Palmitoyl Tetrapeptide-10 powder CAS 887140-79-6 | Crystal Skin & Lucidity Expert | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: Certified high-purity for consistent chaperone protein research.

✅ α-Crystallin Targeting: Effectively studied for its impact on skin transparency and lucidity.

✅ Enhanced Skin Surface: Promotes the "crystal skin" effect in laboratory research models.

✅ China Peptide Manufacturer: Professional production facility specializing in advanced lipopeptides.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and HPLC.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance.

What Is Palmitoyl Tetrapeptide-10 Powder?

Palmitoyl Tetrapeptide-10 is a synthetic lipopeptide that conjugates a specific tetrapeptide sequence with palmitic acid to enhance metabolic stability and skin-model penetration. In laboratory research, it is recognized for its unique ability to target the chaperone protein α-crystallin. Palmitoyl Tetrapeptide-10 powder functions by preventing protein denaturation in the skin, which helps maintain cellular quality and leads to a more uniform and transparent skin appearance. This mechanism makes it a primary tool for investigating the "glass skin" effect and the improvement of skin lucidity in 3D skin-equivalent models.

The production of this lipopeptide requires precise control over the palmitoylation process to ensure a homogeneous final product. HDM BIO utilizes advanced solid-phase peptide synthesis (SPPS) and high-resolution purification to eliminate residual coupling agents and truncated sequences. We supply this high-stability powder to global cosmetic R&D centers and pharmaceutical research institutes focusing on skin transparency biotechnology.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.97%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Palmitoyl Tetrapeptide-10 vs. Niacinamide: What Are The Differences?

Feature	Palmitoyl Tetrapeptide-10	Niacinamide (Vitamin B3)
Mechanism	α-Crystallin Chaperone Support	Melanosome Transfer Inhibition
Primary Effect	Transparency & Lucidity	Tone Uniformity
Research Focus	Protein Quality & "Glass Skin"	Pigmentation & Barrier
Stability	High (Lipopeptide Conjugate)	High
CAS Number	887140-79-6	98-92-0

Explore more Lucidity Peptides: Acetyl Tetrapeptide-2 · Nonapeptide-1 · Palmitoyl Tripeptide-5 · Hexapeptide-11

How Is Palmitoyl Tetrapeptide-10 Manufactured?

Our production follows a standardized lipopeptide synthesis protocol:

Chain Assembly: Stepwise synthesis of the tetrapeptide sequence on a Rink Amide resin via Fmoc-SPPS.
Palmitoylation: Precision capping of the N-terminus with high-purity Palmitic acid to enhance protease resistance.
Acidic Cleavage: Selective removal of the lipopeptide from the resin while preserving side-chain integrity.
RP-HPLC Purification: Preparative reverse-phase HPLC isolation of the ≥98% pure monomeric fraction.
Quality Release: Final confirmation via high-resolution LC-MS to verify identity.

Structural Stability Control:

The efficacy of the peptide depends on the integrity of the palmitoyl bond and the correct sequence fidelity. HDM BIO monitors every synthesis step to ensure our products meet the highest analytical standards for research reproducibility.

What Is The Difference Between Research Grade And Cosmetic Grade?

Category	Research Grade	Cosmetic Grade
Primary Purpose	Pre-clinical / Lab research	Cosmetic formulation
Documentation	COA / HPLC / LC-MS / AAA	MSDS / COA / TDS
Purity Standard	Typically ≥98%	Typically ≥95%
Supply Channel	Specialized R&D Suppliers	Cosmetic Raw Material Suppliers

Why Is Supplier Qualification Important Before Purchasing Palmitoyl Tetrapeptide-10?

Supplier qualification ensures that the lipopeptide has been fully palmitoylated and is free from residual catalysts. For Palmitoyl Tetrapeptide-10 powder, it is critical that the manufacturer validates the structural identity through LC-MS, as impurities can lead to unpredictable cellular responses in transparency research. Reliable suppliers provide batch-specific chromatograms and ensure the removal of trifluoroacetic acid (TFA) to protect sensitive cell cultures.

Price & Bulk Order Guide 2026

MOQ: Flexible; from milligram research samples to kilogram-scale bulk orders.
Samples: Paid test samples available with full analytical QC documentation.
Bulk pricing: Tiered pricing structure; larger volumes deliver highly competitive unit costs.
Lead time: Standard batches are usually in stock; bulk custom orders take 2-3 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific purity requirements.

Why Choose HDM BIO As Your Supplier?

Transparency Peptide Experts: Over 10 years of experience in the synthesis of functional lipopeptides.
High-Purity Guarantee: Advanced purification ensuring ≥98% purity and zero residual catalysts.
Rigorous Analytical QC: Every batch confirmed by HPLC and high-resolution LC-MS.
Global Shipping Support: Fast, secure export to 70+ countries with customs-ready documentation.
Technical Support: Direct assistance with solubility, pH stability, and peptide formulation research.

Main Research Applications

Protein Quality Control: Investigating the upregulation of α-crystallin in epidermal cells.
Skin Lucidity Assays: Measuring the improvement of light reflection in 3D skin models.
Keratinocyte Maturation: Studying the impact of peptides on the uniform distribution of keratin.
Anti-Aging R&D: Evaluating the reduction of "dullness" markers in aged skin equivalents.

FAQs

Q: What is the main research focus for Palmitoyl Tetrapeptide-10 powder?

A: It is primarily used to study skin lucidity and transparency. Researchers utilize it to investigate how chaperone proteins like α-crystallin prevent the accumulation of damaged proteins, resulting in a clearer, "glass-like" skin appearance.

Q: Is this peptide soluble in water?

A: Due to the palmitoyl chain, it has limited solubility in pure water. For research, it is often dissolved in mixtures of water and glycols (like Propanediol) or small amounts of ethanol to ensure full dispersion.

Q: How does it differ from traditional brightening peptides?

A: Traditional peptides usually target melanin synthesis. This peptide targets protein quality and light reflection, focusing on the physical transparency of the skin layers rather than just pigmentation.

Q: How should I store the lyophilized powder?

A: Palmitoyl Tetrapeptide-10 powder should be stored sealed at -20°C, protected from light and moisture. When stored correctly, it remains stable for up to 24 months.