Acetyl Tetrapeptide-40 Powder

Acetyl Tetrapeptide-40 Powder Manufacturer | High Purity Cosmetic Peptide Supplier for Sensitive Skin Care

Core Selling Points

• Cosmetic-grade high purity
• GMP-compliant peptide manufacturing
• Batch-specific COA documentation
• Standardized HPLC & MS verification
• Stable bulk supply capacity
• Worldwide delivery support
• Broad formulation compatibility
• Professional formulation technical support

HDM BIO is a China-based Acetyl Tetrapeptide-40 manufacturer supplying bulk powder for global skincare brands, cosmetic formulators, and private-label manufacturers.

As a specialized acetylated soothing peptide, Acetyl Tetrapeptide-40 Powder is designed for gentle sensitive skin and calming cosmetic formulations. Produced via controlled solid-phase peptide synthesis under GMP conditions, the N-terminal acetyl modification enhances skin affinity and formulation stability compared to unmodified short peptides, with excellent compatibility with water-based and emulsion delivery systems.

This ingredient is selected by premium skincare formulators for its consistent purity, mild skin profile and reliable batch-to-batch performance. As part of HDM BIO's sensitive skin peptide portfolio, it is supplied with full batch documentation including HPLC purity testing and mass spectrometry identity verification, supporting product registration and quality assurance for global markets.

Every production batch of Acetyl Tetrapeptide-40 Powder undergoes a defined quality testing protocol before release, with batch-specific COA provided for every shipment.

• Verified purity supporting consistent formulation performance in cosmetic applications.
• Features caprooyl lipid conjugation designed for improved skin affinity and stability in anti-aging formulations.
• Reliable batch consistency supporting large-scale commercial manufacturing.
• Full technical documentation for international regulatory compliance.
• Scalable supply chain from laboratory samples to industrial quantities.
• OEM and ODM capability for customized peptide concentration and formats.

Global demand for gentle, skin-friendly cosmetic actives continues to rise as premium skincare shifts toward microbiome-friendly and barrier-focused formulations. Acetyl Tetrapeptide-40 has grown in formulation adoption for several key reasons:

• Growing consumer demand for sensitive skin-specific products, driving demand for mild peptide-based soothing ingredients
• Rising popularity of post-procedure skincare, requiring gentle, non-irritating active ingredients compatible with fragile skin states
• Compatibility with clean beauty and microbiome-friendly formulation concepts, fitting modern clean label product positioning
• Stable performance across common cosmetic pH ranges, supporting formulation flexibility for multi-active sensitive skin lines

As a representative acetylated soothing tetrapeptide, it has become a common active in high-end calming and skin comfort-focused skincare lines worldwide.

• Soothing facial serums – Core active for sensitive skin calming formulations
• Barrier-focused moisturizers – Suitable for gentle skin resilience-supporting product lines
• Calming anti-redness products – Formulated for products targeting the appearance of more even, calmed skin
• Post-procedure care products – Gentle active for post-treatment soothing skincare routines
• Calming facial essences – Compatible with layered sensitive skin care regimens
• Professional salon skincare – Used in professional facial soothing treatment lines
• Private-label sensitive skin collections – Custom OEM calming product development

Standard Production Workflow

Raw Material Inspection →Fmoc SPPS Sequential Coupling → N-terminal Acetylation Modification → Resin Cleavage & Side-chain Deprotection → Preparative HPLC Purification → Vacuum Lyophilization → Finished Product QC Testing → Batch COA Issuance → Sealed Protective Packaging

Detailed Production Stages

1. Raw Material Inspection – All protected amino acid raw materials undergo incoming quality testing and traceability verification.
2. Sequential SPPS Coupling – Stepwise Fmoc-SPPS coupling of four amino acid residues to build the complete tetrapeptide chain.
3. Acetylation Modification – N-terminal acetyl group conjugation to improve skin affinity and formulation stability.
4. Cleavage & Deprotection – Cleavage from solid-phase resin with full side-chain deprotection to collect crude peptide.
5. HPLC Purification – Multi-stage preparative chromatography to achieve ≥98% cosmetic grade purity.
6. Lyophilization – Vacuum freeze-drying under low-temperature conditions to form uniform fine powder.
7. Final QC Release – Full batch testing including HPLC purity assay and MS identity confirmation.
8. Packaging & Delivery – Vacuum-sealed packaging with full documentation for global shipment.

