Metamizole Sodium Powder Supplier China | ≥98% Pyrazolone NSAID Analgesic Manufacturer CAS 68-89-3

Key Selling Points

✓ Pyrazolone-Class NSAID (Analgesic + Antipyretic + Spasmolytic)

✓ Cyclooxygenase (COX) Inhibition - Prostaglandin E2 Suppression

✓ Water-Soluble Sodium Salt for IV/IM Injectable Formulations

✓ Unique Smooth Muscle Spasmolytic Action (Colic Relief)

✓ Also Known as Dipyrone / Analgin / Novaminsulfone

✓ Equine, Bovine, Swine & Canine Pain and Fever Research

What Is Metamizole Sodium Powder?

Metamizole Sodium Powder is the water-soluble sodium salt of metamizole (dipyrone), a pyrazolone-class non-steroidal anti-inflammatory drug widely used in veterinary medicine as an analgesic, antipyretic and spasmolytic agent. It is administered by intravenous or intramuscular injection to horses, cattle, pigs and dogs for the relief of pain, fever and smooth muscle spasms.

Also known as Analgin or Novaminsulfone, it is valued in veterinary practice for its rapid and potent antipyretic and analgesic effects, as well as its unique spasmolytic action on smooth muscle - a property not shared by most other NSAIDs. Its high water solubility as the sodium salt makes it well suited for injectable formulations.

How Does Metamizole Sodium Powder Work?

Metamizole Sodium Powder exerts its pharmacological effects primarily through inhibition of cyclooxygenase (COX), reducing the synthesis of prostaglandins - particularly prostaglandin E2 - which are involved in pain perception, fever and inflammation. Its analgesic effect is mediated both peripherally and through action on central nervous system pain centers, while its antipyretic effect results from resetting the hypothalamic thermoregulatory set point.

Beyond COX inhibition, Metamizole Sodium Powder exhibits a direct spasmolytic effect on smooth muscle fibers, reducing excitability and relieving spasms of the gastrointestinal, urogenital and biliary tracts. It also antagonizes the effects of bradykinin and histamine and produces a mild vasodilator effect that improves perfusion of affected areas.

What Are the Applications of Metamizole Sodium Powder?

Fever Control: Used in formulation research for febrile states of various etiologies in horses, cattle, pigs and dogs, including high fever associated with bacterial or viral infections.
Pain Relief: Evaluated for musculoskeletal pain, joint and muscular rheumatism, neuralgia and post-procedural analgesia in large and small animals.
Smooth Muscle Spasm & Colic: Studied for gastrointestinal colic, meteorism, intestinal constipation, urinary and biliary tract spasms, and uterine cervical spasm during parturition in horses and cattle.
Anti-Inflammatory Adjunct: Used as an adjunct in inflammatory conditions requiring pain and fever management.
Species Coverage: Research formulations target equine, bovine, ovine, caprine, porcine and canine patients, typically via IV or IM injection.

What Is the Difference Between Metamizole and Metamizole Sodium?

Feature	Metamizole	Metamizole Sodium
CAS	68-89-3 (free acid form varies)	68-89-3 (anhydrous) / 5907-38-0 (monohydrate)
Form	Free acid	Sodium salt
Molecular Formula	C₁₃H₁₇N₃O₄S	C₁₃H₁₆N₃NaO₄S
Molecular Weight	335.35	333.34
Solubility	Less soluble in water	Freely soluble in water
Typical Use	Research standard	IV/IM injectable solution

How Does Metamizole Sodium Compare With Other Veterinary NSAIDs?

Feature	Metamizole Sodium	Flunixin Meglumine	Meloxicam	Phenylbutazone
CAS	68-89-3	42461-84-7	71125-38-7	50-33-9
Class	Pyrazolone	Nicotinic acid derivative	Oxicam (COX-2 preferential)	Pyrazolone
Analgesic	Strong	Strong	Moderate	Moderate
Antipyretic	Strong	Strong	Moderate	Weak
Spasmolytic	Yes (unique)	No	No	No
Anti-Inflammatory	Moderate	Strong	Strong	Strong
Primary Route	IV/IM	IV/IM	IV/IM/oral	IV/oral
Primary Species	Horse, cattle, pig, dog	Horse, cattle, pig	Dog, cat, cattle	Horse

How Is Metamizole Sodium Powder Manufactured?

