Decapeptide-12 Powder CAS 137665-91-9 | Skin Brightening Peptide Manufacturer for Bulk Cosmetic Formulations

Core Selling Points

Gentle multi-path brightening
Fades dark spots & dullness
Brightening & anti-aging dual-effect
High purity & stable quality
Mild for diverse skin types
Ideal for premium formulas
Global compliant & OEM available

What Is Decapeptide-12 Powder?

HDM BIO is a professional cosmetic peptide manufacturer supplying Decapeptide-12 Powder (CAS 137665-91-9), a synthetic biomimetic peptide developed for skin brightening, uneven tone improvement and pigmentation care.

Decapeptide-12 supports the melanogenesis pathway by reducing dopaquinone and dopachrome formation, helping improve the appearance of dark spots, uneven skin tone, sun-induced dullness and pigmentation concerns. It also provides complementary skin rejuvenation benefits for advanced cosmetic formulations.

Manufactured through GMP-compliant solid-phase peptide synthesis (SPPS) and HPLC purification, Decapeptide-12 Powder offers ≥98% purity, consistent batch quality and excellent compatibility with serums, creams and brightening skincare products.

What Are the Official Quality Specifications of Decapeptide-12 Powder?

Every production batch of Decapeptide-12 Powder undergoes rigorous analytical testing at HDM BIO's QC laboratory, with unique batch COA issued for all bulk orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.63%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Why Do Formulators Prefer Decapeptide-12?

Multi-pathway brightening mechanism: Modulates upstream melanin synthesis precursors for comprehensive tone evening, more effective than single-ingredient brightening actives
Improves multiple pigmentation concerns: Visibly improves uneven tone, sun spots, age spots, post-acne discoloration and melasma-related dullness
Dual brightening & anti-aging effect: Balances pigmentation appearance while supporting skin texture renewal
Mild & skin-friendly: No harsh bleaching ingredients, safe for long-term continuous formulation use
Accelerates post-inflammatory tone recovery: Helps fade residual discoloration for clearer skin appearance
Stable high-purity batch quality: Ensures consistent formula performance for mass production
Complete compliance documents: Supports global brand registration and formulation debugging

Decapeptide-12 vs Nonapeptide-1 vs Oligopeptide-68: Which Brightening Peptide Is Better?

Ingredient	Brightening Mechanism	Cosmetic Application Focus
Decapeptide-12	Melanogenesis pathway modulation, reduces dopaquinone & dopachrome precursors + skin renewal support	Stubborn pigmentation, melasma-related dullness, PIH, sun damage tone recovery
Nonapeptide-1	Blocks α-MSH melanin signaling at the source	Daily dullness prevention, sun spot improvement, overall tone evening
Hexapeptide-2	Inhibits melanin transfer to keratinocytes	Uniform complexion improvement, dull skin brightening
Oligopeptide-68	Downregulates MITF & tyrosinase activity	Rapid brightening, transient dullness improvement

Common Skincare Applications

Dark spot correcting serums – Targeted brightening for stubborn visible discoloration
Pigmentation evening formulas – Improve uneven skin tone and facial dullness
Post-inflammatory tone repair products – Fade post-acne and trauma-related marks
Daily radiance maintenance creams – Sustain long-term clear and luminous complexion
Anti-aging brightening essences – Dual-effect tone correction + skin rejuvenation
Sun damage recovery skincare – Repair photo-induced pigmentation dullness
Private label OEM brightening collections – Custom multi-peptide brightening systems

How Is Decapeptide-12 Powder Manufactured & Quality Controlled?

Production Workflow

Raw Material Inspection → Fmoc SPPS Sequential Coupling (10 Amino Acid Sequence) → Resin Cleavage → Deprotection → HPLC Purification → Lyophilization → QC Testing → Batch COA Issuance → Sealed Light-Proof Packaging

Core Production Advantages

HDM BIO precisely assembles the complete Decapeptide-12 sequence (Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr) via professional Fmoc solid-phase synthesis. Every coupling step is strictly monitored to ensure sequence accuracy. Multi-stage high-precision HPLC removes residual impurities and defective sequences, guaranteeing stable ≥98% high purity. All products are vacuum-sealed and light-proof packaged to maintain stable peptide activity during global transportation and long-term storage.

How Can Formulators Maximize the Performance of Decapeptide-12 Powder?

