Cefquinome Sulfate API Manufacturer China | ≥98% Fourth-Generation Cephalosporin Veterinary Antibiotic CAS 118443-89-3

Key Selling Points

✓ Fourth-Generation Veterinary Cephalosporin - Broadest Spectrum Among Animal-Exclusive β-Lactams

✓ Zwitterionic Quinolinium Structure - Enhanced Gram-Negative Outer Membrane Penetration (incl. Pseudomonas)

✓ Highly β-Lactamase-Stable - Resistant to Penicillinases & Many Cephalosporinases

✓ Bovine Mastitis Gold Standard - Lactating & Dry Cow Intramammary (Staph, Strep, E. coli)

✓ Swine MMA & Respiratory API - Pasteurella, Actinobacillus, Haemophilus parasuis, Streptococcus suis

✓ Wide Safety Margin - IM/SC/Intramammary; Mild Injection Site Reactions

What Is Cefquinome Sulfate Powder?

Cefquinome Sulfate Powder is the sulfate salt of cefquinome, a fourth-generation cephalosporin antibiotic developed exclusively for veterinary use. Its advanced cephalosporin structure provides enhanced penetration into Gram-negative bacteria and improved stability against many β-lactamases compared with earlier-generation cephalosporins.

It shows broad-spectrum activity against susceptible Gram-positive and Gram-negative bacteria, including Streptococcus, Staphylococcus, E. coli, Pasteurella multocida, Mannheimia haemolytica and Actinobacillus pleuropneumoniae. It is widely used as a veterinary pharmaceutical raw material for respiratory infections, mastitis, metritis, foot rot and other bacterial disease formulation development.

How Does Cefquinome Sulfate Powder Work?

Cefquinome Sulfate Powder works by binding to bacterial penicillin-binding proteins (PBPs), inhibiting the final stage of peptidoglycan cross-linking required for cell wall formation. This weakens the bacterial cell wall and leads to osmotic lysis of actively dividing bacteria.

Its structural features enhance Gram-negative bacterial penetration and provide resistance against many β-lactamases, contributing to activity against strains resistant to some earlier cephalosporins. As a time-dependent β-lactam antibiotic, its antibacterial effect is related to maintaining drug concentration above the minimum inhibitory concentration (MIC).

What Are the Applications of Cefquinome Sulfate Powder?

Bovine Respiratory Disease (BRD): Treatment of Mannheimia haemolytica, Pasteurella multocida and Histophilus somni infections in cattle.
Bovine Mastitis: Intramammary infusion for lactating cow clinical mastitis and dry cow subclinical mastitis (Staphylococcus, Streptococcus uberis/dysgalactiae, E. coli).
Bovine Foot Rot & Digital Dermatitis: Treatment of interdigital necrobacillosis, foot rot and digital dermatitis (Fusobacterium, Bacteroides).
Bovine Metritis & Calf Septicaemia: Acute postpartum metritis and neonatal septicaemia in calves.
Swine Respiratory & MMA: Swine respiratory disease (Pasteurella, Haemophilus parasuis, Actinobacillus, Streptococcus suis) and mastitis-metritis-agalactia (MMA) syndrome (E. coli, Staphylococcus, Streptococcus); reduction of early mortality in piglets.

What Is the Difference Between Cefquinome and Ceftiofur?

Feature	Cefquinome (Sulfate)	Ceftiofur (Sodium/HCl/Free Acid)
CAS (salt)	118443-89-3	104010-37-9 / 103980-44-5 / 80370-57-6
Generation	4th	3rd
3-Position Group	Quinolinium (zwitterionic)	Furanylcarbonylthiomethyl
Gram-Negative Penetration	Very high (zwitterion)	High
β-Lactamase Stability	Very high (incl. many AmpC)	High (plasmid-mediated)
Pseudomonas aeruginosa	Active	Not active
Mastitis Use	Lactating + dry cow (intramammary)	Limited (some formulations)
Swine MMA	Approved	Not primary indication
Aqueous pH	1.5–2.5 (acidic)	4.5–7.5
Antibacterial Activity	Broader	Broad

How Does Cefquinome Compare With Other Veterinary Cephalosporins?

Feature	Cefquinome	Ceftiofur	Cefazolin	Cephalexin
CAS (salt)	118443-89-3	84957-30-2	25953-19-9	15686-71-2
Generation	4th	3rd	1st	1st
β-Lactamase Stability	Very high	High	Low	Low
Gram-Negative	Very broad (incl. Pseudomonas)	Broad	Narrow	Narrow
Anaerobic	Yes	Yes (Fusobacterium)	No	No
Pseudomonas	Yes	No	No	No
Mastitis	Lactating + dry cow	Limited	No	No
Typical Use	BRD, mastitis, MMA, foot rot	BRD, foot rot, swine	Surgical prophylaxis	Canine skin/UTI

How Is Cefquinome Sulfate Powder Manufactured?

Cefquinome Sulfate Powder is manufactured through multi-step semi-synthesis from 7-ACA (7-aminocephalosporic acid), involving side-chain acylation, 3-position quinolinium substitution and sulfate salt formation.

