Streptomycin Sulfate Powder Supplier China | ≥98% Aminoglycoside Antibiotic Manufacturer CAS 3810-74-0
Key Selling Points
✓ First-in-Class Aminoglycoside from Streptomyces griseus
✓ Bactericidal 30S Ribosomal Protein Synthesis Inhibition
✓ ≥720 IU/mg Potency, White to Off-White Powder
✓ Broad-Spectrum: Gram-Negative + Gram-Positive + Mycobacterium
✓ Synergistic with Beta-Lactam Antibiotics
✓ Livestock, Poultry & Companion Animal Research
What Is Streptomycin Sulfate?
Streptomycin Sulfate Powder is the water-soluble sulfate salt of streptomycin, the first-in-class aminoglycoside antibiotic originally derived from Streptomyces griseus. It is widely used in veterinary medicine for the treatment of bacterial infections in livestock, poultry and companion animals, with activity against gram-negative bacteria, gram-positive bacteria and Mycobacterium species.
As the sulfate salt, it is freely soluble in water, making it suitable for injectable formulations and drinking-water medication. It is distinct from most other aminoglycosides as it lacks the common 2-deoxystreptamine moiety, possessing a unique streptidine ring structure.
How Does Streptomycin Sulfate Work?
Streptomycin Sulfate exerts its bactericidal effect by entering bacterial cells through active transport and passive diffusion, then irreversibly binding to ribosomal RNA on the 30S ribosomal subunit. This interferes with protein synthesis by causing misreading of the mRNA genetic code, leading to incorporation of incorrect amino acids and premature termination of peptide chains, ultimately resulting in bacterial cell death.
Its concentration-dependent bactericidal activity and well-characterized ribosomal inhibition mechanism make Streptomycin Sulfate Powder a valuable reference compound for veterinary antimicrobial research and formulation development. It also exhibits synergistic activity when combined with beta-lactam antibiotics.
What Are the Applications of Streptomycin Sulfate?
- Livestock Systemic Infections: Used in formulation research for respiratory tract infections, urinary tract infections, mastitis, endometritis, pleuritis, sepsis and endocarditis in cattle, sheep, pigs and horses.
- Cattle-Specific Conditions: Evaluated for malignant catarrhal fever, campylobacteriosis and actinomycosis research.
- Poultry Health: Studied for bacterial infections in chickens and turkeys, often in combination with penicillin for expanded spectrum.
- Companion Animals: Used in research for dogs, cats and fur-bearing animals with susceptible bacterial infections.
- Mycobacterial Research: Active against Mycobacterium species, serving as a reference tool in veterinary mycobacterial studies.
What Is the Difference Between Streptomycin and Streptomycin Sulfate?
| Feature | Streptomycin | Streptomycin Sulfate |
|---|---|---|
| CAS | 57-92-1 | 3810-74-0 |
| Form | Free base | Sulfate salt |
| Solubility | Slightly soluble in water | Freely soluble in water |
| Typical Use | Research standard | Injectable solution / drinking water |
How Does Streptomycin Sulfate Compare With Other Aminoglycosides?
| Feature | Streptomycin Sulfate | Gentamicin Sulfate | Kanamycin Sulfate |
|---|---|---|---|
| CAS | 3810-74-0 | 1405-41-0 | 25389-94-0 |
| Origin | Streptomyces griseus | Micromonospora purpurea | Streptomyces kanamyceticus |
| Structural Class | Atypical (no 2-DOS) | 4,6-disubstituted 2-DOS | 4,6-disubstituted 2-DOS |
| Spectrum | Gram-negatives + Mycobacterium | Broader gram-negative | Gram-negative |
| Nephrotoxicity | Lower | Moderate | Moderate |
| Ototoxicity | Vestibular | Vestibular + cochlear | Cochlear |
| Resistance Development | Faster | Slower | Slower |
How Is Streptomycin Sulfate Manufactured?
Streptomycin Sulfate is manufactured by fermentation of Streptomyces griseus to produce the streptomycin free base, followed by extraction, purification and salt formation with sulfuric acid to yield the water-soluble sulfate salt.
Raw Material QC → Fermentation (Streptomyces griseus) → Extraction → Purification → Sulfate Salt Formation → Crystallization → Drying → Final QC → Packaging
HDM BIO controls key fermentation, extraction, salt-formation and drying parameters to maintain consistent purity, potency and batch quality.
