Pasireotide Powder

Pasireotide Powder CAS 396091-73-9 | Somatostatin Analog Peptide Supplier China | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: High-purity Pasireotide powder ensures consistent binding affinity in multi-receptor studies.

✅ Broad Receptor Profile: Exceptional affinity for somatostatin receptors SSTR1, 2, 3, and especially SSTR5.

✅ Cyclization Expertise: Precision head-to-tail cyclization ensures high thermodynamic stability and bioactivity.

✅ China Peptide Manufacturer: GMP-aligned production facility specializing in complex cyclic and modified peptides.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and purity chromatogram.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance documents.

Pasireotide powder is a synthetic cyclohexapeptide somatostatin analog. Unlike first-generation analogs like octreotide, Pasireotide exhibits a much broader binding profile, with up to 40 times higher affinity for the SSTR5 receptor. This unique characteristic makes it a primary research tool for studying conditions where multiple receptor subtypes are involved, such as Cushing's disease and resistant acromegaly.

The synthesis of Pasireotide is highly demanding due to the incorporation of specialty amino acids-including L-phenylglycine and modified hydroxyproline-followed by a critical head-to-tail cyclization step. HDM BIO utilizes optimized coupling reagents and high-resolution purification to ensure the absence of linear precursors and dimers. We supply this research-grade peptide to global university labs and pharmaceutical R&D teams. Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

Our Pasireotide powder manufacturing follows a specialized cyclic peptide protocol:

• Chain Assembly: Stepwise synthesis of the linear hexapeptide on a hyper-acid-sensitive resin using high-purity modified amino acids.
• Side-Chain Modification: Precision attachment of the (2-aminoethyl)carbamoyloxy group to the proline residue.
• Head-to-Tail Cyclization: Optimized high-dilution cyclization in the liquid phase to ensure the formation of the macrocycle.
• RP-HPLC Purification: Multi-stage preparative HPLC to remove linear fragments and epimeric impurities.
• Quality Release: Final confirmation via LC-MS to verify the exact mass and HPLC for purity.

Structural Integrity Control

The broad bioactivity of Pasireotide depends on its precise cyclic conformation. HDM BIO monitors the cyclization efficiency to ensure every batch meets the strict ≥98% purity standard with no residual linear by-products.

HDM BIO supplies research-grade Pasireotide powder for laboratory and pre-clinical applications only.

• Cyclization Purity: Linear precursors can interfere with receptor binding data.
• Modified Amino Acid Quality: The purity of building blocks like 4-benzyloxy-L-tyrosine is essential for batch consistency.
• Analytical Verification: Reliable suppliers must provide high-resolution LC-MS data for molecular confirmation.
• Export Experience: Knowledge of international customs requirements for specialty peptides ensures fast delivery.

1. MOQ: Flexible; milligram samples and bulk gram-scale orders available.
2. Samples: Paid test samples available with full QC documentation.
3. Bulk pricing: Tiered pricing structure; larger volumes deliver competitive unit costs.
4. Lead time: Standard batches are usually in stock; custom synthesis takes 3-4 weeks.
5. Quotation: Contact our sales team for the latest formal quotation based on your specific purity requirements.

• Multi-SSTR Receptor Pharmacology: Studying the binding affinity across SSTR subtypes 1, 2, 3, and 5.
• Cushing's Disease Models: Investigating the suppression of ACTH secretion in pituitary corticotroph adenomas.
• Acromegaly Research: Studying growth hormone (GH) regulation in SSTR2-resistant models.
• Neuroendocrine Tumor (NET) Studies: Pre-clinical evaluation of anti-proliferative effects in various tumor lines.
• Drug Delivery Systems: Development of long-acting injectable or implantable formulations for cyclohexapeptides.

Q: What is the CAS number of Pasireotide powder?
A: The CAS registry number is 396091-73-9.

Q: Is Pasireotide more potent than Octreotide?
A: Pasireotide Powder has a much broader binding profile and is significantly more potent at the SSTR5 receptor.

Q: Where can I buy Pasireotide powder from China?
A: HDM BIO is a professional peptide manufacturer in China supplying high-purity Pasireotide globally.

Q: How should the powder be stored?
A: Store sealed at -20°C, protected from light and moisture. For long-term storage, -80°C is recommended.

Q: What is the purity of your Pasireotide?
A: Our standard research-grade purity is ≥98% HPLC.

We provide professional one-stop procurement and technical support for global peptide R&D projects:

• Batch-specific COA
• MSDS Safety Data Sheet
• GMP & ISO Certification Documents
• Custom Bulk Wholesale Pricing
• Free Samples Available
• Dedicated Technical Formulation Support

Request COA Get Bulk Pricing Request Sample

WhatsApp: +86 19991242181

Email: sales@hdmbio.com

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