Nafarelin Acetate Powder CAS 76932‑56‑4 | High Purity GnRH Super‑Agonist Peptide Supplier China

Core Selling Points

✅ ≥98% HPLC Purity Research‑Grade Peptide Material

✅ LC‑MS Full Cyclic Octapeptide Sequence & Disulfide Bond Verification

✅ Batch‑Specific COA, HPLC & MS Test Reports Available

✅ Optimized Fmoc SPPS Cyclization Workflow, In‑house Independent QC Laboratory

✅ Global Export Documentation & Cross‑border Cold‑chain Logistics Support

✅ Custom Peptide Purification & Salt‑form Adjustment Service

What Is Nafarelin Acetate Powder?

Nafarelin Acetate powder is a potent synthetic gonadotropin‑releasing hormone (GnRH) super‑agonist decapeptide. Compared with native GnRH, it carries D‑2‑naphthylalanine substitution at position‑2, significantly improving metabolic stability and receptor binding affinity. This peptide acts on pituitary GnRH receptors to modulate gonadotropin release, widely used in reproductive endocrinology, gynecological disease mechanism, GnRH receptor pharmacology and pre‑clinical drug‑candidate screening research.

Produced via optimized Fmoc solid‑phase peptide synthesis, multi‑stage gradient HPLC purification and strict lyophilization workflow, our Nafarelin Acetate powder effectively controls D‑Nal epimerization risk, deletion‑sequence impurities and oxidation‑related by‑products, ensuring stable biological activity and consistent batch‑to‑batch performance. HDM BIO supports global biochemistry labs, pharmaceutical R&D institutes and bioreagent manufacturers, covering milligram‑level lab samples to kilogram‑scale bulk procurement. This peptide raw material is for laboratory research only and shall not be directly used for human clinical administration.

What Are the Official Quality Specifications of Nafarelin Acetate Powder?

Every production batch of Nafarelin Acetate undergoes dual QC testing (HPLC + LC‑MS) in HDM BIO in‑house analytical laboratory. Batch‑specific COA will be issued for all bulk purchase orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.97%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Nafarelin Acetate vs Other GnRH‑Family Peptides

For buyers sourcing GnRH agonist peptides for reproductive endocrinology research, the comparison table below supports efficient raw‑material selection:

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Nafarelin Acetate	GnRH super‑agonist, long‑acting pituitary desensitization	Decapeptide, D‑2‑Nal² modification	Reproductive endocrinology, hormone‑dependent disease model, GnRH receptor assay	76932‑56‑4
Gonadorelin Acetate	Native GnRH, short‑acting agonist	Unmodified natural decapeptide	Baseline control, endogenous hormone‑related research	34973‑08‑5
Goserelin Acetate	GnRH super‑agonist	D‑Ser(tBu)⁶ modified decapeptide	Prostate & breast cancer pre‑clinical model, sustained‑release formulation study	145781‑92‑6

This section covers long‑tail keywords: nafarelin acetate GnRH super agonist, D‑2‑napthylalanine peptide, gonadorelin analog research peptide.

How to Buy Nafarelin Acetate Powder from a Trustworthy Supplier?

When sourcing Nafarelin Acetate powder for reproductive endocrinology and GnRH‑receptor pre‑clinical research, R&D teams and international purchasers need to assess five core criteria to avoid supply‑quality risks:

HPLC purity validation: Confirm ≥98% HPLC purity with full impurity chromatogram, focus on D‑Nal epimer impurities which strongly affect receptor‑binding activity
LC‑MS structural confirmation: Verify full decapeptide molecular weight and D‑2‑naphthylalanine modified‑residue mass signature
Batch‑specific documentation: Ensure each order obtains independent batch COA, HPLC and LC‑MS test reports
Mature synthesis capability: Choose suppliers with proven manufacturing experience for D‑naphthylalanine‑containing modified GnRH analogs
Global export capability: Confirm supplier can provide complete documents for international customs clearance

HDM BIO provides research‑grade Nafarelin Acetate with full traceable quality records, flexible MOQ for lab trial batches and long‑term bulk procurement.

Nafarelin Acetate Powder Price & Bulk Ordering Guide 2026

If you are searching for Nafarelin Acetate powder price, bulk quotation and delivery terms, please refer to key procurement information as follows:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑scale laboratory trial samples available; kilogram‑level bulk supply for sustained research projects
Sample Access: Trial samples for lab evaluation; contact sales team to get formal sample quotation
Bulk Kilogram Pricing: Tiered pricing structure; larger bulk volume brings competitive unit price
Production Lead Time: Lead time varies with order quantity; D‑Nal modified residue requires dedicated coupling process; sales will confirm exact schedule upon formal inquiry
Shipping Options: Standard sealed cold‑recommended shipping; we supply commercial invoice, packing list and MSDS for global customs clearance

Final quotation is affected by purity grade, extra custom testing items, special packaging and international logistics fees. Please contact our sales team for up‑to‑date formal quotation.

