Acetyl Hexapeptide-49 Powder (CAS 1459205-54-9) | GMP Cosmetic Peptide Manufacturer & Bulk Supplier

Core Selling Points

PAR-2 targeted soothing peptide for sensitive & redness-prone skin
Relieves skin tingling, itchiness and neurogenic skin discomfort
Supports damaged skin barrier repair & reduces transepidermal water loss
Water-soluble cosmetic peptide, compatible with serum, cream, mask formulations
Gentle calming active for post-procedure recovery skincare formulas
Reduces release of redness mediators IL-6, IL-8 for reactive skin

What Do You Need to Know About Acetyl Hexapeptide-49 Powder?

Acetyl Hexapeptide-49 is a premium cosmetic-grade acetylated hexapeptide ingredient widely used in soothing and sensitive skin care formulations. Produced via solid-phase peptide synthesis (SPPS) under GMP quality systems, it is supplied as a fine white powder with high HPLC purity, suitable for incorporation into serums, creams, lotions and gels for reactive and redness-prone skin.

HDM BIO is a China-based cosmetic peptide manufacturer and bulk supplier offering full batch documentation, flexible OEM services and global export support for skincare brands, formulators and distributors worldwide.

What Is Acetyl Hexapeptide-49 Powder?

HDM BIO is a professional cosmetic peptide manufacturer supplying Acetyl Hexapeptide-49 Powder (CAS 1459205-54-9), an advanced acetylated hexapeptide ingredient developed for soothing care and sensitive skin cosmetic formulations.

Recognized for its neurocosmetic and gentle skin-calming properties, this biomimetic peptide works by modulating PAR-2 pathway related skin discomfort reactions, helping calm reactive skin sensations and discomfort associated with sensitivity.

Manufactured through GMP-controlled solid-phase peptide synthesis (SPPS) and precision HPLC purification, Acetyl Hexapeptide-49 Powder features high HPLC purity, stable batch consistency and reliable formulation compatibility. Its molecular profile allows seamless incorporation into creams, serums, lotions and gel systems, helping formulators develop targeted soothing, redness-relief and sensitive skin care products.

What Does a Typical Acetyl Hexapeptide-49 COA Report Include?

Every production batch of Acetyl Hexapeptide-49 Powder undergoes rigorous analytical testing at HDM BIO's in-house QC laboratory, with a unique batch COA issued for all bulk orders.

Appearance	White to off White powder	Consistent
Purity (HPLC)	≥98.0%	99.31%
MS	Consistent	Consistent
Conclusion	The product complies with the requirements

What Are the Core Skincare Benefits of Acetyl Hexapeptide-49 Powder?

Soothing skin care efficacy: Targets the PAR-2 pathway to help calm reactive and sensitive skin, supporting overall skin comfort
Discomfort relief support: Helps reduce tingling sensations and irritation associated with sensitive skin conditions
Skin conditioning benefits: Helps maintain skin in good condition, supporting barrier integrity and long-term skin comfort
Broad formulation compatibility: Adaptable to cream, serum, lotion, gel and emulsion systems for face and body care
Stable high-purity quality: High HPLC purity supports consistent performance in mass cosmetic manufacturing
Complete documentation support: Batch COA, MS reports and full technical documents available for global buyers

How Does Acetyl Hexapeptide-49 Work?

Acetyl Hexapeptide-49 acts as a biomimetic neurocosmetic peptide that interacts with skin cell pathways related to sensitivity reactions. By modulating PAR-2 associated signaling, it helps reduce the release of factors linked to skin discomfort, supporting a calmer, more balanced skin state. Its small molecular structure allows good penetration in topical formulations, delivering targeted soothing benefits for sensitive and reactive skin types.

Which Skincare Products Commonly Use Acetyl Hexapeptide-49 Powder?

This peptide is widely used in the following skincare product categories:

Soothing & calming serums – Core active for reducing visible skin redness and reactivity
Daily gentle care creams – Support comfort for irritated and stressed skin throughout the day
Sensitive skin rescue masks – Intensive soothing care for reactive skin episodes
Post-procedure recovery formulations – Gentle care support after professional skincare cares
Redness-prone skin lotions – Targeted care for easily reddened complexions
Private label sensitive skin collections – Custom OEM specialized soothing and calming cosmetic formulas

How Does Acetyl Hexapeptide-49 Compare With Other Cosmetic Peptides?

Ingredient	Primary Skin Benefit	Water Solubility	Typical Applications
Acetyl Hexapeptide-49	Soothing care, sensitive skin comfort support	Good	Soothing creams, redness-relief serums, sensitive skin lotions
Nonapeptide-1	Skin tone brightening, even complexion support	Good	Brightening serums, tone-evening creams
Decapeptide-12	Radiance support, more even skin appearance	Good	Dark spot care serums, radiance essences
Acetyl Octapeptide-3	Expression line smoothing, anti-wrinkle support	Excellent	Anti-wrinkle serums, eye creams

How Is Acetyl Hexapeptide-49 Powder Manufactured at Scale?

Production Workflow

Raw Material Inspection → Fmoc SPPS Sequential Coupling → Resin Cleavage → Deprotection → HPLC Purification → Lyophilization → QC Testing → Batch COA Issuance → Sealed Light-Proof Packaging

Key Process Highlights

All synthesis processes run inside GMP-compliant clean workshops with full raw material traceability. Multi-stage high-precision HPLC purification thoroughly removes synthesis byproducts and residual impurities, ensuring consistent high purity and reliable batch-to-batch quality. Finished Acetyl Hexapeptide-49 Powder is vacuum and light-proof packed to stabilize peptide activity during long-distance global bulk shipping and storage.

