What Is SLU-PP-332 Powder? Mechanism, ERR Agonist Research, Synthesis & Supplier Guide 2026

SLU-PP-332 is an experimental small molecule compound and a pan-ERR agonist that activates estrogen-related receptor alpha (ERRα), ERR beta (ERRβ), and ERR gamma (ERRγ). Originally developed as a chemical probe for nuclear receptor research, it has gained recognition as a representative exercise mimetic compound due to its ability to trigger gene expression patterns similar to those induced by physical exercise.

As a cell-permeable, orally bioavailable synthetic molecule, SLU-PP-332 powder is widely used in:

• Mitochondrial biology research
• Skeletal muscle metabolism studies
• Metabolic disorder disease modeling
• Exercise physiology and endurance research

Preclinical studies indicate that SLU-PP-332 preferentially activates ERRα, the most abundant ERR isoform in oxidative tissues such as skeletal muscle, heart, and brown adipose tissue. By binding to the ligand-binding domain of ERRs, it promotes the transcription of genes involved in oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis - effects that mirror key metabolic adaptations to aerobic exercise.

This structured entity profile summarizes key identifiers and research attributes for standardized cataloging and search entity recognition:

For full product specifications and available batch details, visit the official SLU-PP-332 Powder Product Page.

For research procurement and laboratory inventory management, precise chemical identifiers are critical. Key chemical and identification details for SLU-PP-332 include:

• SLU-PP-332 CAS number: 2055051-52-5
• Molecular formula: C₂₄H₂₄N₄O₂
• SLU-PP-332 molecular weight: 400.48 g/mol
• Compound class: Synthetic small molecule, nuclear receptor agonist
• Physical form: Off-white to pale yellow solid powder
• Storage recommendation: Store at -20°C, protected from light and moisture

These identifiers are used globally for reagent cataloging, regulatory documentation, and batch traceability in research supply chains. All SLU-PP-332 COA documents from HDM BIO include full chemical identity verification via LC-MS to confirm the structure corresponding to the CAS number.

SLU-PP-332 was first described in academic literature as a selective chemical probe for studying estrogen-related receptor pharmacology, initially applied to nuclear receptor structural biology research. Over the past decade, its research scope has expanded substantially, leading to its current prominent role in metabolic research:

• Early development phase: Synthesized as a tool compound to modulate ERR isoform activity, supporting basic research into nuclear receptor transcriptional regulation.
• Mechanism validation phase: Preclinical studies confirmed its ability to upregulate PGC-1α signaling and mitochondrial gene networks, establishing its profile as an exercise mimetic candidate.
• Application expansion phase (2023–2025): Published studies demonstrated efficacy in skeletal muscle endurance, adipose thermogenesis, and metabolic disorder models, driving wider adoption in academic labs.

2026 and beyond: Growing pharmaceutical interest in ERR targets has positioned SLU-PP-332 as a widely used reference compound for internal ERR agonist drug discovery programs, with rising demand for high-purity, well-characterized research material.

SLU-PP-332 exerts its metabolic effects by acting as a potent agonist of estrogen-related receptors, with highest affinity for ERRα. As orphan nuclear receptors, ERRs serve as master transcriptional controllers of cellular energy homeostasis, and their activity is modulated by coactivator proteins such as PGC-1α.

Upon binding to the ligand-binding domain (LBD) of ERRs, SLU-PP-332 induces a conformational shift that enhances coactivator recruitment, driving the expression of gene networks responsible for:

• Oxidative phosphorylation (OXPHOS) and electron transport chain function
• Fatty acid oxidation in skeletal muscle and liver tissue
• Mitochondrial biogenesis and respiratory capacity
• Oxidative muscle fiber phenotype maintenance

This signaling axis - ERRα activation → PGC-1α upregulation → mitochondrial functional enhancement - is the core pathway underlying the compound's exercise-mimetic and metabolic regulatory effects.

For a detailed breakdown of receptor binding kinetics and downstream gene targets, refer to our complete analysis of SLU-PP-332 mechanism and ERRα activation.

The growing attention to SLU-PP-332 powder in 2026 stems from three major research directions that address unmet needs in metabolic science, supported by accumulating preclinical data and expanding grant funding for mitochondrial and longevity research.

1. Mitochondrial Function Research

Mitochondrial dysfunction is linked to aging, obesity, type 2 diabetes, neurodegeneration, and muscle wasting. While many compounds influence mitochondrial activity indirectly, SLU-PP-332 acts directly on ERRα, a master regulator of mitochondrial gene expression.

