Palmitoyl Dipeptide-5 powder | DEJ Structural Integrity Specialist | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: Certified high-purity for consistent structural signaling research.

✅ DEJ Protein Targeting: Effectively studied for its impact on Collagen types IV, VII, XVII, and Laminin-5.

✅ Lipopeptide Stability: The palmitoyl chain ensures superior metabolic stability and skin-model penetration.

✅ China Peptide Manufacturer: Professional production facility specializing in advanced functional lipopeptides.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and purity chromatograms.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance documents.

What Is Palmitoyl Dipeptide-5 Powder?

Palmitoyl Dipeptide-5 (available as Diaminobutyroyl Hydroxythreonine or Diaminohydroxybutyrate) is a synthetic lipopeptide that conjugates a functional dipeptide sequence with palmitic acid. In laboratory research, it is recognized for its unique ability to communicate with the Dermal-Epidermal Junction (DEJ), the critical interface that ensures nutrient exchange and mechanical cohesion between the epidermis and dermis. Palmitoyl Dipeptide-5 powder acts by stimulating the production of anchoring proteins that prevent skin sagging and maintain the structural integrity of the dermal matrix.

The production of this lipopeptide requires precise control over the palmitoylation process to ensure a homogeneous final product. HDM BIO utilizes advanced solid-phase peptide synthesis (SPPS) and high-resolution purification to eliminate residual coupling agents and unreacted fatty acids. We supply this high-stability Palmitoyl Dipeptide-5 powder to global cosmetic R&D centers and pharmaceutical research institutes focusing on age-delaying biotechnology and regenerative skin models.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.98%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Palmitoyl Dipeptide-5 vs. Palmitoyl Dipeptide-6: What Are The Differences?

Feature	Palmitoyl Dipeptide-5	Palmitoyl Dipeptide-6
Peptide Sequence	Diaminobutyroyl Hydroxythreonine	Diaminobutyroyl Valine
Primary Target	Dermal-Epidermal Junction (DEJ)	DEJ & Anchoring Fibrils
Key Proteins	Collagen IV, VII, XVII, Laminin-5	Laminin-5, Collagen IV, VII
Research Focus	Cohesion & Nutrient Exchange	Structural Repair & Firming
Synergy	Highly synergistic when used as a duo	Essential partner for DEJ research

Explore more Lipopeptides: Palmitoyl Pentapeptide-4 (Matrixyl) · Palmitoyl Tripeptide-5 · Palmitoyl Dipeptide-7 · Acetyl Tetrapeptide-9

How Is Palmitoyl Dipeptide-5 Manufactured?

Our production follows a standardized lipopeptide synthesis protocol:

Chain Assembly: Stepwise synthesis of the dipeptide sequence on a Rink Amide resin via Fmoc-SPPS.
Palmitoylation: Precision capping of the N-terminus with high-purity Palmitic acid to enhance protease resistance.
Acidic Cleavage: Selective removal of the lipopeptide from the resin while preserving side-chain integrity.
RP-HPLC Purification: Preparative reverse-phase HPLC isolation of the ≥98% pure monomeric fraction.
Quality Release: Final confirmation via high-resolution LC-MS to verify the identity of the Palmitoyl Dipeptide-5 powder.

Structural Stability Control

The efficacy of the peptide depends on the efficiency of the palmitoylation and the purity of the lipophilic fraction. HDM BIO monitors every synthesis step to ensure our products meet the highest analytical standards for research reproducibility.

What Is The Difference Between Research Grade And Cosmetic Grade?

Category	Research Grade	Cosmetic Grade
Primary Purpose	Pre-clinical / Lab research	Cosmetic formulation
Documentation	COA / HPLC / LC-MS / AAA	MSDS / COA / TDS
Purity Standard	Typically ≥98%	Typically ≥95%
Supply Channel	Specialized R&D Suppliers	Cosmetic Raw Material Suppliers

Why Is Supplier Qualification Important Before Purchasing Palmitoyl Dipeptide-5?

Palmitoylation Efficiency: Qualification ensures that the peptide is fully palmitoylated; incomplete reaction leads to free peptides with different solubility and bioactivity.
Lipophilic Purity: Qualification ensures the removal of residual free palmitic acid, which can interfere with formulation stability and cellular assays.
Analytical Transparency: Reliable suppliers provide batch-specific LC-MS and HPLC chromatograms to prove the molecular identity of the lipopeptide.
Zero Residual TFA: Efficient removal of trifluoroacetic acid (TFA) is critical for maintaining cell viability in 3D skin models and sensitive biological research.

Palmitoyl Dipeptide-5 Price & Bulk Order Guide 2026

MOQ: Flexible; milligram research samples and bulk kilogram-scale orders available.
Samples: Paid test samples available with full QC documentation.
Bulk pricing: Tiered pricing structure; larger volumes deliver highly competitive unit costs.
Lead time: Standard batches are usually in stock; bulk custom orders take 2-3 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific requirements.

Why Choose HDM BIO As Your Supplier?

Lipopeptide Experts: Over 10 years of experience in the synthesis of fatty-acid-conjugated peptides.
High-Purity Guarantee: Advanced purification ensuring ≥98% purity and zero residual catalysts.
Rigorous Analytical QC: Every batch confirmed by HPLC and high-resolution LC-MS.
Global Shipping Support: Fast, secure export to 70+ countries with customs-ready documentation.
Technical Support: Direct assistance with solubility, pH stability, and peptide formulation research.

Main Research Applications

DEJ Structural Mapping: Investigating the impact of peptides on Collagen IV, VII, XVII, and Laminin-5.
Dermal Cohesion Research: Measuring the improvement of nutrient exchange between skin layers in models.
Lipopeptide Penetration Studies: Evaluating how the palmitoyl chain affects transport across the stratum corneum.
Anti-Sagging Assays: Measuring the improvement of skin mechanical properties in 3D tissue equivalents.

FAQs

Q: What is the benefit of Palmitoyl Dipeptide-5 for skin research?

A: It is primarily used to study the reinforcement of the Dermal-Epidermal Junction (DEJ). Researchers utilize it to investigate how lipopeptides can improve skin firmness, enhance interlayer cohesion, and boost the production of vital anchoring proteins.

Q: Why is it often combined with Palmitoyl Dipeptide-6?

A: They are often researched as a duo because they target different but complementary proteins at the DEJ. Together, they provide a comprehensive model for studying the reconstruction of the skin's basement membrane.

Q: How do you dissolve Palmitoyl Dipeptide-5 powder?

A: Due to the palmitoyl chain, it has limited solubility in pure water. For research, it is often dissolved in mixtures of water and glycols (like Propanediol) or small amounts of ethanol/DMSO to ensure full dispersion.

Q: How should I store the powder to maintain its bioactivity?

A: Lyophilized powder should be stored sealed at -20°C, protected from light and moisture. The lipopeptide structure is stable, but moisture can lead to degradation over long periods.