Metamizole Sodium Powder is manufactured synthetically from 4-aminoantipyrine through methylation, condensation with formaldehyde and sodium bisulfite, followed by purification, crystallization and drying.

Raw Material QC → 4-Aminoantipyrine Starting Material → Methylation → Mannich Condensation (Formaldehyde + Sodium Bisulfite) → Purification → Crystallization → Drying → Final QC → Packaging

HDM BIO controls key reaction, purification and crystallization parameters to maintain consistent purity, water solubility and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White or off-white powder	Consistent
Assay (HPLC)	≥98%	99.0%
Identity (IR)	Conforms to reference standard	Confirmed
Melting Point	~221°C	220.5°C
Related Substances	Within specification	Pass
Loss on Drying	≤5.5% (monohydrate)	4.8%
Residue on Ignition	≤0.5%	Compliant
Heavy Metals	≤10 ppm	Compliant
pH (10% solution)	5.0–7.0	6.1

What Quality Control Tests Are Performed for Metamizole Sodium Powder?

Each batch undergoes multi-step quality control before release to verify identity, purity and physical properties.

Raw Material QC → In-Process Control → HPLC Assay → IR Identity Verification → Melting Point Determination → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Residue on Ignition → pH Test → Final Batch Release

Key evaluations include identification via infrared (IR) spectroscopy, HPLC active content assay, melting point determination, related substances analysis, loss on drying, heavy metal limits, residue on ignition and pH verification. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Metamizole Sodium Powder Bulk Price?

Metamizole Sodium Powder bulk pricing is driven by several key factors:

Synthesis Costs: 4-aminoantipyrine and reagent costs, multi-step chemical synthesis expenses directly influence manufacturing costs.
Purity & Hydrate Grade: Higher assay percentages and controlled hydrate content (anhydrous vs monohydrate) cost more to produce.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price.
Order Volume: Large-scale industrial or wholesale contracts receive steeper per-kilogram discounts than small-batch specialty orders.
Logistics & Geography: Shipping distance, cold-chain (2–8°C) and light-protection requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Metamizole Sodium Powder Supplier?

High-purity (≥98% / typical 99%+) pyrazolone NSAID with controlled hydrate content
Unique triple-action profile: analgesic + antipyretic + spasmolytic
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Metamizole Sodium Powder

Q1: What is Metamizole Sodium Powder?

A: The water-soluble sodium salt of metamizole (dipyrone), a pyrazolone-class NSAID supplied as veterinary raw material for injectable analgesic, antipyretic and spasmolytic formulations.

Q2: What is the CAS number?

A: 68-89-3 (anhydrous); the monohydrate form is 5907-38-0.

Q3: Is Metamizole Sodium an antibiotic?

A: No. It is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and spasmolytic effects, not an antibacterial agent.

Q4: How does it work?

A: It inhibits cyclooxygenase (COX), reducing prostaglandin E2 synthesis. It also acts centrally on pain centers and exerts a direct spasmolytic effect on smooth muscle.

Q5: What animals is it used for?

A: Primarily horses, cattle, pigs and dogs, administered by IV or IM injection for fever, pain and smooth muscle spasm (colic).

Q6: What documents are provided with each batch?

A: Batch-specific COA, HPLC report, IR identity records, melting point data, MSDS/SDS and relevant export documentation are available according to order requirements.

Q7: What purity do you supply?

A: Standard ≥98% HPLC; typical batch result 99%. Higher grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Metamizole Sodium Powder with batch COA and global export support.

Q9: How much does Metamizole Sodium Powder cost?

A: Bulk pricing depends on synthesis costs, purity/hydrate grade, regulatory compliance, order volume and cold-chain logistics. Contact HDM BIO for a current quotation.

Q10: Is this product for human clinical use?

A: It is supplied as veterinary raw material and is not intended for direct clinical administration. Finished products manufactured from the material must comply with applicable local regulatory requirements.