How Is GMP Quality Control Enforced for Acetyl Hexapeptide-49?

QC Inspection Workflow

Incoming Raw Material QC → In-process Production Monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification → Moisture Content & Heavy Metal Testing → Final Batch Release Approval

HDM BIO operates a closed-loop quality management system certified under ISO and HACCP standards, with full traceability from raw material input to finished product shipment. Every batch is tested against predefined specifications before release, with complete records retained for audit purposes.

How to Maximize Acetyl Hexapeptide-49 Performance in Your Formulas?

Compatible ingredients: Optimal synergy with niacinamide, centella asiatica extract, panthenol and ceramides for soothing and barrier-support composite formulas
Recommended pH: Maintain pH 5.0–7.0 to stabilize molecular structure and maximize soothing activity
Addition timing: Add during the cooling phase below 45°C to avoid high-temperature induced activity reduction
Formula compatibility: Excellent tolerance in cream, serum, gel and lotion systems, suitable for leave-on and rinse-off products
Finished goods storage: Seal and store away from high temperature, humidity and strong light to extend shelf life and activity stability

Why Choose HDM BIO as Your Acetyl Hexapeptide-49 Powder Supplier?

10+ years of professional cosmetic peptide manufacturing experience
Full batch traceability for every Acetyl Hexapeptide-49 Powder production lot
Dedicated GMP clean production workshops for peptide synthesis
Export experience serving 70+ countries and regions worldwide
ISO & HACCP dual certified quality management system
Dedicated technical team supporting formulation consultation
Flexible sample trial and large bulk OEM & ODM order options
Fast global air & sea logistics for stable delivery

Where To Buy Bulk Acetyl Hexapeptide-49 Powder?

HDM BIO supplies Acetyl Hexapeptide-49 Powder directly from our China GMP peptide manufacturing facilities, serving cosmetic formulation companies, distributors and skincare brands worldwide.

Available bulk supply services:

✅ Bulk wholesale supply of cosmetic grade peptide powder

✅ Batch-specific COA verification and quality documentation

✅ Full MSDS and regulatory export documentation

✅ OEM / private label custom packaging support

✅ Worldwide export shipping and customs document assistance

✅ Custom purity and packaging specifications on request

Our Acetyl Hexapeptide-49 is manufactured using controlled SPPS technology with high HPLC purity, suitable for all types of soothing and sensitive skin care formulation projects.

What Are Common Questions About Acetyl Hexapeptide-49 Powder?

Q: What is Acetyl Hexapeptide-49 Powder used for in cosmetics?

A: Acetyl Hexapeptide-49 Powder is a cosmetic peptide ingredient primarily used for its soothing and skin-calming properties. It is widely applied in sensitive skin care formulations, helping reduce visible redness and tingling sensations associated with skin sensitivity.

Q: Is Acetyl Hexapeptide-49 Powder water-soluble?

A: Yes, it features good water solubility, performing well in creams, serums, lotions and gel systems for sensitive and reactive skin care.

Q: What cosmetic benefits does Acetyl Hexapeptide-49 provide?

A: It helps modulate PAR-2 pathway related skin reactions, supports skin comfort, reduces sensations of irritation, and helps maintain overall skin barrier function and balance.

Q: Is Acetyl Hexapeptide-49 suitable for sensitive and reactive skin formulas?

A: Yes, it is specifically developed for sensitive, reactive and redness-prone skin types. Its gentle soothing profile makes it an ideal ingredient for calming cosmetic formulations.

Q: Can Acetyl Hexapeptide-49 be combined with other cosmetic peptides?

A: Yes, it works synergistically with other soothing, anti-aging and barrier-support peptides to build multi-effect sensitive skin care formulas.

Q: Where can I buy bulk Acetyl Hexapeptide-49 Powder?

A: Bulk Acetyl Hexapeptide-49 Powder can be purchased directly from HDM BIO, a professional China GMP peptide factory. We provide sample evaluation, flexible bulk pricing and full technical formulation guidance for global wholesale buyers.

Q: What is the INCI Name of Acetyl Hexapeptide-49?

A: The official cosmetic ingredient INCI name is Acetyl Hexapeptide-49, a biomimetic acetylated peptide for soothing and sensitive skin care.

Q: What factors affect Acetyl Hexapeptide-49 Powder price?

A: The bulk price of Acetyl Hexapeptide-49 Powder depends on order quantity, purity requirements, packaging specifications and shipping destination. HDM BIO provides competitive factory pricing for cosmetic brands, distributors and formulation companies.

Q: Is Acetyl Hexapeptide-49 FDA approved? A

A: cetyl Hexapeptide-49 is supplied as a cosmetic ingredient for topical skincare formulations. Regulatory status depends on the final cosmetic product and local market requirements.

What Compliance & Quality Standards Apply to Acetyl Hexapeptide-49?

Reviewed by: HDM BIO Cosmetic Peptide Manufacturing Technical Team

Last Reviewed: July 2026

Manufacturer: HDM BIO

Production Location: China

Quality Standards: GMP, ISO, HACCP

Expertise: Solid-phase peptide synthesis, acetylated peptide modification, HPLC purification, QC systems, GMP compliance

Review Scope: Process validation, specification review, and quality documentation

Intended Use: Cosmetic raw material for topical skincare formulations only

Disclaimer

This product is a cosmetic ingredient intended for topical skincare formulations only. It shall not be used for pharmaceutical drugs, oral health supplements or injectable preparations. All page content is for B2B raw material procurement reference only. Formulators need to complete independent compatibility and stability testing before mass production.