Strict QC Inspection System

Incoming Raw Material QC → In-process Production Monitoring → HPLC Purity Testing → Mass Spectrometry Identity Verification → Moisture & Heavy Metal Detection → Final Batch Release Approval

Synergistic ingredients: Niacinamide, tranexamic acid, vitamin C derivatives, alpha-arbutin, Nonapeptide-1 for multi-pathway brightening formulas
Stable pH range: pH 5.0–7.0 to maintain molecular stability and brightening activity
Adding temperature: Add below 45°C cooling phase to avoid peptide activity degradation
Formula compatibility: Suitable for serums, creams, gels and emulsions
Usage suggestion: Combine with daily SPF protection for optimized long-term brightening results

Why Choose HDM BIO as Your Decapeptide-12 Supplier?

10+ Years professional cosmetic peptide manufacturing experience
Full batch traceability for every Nonapeptide-1 Powder production lot
Complete GMP closed production workshops
Exports to more than 70 countries & regions worldwide
ISO & HACCP dual certified quality management system
Dedicated cosmetic formulation technical team support
Flexible sample trial and large bulk OEM & ODM orders
Fast global air & sea logistics for stable delivery

Where Can You Buy Bulk Decapeptide-12 Powder?

HDM BIO supplies high-purity Decapeptide-12 Powder directly from our China GMP cosmetic peptide manufacturing facilities, serving global cosmetic manufacturers, skincare brands and distributors with factory-direct bulk supply.

Our full supply service includes:

≥98% HPLC cosmetic-grade Decapeptide-12 powder
Batch-specific COA and MS verification reports
Complete MSDS and global customs clearance documents
Custom OEM private label packaging service
Flexible MOQ for sample testing and bulk wholesale
Professional brightening formula technical support

What Are the Most Frequently Asked Questions About Decapeptide-12 Powder?

Q1: What is Decapeptide-12 used for in cosmetics?

A: Decapeptide-12 is a high-end synthetic brightening peptide. It modulates melanin formation pathways to improve uneven skin tone, fade visible dark spots and pigmentation concerns, while supporting skin renewal for dual brightening and anti-aging cosmetic effects.

Q2: Is Decapeptide-12 the same as Lumixyl?

A: Lumixyl is a branded finished formula that uses Decapeptide-12 as its core active ingredient. Our pure Decapeptide-12 bulk powder offers the identical active peptide with high purity, providing cost-effective raw material sourcing for cosmetic formulators.

Q3: Can Decapeptide-12 help improve the appearance of melasma?

A: Decapeptide-12 is studied for improving the appearance of melasma-related pigmentation concerns. It gently smooths uneven tone caused by melasma without harsh irritation, suitable for targeted brightening cosmetic formulas.

Q4: How long to see brightening results with Decapeptide-12?

A: Continuous consistent use brings visible tone evening and spot fading effects within 4–8 weeks, with cumulative optimized brightening effects after 12 weeks of persistent application.

Q5: Is Decapeptide-12 suitable for different skin types?

A: Yes. Decapeptide-12 features a mild, non-cytotoxic formula profile, suitable for most skin types and skin tones for long-term daily brightening skincare use.

Q6: Where to buy bulk Decapeptide-12 Powder?

A: Global buyers can purchase factory-direct bulk Decapeptide-12 Powder from HDM BIO. We provide free formula test samples, flexible bulk pricing and one-stop technical support.

Q7: What is the INCI name of Decapeptide-12?

A: The official cosmetic INCI name is Decapeptide-12.

Q8: What is the CAS number of Decapeptide-12?

A: The exclusive CAS identification number is 137665-91-9

What Is the Technical & Compliance Review for This Peptide?

Reviewed by: HDM BIO Cosmetic Peptide Manufacturing Technical Team
Last Reviewed: July 2026
Manufacturer: HDM BIO
Location: China
Standard: GMP, ISO, HACCP
Expertise: Solid-phase peptide synthesis, D-amino acid peptide synthesis, MC1R antagonist peptide design, HPLC purification, QC systems, GMP compliance
Review Scope: Process validation, specification review, and quality documentation
Quality System: Full GMP-compliant manufacturing and testing environment
Documentation: Batch-specific COA, MSDS and specification data provided
Category: Cosmetic peptide ingredient
Intended Use: Cosmetic raw material for topical skin brightening formulations only

Disclaimer: This product is a cosmetic ingredient intended for topical skincare formulations only. It shall not be used for pharmaceutical drugs, oral health supplements or injectable preparations. This product is not intended to diagnose, treat, cure or prevent any disease. All page content is for B2B raw material procurement reference only. Formulators need to complete independent compatibility and stability testing before mass production.