Metoclopramide Hydrochloride Powder Supplier China | Veterinary Antiemetic API Manufacturer CAS 7232-21-5

Key Selling Points

✓ Dual-Action Antiemetic & Prokinetic - Central D2 + Peripheral 5-HT3/5-HT4 Mechanism

✓ Gold-Standard Veterinary Antiemetic - Nausea/Vomiting in Dogs & Cats (Surgery, Chemo, Parvovirus, Uremia)

✓ Rapid Onset 30–60 Min - Short Duration 6–8 hr, Flexible IV/IM/SC/Oral Dosing

✓ Upper GI Prokinetic - Reflux Esophagitis, Gastric Stasis, Delayed Gastric Emptying, Diabetic Gastroparesis

✓ Well-Established Human & Veterinary API - Decades of Clinical Use, Benzamide Derivative

✓ Very Water-Soluble - Suitable for Injectable Solutions, Tablets, Oral Suspensions

What Is Metoclopramide Hydrochloride Powder?

Metoclopramide Hydrochloride Powder (C₁₄H₂₃Cl₂N₃O₂, MW 336.26) is a benzamide derivative and dopamine D2 receptor antagonist with dual antiemetic and prokinetic activity. Its central action on the medullary chemoreceptor trigger zone (CTZ) produces antiemetic effects, while peripheral 5-HT4 agonism stimulates acetylcholine release to enhance upper gastrointestinal motility. It has rapid onset (30–60 min) and short duration (6–8 hours), with flexible IV/IM/SC/oral dosing.

It is widely used as a pharmaceutical and veterinary raw material for antiemetic therapy (chemotherapy-, surgery-, parvovirus- and uremia-induced nausea and vomiting in dogs and cats), reflux esophagitis, gastric stasis, delayed gastric emptying and diabetic gastroparesis. It is very water-soluble, making it suitable for injectable solutions, tablets and oral suspensions.

How Does Metoclopramide Hydrochloride Powder Work?

Metoclopramide Hydrochloride Powder exerts antiemetic activity primarily through central dopamine D2 receptor antagonism at the chemoreceptor trigger zone (CTZ), with additional peripheral 5-HT3 receptor antagonism enhancing the antiemetic effect. Its prokinetic action arises from peripheral 5-HT4 receptor agonism, which stimulates acetylcholine release from enteric neurons, increasing lower esophageal sphincter tone and coordinating gastric, pyloric and duodenal motor activity.

Because Metoclopramide Hydrochloride Powder is rapidly absorbed with onset in 30–60 minutes and duration of 6–8 hours, frequent dosing or continuous infusion is used for sustained antiemetic/prokinetic effect. It does not affect gastric acid secretion. At high plasma concentrations or rapid IV injection, central dopaminergic blockade may cause extrapyramidal signs (agitation, ataxia, tremors, abnormal postures) - typically reversible on discontinuation. Excretion is primarily renal; dose reduction is required in renal impairment.

What Are the Applications of Metoclopramide Hydrochloride Powder?

Antiemetic Therapy: Nausea and vomiting associated with chemotherapy, surgery, parvovirus infection, uremic gastritis, migraine and drug-induced emesis in dogs, cats and humans.
Reflux Esophagitis: Increases lower esophageal sphincter tone and esophageal clearance, reducing gastroesophageal reflux.
Gastric Stasis & Delayed Emptying: Promotes gastric motility in diabetic gastroparesis, post-surgical ileus, chronic gastritis and acute gastric dilatation recovery.
Diagnostic Adjunct: Facilitates small intestinal intubation and accelerates barium transit in radiographic studies.
Pharmaceutical Formulations: Raw material for injectable solutions (IV/IM/SC), tablets, oral suspensions and syrups.

What Is the Difference Between Metoclopramide and Maropitant?

