Palmitoyl Tripeptide-38 Powder

Palmitoyl Tripeptide‑38 Powder | Bulk Cosmetic Peptide Manufacturer China

Key Features:

• Stimulates synthesis of collagen & elastin, reduces visible fine lines and wrinkles
• Improves skin density, supports dermal matrix reconstruction
• Boosts hyaluronic acid production for better skin hydration
• Compatible with most cosmetic formulations, stable in common skincare bases
• Targets multi‑layer anti‑aging effect for mature‑skin products

Palmitoyl Tripeptide-38 Powder (CAS 1447824-23-8) is a synthetic palmitoylated cosmetic peptide of sequence Pal-Lys-Met(O2)-Lys, also known commercially as Matrixyl Synthe'6. It is a matrikine-inspired lipopeptide designed for multi-target extracellular-matrix (ECM)-oriented formulation development and anti-wrinkle cosmetic research.

Palmitoyl Tripeptide-38 should not be confused with Palmitoyl Tripeptide-1 (Pal-GHK). Although the names are similar, they are different peptides with different sequences, molecular structures and CAS numbers.

HDM Biotech supplies Palmitoyl Tripeptide-38 for cosmetic formulation R&D, laboratory research, distributor sourcing and B2B bulk procurement, with batch-specific analytical documentation available according to the supplied specification.

Palmitoyl Tripeptide-38 is manufactured by solid-phase peptide synthesis (SPPS) followed by purification and analytical quality assessment according to the applicable product specification. Identity is confirmed by mass spectrometry against the specified molecular weight; batch-specific COA, HPLC and MS/LC-MS data are available on request.

• ≥98% HPLC purity with batch-specific analytical verification

• Pal-Lys-Met(O2)-Lys identity confirmed by MS/LC-MS

• Matrikine-inspired lipopeptide for ECM-oriented formulation research

• Developed for anti-wrinkle and skin-conditioning formulation development

• Batch-specific COA, HPLC and MS data available

• Research, pilot-scale and bulk supply options

Formulators select Palmitoyl Tripeptide-38 as a cosmetic peptide raw material for formulation development and scientific research. Compatibility, concentration, stability and processing conditions should be evaluated in the final formulation rather than assumed from the individual raw material. Finished-product efficacy claims should be supported by formulation-specific evidence and comply with applicable cosmetic regulations.

A typical production workflow includes: solid-support preparation, stepwise Fmoc-SPPS coupling according to the matrikine-inspired sequence, N-terminal palmitic acid lipidation, cleavage and deprotection, purification, analytical quality control, and final packaging. The exact procedure depends on the sequence, specification, batch size and applicable production requirements.

Palmitoyl Tripeptide-38 and Palmitoyl Tripeptide-1 are sometimes confused because of their similar INCI-style names. They are different peptides.

Palmitoyl Tripeptide-38 ≠ Palmitoyl Tripeptide-1. When sourcing cosmetic peptides, buyers should verify the exact peptide name, sequence, CAS number and batch specification rather than relying only on similar product names.

HDM Biotech uses controlled peptide synthesis, purification and analytical procedures for synthetic peptide production. Depending on the supplied batch and customer requirements, supporting documentation may include: batch-specific COA, HPLC purity data, MS/LC-MS identity data, product specification, storage and handling information, and batch or lot identification. The actual analytical result for an individual order should always be confirmed from the batch-specific COA, rather than inferred from representative website data.

Q1. What is Palmitoyl Tripeptide-38 used for in cosmetics?

Palmitoyl Tripeptide-38 Powder is a matrikine-inspired lipopeptide used in anti-wrinkle and ECM-oriented cosmetic formulation research. It is evaluated in premium serums, creams and eye-care products.

Q2. What purity is available?

The listed product specification is ≥98% by HPLC. Actual purity and other analytical results should be confirmed from the batch-specific COA supplied with each order.

Q3. What analytical documentation is available?

Depending on the supplied batch and order requirements, documentation may include a batch-specific COA, HPLC chromatogram, MS/LC-MS identity data, product specification and relevant storage information.

Q4. Is Palmitoyl Tripeptide-38 water-soluble?

Due to its palmitoyl modification, the peptide is more lipophilic than standard tripeptides. It is reported for use in organic-solvent-based systems and compatible formulation vehicles; actual solubility and compatibility should be evaluated under the intended formulation conditions.

Q5. Do you supply bulk Palmitoyl Tripeptide-38?

Yes. Research-scale, pilot-scale and bulk quantities can be discussed according to project requirements. Contact HDM Biotech with the required purity, quantity, application and documentation requirements for a quotation.

Reviewed by: HDM Biotech Cosmetic Peptide Manufacturing Technical Team

Last Reviewed: July 2026

Manufacturer: HDM Biotech | Location: China

Standard: Manufactured under controlled peptide-manufacturing procedures; applicable quality-system certificates available with batch documentation upon request.

Review Scope: Process validation, specification review, and quality documentation

Documentation: Batch-specific COA, HPLC and MS data provided

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