Nafarelin Acetate Powder Procurement Guide for Global Buyers

Before placing purchase orders for D‑amino‑acid‑modified GnRH peptide raw materials, international procurement teams should finish these verification steps to mitigate potential risks:

Supplier qualification check: Confirm the manufacturer owns independent peptide synthesis workshop and QC lab with rich experience on D‑naphthylalanine‑containing peptide production
Document inspection: Request pre‑shipment batch COA, HPLC chromatogram and LC‑MS report; pay special attention to epimer impurity testing data
Product confirmation: Confirm purity standard, impurity profile and cold‑storage requirement match your experimental design; aqueous reconstituted solution is prone to Trp‑related oxidation
MOQ & lead‑time confirmation: Verify sample / bulk availability, production cycle and order adjustment policy
Shipping‑document confirmation: Make sure supplier can provide all required paperwork for import customs clearance of your target region

About HDM BIO Nafarelin Acetate Manufacturing Capability

HDM BIO has more than 10‑year expertise in Fmoc solid‑phase peptide synthesis and complex D‑modified‑residue GnRH‑family peptide manufacturing.

Dedicated SPPS production lines equipped for D‑2‑naphthylalanine building‑block coupling, optimized base system for epimer suppression
Independent analytical laboratory equipped with HPLC, LC‑MS, moisture tester and heavy‑metal detection instruments; special analytical method to separate and quantify D‑Nal epimer impurities
Peptide products exported to over 70 countries, supporting university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team experienced in GnRH‑family peptide synthesis, epimer‑process optimization and related analog custom modification

Our peptide manufacturing site runs dedicated Fmoc‑SPPS production lines, in‑house preparative‑HPLC purification and complete LC‑MS analytical workflow.

What Technical Challenges Exist in Nafarelin Acetate Synthesis & Production?

Nafarelin Acetate is a modified GnRH decapeptide featuring D‑2‑naphthylalanine at position‑2. Controlling D‑Nal epimerization and tryptophan oxidation constitute the core technical difficulty separating qualified peptide manufacturers from low‑level suppliers.

Key production challenges:

D‑2‑naphthylalanine residue is highly susceptible to epimerization under basic coupling and cleavage conditions, generating hard‑to‑remove L‑Nal epimer impurity
Multi‑step sequential coupling for decapeptide accumulates deletion‑sequence impurities
D‑tryptophan side‑chain is vulnerable to oxidation during cleavage, purification and lyophilization, reducing biological potency
N‑terminal pyroglutamate cyclization state must be strictly controlled; incomplete cyclization creates related impurity
Even high nominal HPLC purity cannot guarantee correct D‑configuration; epimer‑specific testing is mandatory for receptor‑binding functional assays

HDM BIO applies epimer‑suppressing coupling reagent system, inert‑atmosphere anti‑oxidation protection for tryptophan residue, multi‑stage high‑resolution preparative‑HPLC for epimer separation, full‑batch LC‑MS monitoring and strict impurity profiling. These measures minimize epimer, deletion‑sequence and oxidized by‑products, ensuring correct decapeptide structure and stable batch‑to‑batch biological performance.

How Does Nafarelin Acetate Powder Work in Laboratory Research?

As a well‑studied GnRH super‑agonist, Nafarelin Acetate powder binds to pituitary gonadotropin‑releasing hormone receptors. Initial receptor activation triggers LH/FSH secretion; sustained exposure induces pituitary receptor desensitization and down‑regulation, suppressing gonadal hormone output. Owing to D‑Nal modification, it possesses stronger receptor affinity and better enzymatic stability compared with native gonadorelin.

It is widely adopted as key reference compound for reproductive‑endocrinology mechanism, hormone‑dependent tissue disease models, GnRH receptor pharmacology and agonist drug‑candidate screening. All mechanism descriptions are limited to in‑vitro and pre‑clinical animal research scenarios only.

How Is Nafarelin Acetate Powder Manufactured at HDM BIO?

Nafarelin Acetate needs strict full‑process control for D‑Nal epimer suppression, tryptophan anti‑oxidation, pyroglutamate formation and acetate‑salt buffer‑exchange across synthesis, cleavage, purification and lyophilization.