Feature	Metoclopramide	Maropitant (Cerenia)
CAS (HCl)	7232-21-5	130104-78-8
Mechanism	D2 + 5-HT3 antagonist, 5-HT4 agonist (prokinetic)	NK1 (substance P) receptor antagonist
Antiemetic	Yes (central CTZ)	Yes (central + peripheral)
Prokinetic	Yes (upper GI)	No
Onset	30–60 min	~30–60 min
Duration	6–8 hr	~24 hr
Extrapyramidal Risk	Yes (high dose / rapid IV)	Very low
Typical Use	Antiemetic + reflux + gastric stasis	Broad-spectrum antiemetic (motion sickness, chemo, gastroenteritis)
Cost	Lower	Higher

How Does Metoclopramide Compare With Other GI Prokinetics?

Feature	Metoclopramide	Domperidone	Cisapride	Ranitidine
CAS (HCl)	7232-21-5	57808-66-9	81098-60-4	66357-59-3
Mechanism	D2 antag + 5-HT4 ag	Peripheral D2 antag	5-HT4 ag (withdrawn)	H2 antag + prokinetic
BBB Penetration	Yes (CNS side effects)	Minimal	Yes	Minimal
Prokinetic Site	Upper GI (esophagus, stomach, duodenum)	Upper GI	Entire GI (esophagus to colon)	Upper GI
Antiemetic	Yes (central)	Yes (peripheral CTZ)	Minimal	Minimal
Extrapyramidal Risk	Yes	Very low	Cardiac (QT prolongation)	Very low
Typical Use	Antiemetic + reflux + gastroparesis	Reflux + gastroparesis (less CNS effects)	GI motility disorders (withdrawn in many countries)	Acid suppression + mild prokinetic

How Is Metoclopramide Hydrochloride Powder Manufactured?

Metoclopramide Hydrochloride Powder is manufactured through multi-step chemical synthesis involving amide bond formation and hydrochloride salt formation.

Raw Material QC → 4-Amino-5-chloro-2-methoxybenzoic Acid Preparation → Amide Coupling (with N,N-Diethylethylenediamine) → Crude Metoclopramide Base → Purification (Recrystallization / Chromatography) → Hydrochloride Salt Formation (HCl) → Crystallization → Centrifugation → Drying → Milling → Final QC → Packaging

HDM BIO controls key amide coupling, salt formation and crystallization parameters to maintain consistent purity, particle size and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Assay (HPLC)	≥98.0%	99.0%
Identity (IR / HPLC)	Conforms to reference standard	Confirmed
Melting Point	182–184°C	183°C
Loss on Drying	≤0.5% (anhydrous)	0.2%
pH (1% solution)	4.0–6.0	5.2
Related Substances	Within specification	Pass
Heavy Metals	≤10 ppm	Compliant
Residual Solvents	Within specification	Pass
Sterility (injectable grade)	Sterile	Compliant
Bacterial Endotoxins (injectable grade)	≤0.5 EU/mg	Compliant

What Quality Control Tests Are Performed for Metoclopramide Hydrochloride Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity and key quality attributes.

Raw Material QC → In-Process Control → HPLC Assay → IR Identity Verification → Melting Point Determination → Loss on Drying → pH Determination → Related Substances (HPLC) → Heavy Metals → Residual Solvents → Sterility Test (injectable grade) → Bacterial Endotoxin Test (LAL, injectable grade) → Final Batch Release

Key evaluations include HPLC assay (≥98%), IR identity, melting point, loss on drying (critical for anhydrous form), pH, related substances, heavy metals, residual solvents, and for injectable grade: sterility and bacterial endotoxin (LAL) testing. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Metoclopramide Hydrochloride Powder Bulk Price?

Metoclopramide Hydrochloride Powder bulk pricing is driven by several key factors:

Raw Material Costs: 4-amino-5-chloro-2-methoxybenzoic acid and N,N-diethylethylenediamine intermediates directly influence manufacturing expenses.
Purity & Grade: Injectable grade (sterile, endotoxin-controlled, ≥98%) commands a significant premium over oral/technical grade.
Sterility & Endotoxin Specification: Aseptic processing and LAL-tested batches for injection carry higher production costs.
Regulatory Compliance & Certification: GMP-standard API with DMF/CEP and consistent COA demands a higher price.
Order Volume: Large-scale pharmaceutical contracts receive steeper per-kilogram discounts.
Logistics & Geography: Light-protected / moisture-proof packaging and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Metoclopramide Hydrochloride Powder Supplier?