Raw Material QC → 7-ACA Preparation → 7-Position Acylation (Aminothiazole-Methoxyimino Acetic Acid) → 3-Position Quinolinium Substitution (5,6,7,8-Tetrahydroquinoline) → Purification (Chromatography) → Sulfate Salt Formation (Sulfuric Acid) → Crystallization → Centrifugation → Drying → Milling → Final QC → Packaging

HDM BIO controls key acylation, quinolinium substitution and salt formation parameters to maintain consistent purity, β-lactam integrity and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Assay (HPLC, as cefquinome)	≥80.0%	82.0%
Purity (HPLC)	≥98.0%	99.0%
Identity (IR / HPLC)	Conforms to reference standard	Confirmed
pH (1% Aqueous Solution)	1.5–2.5	2.0
Loss on Drying	≤3.0%	1.0%
Specific Optical Rotation	+50° to +70°	+60°
Related Substances	Within specification	Pass
Heavy Metals	≤10 ppm	Compliant
Residual Solvents	Within specification	Pass
Sulfate Content	14.0–18.0%	16.0%

What Quality Control Tests Are Performed for Cefquinome Sulfate Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity, β-lactam integrity and sulfate content.

Raw Material QC → In-Process Control → HPLC Assay (as cefquinome) → HPLC Purity → IR Identity Verification → pH Determination → Loss on Drying → Specific Optical Rotation → Related Substances (HPLC) → Heavy Metals → Residual Solvents → Sulfate Content Assay → Final Batch Release

Key evaluations include HPLC assay (≥80% as cefquinome), HPLC purity (≥98%), IR identity, pH, loss on drying, specific optical rotation, related substances, heavy metals, residual solvents and sulfate content. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Cefquinome Sulfate Powder Bulk Price?

Cefquinome Sulfate Powder bulk pricing is driven by several key factors:

Raw Material Costs: 7-ACA and specialized side-chain intermediates (aminothiazole-methoxyimino acetic acid, tetrahydroquinoline) directly influence manufacturing expenses.
Purity & Grade: ≥98% HPLC API with full documentation commands a premium over technical grade.
Regulatory Compliance & Certification: GMP-standard veterinary API with complete COA demands a higher price.
Order Volume: Large-scale veterinary pharmaceutical contracts receive steeper per-kilogram discounts.
Logistics & Geography: Cold-chain (2–8°C) / light-protected / moisture-proof packaging and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Cefquinome Sulfate Powder Supplier?

High-purity (≥98% / typical 99%) veterinary-exclusive fourth-generation cephalosporin for injectable and intramammary formulations
Verified broad spectrum incl. Pseudomonas; high β-lactamase stability; consistent sulfate content and zwitterionic quinolinium structure
Gold-standard bovine mastitis (lactating + dry cow) and swine MMA/respiratory API
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: kilogram samples to ton-level bulk API orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed at 2–8°C in a dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Cefquinome Sulfate Powder

Q1: What is Cefquinome Sulfate Powder?

A: Cefquinome sulfate is the sulfate salt of cefquinome, the first fourth-generation cephalosporin developed exclusively for veterinary medicine. Its zwitterionic quinolinium structure enhances Gram-negative penetration and β-lactamase stability, giving broader spectrum than third-generation cephalosporins (including activity against Pseudomonas aeruginosa). Used for bovine mastitis, BRD, foot rot, swine MMA and respiratory disease.

Q2: What is the CAS number?

A: The CAS number for cefquinome sulfate is 118443-89-3 (sulfate salt); cefquinome free base is CAS 84957-30-2.

Q3: How does cefquinome sulfate work?

A: It binds to bacterial penicillin-binding proteins (PBPs), inhibiting the final stage of peptidoglycan cross-linking required for cell wall formation, weakening the wall and causing osmotic lysis. It is bactericidal and time-dependent; its zwitterionic quinolinium group enhances Gram-negative porin penetration and β-lactamase stability.

Q4: What is cefquinome sulfate used for?

A: Bovine respiratory disease (Pasteurella, Mannheimia, Histophilus), bovine mastitis (lactating and dry-cow intramammary), foot rot/digital dermatitis, acute metritis, calf neonatal septicaemia; swine respiratory disease (Pasteurella, Actinobacillus, Streptococcus suis, Haemophilus parasuis), MMA syndrome, and reduction of early piglet mortality.

Q5: What documents are provided with each batch?

A: Batch-specific COA, HPLC assay report, IR identity, loss on drying, related substances, heavy metals, residual solvents, pH, particle size, MSDS/SDS.

Q6: What purity do you supply?

A: Standard ≥98.0% HPLC (cefquinome content ≥80.0% as labeled); typical batch result 99%. Custom particle size and injectable-grade specifications available on request.

Q7: Where can I buy it from China?

A: HDM BIO supplies bulk Cefquinome Sulfate Powder with batch COA and global export support.

Q8: How much does Cefquinome Sulfate Powder cost?

A: Bulk pricing depends on 7-ACA/side-chain raw material costs, purity/grade, particle size specification, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q9: Are there any safety concerns?

A: Rare cephalosporin hypersensitivity (possible cross-reactivity with penicillins). Mild injection site reactions may occur. Aqueous solutions are strongly acidic (pH 1.5–2.5) with potential local irritation. Meat/milk withdrawal periods apply. Cold-chain storage (2–8°C) recommended. Not for human use.

Q10: What is the difference between cefquinome and ceftiofur?

A: Both are veterinary-exclusive cephalosporins, but cefquinome is fourth-generation while ceftiofur is third-generation. Cefquinome's zwitterionic quinolinium group gives broader Gram-negative coverage (including Pseudomonas aeruginosa) and greater stability against chromosomal AmpC cephalosporinases. Ceftiofur is available as sodium, hydrochloride and crystalline free acid forms; cefquinome is primarily supplied as sulfate salt for injection and intramammary use.