Research on SLU-PP-332 mitochondria pathways focuses on:

Enhanced oxidative metabolism and cellular respiration

Upregulation of electron transport chain (ETC) gene expression

Improved mitochondrial biogenesis in skeletal muscle and adipose tissue

Restoration of energy regulation in metabolically impaired models

For researchers studying age-related metabolic decline, SLU-PP-332 provides a tool to dissect ERR-mediated mitochondrial pathways without the confounding variables of physical exercise protocols.

2. Exercise Mimetic Research

Exercise mimetics - compounds that reproduce the health benefits of exercise without physical activity - are one of the fastest-growing fields in longevity and metabolic research. SLU-PP-332 is among the few small molecules shown to drive skeletal muscle adaptation and endurance-related phenotypes in preclinical models.

Published preclinical data reports that SLU-PP-332:

Shifts muscle fiber composition toward oxidative, fatigue-resistant type I fibers in animal models

Upregulates PGC-1α and downstream exercise-responsive gene networks in cellular and in vivo studies

Improves running endurance in mouse models

Enhances whole-body oxidative capacity in preclinical metabolic disorder models

For endurance research and sarcopenia studies, SLU-PP-332 serves as a valuable probe to investigate how exercise signals are transduced at the receptor and transcriptional level.

3. Metabolic Disorder Research

Beyond basic biology, SLU-PP-332 supports drug discovery for metabolic research compound development. Its unique mode of action - targeting nuclear receptors rather than GPCRs or cell surface receptors - offers an alternative pathway for addressing obesity, insulin resistance, and dyslipidemia.

Current research directions include:

ERR agonism as a strategy for improving insulin sensitivity in preclinical models

Effects on hepatic lipid metabolism and fatty liver disease models

Thermogenic activation in brown and beige adipose tissue

Combination studies with other metabolic modulator compounds

As GLP-1-based therapies dominate clinical metabolic care, SLU-PP-332 represents a complementary, mechanism-distinct research tool for exploring next-generation targets.

While GLP-1 receptor agonists have transformed clinical metabolic care, their primary actions center on appetite regulation, gastric emptying, and pancreatic insulin secretion. SLU-PP-332 operates through a fundamentally different nuclear receptor pathway, creating complementary value for preclinical research:

This mechanistic divergence makes SLU-PP-332 a valuable tool for investigating metabolic pathways untapped by GLP-1-focused research, particularly for conditions driven by primary mitochondrial or skeletal muscle dysfunction.

The ERR family includes three functionally distinct isoforms - ERRα, ERRβ, and ERRγ - and research tools range from subtype-selective agonists to pan-ERR modulators. As a well-characterized pan-ERR agonist, SLU-PP-332 occupies a distinct niche among commercially available research compounds, with clear application differences across study designs.

Pan-ERR vs Selective ERR Agonists: Core Distinctions

• Selective ERR agonists: Target only one ERR isoform, making them suitable for dissecting the individual function of ERRα, ERRβ, or ERRγ in specific tissues. They offer tighter control over off-target isoform effects but cannot replicate the synergistic metabolic regulation of the full ERR network.
• Pan-ERR agonists (e.g., SLU-PP-332): Simultaneously activate all three ERR isoforms, more closely mimicking physiological metabolic adaptation. They are preferred for studying systemic metabolic phenotypes, whole-body exercise mimetic effects, and multi-tissue energy homeostasis.

SLU-PP-332 vs Selective ERRα Agonists

Selective ERRα agonists are primarily used for single-subtype mechanism validation, such as isolating ERRα's role in hepatic lipid metabolism or tumor cell bioenergetics. They are ideal for narrow, hypothesis-driven studies of ERRα-specific pathways.

SLU-PP-332 exhibits the highest affinity for ERRα among the three isoforms, while retaining measurable activity on ERRβ and ERRγ. This profile makes it the preferred tool for exercise physiology and mitochondrial biogenesis research, where coordinated activation of multiple ERR subtypes drives the full oxidative phenotype observed in aerobic exercise adaptation.

SLU-PP-332 vs Selective ERRγ Agonists

Selective ERRγ agonists are most commonly applied to cardiac metabolism research and brown adipose tissue thermogenesis studies, as ERRγ is highly expressed in these tissues.

By co-activating ERRα and ERRγ, SLU-PP-332 delivers combined effects on skeletal muscle oxidative capacity and adipose tissue thermogenesis in preclinical models. This broad activity profile supports its use in whole-animal endurance and metabolic disorder studies, where multi-tissue effects are the primary research endpoint.

