Etelcalcetide Powder CAS 1262780-97-1 | High Purity Calcimimetic Peptide Supplier China | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: High-purity Etelcalcetide powder with precise molecular weight confirmation.

✅ D-Peptide Stability: Composed primarily of D-amino acids, offering exceptional resistance to proteolytic degradation.

✅ Expert Disulfide Linkage: Precision conjugation of the L-Cys side chain to the D-Cys residue via a stable disulfide bridge.

✅ China Peptide Manufacturer: GMP-aligned production facility with 10+ years of experience in D-peptide synthesis.

✅ Full Structural Identity: Verified by high-resolution LC-MS to ensure the correct salt form and conjugation.

✅ Complete Documentation: COA, HPLC chromatogram, LC-MS report, and MSDS included with every batch.

What Is Etelcalcetide Powder?

Etelcalcetide powder (formerly AMG 416) is a synthetic peptide calcimimetic. Structurally, it is a linear heptapeptide composed of D-amino acids with an L-cysteine molecule linked to the N-terminal D-cysteine via a disulfide bond. Unlike traditional L-peptides, its D-isomer configuration provides enhanced metabolic stability and a prolonged half-life.

Etelcalcetide functions as an allosteric agonist of the calcium-sensing receptor (CaSR) on the parathyroid gland. By binding to the receptor, it enhances its sensitivity to extracellular calcium, thereby suppressing the secretion of parathyroid hormone (PTH). HDM BIO supplies this high-purity research-grade peptide to global university labs and pharmaceutical R&D teams focusing on secondary hyperparathyroidism (SHPT) and mineral metabolism.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.36%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Etelcalcetide vs Cinacalcet: What Are The Differences?

Feature	Etelcalcetide	Cinacalcet
Molecule Type	Synthetic D-Peptide	Small Molecule
Administration	Injectable (Intravenous)	Oral
Binding Mechanism	Disulfide link to CaSR Cys482	Hydrophobic pocket binding
CAS Number	1262780-97-1	226256-56-0

How Is Etelcalcetide Manufactured?

Our Etelcalcetide powder manufacturing process requires specialized D-amino acid handling:

D-Chain Elongation: Stepwise synthesis of the D-Cys-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH₂ sequence via Fmoc-SPPS.
Selective Deprotection: Careful removal of the N-terminal D-Cys protecting group while maintaining the integrity of the Arg side chains.
Disulfide Conjugation: Reaction with activated L-Cysteine to form the critical asymmetric disulfide bridge.
RP-HPLC Purification: Multi-stage preparative HPLC to remove residual coupling agents and unconjugated fragments.
Quality Confirmation: Final verification via LC-MS to confirm the exact mass of the conjugate.

Challenges in Etelcalcetide Synthesis

The synthesis of full D-peptides requires high-purity D-amino acid building blocks. Furthermore, the asymmetric disulfide linkage between L-Cys and D-Cys requires precise redox control to prevent the formation of homodimers.

What Is The Difference Between Research Grade And Pharmaceutical Grade Etelcalcetide?

Category	Research Grade	Pharmaceutical Grade
Primary Purpose	Laboratory preclinical studies	Approved drug manufacturing
Documentation	COA / HPLC / LC-MS / MSDS	Full GMP / CMC Regulatory Dossier
Application	Academic and R&D use	Human medication (e.g., Parsabiv)
Supply Channel	Specialty Research Suppliers	Licensed API Manufacturers

HDM BIO supplies research-grade Etelcalcetide powder for laboratory and preclinical applications only.

Why Is Supplier Qualification Important Before Purchasing Etelcalcetide?

D-Amino Acid Purity: Low-quality D-amino acids lead to L-isomer contamination and inconsistent results.
Conjugation Efficiency: Incomplete conjugation reduces the effective concentration of the active peptide.
Analytical Expertise: Suppliers must be able to demonstrate structural identity through high-resolution MS.
Stable Supply Chain: Consistent sourcing of specialty D-building blocks ensures batch-to-batch reproducibility.

Etelcalcetide Powder Price & Bulk Order Guide 2026

MOQ: Flexible; milligram samples for pilot studies and bulk gram-scale orders available.
Samples: Paid test samples available with full analytical QC documents.
Bulk pricing: Tiered pricing structure; larger volumes deliver significant cost savings.
Lead time: Standard batches are usually in stock; custom synthesis takes 3-4 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific purity requirements.

Why Choose HDM BIO As Your Supplier?

Cyclic Peptide Experts: Over 10 years of experience in multi-disulfide bridge peptide synthesis.
High-Resolution Purification: ≥98% purity guaranteed through advanced RP-HPLC.
Rigorous Identity Testing: Every batch undergoes LC-MS identity confirmation.
Global Shipping Support: Exported to 70+ countries with full customs-ready documentation.
Flexible Customization: Capability to provide custom salt forms or higher purity grades upon request.

What Are The Main Research Applications?

CaSR Pharmacology: Investigating the mechanism of allosteric calcium-sensing receptor activation.
Parathyroid Regulation: Researching the suppression of PTH synthesis and secretion.
Bone & Mineral Metabolism: Pre-clinical studies on renal osteodystrophy and vascular calcification.
D-Peptide PK/PD Studies: Investigating the pharmacokinetic advantages of D-amino acid peptides.
Renal Disease Models: Evaluating calcimimetics in animal models of chronic kidney disease (CKD).

FAQs

Q: What is the CAS number of Etelcalcetide powder?
A: The CAS registry number is 1262780-97-1.

Q: Is Etelcalcetide a D-peptide?
A: Yes, the heptapeptide backbone consists of D-amino acids, while the linked cysteine is an L-isomer.

Q: Where can I buy Etelcalcetide powder from China?
A: HDM BIO is a professional peptide manufacturer supplying high-purity Etelcalcetide worldwide.

Q: What documents are provided with each order?
A: Each batch includes a COA, HPLC chromatogram, LC-MS report, and MSDS.

Q: How should the powder be stored?
A: Store sealed at -20°C, protected from light and moisture. D-peptides are generally very stable, but moisture should be avoided.