	Trimethoprim Lactate	Sulfadiazine Sodium	Enrofloxacin Hydrochloride
CAS	23256-42-0	547-32-0	112732-17-9
Class	Diaminopyrimidine	Sulfonamide	Fluoroquinolone
Target	DHFR	DHPS	DNA gyrase
Water Solubility	High (20 mg/mL)	High	High
Primary Use	Veterinary injection (with sulfonamide)	Veterinary injection/UTI	Veterinary broad-spectrum
Synergy Partner	Sulfonamides (sequential blockade)	Trimethoprim	None
Bactericidal	With sulfonamide (alone static)	With TMP (alone static)	Yes
Typical Form	Injectable solution	Injectable solution / oral	Injectable / oral

How Is Trimethoprim Lactate Powder Manufactured?

Trimethoprim Lactate Powder is manufactured by first synthesizing free trimethoprim, then forming the lactate salt via acid-base reaction with lactic acid, followed by purification and crystallization.

Raw Material QC → Free Trimethoprim Synthesis (Condensation + Reduction) → Lactic Acid Salt Formation → Purification (Recrystallization) → Drying → Milling → Final QC → Packaging

HDM BIO controls key salt formation, crystallization and drying parameters to maintain consistent purity, water solubility and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Assay (HPLC, as TMP)	≥98.0%	99.0%
Identity (IR)	Conforms to reference standard	Confirmed
Melting Point	170–172°C	171°C
Water Solubility	20 mg/mL, clear solution	Compliant
Loss on Drying	≤0.5%	0.2%
Residue on Ignition	≤0.1%	Compliant
Heavy Metals	≤10 ppm	Compliant
Arsenic	≤2 ppm	Compliant
Related Substances	Within specification	Pass
Residual Solvents	Within specification	Pass
Lactic Acid Content	Stoichiometric (1:1)	Confirmed

What Quality Control Tests Are Performed for Trimethoprim Lactate Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity, salt stoichiometry and water solubility.

Raw Material QC → In-Process Control → HPLC Assay (as TMP) → IR Identity Verification → Melting Point Determination → Water Solubility Test → Lactic Acid Content Assay → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Arsenic → Residue on Ignition → Residual Solvents → Final Batch Release

Key evaluations include identification via infrared (IR) spectroscopy, HPLC active content assay (expressed as trimethoprim), melting point determination, water solubility verification (20 mg/mL clear solution), lactic acid stoichiometric content assay, related substances analysis, loss on drying, heavy metal and arsenic limits, residue on ignition and residual solvent testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Trimethoprim Lactate Powder Bulk Price?

Trimethoprim Lactate Powder bulk pricing is driven by several key factors:

Synthesis & Salt Formation Costs: Multi-step free trimethoprim synthesis plus lactic acid salt formation and recrystallization directly influence manufacturing expenses.
Purity & Grade: Higher purity (≥99%) and pharmaceutical-grade batches command premiums over standard grade.
Water Solubility Specification: Batches verified to meet the 20 mg/mL solubility standard for injectable use may carry a premium.
Regulatory Compliance & Certification: GMP-standard API batches with DMF/CEP and consistent COA demand a higher price.
Order Volume: Large-scale veterinary pharmaceutical contracts receive steeper per-kilogram discounts than small-batch orders.
Logistics & Geography: Cool storage / light-protected packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Trimethoprim Lactate Powder Supplier?

High-purity (≥98% / typical 99%) water-soluble trimethoprim lactate for veterinary injectable and oral solution formulations
Verified 20 mg/mL water solubility - ideal for high-concentration injectable solutions
Same antibacterial activity as free TMP with superior formulation flexibility
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: kilogram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Trimethoprim Lactate Powder

Q1: What is Trimethoprim Lactate Powder?

A: The water-soluble lactate salt of trimethoprim (TMP), a diaminopyrimidine DHFR inhibitor. Its high aqueous solubility (~20 mg/mL) makes it the preferred form for veterinary injectable solutions and oral liquids.

Q2: What is the CAS number?

A: 23256-42-0.

Q3: How does trimethoprim lactate differ from free trimethoprim?

A: The antibacterial activity is identical - lactate is an inert counter-ion. The key difference is water solubility: ~20 mg/mL for the lactate salt vs slightly soluble for the free base, making the lactate form suitable for injections and oral solutions.

Q4: What is trimethoprim lactate used for?

A: Primarily veterinary injectable solutions and oral liquids formulated with sulfonamides (e.g., sulfadiazine/TMP 200/40 mg/mL injection) for respiratory, GI and urinary infections in cattle, pigs, dogs, cats, horses and poultry.

Q5: What documents are provided with each batch?

A: Batch-specific COA, HPLC report, IR identity records, melting point data, water solubility test, lactic acid content assay, MSDS/SDS and relevant export documentation.

Q6: What purity do you supply?

A: Standard ≥98% HPLC (as trimethoprim); typical batch result 99%. USP/EP-grade available on request.

Q7: Where can I buy it from China?

A: HDM BIO supplies bulk Trimethoprim Lactate Powder with batch COA and global export support.

Q8: How much does Trimethoprim Lactate Powder cost?

A: Bulk pricing depends on synthesis/salt formation costs, purity/grade, solubility specification, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q9: Are there any safety concerns?

A: Trimethoprim is generally well tolerated, but high/prolonged doses may cause folate deficiency (manageable with folinic acid). Most serious adverse effects in potentiated sulfonamide therapy are attributable to the sulfonamide component. Dose adjustment required in renal impairment. Not for direct clinical administration.

Q10: Is the lactate salt suitable for human use?

A: While the active ingredient is the same, trimethoprim lactate is primarily used in veterinary liquid formulations. Human formulations typically use free trimethoprim in tablet form. Use according to applicable regulatory requirements.