CAS 135679-88-8 Pentapeptide-3 powder | Post-Synaptic Muscle Relaxant Specialist | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: Certified high-purity CAS 135679-88-8 Pentapeptide-3 powder for consistent research reproducibility.

✅ Targeted AChR Antagonism: Effectively blocks the post-synaptic acetylcholine receptor to study muscle contraction inhibition.

✅ Synthesis Expertise: Optimized SPPS protocol ensures high metabolic stability and zero residual coupling agents.

✅ China Peptide Manufacturer: Professional production facility specializing in neuro-transmitter modulating research peptides.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and purity chromatograms.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance documents.

What Is Pentapeptide-3 Powder?

Pentapeptide-3, also known in research circles as Vialox, is a synthetic peptide (sequence: Gly-Pro-Arg-Pro-Ala) that functions as a competitive antagonist at the nicotinic acetylcholine receptor (AChR). In laboratory research, it is utilized to study the blockade of neuromuscular signaling at the post-synaptic level. By competing with acetylcholine for the receptor site, CAS 135679-88-8 Pentapeptide-3 powder prevents the muscle fiber from de-polarizing, providing a unique model for studying the attenuation of expression lines and muscle relaxation in skin-equivalent assays.

The production of this peptide requires precise control over the amino acid coupling sequence and the protection of side-chain reactive groups (particularly the Arginine residue) to ensure a homogeneous final product. HDM BIO utilizes advanced solid-phase peptide synthesis (SPPS) and preparative RP-HPLC to eliminate truncated fragments and diastereomers. We supply this high-stability powder to global cosmetic R&D centers and neuro-dermatology research institutes.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.98%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Pentapeptide-3 vs Argireline: What Are The Differences?

Feature	Pentapeptide-3 (Vialox)	Argireline (Acetyl Hexapeptide-8)
Mechanism	Post-synaptic (AChR Antagonist)	Pre-synaptic (SNAP-25 Mimetic)
Action Site	Acetylcholine Receptor	SNARE Complex
Primary Effect	Blocks signal reception	Inhibits signal release
Research Focus	Fast-acting muscle relaxation	Long-term expression line reduction
CAS Number	135679-88-8	616204-22-9

Explore more Anti-Aging Peptides: Syn-Ake · Acetyl Tetrapeptide-5 · Argireline · Palmitoyl Tripeptide-5

How Is Pentapeptide-3 Manufactured?

Our production follows a standardized cosmetic peptide synthesis protocol:

Chain Assembly: Stepwise synthesis of the sequence GPRPA on a Rink Amide resin via Fmoc-SPPS.
Side-Chain Protection: Specialized handling of the Arginine (Arg) residue to prevent branched by-products.
Acidic Cleavage: Selective removal of the peptide from the resin while preserving the structural integrity of the terminal alanine.
RP-HPLC Purification: Preparative reverse-phase HPLC isolation of the ≥98% pure monomeric fraction.
Quality Release: Final confirmation via high-resolution LC-MS to verify identity and HPLC for purity.

Structural Stability Control

The efficacy of the peptide depends on the precise sequence integrity and the purity of the L-amino acid isomers. HDM BIO monitors every synthesis step to ensure our CAS 135679-88-8 Pentapeptide-3 powder meets the highest analytical standards for research reproducibility.

What Is The Difference Between Research Grade And Cosmetic Grade?

Category	Research Grade	Cosmetic Grade
Primary Purpose	Pre-clinical / Lab research	Cosmetic formulation
Documentation	COA / HPLC / LC-MS / AAA	MSDS / COA / TDS
Purity Standard	Typically ≥98%	Typically ≥95%
Supply Channel	Specialized R&D Suppliers	Cosmetic Raw Material Suppliers

Why Is Supplier Qualification Important Before Purchasing Pentapeptide-3?

Coupling Efficiency: Incomplete coupling in the GPRPA sequence leads to inactive truncated fragments that are difficult to remove without high-res HPLC.
Zero Residual TFA: Qualification ensures the removal of residual trifluoroacetic acid (TFA), which can interfere with cell viability in sensitive skin-model assays.
Analytical Transparency: Reliable suppliers provide full HPLC and LC-MS chromatograms for every batch to verify molecular weight and purity.
Bulk Consistency: Capability to provide uniform batches for long-term longitudinal research and formulation stability studies.

Pentapeptide-3 Price & Bulk Order Guide 2026

MOQ: Flexible; from milligram research samples to kilogram-scale bulk orders.
Samples: Paid test samples available with full QC documentation.
Bulk pricing: Tiered pricing structure; larger volumes deliver highly competitive unit costs.
Lead time: Standard batches are usually in stock; bulk custom orders take 2-3 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific requirements.

What Are The Main Research Applications?

Neuromuscular Junction Dynamics: Investigating the competitive binding at the post-synaptic membrane.
Expression Line Attenuation: Measuring the reduction of muscle contraction in 3D muscle-skin co-culture models.
Acetylcholine Pathway Research: Studying the blockade of ACh signaling in specialized cell lines.
Topical Formulation Stability: Evaluating the impact of pH and temperature on peptide degradation in emulsions.

Why Choose HDM BIO As Your Supplier?

Muscle Relaxant Experts: Over 10 years of experience in the synthesis of neurotransmitter-modulating peptides.
High-Purity Guarantee: Advanced purification ensuring ≥98% purity and zero residual coupling agents.
Rigorous Analytical QC: Every batch confirmed by HPLC and high-resolution LC-MS.
Global Shipping Support: Fast, secure export to 70+ countries with customs-ready documentation.
Technical Support: Direct assistance with solubility, pH stability, and peptide formulation research.

FAQs

Q: What is the mechanism of Pentapeptide-3 in anti-aging research?

A: Pentapeptide-3 powder works as a competitive antagonist of the acetylcholine receptor. It binds to the receptor at the neuromuscular junction, preventing acetylcholine from triggering a contraction, which provides a model for reducing expression-related wrinkles.

Q: How does Pentapeptide-3 compare to Botox injections?

A: In research contexts, Pentapeptide-3 is considered a non-toxic alternative. While Botox proteolytically cleaves the SNARE complex (irreversible), Pentapeptide-3 works through reversible competitive inhibition at the receptor, making it safer for topical and in-vitro research.

Q: What is the recommended storage for Pentapeptide-3 powder?

A: Lyophilized powder should be stored sealed at -20°C, protected from light and moisture. Once reconstituted, avoid repeated freeze-thaw cycles. Correct storage ensures stability for up to 24 months.

Q: Is Pentapeptide-3 soluble in oils or water?

A: Pentapeptide-3 is highly water-soluble. For research, it should be dissolved in deionized water or PBS. It is recommended to maintain the solution pH between 3.5 and 5.5 for optimal stability.