PE 22 28 Powder

PE 22 28 Powder | Spadin-Derived TREK-1 Antagonist Heptapeptide | GMP China Manufacturer

Key Product Highlights:

• Highly selective TREK-1 potassium channel antagonist with minimal off-target effects
• Reported fast-acting mood-related activity in rodent preclinical research models
• Good aqueous solubility, low endotoxin level, suitable for cell-based and in vivo laboratory studies
• Manufactured through controlled GMP production processes with consistent batch quality
• Complete COA documentation and quality testing records available for each batch

PE 22 28 Powder is a lyophilized research-grade peptide raw material produced using established Fmoc solid-phase peptide synthesis (Fmoc-SPPS) technology. Consisting of seven amino acids with the sequence GVSWGLR, it is a truncated derivative of the endogenous peptide Spadin, designed to maintain TREK-1 inhibitory activity while improving structural stability and research applicability.

This peptide selectively interacts with neuronal TREK-1 two-pore domain potassium channels, making it a valuable research tool for neuroscience, ion channel studies, and preclinical psychopharmacology investigations.

The product appears as a white to off-white lyophilized powder with consistent HPLC purity of ≥98%. It shows good solubility in commonly used laboratory solvents, including purified water, PBS buffer, and cell culture media. We supply high-purity peptide raw materials to academic institutions, biotechnology companies, and pharmaceutical R&D laboratories worldwide, offering flexible package sizes from analytical samples to bulk research quantities.

1. High Target Selectivity

PE 22 28 selectively targets TREK-1 potassium channels with limited interaction with related potassium channels, including TREK-2 and TRAAK. This high selectivity helps reduce experimental variables and improves the reliability of neuroscience research data.

2. Enhanced TREK-1 Modulation Activity

Compared with the native Spadin peptide, this optimized peptide derivative has demonstrated improved TREK-1 inhibitory activity in preclinical research settings, supporting studies focused on ion channel regulation and neuronal signaling mechanisms.

3. Improved Structural Stability

The optimized peptide structure provides enhanced resistance against enzymatic degradation, helping maintain peptide activity during laboratory experiments and supporting extended research observation periods.

4. Reliable Storage Stability

When properly stored under recommended conditions, the sealed lyophilized powder maintains stability for up to 2 years. After reconstitution, the peptide remains suitable for short-term laboratory use under appropriate storage conditions.

5. Low Experimental Interference

Strict control of purity, impurities, and endotoxin levels helps minimize unwanted variables in cell-based assays and animal research models, supporting more consistent experimental outcomes.

6. Convenient Laboratory Preparation

The powder can be readily prepared using commonly used laboratory solvents without requiring complex solubilization procedures, improving workflow efficiency for researchers.

All research activities described below are based on in vitro studies and animal preclinical models only. They do not represent confirmed human therapeutic effects, and further clinical investigation is required to evaluate safety and efficacy in humans.

1. Neuronal Excitability Regulation

PE 22 28 has been investigated for its ability to regulate neuronal excitability through TREK-1 potassium channel modulation. By reducing excessive potassium ion efflux, it may influence neuronal membrane potential and support studies exploring the relationship between ion channel activity and neural signaling pathways.

2. Central Neurotransmission Research

Preclinical studies have explored the potential relationship between TREK-1 inhibition and neurotransmitter regulation, including serotonergic signaling pathways and stress-related neural mechanisms. These findings provide a foundation for investigating the role of potassium channels in mood-related neuroscience research.

3. Neuroplasticity Pathway Studies

Research models have investigated the effects of TREK-1 modulation on neuroplasticity-related pathways, including the expression of brain-derived neurotrophic factor (BDNF) and synaptic signaling proteins. These studies support further exploration of neuronal adaptation mechanisms.

4. Neuroprotection and Oxidative Stress Research

PE 22 28 has been studied in experimental models related to oxidative stress and neuronal damage. Research has investigated its potential influence on reactive oxygen species (ROS) regulation, mitochondrial function, and cellular protection pathways.

5. Neuroinflammation Research

Preclinical research has explored the relationship between TREK-1 signaling and inflammatory pathways. PE 22 28 may serve as a research tool for investigating inflammatory mediator regulation, including factors associated with neuronal stress responses.

1. Controlled Full-Process Peptide Manufacturing

Our production platform integrates peptide synthesis, purification, quality testing, and lyophilization processes under controlled manufacturing conditions. Advanced Fmoc solid-phase peptide synthesis technology ensures accurate amino acid sequence assembly and product consistency.

