Dexamethasone Sodium Phosphate Powder Supplier China | Veterinary Corticosteroid API Manufacturer CAS 55203-24-2

Key Selling Points

✓ Long-Acting Water-Soluble Glucocorticoid - Rapid Onset Even After IM Injection (36–72 hr Biological Effect)

✓ Potent Anti-Inflammatory & Anti-Allergic - Minimal Mineralocorticoid Activity (No Water Retention)

✓ Bovine Ketosis Gold-Standard Treatment - Primary Acetonemia in Cattle & Goats

✓ Multi-Species Veterinary API - Cattle, Horse, Pig, Dog, Cat, Goat (Arthritis, Shock, Allergy, Parturition Induction)

✓ HPA Axis Suppression & Cushing's Diagnosis - Dexamethasone Suppression Test Utility

✓ Freely Water-Soluble & Rapidly Absorbed - Suitable for IV/IM Injection, Ophthalmic & Topical Formulations

What Is Dexamethasone Sodium Phosphate Powder?

Dexamethasone Sodium Phosphate Powder (C₂₂H₂₈FNa₂O₈P, MW 516.4) is the water-soluble 21-phosphate disodium ester of dexamethasone, a synthetic long-acting glucocorticoid. Its phosphate ester form provides rapid systemic absorption even after intramuscular injection, with biological effects lasting 36–72 hours and minimal mineralocorticoid activity (no significant water/sodium retention).

It shows potent anti-inflammatory, anti-allergic, immunosuppressive and anti-shock activity. Widely used as a veterinary pharmaceutical raw material for bovine primary ketosis (acetonemia), inflammatory and allergic conditions in cattle/horses/pigs/dogs/cats/goats, equine arthritis/bursitis/tenosynovitis, shock adjunct therapy, parturition induction in cattle, and the dexamethasone suppression test for Cushing's diagnosis in dogs. It is exceedingly hygroscopic and requires strict sealed dry storage.

How Does Dexamethasone Sodium Phosphate Powder Work?

Dexamethasone Sodium Phosphate Powder exerts its effects by binding to intracellular glucocorticoid receptors (GR); the receptor-ligand complex translocates to the nucleus and modulates gene transcription, suppressing pro-inflammatory cytokines (IL-1, IL-2, IL-6, TNF-α, IFN-γ), inhibiting phospholipase A2 (reducing arachidonic acid-derived prostaglandins and leukotrienes), stabilizing lysosomal membranes and suppressing fibroblast activity.

Because Dexamethasone Sodium Phosphate Powder is a long-acting glucocorticoid, a single dose suppresses the hypothalamic-pituitary-adrenal (HPA) axis for 36–72 hours - the basis of the low-dose dexamethasone suppression test for canine Cushing's disease. It provides potent immunosuppression (inhibiting T-cell proliferation and antibody production) and anti-shock activity (enhancing cardiovascular responsiveness to catecholamines). The phosphate ester is rapidly hydrolyzed in vivo to release active dexamethasone. Excretion is primarily renal and fecal (half-life ~48 hours in dogs). Long-term use carries risks of iatrogenic hyperadrenocorticism, HPA axis suppression, secondary infections, GI ulceration and osteoporosis.

What Are the Applications of Dexamethasone Sodium Phosphate Powder?

Bovine Primary Ketosis (Acetonemia): Gold-standard treatment for primary ketosis in cattle and goats (rapid correction of negative energy balance).
Anti-Inflammatory & Anti-Allergic: Inflammatory and allergic conditions in cattle, horses, pigs, dogs, cats and goats - arthritis, dermatitis, allergic reactions, shock adjunct therapy.
Equine Musculoskeletal: Arthritis, bursitis and tenosynovitis in horses (caution: may induce laminitis).
Parturition Induction: Induction of parturition in cattle (may increase retained placenta rate and delay lactation).
Canine/Feline: Immune-mediated diseases, asthma acute exacerbation (cats), shock, allergic reactions, and the dexamethasone suppression test for Cushing's disease diagnosis.
Pharmaceutical Formulations: Raw material for injectable solutions (IV/IM), ophthalmic preparations, topical creams and oral formulations.

What Is the Difference Between Dexamethasone Sodium Phosphate and Dexamethasone?