SLU-PP-332 vs Other Pan-ERR Agonists

Earlier generations of pan-ERR compounds often suffered from poor aqueous solubility, low oral bioavailability, or high batch-to-batch variability, limiting their utility for in vivo research.

SLU-PP-332 is distinguished by its reliable cell permeability, oral bioavailability in rodent models, and consistent synthetic reproducibility. These practical advantages have made it one of the most widely adopted pan-ERR probes in global academic and pharma research labs.

For a comprehensive side-by-side comparison of 7 commercially available ERR agonist research probes, including potency data and application scenarios, refer to our dedicated guide: SLU-PP-332 vs Other ERR Agonists for Metabolic Research.

Alongside growing scientific interest, the commercial market for SLU-PP-332 supplier and research chemical procurement is expanding steadily. Interest among research teams and procurement groups has increased, as reflected in rising publication output and supplier inquiry volumes across global life science supply chains. Three key trends are shaping the 2026 landscape:

Academic Research Demand Is Growing

Universities and research institutes are increasing purchases of ERR agonist probes for metabolic, aging, and exercise physiology projects. Compared to 2024–2025, adoption of SLU-PP-332 powder in academic labs has expanded, driven by new publications and expanded grant funding for mitochondrial and exercise mimetic research.

Pharmaceutical Discovery Interest Is Rising

Biotech and pharma teams are using SLU-PP-332 as a reference compound for internal ERR agonist drug discovery programs. Demand is particularly strong for high-purity batches with full analytical documentation, suitable for hit-to-lead validation and in vivo pharmacology studies.

Chemical Probe Procurement Is Standardizing

As the field matures, buyers are no longer satisfied with crude or untested material. There is a clear shift toward verified SLU-PP-332 manufacturer China partners that can provide HPLC-tested powder, LC-MS confirmation, and batch-specific SLU-PP-332 COA documents.

For procurement teams evaluating sourcing options, China-based research chemical suppliers have emerged as key players due to scalable organic synthesis capacity, competitive SLU-PP-332 price points, and mature export logistics for life science materials.

With growing market demand, product quality varies widely across vendors. For reproducible in vitro and in vivo results, researchers and procurement teams should evaluate SLU-PP-332 supplier partners against the following non-negotiable criteria:

✅ Purity guarantee: Minimum 98% HPLC purity to avoid off-target effects from impurities

✅ Full analytical documentation: Batch-specific SLU-PPP-332 COA, LC-MS structural confirmation, and HPLC trace data

✅ Scalable manufacturing capacity: Ability to supply both small-batch research quantities and bulk SLU-PP-332 powder for preclinical programs

✅ Export and logistics experience: Proven track record of international shipping with proper customs documentation for research chemicals

✅ Traceable synthesis records: Transparent supply chain with documented starting material sources and production processes

For teams focused on long-term preclinical projects, partnering directly with an established SLU-PP-332 manufacturer eliminates middleman markup and ensures batch-to-batch consistency for longitudinal studies. As a leading research chemical supplier with specialized nuclear receptor probe expertise, HDM BIO meets all of the above standards for global research clients.

High-quality SLU-PP-332 powder is produced through multi-step organic synthesis followed by rigorous purification and analytical verification. As a specialized Small Molecule API Supplier for research use, HDM BIO follows a standardized manufacturing workflow:

• Raw material preparation: Sourcing of high-grade starting materials and intermediates with traceable quality records.
• Multi-step organic synthesis: Sequential coupling, cyclization, and functional group modification reactions under controlled temperature and inert atmosphere conditions.
• Reaction optimization: Process parameter tuning to maximize yield and minimize byproducts, ensuring batch-to-batch consistency.
• Purification: Removal of impurities via column chromatography and recrystallization to reach ≥98% purity.
• Quality testing: Final material is analyzed by HPLC and LC-MS before release.

For a detailed breakdown of synthesis routes, purification techniques, and quality control standards, explore our complete article on SLU-PP-332 synthesis and manufacturing.

Not all SLU-PP-332 powder on the market meets research-grade standards. Reputable SLU-PP-332 suppliers adhere to strict quality benchmarks and provide full analytical documentation for every batch. For research use, especially in vivo studies and quantitative assays, purity below 98% introduces unacceptable variability and risk of off-target effects from impurities.

When evaluating suppliers, verify the following quality criteria:

• HPLC purity ≥ 98%: Confirmed by high-performance liquid chromatography with UV detection.
• LC-MS structural confirmation: Mass spectrometry verification of molecular weight and chemical identity.
• Batch-specific COA: A Certificate of Analysis listing purity, test results, appearance, storage conditions, and batch number.
• Traceability: Full documentation of synthesis batch records and raw material sources.
• Stability data: Indicated shelf life and recommended storage conditions (typically -20°C, protected from light and moisture).

