PNC27 Peptide Powder | HDM-2 Targeting Chimeric Anticancer Peptide GMP Manufacturer in China | Membrane Disruption Tumor Necrosis Research API Bulk Supply

Key Product Highlights:

HDM-2–targeted cancer cell membrane–active peptide
Highly selective cytotoxicity toward tumor cells
Membrane disruption–induced necrotic cell death
Bypasses apoptosis resistance pathways
Effective in solid tumor and hematologic cancer models
Low endotoxin, high stability GMP-grade API
Excellent batch consistency with full traceability

What Is PNC27 Powder and How Does It Work as an HDM-2 Targeting Chimeric Anticancer Peptide?

PNC27 Powder is a synthetic chimeric anticancer peptide derived from a functional domain of p53 and manufactured via advanced Fmoc solid-phase peptide synthesis (SPPS). The final product is supplied as a sterile lyophilized research-grade API.

Unlike conventional intracellular p53-targeting compounds, PNC27 peptide acts through a distinct membrane-targeting mechanism. It selectively binds to HDM-2 proteins abnormally expressed on the surface of cancer cells, leading to membrane destabilization and subsequent tumor cell necrosis, while showing minimal toxicity toward normal cells.

This selective mechanism makes it highly suitable for cancer biology research, tumor signaling studies, apoptosis-resistance investigation, and anticancer drug screening platforms.

PNC27 demonstrates good aqueous solubility and stable biological performance in both in vitro and in vivo experimental systems, ensuring high reproducibility.

What Does the Certificate of Analysis (COA) Include for PNC27 Peptide?

Item	Specification	Result
Appearance	White to off White powder	Consistent
Purity(HPLC)	≥98%	99.33%
MS	Consistent	Consistent
Conclusion	The product complies with the requirements

What Are the Key Advantages of PNC27 Powder for Tumor Selectivity and Membrane Disruption Research?

High tumor selectivity: targets HDM-2 overexpressed on cancer cell membranes
Membrane disruption mechanism: induces pore formation and necrotic cell death
Apoptosis-independent pathway: effective against apoptosis-resistant cancer cells
Broad cancer model applicability: suitable for solid and hematologic tumor studies
Excellent solubility: fully soluble in water, PBS, and standard culture media
Low biological interference: low endotoxin and minimal nonspecific cytotoxicity
Stable experimental performance: moderate enzymatic resistance for reproducibility

What Pharmacological Research Functions Does PNC27 Powder Demonstrate in Cancer Studies?

Selective binding to HDM-2–positive tumor cell membranes
Induction of membrane pore formation and tumor cell necrosis
Disruption of mitochondrial membrane integrity in cancer cells
Inhibition of tumor proliferation and invasion pathways
Model for apoptosis-resistant cancer mechanism studies
Evaluation of tumor selectivity versus normal cell safety

What Are the Main Research Applications of PNC27 Powder in Oncology and Drug Development?

Solid tumor mechanism research (breast, pancreatic, colon, cervical, ovarian cancers)
Hematologic malignancy and drug resistance studies
HDM-2 target validation and p53 pathway comparative research
Tumor membrane-targeted drug development
Cancer necrosis and mitochondrial dysfunction studies
Preclinical screening in academic and pharmaceutical R&D

What Are the Core Manufacturing Advantages of GMP PNC27 Peptide Powder Production in China?

Precise peptide synthesis via Fmoc-SPPS platform
High-purity multi-step chromatographic purification
GMP-controlled cleanroom manufacturing (Class 100,000)
Scalable production from milligram to kilogram level
Excellent batch-to-batch consistency
Full technical support for research applications

What Is the Mechanism of Action of PNC27 Powder in HDM-2 Targeted Tumor Necrosis?

PNC27 peptide exhibits a dual anticancer mechanism distinct from conventional apoptosis-inducing agents.

1. Membrane Targeting and Pore Formation

PNC27 Powder selectively binds to HDM-2 proteins overexpressed on cancer cell membranes. This interaction destabilizes the lipid bilayer and leads to membrane pore formation, resulting in rapid tumor cell necrosis via loss of cellular homeostasis.

2. Mitochondrial Disruption Mechanism

Following membrane penetration, PNC27 interacts with mitochondrial membranes, disrupting mitochondrial integrity and energy metabolism, thereby further inhibiting tumor cell survival and proliferation.

Unlike p53-dependent apoptosis pathways, this mechanism remains effective in apoptosis-resistant tumor models, making it valuable for drug resistance and tumor selectivity research.

How Is Quality Assurance Ensured for PNC27 Powder Under GMP Manufacturing Standards?

GMP-certified cleanroom manufacturing system
Pharmaceutical-grade raw material sourcing
Multi-stage in-process quality control
Final batch release testing before shipment
2-year retained sample traceability system
Complete export documentation (COA / MSDS / non-hazard certificate)
Vacuum-sealed, moisture-proof packaging

What Are the Most Frequently Asked Questions About PNC27 Powder Research Use?

Q1: What is the research value of PNC27 peptide?
PNC27 is a HDM-2–targeting chimeric peptide used for tumor selectivity, membrane necrosis mechanism studies, and apoptosis-resistant cancer research. It is strictly for laboratory and animal research use only.

Q2: Is it suitable for human use?
No. This product is strictly for research use only and not intended for human clinical application.