Palmitoyl Tripeptide-38 Powder

Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) | GMP Cosmetic Peptide Manufacturer & Bulk Supplier

Key Features:

✓ Purity ≥98% by HPLC

✓ GMP-Compliant Manufacturing

✓ COA & MS Documentation

✓ Bulk Supply from 1g Samples to Commercial Orders

✓ OEM & ODM Cosmetic Ingredient Solutions

HDM BIO is a China-based cosmetic peptide manufacturer supplying bulk Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) for global skincare brands, cosmetic formulators, and private-label manufacturers.

Palmitoyl Tripeptide-38 Powder is a matrikine-inspired lipopeptide commercially known as Matrixyl Synthe'6. This ingredient is designed for multi-target ECM approaches in anti-wrinkle cosmetic formulations. Produced through controlled solid-phase synthesis and N-terminal lipidation, it represents an advanced member of the globally recognized Matrixyl peptide family used by premium skincare brands.

This peptide is selected by formulators for its high purity, its multi-target formulation approach and emulsion stability, and consistent quality, making it suitable for premium skincare development. As part of HDM BIO's cosmetic peptide ingredient portfolio, it is supplied with full batch documentation including HPLC and MS testing data, supporting product registration and quality assurance requirements.

As a professional Matrixyl Synthe'6 supplier, HDM BIO provides cosmetic-grade peptide raw materials with complete quality documentation for international skincare manufacturers.

Every production batch of Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) powder undergoes a defined quality testing protocol before release. Testing documentation is provided as a Certificate of Analysis (COA) specific to each batch.

• Verified purity. HPLC analysis confirms ≥98% purity for every production batch.
• Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) structural feature. As a matrikine-inspired multi-target lipopeptide, this ingredient features a specific sequence designed for comprehensive ECM-oriented formulation strategies.
• Batch consistency. GMP-controlled manufacturing with standardized protocols delivers reliable results.
• Full documentation. COA, MS, and HPLC data accompany every shipment for quality assurance.
• Scalable supply. Available from laboratory evaluation quantities through to commercial production volumes.
• OEM and ODM capability. Technical formulation support for brands developing private-label skincare products.

Cosmetic formulators choose Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) because of its multi-target formulation approach and emulsion stability and reliable batch consistency.

Its physicochemical properties allow integration into various advanced emulsion systems, serum concentrates, and lipid-based delivery formats. The ingredient is supplied with comprehensive quality documentation that supports cosmetic product registration and compliance requirements.

The ingredient is commonly selected by cosmetic brands developing premium Matrixyl Synthe'6 anti-wrinkle products that require consistent quality and reliable supply. HDM BIO provides technical support for formulation integration.

HDM BIO produces Palmitoyl Tripeptide-38 (Matrixyl Synthe'6) through a controlled solid-phase peptide synthesis process that includes the following stages:

1. Resin Loading - Preparation of the solid support for the specific peptide sequence.
2. Sequential Coupling - Stepwise Fmoc-SPPS coupling according to the matrikine-inspired sequence.
3. Palmitoyl Lipidation - N-terminal palmitic acid conjugation for enhanced skin affinity.
4. Cleavage - Removal of the lipidated peptide from the resin support.
5. HPLC Purification - Advanced chromatographic purification to achieve ≥98% purity specification.
6. Lyophilization - Freeze-drying process to produce a stable, high-purity powder.
7. Final QC Release - Comprehensive testing including HPLC and MS for batch documentation.

The entire process is performed in HDM BIO's GMP-certified facility with environmental monitoring, personnel training records, and equipment validation programs in place.

• Raw material qualification. All amino acid derivatives and solvents are tested upon receipt.
• In-process controls. Reaction monitoring ensures process parameters remain within defined limits.
• Purification verification. HPLC analysis confirms target purity at each chromatographic stage.
• Batch release testing. Product testing includes HPLC, MS, appearance, and water content.
• Documentation package. Every shipment includes a batch-specific COA.
• Retained sample program. Samples from each batch are retained for 2 years for quality tracking.
• Stability-oriented packaging. Vacuum-sealed packaging maintains integrity during global transit.

• Tripeptide-1 (GHK) - copper-binding tripeptide
• Tripeptide-2 - anti-wrinkle bioactive tripeptide
• Palmitoyl Tripeptide-8 - soothing palmitoyl peptide
• Acetyl Dipeptide-1 Cetyl Ester - lipid-modified skin firming dipeptide
• Trifluoroacetyl Tripeptide-2 - fluorinated anti-wrinkle peptide
• Dipeptide-6 - short-chain anti-aging dipeptide

Q: What is Palmitoyl Tripeptide-38 used for in cosmetics?

A: Palmitoyl Tripeptide-38 Powder is a cosmetic peptide ingredient used in advanced anti-wrinkle formulations. It is designed for multi-target product strategies and is a popular choice for premium serums and creams. Its lipophilic nature allows it to be integrated into various high-end skincare systems targeting the appearance of skin aging.

Q: Is Palmitoyl Tripeptide-38 water-soluble?

A: Due to its palmitoyl modification, this peptide is more lipophilic than standard tripeptides. It is soluble in organic solvents and is typically integrated into the oil phase of emulsions or used with specific solubilizers in aqueous-based systems to ensure uniform distribution in the final cosmetic product.

Q: What usage concentration is typical for this ingredient?

A: The typical usage level for Palmitoyl Tripeptide-38 depends on the formulator's goals and the specific cosmetic application. Brands usually determine the optimal concentration through their own R&D and stability testing processes to match their product's target performance and positioning.

Q: How is Palmitoyl Tripeptide-38 manufactured at HDM BIO?

A: HDM BIO manufactures this peptide using a GMP-compliant process involving Fmoc solid-phase peptide synthesis and N-terminal lipidation. The process includes stringent HPLC purification to meet the ≥98% purity standard, followed by lyophilization and detailed batch-specific quality verification using mass spectrometry.

Q: What quality testing is performed on each batch?

A: Each production batch is tested for HPLC purity, MS identity, appearance, and water content. We provide a batch-specific COA with every order to support our customers' quality assurance and regulatory requirements, ensuring consistent performance in their cosmetic formulations.

Q: Where can formulators buy bulk Palmitoyl Tripeptide-38 powder?

A: Bulk Palmitoyl Tripeptide-38 powder is available directly from HDM BIO. We supply cosmetic manufacturers globally with GMP-produced peptide ingredients and full technical documentation. Contact our sales department for pricing, lead times, and to request samples for evaluation.

Q: Is Palmitoyl Tripeptide-38 the same as Matrixyl Synthe'6?

A: Yes. Palmitoyl Tripeptide-38 is the INCI-related peptide ingredient commercially known as Matrixyl Synthe'6. It is supplied as a cosmetic peptide raw material for professional skincare formulation development.

• Reviewed by: HDM BIO Cosmetic Peptide Manufacturing Technical Team
• Last Reviewed: July 2026
• Manufacturer: HDM BIO
• Location: China
• Standard: GMP
• Expertise: Peptide synthesis, HPLC purification, QC systems, GMP compliance
• Review Scope: Process validation, specification review, and quality documentation
• Quality System: Full GMP-compliant manufacturing and testing environment
• Documentation: Batch-specific COA, HPLC, and MS data provided
• Category: Cosmetic peptide ingredient
• Intended Use: Cosmetic raw material for topical skincare formulations

This product is a cosmetic ingredient intended for use in topical skincare formulations. It is not intended for use in pharmaceutical products, dietary supplements, or any application requiring drug registration. All information is provided for B2B procurement purposes. Formulators should conduct independent testing to verify suitability for their specific formulations.

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