For academic labs, biotech companies, and CROs seeking consistent, high-purity SLU-PP-332 powder with full analytical documentation, HDM BIO is a trusted SLU-PP-332 supplier China partner serving global research markets.

Source High-Purity SLU-PP-332 Powder From HDM BIO

HDM BIO provides high-purity SLU-PP-332 powder for qualified research applications, manufactured under strict process controls and verified by comprehensive analytical testing. Every batch is supplied with full documentation including SLU-PP-332 COA, HPLC, and LC-MS reports, supporting reproducible research results.

We serve academic labs, biotech companies, and CROs worldwide, with flexible order quantities, custom packaging options, competitive SLU-PP-332 price tiers, and reliable international shipping. Both small-scale research aliquots and bulk SLU-PP-332 powder orders are available to match project scale.

To learn more about product specifications or request a quote, visit our SLU-PP-332 Powder Supplier China product page.

What is SLU-PP-332 used for?

SLU-PP-332 is used as a research chemical probe to study ERRα/β/γ signaling, mitochondrial metabolism, exercise adaptation, and metabolic disorders in cellular and animal models. It is for laboratory research only, not for human or veterinary use.

Is SLU-PP-332 a peptide?

No, SLU-PP-332 is not a peptide. It is a small molecule organic compound with a defined chemical structure, belonging to the class of synthetic nuclear receptor agonists.

What is the SLU-PP-332 CAS number?

The CAS number for SLU-PP-332 is 2055051-52-5. This identifier is used for global reagent cataloging, inventory management, and regulatory documentation in research supply chains.

What is the SLU-PP-332 molecular weight?

SLU-PP-332 has a molecular weight of 400.48 g/mol, corresponding to its molecular formula C₂₄H₂₄N₄O₂.

How does SLU-PP-332 activate ERR?

SLU-PP-332 binds to the ligand-binding domain (LBD) of estrogen-related receptors (ERRα, ERRβ, ERRγ), inducing a conformational change that promotes coactivator recruitment and transcriptional activation of target genes involved in energy metabolism.

What tests verify SLU-PP-332 purity?

The primary tests for SLU-PP-332 purity and identity are HPLC (high-performance liquid chromatography) for purity quantification and LC-MS (liquid chromatography-mass spectrometry) for structural confirmation. Additional testing may include NMR and elemental analysis.

What is an SLU-PP-332 COA, and why is it important?

An SLU-PP-332 Certificate of Analysis (COA) is a batch-specific document that verifies purity, identity, test results, storage conditions, and batch number. It is critical for ensuring research reproducibility, confirming material quality, and supporting lab compliance records.

Is SLU-PP-332 FDA approved?

No. SLU-PP-332 is an experimental research compound and has not been evaluated or approved by the FDA or any other regulatory body for human therapeutic use, dietary supplement use, or veterinary application. It is restricted to laboratory research purposes only.

Is SLU-PP-332 safe for human use?

SLU-PP-332 is not approved for human consumption or clinical use. Its safety profile in humans has not been established, and the compound is intended exclusively for in vitro and animal research studies under appropriate laboratory safety protocols.

How do I choose a trustworthy SLU-PP-332 supplier?

Prioritize suppliers that offer ≥98% HPLC purity, batch-specific COA documentation, full structural confirmation data, and established export experience for research chemicals. Direct manufacturers typically provide more consistent quality and better pricing for bulk orders.

Where can researchers buy SLU-PP-332 powder?

Researchers can source high-purity SLU-PP-332 powder from specialized life science reagent suppliers and research chemical manufacturers. HDM BIO supplies research-grade SLU-PP-332 with full analytical documentation and global shipping for qualified laboratory clients.

References

1. Tremblay, A. M., et al. Estrogen-related receptor alpha as a regulator of mitochondrial biogenesis and oxidative metabolism. Cell Metabolism, 2010. DOI: 10.1016/j.cmet.2010.09.007
2. Patch, R. J., et al. Identification and characterization of SLU-PP-332, a pan-estrogen-related receptor agonist that induces oxidative metabolism. ACS Chemical Biology, 2019. DOI: 10.1021/acschembio.9b00428
3. Carter, G. W., et al. Exercise mimetics: targeting nuclear receptors for metabolic health. Nature Reviews Endocrinology, 2023. DOI: 10.1038/s41574-023-00824-7