Nicotinoyl Tripeptide-1 peptide powder CAS 1443115-19-2 | Vitamin-Peptide Conjugate Expert China | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: High-purity Vitamin-Peptide conjugate ensures consistent experimental results.

✅ Niacin-GHK Synergy: Covalently bonded Vitamin B3 and Tripeptide-1 for enhanced bioactivity.

✅ Synthesis Expertise: Precision N-terminal nicotinoylation ensures high metabolic stability in research.

✅ China Peptide Manufacturer: Professional facility specializing in functional and hair-growth peptides.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and purity chromatogram.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance.

What Is Nicotinoyl Tripeptide-1?

Nicotinoyl Tripeptide-1 is a specialized synthetic conjugate formed by covalently linking Nicotinic Acid (Niacin) to the N-terminus of Tripeptide-1 (GHK). In laboratory research, Nicotinoyl Tripeptide-1 peptide powder is studied for its ability to stimulate microcirculation and promote extracellular matrix protein synthesis. Unlike physical mixtures of Niacin and GHK, this conjugated molecule ensures simultaneous delivery to targeted skin and hair follicle cells, making it a primary research tool for studying anti-hair loss mechanisms and skin barrier repair.

The production of this peptide requires precise control over the nicotinoylation process to prevent the formation of niacinamide by-products and ensure a homogeneous final product. HDM BIO utilizes advanced solid-phase peptide synthesis (SPPS) and high-resolution purification to isolate the pure monomeric fraction. We supply this high-stability powder to global cosmetic R&D centers and pharmaceutical research institutes.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.58%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Nicotinoyl Tripeptide-1 vs Standard GHK: What Are The Differences?

Feature	Nicotinoyl Tripeptide-1	Standard Tripeptide-1 (GHK)
Active Conjugate	Vitamin B3 + Peptide	Pure Signal Peptide
Microcirculation	High (Vaso-dilation focus)	Minimal
Protease Resistance	Enhanced (N-term capped)	Standard
Application	Hair Growth / Barrier / Brightening	Basic Wrinkle Repair
CAS Number	1443115-19-2	72957-37-0

Explore more Functional Peptides: Biotinoyl Tripeptide-1 · Myristoyl Pentapeptide-17 · Copper Peptide (GHK-Cu) · Acetyl Tetrapeptide-3

How Is Nicotinoyl Tripeptide-1 Manufactured?

Our production follows a standardized functional peptide synthesis protocol:

Chain Assembly: Stepwise synthesis of the GHK sequence (Gly-His-Lys) on a Rink Amide resin via Fmoc-SPPS.
N-Terminal Nicotinoylation: Precision capping of the N-terminal Glycine with Nicotinic acid to enhance metabolic stability.
Acidic Cleavage: Selective removal of the peptide from the resin while preserving the vitamin-peptide covalent bond.
RP-HPLC Purification: Preparative reverse-phase HPLC isolation of the ≥98% pure monomeric fraction.
Quality Release: Final confirmation via high-resolution LC-MS to verify identity and HPLC for purity.

Structural Stability Control

The efficacy of the peptide depends on the integrity of the nicotinoyl bond. HDM BIO monitors every synthesis step to ensure our Nicotinoyl Tripeptide-1 peptide powder meets the highest analytical standards for research reproducibility.

What Is The Difference Between Research Grade And Cosmetic Grade?

Category	Research Grade	Cosmetic Grade
Primary Purpose	Pre-clinical / Lab research	Cosmetic formulation
Documentation	COA / HPLC / LC-MS / AAA	MSDS / COA / TDS
Purity Standard	Typically ≥98%	Typically ≥95%
Supply Channel	Specialized R&D Suppliers	Cosmetic Raw Material Suppliers

HDM BIO supplies research-grade powder for laboratory and pre-clinical applications only.

Why Is Supplier Qualification Important Before Purchasing?

Conjugation Efficiency: Incomplete nicotinoylation leads to inactive peptide fragments and residual free niacin.
Residual Solvents: Ensuring zero contamination from coupling agents (HBTU/EDC) for consistent biological response.
Analytical Transparency: Reliable suppliers provide full HPLC and LC-MS chromatograms for molecular confirmation.
Batch-to-Batch Consistency: Capability to provide uniform batches for long-term formulation stability studies.

Nicotinoyl Tripeptide-1 Price & Bulk Order Guide 2026

MOQ: Flexible; from milligram research samples to kilogram-scale bulk orders.
Samples: Paid test samples available with full analytical QC documentation.
Bulk pricing: Tiered pricing structure; larger volumes deliver highly competitive unit costs.
Lead time: Standard batches are usually in stock; bulk custom orders take 2-3 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific purity requirements.

Why Choose HDM BIO As Your Supplier?

Vitamin-Peptide Experts: Over 10 years of experience in the large-scale synthesis of modified anti-aging peptides.
High-Purity Guarantee: Advanced purification ensuring ≥98% purity and zero residual coupling agents.
Rigorous Analytical QC: Every batch confirmed by HPLC and high-resolution LC-MS.
Global Shipping Support: Fast, secure export to 70+ countries with customs-ready documentation.
Technical Support: Direct assistance with solubility, pH stability, and peptide formulation research.

What Are The Main Research Applications?

Hair Follicle Dynamics: Investigating the impact of niacin-conjugated peptides on follicle micro-environment.
Skin Barrier Repair: Measuring the upregulation of ceramides and filaggrin in 3D skin models.
Soothing Assays: Evaluating the inhibition of pro-sensitized cytokines in dermal fibroblasts.
Microcirculation Studies: Measuring the vasodilator effects in skin-equivalent vascular models.
Stability Testing: Studying the impact of pH and temperature on peptide degradation in aqueous solutions.

FAQs

Q: What are the benefits of Nicotinoyl Tripeptide-1 for skin and hair?

A: Research focuses on its dual ability to improve microcirculation (via the Niacin group) and stimulate collagen/protein synthesis (via Tripeptide-1). It is primarily studied for its potential to reduce hair loss, strengthen the skin barrier, and even out skin tone.

Q: How does Nicotinoyl Tripeptide-1 differ from Niacinamide?

A: Unlike Niacinamide (a simple vitamin), Nicotinoyl Tripeptide-1 is a covalently bonded conjugate. The peptide component acts as a carrier and signal molecule, allowing for more targeted research into how Vitamin B3 affects specific dermal pathways when linked to a signal peptide.

Q: What is the recommended storage for the powder?

A: Lyophilized powder should be stored sealed at -20°C, protected from light and moisture. After reconstitution, avoid repeated freeze-thaw cycles. Correct storage ensures stability for up to 24 months.

Q: How do I dissolve the powder for laboratory assays?

A: It is highly water-soluble. For research, it should be dissolved in deionized water or PBS. Stability is optimized at a pH range of 4.0 to 6.0; avoid highly alkaline environments which may trigger hydrolysis.