Feature	Dexamethasone Sodium Phosphate	Dexamethasone (Free Alcohol)
CAS	55203-24-2	50-02-2
Molecular Formula	C₂₂H₂₈FNa₂O₈P	C₂₂H₂₉FO₅
Molecular Weight	516.4	392.47
Water Solubility	Freely soluble	Practically insoluble
Route	IV / IM (rapid onset)	Oral / IM (slower, depot)
Onset	Rapid (even IM)	Slower
Duration	36–72 hr	36–72 hr
Typical Use	Injection, ophthalmic, emergency	Oral tablets, depot injection
Hygroscopicity	Exceedingly hygroscopic	Less hygroscopic
Glucocorticoid Activity	Identical (after hydrolysis)	Identical

How Does Dexamethasone Compare With Other Veterinary Corticosteroids?

Feature	Dexamethasone	Prednisolone	Methylprednisolone	Hydrocortisone
CAS (sodium phosphate)	55203-24-2	125-02-0	2375-03-3	125-04-2
Potency (vs Hydrocortisone)	25–30×	4×	5×	1×
Duration	Long (36–72 hr)	Intermediate (12–36 hr)	Intermediate (12–36 hr)	Short (8–12 hr)
Mineralocorticoid Activity	Very low	Low	Low	High
HPA Suppression	Strong	Moderate	Moderate	Mild
Water Solubility (phosphate salt)	Freely soluble	Soluble	Soluble	Soluble
Typical Veterinary Use	Ketosis, allergy, shock, arthritis	General anti-inflammatory, immune-mediated	Joint injection, allergy	Addison's, shock, emergency

How Is Dexamethasone Sodium Phosphate Powder Manufactured?

Dexamethasone Sodium Phosphate Powder is manufactured through semi-synthesis from dexamethasone, involving 21-position phosphorylation and sodium salt formation.

Raw Material QC → Dexamethasone Starting Material → 21-OH Phosphorylation (Phosphorylating Agent) → Ester Formation → Purification (Chromatography / Recrystallization) → Disodium Salt Formation (Sodium Hydroxide) → Crystallization → Centrifugation → Vacuum Drying (Low Temperature) → Milling → Final QC → Airtight Packaging

HDM BIO controls key phosphorylation, salt formation and low-temperature drying parameters to maintain consistent purity, avoid degradation and ensure low residual solvents.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Assay (HPLC)	≥98.0%	99.0%
Identity (IR / HPLC)	Conforms to reference standard	Confirmed
pH (1% solution)	7.5–9.0	8.2
Loss on Drying	≤2.0%	0.8%
Specific Optical Rotation	+45° to +55°	+50°
Related Substances	Within specification	Pass
Free Phosphate	Within specification	Compliant
Heavy Metals	≤10 ppm	Compliant
Residual Solvents	Within specification	Pass
Sterility (injectable grade)	Sterile	Compliant
Bacterial Endotoxins (injectable grade)	≤0.5 EU/mg	Compliant

What Quality Control Tests Are Performed for Dexamethasone Sodium Phosphate Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity and key quality attributes.

Raw Material QC → In-Process Control → HPLC Assay → IR Identity Verification → pH Determination → Loss on Drying → Specific Optical Rotation → Related Substances (HPLC) → Free Phosphate Test → Heavy Metals → Residual Solvents → Sterility Test (injectable grade) → Bacterial Endotoxin Test (LAL, injectable grade) → Final Batch Release

Key evaluations include HPLC assay (≥98%), IR identity, pH, loss on drying (critical for hygroscopic material), specific optical rotation, related substances, free phosphate, heavy metals, residual solvents, and for injectable grade: sterility and bacterial endotoxin (LAL) testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Dexamethasone Sodium Phosphate Powder Bulk Price?

Dexamethasone Sodium Phosphate Powder bulk pricing is driven by several key factors:

Raw Material Costs: Dexamethasone starting material and phosphorylating reagents directly influence manufacturing expenses.
Purity & Grade: Injectable grade (sterile, endotoxin-controlled, ≥98%) commands a significant premium over technical/topical grade.
Sterility & Endotoxin Specification: Aseptic processing and LAL-tested batches for injection carry higher production costs.
Regulatory Compliance & Certification: GMP-standard API with DMF/CEP and consistent COA demands a higher price.
Order Volume: Large-scale pharmaceutical contracts receive steeper per-kilogram discounts.
Logistics & Geography: Cold-chain (2–8°C) / moisture-proof / light-protected packaging and customs compliance add to the landed cost (material is exceedingly hygroscopic).