High-purity (≥98% / typical 99%) antiemetic and prokinetic API for injectable, tablet and oral suspension formulations
Verified very high water solubility, consistent melting point and low related substances; controlled anhydrous moisture content
Gold-standard veterinary antiemetic for dogs and cats with dual D2/5-HT3/5-HT4 mechanism
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC, sterility, LAL)
Flexible supply: kilogram samples to ton-level bulk API orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For pharmaceutical/veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Metoclopramide Hydrochloride Powder

Q1: What is Metoclopramide Hydrochloride Powder?

A: It is a benzamide derivative and dopamine D2 receptor antagonist with dual antiemetic and prokinetic activity. It acts centrally on the chemoreceptor trigger zone to reduce nausea and vomiting, and peripherally via 5-HT4 agonism to enhance upper gastrointestinal motility. Used for antiemetic therapy, reflux esophagitis, gastric stasis and diabetic gastroparesis in humans and veterinary species.

Q2: What is the CAS number?

A: 7232-21-5 (anhydrous hydrochloride).

Q3: How does metoclopramide hydrochloride work?

A: Central D2 receptor antagonism at the CTZ produces antiemetic effects, enhanced by peripheral 5-HT3 antagonism. Peripheral 5-HT4 agonism stimulates acetylcholine release, increasing lower esophageal sphincter tone and coordinating gastric/pyloric/duodenal motility. Rapid onset (30–60 min), duration 6–8 hours. Does not affect gastric acid secretion.

Q4: What is metoclopramide hydrochloride used for?

A: Human: chemotherapy- and surgery-induced nausea/vomiting, GERD, diabetic gastroparesis, diagnostic adjunct. Veterinary: antiemetic in dogs and cats (parvovirus, uremic gastritis, surgery, chemotherapy), reflux esophagitis, gastric stasis, delayed gastric emptying. Also used in horses for gastric emptying delay.

Q5: What documents are provided with each batch?

A: Batch-specific COA, HPLC assay report, IR identity, melting point, loss on drying, pH, related substances, heavy metals, residual solvents, and for injectable grade: sterility and LAL endotoxin results, MSDS/SDS.

Q6: What purity do you supply?

A: Standard ≥98.0% HPLC; typical batch result 99%. Injectable grade with sterility and endotoxin specification available on request.

Q7: Where can I buy it from China?

A: HDM BIO supplies bulk Metoclopramide Hydrochloride Powder with batch COA and global export support.

Q8: How much does Metoclopramide Hydrochloride Powder cost?

A: Bulk pricing depends on raw material costs, purity/grade (oral vs injectable), sterility/endotoxin specification, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q9: Are there any safety concerns?

A: Extrapyramidal signs (agitation, ataxia, tremors, abnormal postures, aggression, vocalization) may occur at high doses or rapid IV injection - typically reversible on discontinuation. Contraindications: GI perforation or obstruction, epilepsy, history of extrapyramidal signs, severe renal impairment (dose reduction required), mammary neoplasia in females, concurrent neuroleptic therapy, pre-anastomotic surgical prophylaxis. Rapid IV injection may cause hypotension and arrhythmia. Overdose may cause serotonin syndrome (especially with concurrent serotonergic drugs). Drowsiness, diarrhea, constipation and polyuria may occur. Not for direct clinical administration.

Q10: What is the difference between metoclopramide and maropitant?

A: Both are antiemetics, but mechanisms differ. Metoclopramide (D2 + 5-HT3 antagonist, 5-HT4 agonist) has both antiemetic and prokinetic effects, with 6–8 hour duration and extrapyramidal risk at high doses. Maropitant (NK1/substance P receptor antagonist) is a pure antiemetic with ~24 hour duration, very low extrapyramidal risk, and covers motion sickness in addition to central/peripheral emesis. Metoclopramide is lower cost and adds prokinetic benefit; maropitant is broader-spectrum and longer-lasting.