2. Advanced Reverse-Phase HPLC Purification

Multi-stage reverse-phase HPLC purification is applied to effectively remove peptide-related impurities and improve product purity, ensuring reliable performance for laboratory research applications.

3. GMP-Compliant Production Facilities

Production activities are performed under GMP-controlled environments, with strict management of raw material selection, synthesis procedures, purification processes, and final packaging to reduce contamination risks and improve batch reliability.

4. Dedicated Lyophilization Process

Professional freeze-drying procedures help maintain peptide stability, improve powder consistency, and reduce quality variations caused by moisture exposure during storage and transportation.

5. Complete Batch Traceability

Each batch undergoes comprehensive quality testing before shipment. COA documentation, analytical records, and batch information are available to support research material verification and quality control requirements.

6. Flexible Packaging Options

Multiple package sizes are available, including:

1 mg analytical samples

5 mg and 10 mg research packages

1 g, 5 g, and 10 g bulk supply options

Customized packaging solutions can also be discussed according to project requirements.

7. Stable Supply Capacity

With established peptide production capabilities, we support long-term procurement programs from research organizations, biotechnology companies, and pharmaceutical development teams with reliable supply planning and competitive bulk pricing options.

PE 22 28 Powder is a Spadin-derived peptide investigated for its interaction with neuronal TREK-1 two-pore domain potassium channels.

TREK-1 channels are potassium channels involved in regulating neuronal membrane potential. Under certain physiological and pathological conditions, increased TREK-1 activity may contribute to neuronal hyperpolarization and reduced neuronal excitability.

By modulating TREK-1 channel activity, PE 22 28 has been studied for its potential effects on:

1. Regulation of Neuronal Activity

TREK-1 modulation may influence potassium ion movement across neuronal membranes, helping researchers investigate mechanisms associated with neuronal excitability and signal transmission.

2. Investigation of Mood-Related Neural Pathways

Preclinical studies have explored connections between TREK-1 regulation and serotonin-related signaling pathways, providing insights into neural mechanisms involved in emotional regulation research.

3. Neuroplasticity Mechanism Studies

Research has examined whether TREK-1 modulation influences neuroplasticity-related factors, including BDNF signaling and synaptic adaptation processes.

4. Oxidative Stress and Cellular Protection Research

Experimental studies have investigated potential relationships between TREK-1 signaling, oxidative stress response, mitochondrial function, and neuronal survival pathways.

5. Neuroinflammation Pathway Investigation

PE 22 28 may serve as a tool compound for exploring the relationship between ion channel regulation and inflammatory signaling mechanisms.

Current research data indicates no significant interaction with μ-opioid or δ-opioid receptors. The compound is not intended for pain research, opioid-related studies, human use, or therapeutic applications.

Q1: Can PE 22 28 Powder Be Used for Human Injection, Oral Administration, or Clinical Treatment?

A: No. This product is supplied strictly for laboratory research purposes, including in vitro studies and preclinical animal research. Human clinical safety and efficacy have not been established. It is not intended for human administration, medical treatment, dietary supplementation, or cosmetic applications.

Q2: How Quickly Can Research Effects Be Observed in Animal Models?

A: In animal research models, changes in neural activity-related indicators may be observed within experimental observation periods reported in published studies. Results can vary depending on species, experimental design, dosage conditions, and research protocols. Animal findings should not be directly interpreted as human effects.

Q3: What Is the Difference Between PE 22 28 and Selank?

A: Both peptides are studied in neuroscience-related research but act through different biological pathways.

Selank research mainly focuses on GABA-related signaling pathways and anxiety-related mechanisms, while PE 22 28 research focuses on TREK-1 potassium channel regulation and ion channel-related neuroscience mechanisms.

Neither compound is approved as a human medicine, and both are limited to laboratory research applications.

Q4: What Is the Difference Between Free-Base PE 22 28 and Acetate PE 22 28?

A: Different peptide salt forms may show variations in stability, solubility, and handling characteristics.

The acetate form is commonly selected when improved formulation stability and solubility are required, while the free-base form may be preferred in certain laboratory research protocols. Selection should depend on specific experimental requirements.

Q5: Does PE 22 28 Have Addictive, Sedative, or Analgesic Effects?

A: Current research information indicates that PE 22 28 does not show known opioid receptor binding activity. It is not designed for analgesic, sedative, or addiction-related applications and should only be used according to approved laboratory research purposes.

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