Read related guide: Modified Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Nafarelin Acetate Powder Manufacturing Workflow

Raw‑material QC of Fmoc‑amino‑acid building blocks (D‑2‑Nal, D‑Trp) → Decapeptide SPPS step‑wise coupling under epimer‑suppressing condition → Resin cleavage & global deprotection (inert gas anti‑oxidation protection) → Crude peptide pretreatment → Multi‑stage preparative‑HPLC purification (remove epimer & deletion impurities) → Buffer‑exchange for acetate‑salt formation → Vacuum lyophilization → Full QC testing (epimer impurity profiling, LC‑MS identity confirmation) → Batch COA issuance → Light‑proof sealed low‑moisture packaging

QC Inspection Workflow

Incoming raw‑material QC → In‑process coupling & epimer‑state monitoring → HPLC purity testing → LC‑MS molecular‑weight verification → Epimer impurity quantitative analysis → Moisture & heavy‑metal testing → Residual‑solvent detection → Final batch release approval

Core Process Highlights

Epimer‑suppressing coupling protocol specially optimized for D‑2‑naphthylalanine residue

Inert‑gas protection workflow to inhibit D‑Trp oxidative degradation

Strict N‑terminal pyroglutamate cyclization quality control

Multi‑step high‑resolution HPLC to separate structurally‑similar epimer and deletion‑sequence impurities

LC‑MS confirmation for full modified decapeptide molecular signature

Acetate‑salt buffer‑exchange process to guarantee consistent counter‑ion form; lyophilized solid stable stored at −20 °C; aqueous solution is oxidation‑prone, aliquot and freeze quickly after reconstitution.

What Are the Main Application Scenarios of Nafarelin Acetate Powder?

Reproductive endocrinology research: Gonadotropin secretion regulation, pituitary‑gonadal axis cell and animal‑model experiments
GnRH‑receptor pharmacology: GnRH receptor binding assay, agonist structure‑activity‑relationship exploration
Hormone‑dependent disease research: Pre‑clinical models for hormone‑sensitive tissue‑related disorders
Peptide formulation development: Sustained‑release peptide delivery system feasibility study
Biomedical reagent preparation: Reference standards and experimental control reagents for GnRH‑family peptide research
Modified‑peptide technology development: D‑amino‑acid substituted decapeptide process‑development benchmark compound

Why Choose HDM BIO As Your Nafarelin Acetate Powder Supplier?

10+ years China‑based peptide manufacturing experience, specialized in D‑modified‑residue GnRH‑series peptides
Mature epimer‑suppressing SPPS workflow, effectively reduce D‑Nal epimer and deletion‑sequence impurities
Full‑batch epimer impurity profiling and LC‑MS modified‑structure validation for every production lot
Complete batch‑wise production traceability documents for Nafarelin Acetate
Flexible supply capacity: milligram lab samples to kilogram‑scale bulk peptide orders
Global export service covering more than 70 countries worldwide
Professional technical team supporting GnRH‑family peptide research and custom analog synthesis consulting

FAQs About Nafarelin Acetate Powder

Q: Where can I buy Nafarelin Acetate powder from China?

A: HDM BIO is a Chinese D‑modified‑residue GnRH peptide supplier delivering high‑purity Nafarelin Acetate powder for global pharmaceutical R&D teams and bioreagent laboratories. We provide small research samples and large‑volume bulk orders, with full export documents and international shipping support.

Q: What documents should a qualified Nafarelin Acetate supplier provide?

A: Reliable supplier shall supply batch‑specific COA, HPLC chromatogram, LC‑MS identity report, MSDS and complete production traceability records; D‑Nal epimer impurity test data is available upon request.

Q: What is the CAS number of Nafarelin Acetate?

A: The CAS registry number of Nafarelin Acetate is 76932‑56‑4.

Q: What purity grade of Nafarelin Acetate powder can you deliver?

A: Standard research‑grade ≥98% HPLC purity. Higher‑purity specifications and GnRH‑series custom peptide analog synthesis are available for special experimental requirements.

Q: How should lyophilized Nafarelin Acetate powder be stored?

A: Store sealed at −20 °C, keep away from light and moisture. Avoid repeated freeze‑thaw cycles. Aqueous reconstituted solution tends to produce tryptophan oxidation; prepare single‑use aliquots and store at −80 °C, do not store long‑term under refrigeration.

Q: Can I get Nafarelin Acetate samples before bulk purchase?

A: Yes. We provide milligram‑to‑gram‑level trial samples attached with complete COA and test documents for laboratory assessment.

Q: What is the MOQ for bulk Nafarelin Acetate powder?

A: MOQ is flexible depending on purity grade and packaging specifications. We support small‑scale research batches and large‑volume bulk orders for different‑project requirements.

Q: What is the amino‑acid sequence of Nafarelin Acetate?

A: p‑Glu‑His‑D‑2‑Nal‑Ser‑Tyr‑D‑Trp‑Leu‑Arg‑Pro‑Gly‑NH₂ acetate salt.

Scientific Review

Reviewed by: HDM BIO Peptide Technical Team Expertise: Peptide synthesis D‑amino‑acid modified GnRH‑family peptide manufacturing Analytical chemistry & epimer impurity profiling

Last Updated: August 2026

Disclaimer: All product content serves academic research and laboratory raw‑material reference only. Not for human clinical use, diagnosis or treatment.