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Dexamethasone Sodium Phosphate Powder Supplier?

High-purity (≥98% / typical 99%) long-acting glucocorticoid API for injectable, ophthalmic and topical formulations
Verified rapid water solubility, consistent optical rotation and low related substances; controlled hygroscopicity packaging
Bovine ketosis gold-standard API with multi-species veterinary applications (cattle, horse, pig, dog, cat, goat)
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC, sterility, LAL)
Flexible supply: kilogram samples to ton-level bulk API orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders (exceedingly hygroscopic - sealed under dry conditions).
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed at 2–8°C in a dry, light-protected environment. Shelf life: 24 months.
Handling: For pharmaceutical/veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Dexamethasone Sodium Phosphate Powder

Q1: What is Dexamethasone Sodium Phosphate Powder?

A: It is the water-soluble 21-phosphate disodium ester of dexamethasone, a synthetic long-acting glucocorticoid. It provides rapid onset even after IM injection, with biological effects lasting 36–72 hours and minimal mineralocorticoid activity. Used for bovine ketosis, anti-inflammatory/anti-allergic conditions, equine arthritis, shock, parturition induction and Cushing's diagnosis.

Q2: What is the CAS number?

A: 55203-24-2.

Q3: How does dexamethasone sodium phosphate work?

A: It binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress pro-inflammatory cytokines, inhibit phospholipase A2 (reducing prostaglandins/leukotrienes), stabilize lysosomal membranes and suppress immune responses. It is long-acting (36–72 hr), potently suppresses the HPA axis, and the phosphate ester is rapidly hydrolyzed to active dexamethasone in vivo.

Q4: What is dexamethasone sodium phosphate used for?

A: Veterinary: bovine primary ketosis (acetonemia), inflammatory/allergic conditions in cattle/horses/pigs/dogs/cats/goats, equine arthritis/bursitis/tenosynovitis, shock adjunct therapy, parturition induction in cattle, canine/feline immune-mediated diseases and asthma, and the dexamethasone suppression test for Cushing's disease. Human: severe allergy, asthma, cerebral edema, autoimmune disease, shock, ophthalmic inflammation.

Q5: What documents are provided with each batch?

A: Batch-specific COA, HPLC assay report, IR identity, pH, loss on drying, optical rotation, related substances, free phosphate, heavy metals, residual solvents, and for injectable grade: sterility and LAL endotoxin results, MSDS/SDS.

Q6: What purity do you supply?

A: Standard ≥98.0% HPLC; typical batch result 99%. Injectable grade with sterility and endotoxin specification available on request.

Q7: Where can I buy it from China?

A: HDM BIO supplies bulk Dexamethasone Sodium Phosphate Powder with batch COA and global export support.

Q8: How much does Dexamethasone Sodium Phosphate Powder cost?

A: Bulk pricing depends on dexamethasone raw material costs, purity/grade (topical vs injectable), sterility/endotoxin specification, regulatory compliance, order volume and logistics (cold-chain/moisture-proof). Contact HDM BIO for a current quotation.

Q9: Are there any safety concerns?
A: Dexamethasone Sodium Phosphate should be used with attention to corticosteroid-related risks. Long-term exposure may cause HPA axis suppression, secondary infections, gastrointestinal issues, metabolic changes and other glucocorticoid-related effects. It requires proper storage because of its high hygroscopicity. Store in a tightly sealed, dry environment according to supplier recommendations. Not for direct clinical administration.

Q10: What is the difference between dexamethasone sodium phosphate and dexamethasone?

A: Glucocorticoid activity is identical (the phosphate ester is hydrolyzed in vivo to dexamethasone). The sodium phosphate salt (CAS 55203-24-2) is freely water-soluble, suitable for IV/IM injection with rapid onset, and is exceedingly hygroscopic. Dexamethasone free alcohol (CAS 50-02-2) is practically insoluble in water, used for oral tablets and depot IM injections, and is less hygroscopic.