Spectinomycin Hydrochloride API CAS 21736-83-4 | High Purity Veterinary Antibiotic Manufacturer & Bulk Supplier China

Key Selling Points

✓ Aminocyclitol Antibiotic - 30S Ribosome Protein Synthesis Inhibitor

✓ Active Against Mycoplasma + Gram-Negative Bacteria (E. coli, Salmonella)

✓ Synergistic with Lincomycin for Swine Dysentery & Anaerobes

✓ Oral Non-Absorbable - Targeted Intestinal & Respiratory Action

✓ Neonatal Piglet Colibacillosis (White Scours) + Poultry CRD Reference

✓ Broad Spectrum: Mycoplasma, E. coli, Salmonella, Pasteurella

What Is Spectinomycin Hydrochloride Powder?

Spectinomycin Hydrochloride Powder is an aminocyclitol antibiotic produced by fermentation of Streptomyces spectabilis, supplied as the monohydrochloride anhydrous salt (CAS 21736-83-4) for improved water solubility. It is widely used in veterinary medicine for bacterial enteric and respiratory infections, particularly in neonatal piglets and poultry.

Unlike typical aminoglycosides, spectinomycin belongs to the aminocyclitol class and exhibits notable activity against Mycoplasma species as well as Gram-negative bacteria. It is frequently formulated in combination with lincomycin (Linco-Spectin type products) for synergistic activity against anaerobes and swine dysentery. Oral administration results in poor systemic absorption, achieving high local concentrations in the gastrointestinal and respiratory tracts.

How Does Spectinomycin Hydrochloride Powder Work?

Spectinomycin Hydrochloride Powder exerts its antibacterial effect by binding to the bacterial 30S ribosomal subunit, interfering with the translocation step of protein synthesis and preventing polypeptide chain elongation. It also disrupts messenger RNA ordering and causes misreading of the genetic code by transfer RNA, ultimately inhibiting bacterial protein synthesis and growth.

Its spectrum includes Mycoplasma spp. (M. hyopneumoniae, M. gallisepticum, M. synoviae) and Gram-negative bacteria such as Escherichia coli, Salmonella spp. and Pasteurella multocida, with weaker activity against Gram-positive organisms. Because Spectinomycin Hydrochloride Powder is poorly absorbed after oral administration, it reaches high concentrations in the intestinal tract, making it effective for enteric infections. Chromosomal mutation-mediated resistance in E. coli is relatively common, but resistant strains do not show cross-resistance with aminoglycosides. When combined with lincomycin, the two agents act synergistically against anaerobes involved in swine dysentery pathogenesis.

What Are the Applications of Spectinomycin Hydrochloride Powder?

Neonatal Piglet Colibacillosis: Used for bacterial enteritis (white scours) associated with E. coli in pigs younger than 4 weeks of age.
Swine Respiratory & Enteric Disease: Evaluated for enzootic pneumonia (Mycoplasma hyopneumoniae), swine dysentery, arthritis, erysipelas and E. coli diarrhea, often in lincomycin combination formulations.
Poultry CRD & Colibacillosis: Studied for chronic respiratory disease (Mycoplasma gallisepticum), E. coli infections, salmonellosis, air sacculitis, synovitis, septicemia and navel infections in chickens.
Calf & Young Ruminant Infections: Used for pneumonia and diarrhea in calves, and foot rot in goats and sheep.
Lincomycin Combination Formulations: Serves as the spectinomycin component in compound lincomycin-spectinomycin products for broad-spectrum coverage of Mycoplasma, Gram-negative bacteria and anaerobes.

What Is the Difference Between Spectinomycin Hydrochloride and Spectinomycin?

Feature	Spectinomycin Hydrochloride	Spectinomycin (Free Base)
CAS	21736-83-4	1695-77-8
Form	Monohydrochloride (anhydrous)	Free base
Molecular Formula	C₁₄H₂₅ClN₂O₇	C₁₄H₂₄N₂O₇
Molecular Weight	368.81	332.35
Water Solubility	Freely soluble	Soluble
Typical Formulation	Water-soluble powder / injection	Rarely used directly
Stability	More stable	Less stable

How Does Spectinomycin Hydrochloride Compare With Other Veterinary Aminocyclitols?

Feature	Spectinomycin HCl	Apramycin Sulfate	Neomycin Sulfate	Streptomycin Sulfate
CAS	21736-83-4	65710-07-8	1405-10-3	3810-74-0
Class	Aminocyclitol	Aminoglycoside	Aminoglycoside	Aminoglycoside
Source	S. spectabilis	S. tenebrarius	S. fradiae	S. griseus
Mycoplasma Activity	Yes	Some	No	No
E. coli Activity	Good	Excellent	Good	Moderate
Salmonella Activity	Good	Good	Moderate	Moderate
Lincomycin Synergy	Yes	No	No	No
Oral Absorption	Poor	Poor	Poor	Poor
Primary Use	CRD, colibacillosis, white scours	Colibacillosis, salmonellosis	Enteric infection	TB, gram -

How Is Spectinomycin Hydrochloride Powder Manufactured?

