FGL Peptide

FGL Peptide FGFR1 Agonist | Neuroprotection and Synaptic Plasticity Research Peptide GMP Supplier China

Key Product Highlights:

• FGFR1-selective neuroactive peptide
• Promotes synaptic plasticity and neurite outgrowth
• Supports neuronal survival and neuroprotection
• Modulates neuroinflammation and oxidative stress
• High batch consistency with controlled purity
• Suitable for cognition and neurodegeneration research models

FGL Peptide is a synthetic short peptide derived from the functional domain of NCAM (neural cell adhesion molecule), designed as a FGFR1-selective agonist. It mediates downstream ERK and CREB signaling cascades independent of cell adhesion, enabling more precise neurobiological investigation in experimental systems.

• Selective FGFR1 activation improves experimental reproducibility
• Enhanced enzymatic stability compared with full-length NCAM protein
• Excellent solubility in water, PBS, and neuronal culture media
• Low endotoxin profile reduces microglial overactivation interference
• Low cytotoxicity supports long-term neuronal experiments
• Flexible GMP supply from mg to kg scale in China

• Enhances synaptic plasticity via BDNF and CREB regulation
• Promotes neurite extension and neuronal differentiation
• Supports neural stem cell maturation in vitro
• Reduces neuroinflammation and oxidative stress damage
• Improves learning- and memory-related behavioral outcomes in models
• Stabilizes brain microenvironment in chronic conditions

• Mature Fmoc solid-phase peptide synthesis (SPPS) platform
• High sequence fidelity with minimal side-product formation
• Reduced requirement for secondary purification
• Strong batch-to-batch consistency for long-term studies
• GMP manufacturing system in China for global supply
• Technical support for dissolution and experimental design

FGL Peptide binds selectively to FGFR1 receptors and regulates downstream ERK and CREB signaling pathways, leading to increased expression of neurotrophic factors such as BDNF and GAP-43.

This results in:

• Enhanced synaptic formation and neuronal connectivity
• Suppression of neuroinflammatory activation
• Reduction of oxidative stress-induced neuronal apoptosis
• Improved neuronal plasticity and functional signaling

• GMP-grade cleanroom manufacturing environment
• Pharmaceutical-grade amino acid raw materials
• Multi-step synthesis, purification, and sterile lyophilization process
• Full batch release testing prior to shipment
• 2-year retained sample traceability system
• Complete export documentation (COA / MSDS / non-hazard classification)

Q1: Can FGL Peptide replace full-length NCAM protein in research?
Yes. It preserves key FGFR1-mediated signaling while eliminating structural complexity and non-specific protein interactions, improving experimental precision.

Q2: Why does slight turbidity appear after dissolution?
This is normal and can be resolved with PBS buffer or gentle mixing without affecting peptide activity.

Q3: Is this suitable for human clinical use?
No. It is strictly intended for in vitro and animal research use only.

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