Carnosine powder CAS 305-84-0 | Anti-Glycation & Antioxidant Specialist | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: Certified high-purity for consistent antioxidant research results.

✅ Potent Anti-Glycation: Effectively inhibits the formation of Advanced Glycation End-products (AGEs).

✅ Dual-Action Dipeptide: Functions as both a pH buffer and a heavy metal chelator in research.

✅ China Direct Manufacturer: Professional facility specializing in large-scale L-Carnosine synthesis.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and NMR.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance.

What Is Carnosine Powder?

Carnosine (L-Carnosine) is a naturally occurring dipeptide consisting of beta-alanine and L-histidine. In laboratory research, it is recognized as one of the most effective anti-glycation agents available. Carnosine powder acts by sacrificing itself to react with carbonyl groups on sugars, thereby preventing them from bonding to proteins like collagen and elastin. This mechanism makes it a fundamental research tool for investigating the prevention of "sugar-induced" skin aging, the protection of cellular DNA, and the maintenance of intracellular pH balance in 3D skin-equivalent models.

The production of this high-stability dipeptide requires precise control over the enantiomeric purity of the L-histidine precursor to ensure zero contamination from D-isomers. HDM BIO utilizes optimized chemical synthesis and high-resolution purification to eliminate residual solvents and heavy metals. We supply this high-stability Carnosine powder to global cosmetic R&D centers, pharmaceutical research institutes, and sports nutrition laboratories focusing on oxidative stress and metabolic health.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.87%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Carnosine vs. Glutathione: What Are The Differences?

Feature	Carnosine	Glutathione (GSH)
Primary Mechanism	Anti-Glycation & pH Buffer	Direct Free Radical Scavenger
Target Damage	AGEs (Sugar Damage)	ROS (Oxidative Damage)
Stability	High (Heat & Light Stable)	Low (Easily Oxidized)
Research Focus	Tissue Longevity / Muscle pH	Detoxification / Brightening
CAS Number	305-84-0	70-18-8

Explore more Antioxidant Actives: Ergothioneine (EGT) · Acetyl Tyrosine · Decarboxy Carnosine · Glutathione

How Is Carnosine Manufactured?

Our production follows a standardized high-purity chemical synthesis protocol:

Condensation: Coupling of N-protected beta-alanine with L-histidine methyl ester.
Deprotection: Selective removal of protecting groups via catalytic hydrogenation or acidic treatment.
Recrystallization: Multiple rounds of crystallization to ensure ≥99% purity and remove residual salts.
Identity Verification: Final confirmation via LC-MS and NMR to verify the dipeptide structure.

Structural Stability Control

The efficacy of the dipeptide depends on its chiral purity and the absence of residual heavy metals. HDM BIO monitors every synthesis step to ensure our Carnosine powder meets the highest analytical standards for research reproducibility.

What Is The Difference Between Research Grade And Cosmetic Grade?

Category	Research Grade	Cosmetic Grade
Primary Purpose	Pre-clinical / Lab research	Cosmetic formulation
Documentation	COA / HPLC / LC-MS / NMR	MSDS / COA / TDS
Purity Standard	Typically ≥99%	Typically ≥98%
Heavy Metals	Extremely Low (NMT 10ppm)	Standard

Why Is Supplier Qualification Important Before Purchasing Carnosine?

Chiral Purity (Enantiomer Control): Only L-Carnosine is biologically active. Qualification ensures the supplier uses high-purity L-Histidine and monitors specific rotation.
Heavy Metal Limits: As a chelator, Carnosine can easily carry residual metals. Qualification ensures strict testing for Lead, Arsenic, and Mercury.
Residual Solvent Testing: Ensuring zero residual methanol or other organic solvents used during the crystallization process.
Analytical Transparency: Reliable suppliers provide batch-specific HPLC chromatograms and specific rotation data.

Carnosine Price & Bulk Order Guide 2026

MOQ: Flexible; from 100g research samples to 500kg+ industrial bulk orders.
Samples: Paid test samples available with full QC documentation.
Bulk pricing: Tiered pricing structure; larger volumes deliver highly competitive unit costs.
Lead time: Standard batches are usually in stock; bulk custom orders take 1-2 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific requirements.

Why Choose HDM BIO As Your Supplier?

Dipeptide Specialists: Over 10 years of experience in the large-scale synthesis of L-Carnosine and its derivatives.
High-Purity Guarantee: Advanced crystallization ensuring ≥99% purity and extremely low moisture content.
Rigorous Analytical QC: Every batch confirmed by HPLC, LC-MS, and Specific Rotation.
Global Shipping Support: Fast, secure export to 70+ countries with standard documentation.
Technical Support: Direct assistance with solubility, thermal stability, and chelation research.

Main Research Applications

Anti-Glycation Assays: Investigating the inhibition of protein cross-linking in collagen models.
DNA Protection Studies: Measuring the reduction of oxidative damage in cell cultures.
Muscle Physiology Research: Studying the pH buffering capacity of Carnosine in high-intensity exercise models.
Heavy Metal Chelation: Researching the peptide's ability to neutralize Copper and Zinc toxicity.

FAQs

Q: What is the main benefit of Carnosine for skin research?

A: It is primarily studied for its anti-glycation properties. Researchers use it to investigate how it prevents sugars from damaging collagen fibers, which helps maintain skin elasticity and prevent "yellowing" caused by glycation.

Q: Is L-Carnosine stable in water-based formulations?

A: Yes, it is highly water-soluble and thermally stable. It can be heated to 80°C during formulation research without losing its antioxidant activity, making it much more stable than Vitamin C or Glutathione.

Q: How does Carnosine act as a pH buffer?

A: Because it contains a histidine residue, it has a pKa near physiological pH (approx. 6.8). This allows it to absorb excess hydrogen ions, making it a key tool for studying cellular homeostasis.

Q: How should I store the powder?

A: Store in a cool, dry place, sealed and protected from light. Although it is stable, it is hygroscopic; therefore, keeping it away from moisture is essential for maintaining its crystalline form.