Spectinomycin Hydrochloride Powder is manufactured through fermentation of Streptomyces spectabilis, followed by extraction, purification, hydrochloride salt formation, crystallization and drying.

Strain Culture → Fermentation → Mycelium Separation → Extraction → Ion-Exchange Purification → Hydrochloride Salt Formation → Crystallization → Drying → Final QC → Packaging

HDM BIO controls key fermentation, purification and hydrochloride salt formation parameters to maintain consistent potency, water solubility and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White or off-white powder	Consistent
Potency (as spectinomycin)	≥98%	99.0%
Identity (IR)	Conforms to reference standard	Confirmed
Chloride Content	9.0–10.5%	9.6%
Related Substances	Within specification	Pass
Loss on Drying	≤5.0%	2.1%
Residue on Ignition	≤1.0%	Compliant
Heavy Metals	≤10 ppm	Compliant
pH (1% solution)	3.5–5.5	4.5
Specific Rotation	+15° to +25°	+20°

What Quality Control Tests Are Performed for Spectinomycin Hydrochloride Powder?

Each batch undergoes multi-step quality control before release to verify identity, potency, chloride content and physical properties.

Raw Material QC → In-Process Control → Microbiological Potency Assay → HPLC Assay → IR Identity Verification → Chloride Content → Related Substances → Loss on Drying → Heavy Metals → Residue on Ignition → pH Test → Specific Rotation → Final Batch Release

Key evaluations include identification via infrared (IR) spectroscopy, microbiological potency assay and HPLC content determination, chloride content verification, related substances analysis, loss on drying, heavy metal limits, residue on ignition, pH and specific rotation. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Spectinomycin Hydrochloride Powder Bulk Price?

Spectinomycin Hydrochloride Powder bulk pricing is driven by several key factors:

Fermentation Costs: Streptomyces spectabilis fermentation scale, yield and downstream purification expenses directly influence manufacturing costs.
Potency & Grade: Higher potency percentages and strict impurity control cost more to produce.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price.
Order Volume: Large-scale industrial or wholesale contracts receive steeper per-kilogram discounts than small-batch specialty orders.
Logistics & Geography: Shipping distance, moisture-barrier packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Spectinomycin Hydrochloride Powder Supplier?

High-potency (≥98% / typical 99%) aminocyclitol antibiotic with Mycoplasma and Gram-negative coverage
Synergistic with lincomycin for swine dysentery and anaerobic infections
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Spectinomycin Hydrochloride Powder

Q1: What is Spectinomycin Hydrochloride Powder?

A: An aminocyclitol antibiotic produced by Streptomyces spectabilis fermentation, supplied as the monohydrochloride anhydrous salt (CAS 21736-83-4) for veterinary bacterial enteric and respiratory infection formulation development.

Q2: What is the CAS number?

A: 21736-83-4 (monohydrochloride, anhydrous); free base is 1695-77-8.

Q3: How does spectinomycin work?

A: It binds to the bacterial 30S ribosomal subunit, inhibiting protein synthesis at the translocation stage. It is active against Mycoplasma and Gram-negative bacteria, and is poorly absorbed orally for targeted intestinal action.

Q4: What animals is spectinomycin used for?

A: Primarily neonatal piglets (E. coli white scours), swine (enzootic pneumonia, dysentery), poultry (CRD, colibacillosis, salmonellosis), calves (pneumonia, diarrhea) and small ruminants (foot rot).

Q5: Is spectinomycin an aminoglycoside?

A: It is classified as an aminocyclitol, related to but distinct from typical aminoglycosides. Notably, it has activity against Mycoplasma and shows no cross-resistance with aminoglycosides in chromosomally resistant strains.

Q6: What documents are provided with each batch?

A: Batch-specific COA, HPLC/microbiological assay report, IR identity records, chloride content data, MSDS/SDS and relevant export documentation are available according to order requirements.

Q7: What potency do you supply?

A: Standard ≥98% (as spectinomycin base); typical batch result 99%. Higher grades available on request.

Q8: Where can I buy it from China?

A: HDM BIO supplies bulk Spectinomycin Hydrochloride Powder with batch COA and global export support.

Q9: How much does Spectinomycin Hydrochloride Powder cost?

A: Bulk pricing depends on fermentation/purification costs, potency grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q10: Is this product for human clinical use?

A: It is supplied as veterinary raw material and is not intended for direct clinical administration. Finished products manufactured from the material must comply with applicable local regulatory requirements.