High-Quality Palmitoyl Tetrapeptide-20 Powder | Cosmetic R&D, GMP-Compliant, China Supplier
Core Benefits:
￭ Boosts collagen production
￭ Reduces fine lines
￭ Firms and tones skin
￭ High-purity, stable peptide
￭ Excellent skin absorption
￭ GMP-compliant for research
￭Ideal for anti-aging formulations
Product Overview
Palmitoyl Tetrapeptide-20 Powder (CAS: 221227-05-0), also known as PTP20 or Greyverse™, INCI Name: PALMITOYL TETRAPEPTIDE-20, is a synthetic biomimetic peptide raw material for cosmetic and research purposes. Amino acid sequence: Pal-PEKK (Palmitoyl-Pro-Glu-Lys-Lys). N-terminal palmitoylation optimizes molecular structure, enhancing lipophilicity, stability, and bioactivity. Physicochemical properties meet R&D standards for shampoos, conditioners, creams, serums, and other cosmetic formulations.
Palmitoyl Tetrapeptide-20 Powder is suitable for cosmetic companies, R&D labs, academic institutions, and cross-border procurement in China. Utilizing SPPS technology with DIC/Oxyma coupling and high-efficiency purification, it complies with ICH international raw material QC standards and supports small- to medium-scale cosmetic trials, formulation screening, and pharmacological testing. Provides stable, traceable, and high-activity raw material for hair-care and skin anti-aging product development.
COA
| Item | Specification | Result | |
| Appearance | White to off‑white powder | Complies | |
| Identity by ESI‑MS | Theoretical MW:882.17 | Complies | |
| Purity (HPLC) | ≥98.0% | 99.93% | |
| Water (K.F.) | ≤7.0% | 1.32% | |
| Lead (mg/kg) | ≤10 | < 10 | |
| Arsenic (mg/kg) | ≤2 | < 2 | |
| Mercury (mg/kg) | ≤1 | < 1 | |
| Cadmium (mg/kg) | ≤5 | < 5 | |
| Total plate count (cfu/g) | ≤1000 | Complies | |
| Yeast & mould (cfu/g) | ≤100 | Complies | |
| Conclusion | Conforms to standard | Complies | |
Mechanism of Action
● Hair-care: Activates MC1-R on follicular melanocytes, increases MITF expression, melanin synthesis, accelerates melanosome transfer, protects follicles via catalase/SIRT1 activity.
● Skin anti-aging: Activates TGF-β, stimulates fibroblast proliferation, enhances collagen I/III, regulates microbiome, reduces inflammation, slows skin aging.
● Stability & penetration: N-terminal palmitoylation increases lipid solubility, prevents enzymatic degradation, low immunogenicity, suitable for scalp and facial use.
Product Applications
● Hair-care cosmetics R&D: shampoos, conditioners, hair masks, scalp serums. Recommended 0.01–0.1%; up to 5% for hair sprays.
● Anti-aging cosmetics: creams, serums, eye creams; firms skin, reduces fine lines.
● Oil-control/anti-inflammatory products: balances microbiome, reduces redness and sebum.
● Mechanistic studies: biomimetic peptide synthesis, transdermal absorption, hair pigment research.
● Cross-border sourcing: Chinese buyers can obtain high-activity, stable raw materials for global anti-aging and hair-care products.
● Academic research: peptide synthesis, transdermal mechanisms, hair and skin anti-aging studies.
Detailed Efficacy
● Delays hair graying: Activates MC1-R signaling (AC50: 0.16 nm), promotes melanin synthesis, accelerates melanosome maturation and transfer. Clinical: 10 ppm reduces gray hair density.
● Protects hair follicles: Increases catalase activity, reduces intracellular H₂O₂, upregulates SIRT1, slows follicle aging; H₂O₂ reduced by 30%.
● Firms skin and reduces wrinkles: Activates TGF-β signaling, stimulates fibroblast proliferation, promotes type I/III collagen, increasing dermal density; 2% formulation reduces wrinkle depth by 23% in 8 weeks.
● Regulates skin microbiome: Enhances antimicrobial peptide secretion, inhibits harmful bacteria, reduces IL-6 and TNF-α, minimizing inflammation-mediated collagen degradation.
● Safe for sensitive skin: Peptide closely mimics natural fragment, low immunogenicity, minimal irritation. Suitable for scalp and facial skin R&D.
● Synergistic effects: Works with Vitamin C, Niacinamide, plant extracts, improving anti-oxidation, wrinkle reduction, and hair-care performance.
Core Advantages
1. Dual-action differentiation: hair-care + anti-aging, broad product applicability.
2. Excellent transdermal penetration: N-terminal palmitoylation enhances absorption for scalp and skin.
3. Mature, controllable synthesis: SPPS + DIC/Oxyma ensures stable activity and yield.
4. High-quality indicators: purity ≥99%, no unknown impurities, suitable for multiple cosmetic formulations.
5. Full GMP compliance: COA, MSDS, batch traceability, ICH quality adherence.
6. Flexible supply: multiple packaging, small to scale-up orders.
7. Cross-border delivery: moisture-proof, light-protected, compliant customs documentation.
8. Wide market adoption: trusted by international cosmetic brands; strong market demand.
9. Comprehensive support: dissolution guidance, formulation adaptation, storage consultation.
Quality Assurance
● Full-process control: amino acid selection, SPPS synthesis, palmitoylation, purification, GMP-compliant packaging.
● Strict key indicator management: purity, impurities, moisture, heavy metals monitored.
● Complete batch traceability: unique IDs, full records, supports global regulatory compliance.
● Professional storage and packaging: vacuum-sealed, 2–8°C short-term, ≤-20°C long-term, prevents oxidation and moisture.
● Full after-sales support: guidance on solubility, formulation adaptation, storage, and troubleshooting.
FAQ
Q1: What is the solubility and stability of this product?A1: Soluble in ethanol, propylene glycol and DMSO. Stable for 1 month at 2–8℃; store at ≤-20℃ long-term, avoid repeated freeze-thaw.
Q2: How to ensure the consistency of purity and activity of each batch?A2: Standardized SPPS and multi-stage purification, with HPLC test, activity verification and batch reports for each batch.
Q3: What are the main functions of Palmitoyl Tetrapeptide-20 Powder?A3: Improves skin texture, enhances firmness, reduces fine lines, repairs skin barrier, suitable for anti-aging and firming skin care R&D.
Q4: Can it be compounded with other peptides or active ingredients?A4: Yes. Highly compatible, can be compounded with Acetyl Hexapeptide-8, hyaluronic acid and panthenol for synergistic anti-wrinkle and firming effects.
factory
Certificates
Shipping & Packing
Cooperation & Ordering
Palmitoyl Tetrapeptide-20 Powder, dual-action hair-care and skin anti-aging peptide, high-activity, stable, GMP-compliant, suitable for Chinese buyers and global R&D projects. Supports cross-border sourcing, flexible supply, and technical guidance.
Contact:
Whatsapp & Mobile: +86 19991242181
Email:sales@hdmbio.com
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