Full QC Inspection Workflow

Incoming Raw Material QC→ In-process Production Monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification → Moisture Content Testing → Heavy Metal Detection → Final Batch Release Approval

Quality Assurance Highlights

Raw material qualification with full traceability records

Real-time in-process parameter monitoring

Multi-stage purification verification

Complete batch release testing panel

Batch-specific COA documentation

Full shelf-life retained sample program

Stability-oriented protective packaging

• 10+ Years of Cosmetic Peptide Manufacturing Experience
• Full Batch Traceability for Every Production Lot
• GMP-compliant Production Facility
• Export to 70+ Countries & Regions Worldwide
• ISO & HACCP Certified Quality System
• Dedicated Technical Formulation Support
• Flexible OEM & ODM Customization
• Fast Global Logistics & Stable Supply Capacity

✔ Cosmetic Grade

✔ ≥98% HPLC Verified

✔ Batch-specific COA

✔ GMP Production

✔ Stable Bulk Supply

✔ OEM & ODM

✔ Global Shipping

✔ Samples Available

Looking for a reliable Acetyl Tetrapeptide-40 Powder manufacturer for sensitive skincare formulations? HDM BIO supplies cosmetic-grade peptide raw materials with GMP production, batch-specific COA and stable global bulk supply for skincare brands and formulators worldwide.

Q1: Is Acetyl Tetrapeptide-40 Powder water-soluble?

A: Yes, Acetyl Tetrapeptide-40 Powder has good water solubility and is typically added to the water phase of cosmetic formulations. The acetyl modification also gives it good compatibility with emulsion systems.

Q2: What pH range is recommended for Acetyl Tetrapeptide-40 formulations?

A: A pH range of 5.0 to 7.0 is recommended for optimal stability and activity of Acetyl Tetrapeptide-40 in cosmetic formulations.

Q3: What documents are available for Acetyl Tetrapeptide-40 Powder?

A: Each batch can be supplied with a full documentation package including COA, MSDS, TDS, HPLC testing data, and MS identity confirmation reports, aligned with international cosmetic raw material regulatory requirements.

Q4: Can Acetyl Tetrapeptide-40 be combined with niacinamide?

A: Yes, Acetyl Tetrapeptide-40 is compatible with niacinamide within typical usage concentrations. The combination is common in multi-benefit sensitive skin formulations targeting both skin texture and comfort.

Q5: Is Acetyl Tetrapeptide-40 suitable for post-procedure skincare?

A: Acetyl Tetrapeptide-40 is widely selected for gentle post-procedure soothing formulations due to its mild skin profile. It is commonly included in skincare lines designed for fragile skin after aesthetic treatments.

Q6: Can Acetyl Tetrapeptide-40 be used in sensitive skin serums?

A: Yes, Acetyl Tetrapeptide-40 is a common active ingredient in premium sensitive skin serums. Its mild formulation profile makes it suitable for products targeting reactive and fragile skin types.

Q7: Is Acetyl Tetrapeptide-40 compatible with hyaluronic acid?

A: Yes, Acetyl Tetrapeptide-40 is highly compatible with Sodium Hyaluronate. The combination is widely used in soothing serums to deliver both skin comfort support and enhanced moisturization.

Q8: Where can I buy bulk Acetyl Tetrapeptide-40 Powder?

A: Bulk Acetyl Tetrapeptide-40 Powder can be purchased directly from HDM BIO, a professional GMP cosmetic peptide manufacturer in China. We support flexible MOQ, global shipping and full documentation support.

• Reviewed by: HDM BIO Cosmetic Peptide Manufacturing Technical Team

• Last Reviewed: July 2026

• Manufacturer: HDM BIO

• Location: China

• Standard: GMP, ISO, HACCP

• Expertise: Solid-phase peptide synthesis, cosmetic peptide modification, HPLC purification, QC systems, GMP compliance

• Review Scope: Process validation, specification review, and quality documentation

• Quality System: Full GMP-compliant manufacturing and testing environment Documentation: Batch-specific COA, MSDS and specification data provided

• Category: Cosmetic peptide ingredient Intended Use: Cosmetic raw material for topical skincare formulations

  This product is a cosmetic ingredient intended for use in topical skincare formulations. It is not intended for use in pharmaceutical products, dietary supplements, or any application requiring drug registration. All information is provided for B2B procurement purposes. Formulators should conduct independent testing to verify suitability for their specific formulations.

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