Quality Specifications
| Test Item | Standard | Typical Result |
|---|---|---|
| Appearance | White to off-white powder | Consistent |
| Potency | ≥720 IU/mg | 750 IU/mg |
| Assay (HPLC) | ≥98% | 99.1% |
| Identity (IR) | Conforms to reference standard | Confirmed |
| Related Substances | Within specification | Pass |
| Loss on Drying | ≤4.0% | 2.1% |
| Residue on Ignition | ≤1.0% | Compliant |
| Heavy Metals | ≤10 ppm | Compliant |
| pH (1% solution) | 4.5–7.0 | 5.8 |
What Quality Control Tests Are Performed for Streptomycin Sulfate?
Each batch undergoes multi-step quality control before release to verify identity, potency, purity and physical properties.
Raw Material QC → In-Process Control → Microbiological Potency Assay → HPLC Assay → IR Identity Verification → Related Substances Testing → Loss on Drying → Heavy Metals → Residue on Ignition → pH Test → Final Batch Release
Key evaluations include microbiological potency assay (≥720 IU/mg), HPLC active content assay, infrared (IR) identification, related substances analysis, loss on drying, heavy metal limits, residue on ignition and pH verification. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.
What Factors Affect Streptomycin Sulfate Bulk Price?
Streptomycin Sulfate bulk pricing is driven by several key factors:
- Raw Material & Fermentation Costs: Fluctuations in fermentation substrates, Streptomyces griseus culture and downstream extraction costs directly dictate baseline manufacturing expenses.
- Potency & Purity Grade: Higher potency (IU/mg) and purity grades with strict impurity control cost more to produce.
- Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price than non-certified alternatives.
- Order Volume: Large-scale industrial or wholesale contracts receive steeper per-kilogram discounts than small-batch specialty orders.
- Logistics & Geography: Shipping distance, moisture-barrier packaging requirements and customs compliance add to the landed cost.
Contact HDM BIO for a current quotation and volume-based pricing.
Why Choose HDM BIO as Your Streptomycin Sulfate Supplier?
- High-purity (≥98% / typical 99%+) water-soluble veterinary sulfonamide with minimal impurities
- Short-acting rapid-onset profile suitable for acute infection formulation research
- GMP-aligned production, ISO & HACCP certified quality system
- Full batch traceability and complete documentation (COA, MSDS, HPLC)
- Flexible supply: gram samples to ton-level bulk orders
- Global export to 70+ countries with full customs support
Bulk Packaging, Shipping & Storage
- Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
- Custom Packaging: OEM labeling available.
- Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
- Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
- Handling: For veterinary raw material use only; not for direct clinical administration.
Frequently Asked Questions About Streptomycin Sulfate
Q1: What is Streptomycin Sulfate?
A: The water-soluble sulfate salt of streptomycin, the first-in-class aminoglycoside antibiotic derived from Streptomyces griseus, supplied as veterinary raw material for injectable and drinking-water formulations.
Q2: What is the CAS number?
A: 3810-74-0 (sulfate salt); free base is 57-92-1.
Q3: Is Streptomycin an aminoglycoside antibiotic?
A: Yes. Streptomycin is the first-discovered aminoglycoside antibiotic, acting by irreversibly binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis.
Q4: How does it work?
A: It enters bacterial cells and binds irreversibly to ribosomal RNA, causing mRNA misreading and premature peptide chain termination, resulting in bactericidal activity.
Q5: Is it water soluble?
A: Yes. As the sulfate salt, it is freely soluble in water, suitable for injectable and drinking-water formulations.
Q6: What documents are provided with each batch?
A: Batch-specific COA, HPLC report, microbiological potency assay, IR identity records, MSDS/SDS and relevant export documentation are available according to order requirements.
Q7: What potency do you supply?
A: Standard ≥720 IU per mg; typical batch result 750 IU/mg. Higher potency grades available on request.
Q8: Where can I buy it from China?
A: HDM BIO supplies bulk Streptomycin Sulfate powder with batch COA and global export support.
Q9: How much does Streptomycin Sulfate cost?
A: Bulk pricing depends on fermentation costs, potency/purity grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.
Q10: Is this product for human clinical use?
A: Streptomycin Sulfate Powder is supplied as veterinary raw material and is not intended for direct clinical administration. Finished products manufactured from the material must comply with applicable local regulatory requirements.
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