Histrelin Acetate Powder CAS 220810-26-4 | GMP Peptide Manufacturer China | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC purity Histrelin Acetate powder with official batch-specific COA

✅ Full structural identity verified by HPLC, LC-MS and composition analysis

✅ China peptide manufacturer with GMP-aligned Fmoc-SPPS production system

✅ Expertise in D-amino acid and benzyl-modified peptide impurity control

✅ Complete documentation package for lab audit and global import clearance

✅ Flexible supply chain: milligram research samples to kilogram bulk orders

What Is Histrelin Acetate Powder?

Histrelin Acetate powder is a synthetic modified nonapeptide GnRH agonist analog, defined by D-His(Bzl) substitution at position 6 and C-terminal N-ethylamide modification. These structural features deliver enhanced receptor affinity and improved enzymatic stability compared to native GnRH, making it a standard research tool for pre-clinical gonadotropin regulation and sustained-release formulation studies.

Produced via optimized Fmoc solid-phase peptide synthesis, our product strictly controls deletion fragments, de-benzylation by-products and epimerization impurities. Multi-stage high-resolution HPLC purification ensures reliable structural integrity and consistent batch-to-batch analytical performance. HDM BIO supplies this research-grade peptide to global university labs, biotech institutes and pharma R&D teams.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis or medication.

What Are The Quality Specifications of Histrelin Acetate Powder?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.91%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Histrelin Acetate vs Other GnRH Peptides: What Are The Differences?

Peptide	Core Research Focus	Key Structural Feature	CAS Number
Histrelin Acetate	High-potency GnRH agonist, long-acting implant R&D	D-His(Bzl)⁶ + C-terminal N-ethylamide	220810-26-4
Triptorelin Acetate	Standard GnRH agonist reference compound	D-Trp⁶ modified decapeptide	57773-63-4
Goserelin Acetate	Long-acting depot delivery research	D-Ser(tBu)⁶ + azaglycine C-terminus	145781-92-6

How Is Histrelin Acetate Manufactured?

Our Histrelin Acetate powder follows a controlled peptide manufacturing process via standardized Fmoc SPPS workflow:

Raw material preparation: All Fmoc-protected amino acids, including specialty D-His(Bzl) building blocks, pass incoming QC.
Solid phase chain elongation: Stepwise peptide assembly on resin under optimized coupling parameters.
Cleavage and deprotection: Mild acidic cocktail cleaves peptide from resin with controlled side-reaction conditions.
RP-HPLC purification: Multi-stage preparative reverse-phase HPLC removes residual impurities.
Final LC-MS confirmation: Every finished batch undergoes LC-MS verification before release.

Impurity Control During Histrelin Acetate Synthesis

Critical quality parameters monitored throughout production: incomplete coupling impurities, deletion sequences, benzyl-related side products, oxidation impurities and residual protecting group fragments. Advanced purification strategies ensure consistent analytical purity between batches.

What Is The Difference Between Research Grade And Pharmaceutical Grade Histrelin Acetate?

Category	Research Grade	Pharmaceutical Grade
Primary Purpose	Laboratory preclinical studies	Approved drug manufacturing
Documentation	COA / HPLC / LC-MS / MSDS	Full regulatory GMP dossier
Application Scope	Academic and R&D use	Commercial medicine production
Supply Channel	Specialty research suppliers	Licensed API manufacturers

HDM BIO supplies research-grade Histrelin Acetate powder for laboratory and preclinical applications only.

Why Is Supplier Qualification Important Before Purchasing Histrelin Acetate Powder?

Before sourcing internationally, buyers should evaluate four core supplier capabilities to mitigate quality risks:

Specialized synthesis capability: Histrelin contains D-His(Bzl) modification, requiring controlled coupling efficiency and targeted impurity monitoring.
Independent analytical verification: Reliable suppliers provide HPLC purity chromatogram, LC-MS molecular confirmation and batch-specific COA.
Full documentation transparency: Professional manufacturers support complete COA, MSDS, export documentation and full batch traceability.
Scalable production consistency: Long-term partners must maintain reproducible purification performance and stable raw material sourcing.

Histrelin Acetate Powder Price & Bulk Order Guide 2026

MOQ: Flexible; milligram/gram research samples and kilogram-scale bulk orders available
Samples: Paid test samples with full QC documents for pre-bulk laboratory evaluation
Bulk pricing: Tiered pricing structure; larger volumes deliver more competitive unit cost
Lead time: Production cycle depends on order quantity; sales team will confirm exact timeline upon formal inquiry
Quotation: Final price varies by purity grade, testing package and shipping requirements. Contact sales for the latest formal quotation.

Why Choose HDM BIO As Your Supplier?

Mature Fmoc-SPPS capability: 10+ years of solid-phase peptide synthesis experience under GMP-aligned quality management
Modified peptide expertise: Specialized in D-amino acid and side-chain modified GnRH-family peptide production
High-resolution HPLC purification: Multi-stage RP-HPLC ensures consistent ≥98% purity and controlled impurity profile
Rigorous LC-MS verification: Every batch passes LC-MS identity confirmation for reliable analytical consistency
Global shipping support: Export to 70+ countries with full customs-ready documentation package

What Are The Main Research Applications?

GnRH receptor pharmacology and ligand binding affinity studies
Pituitary gonadotropin regulation and reproductive endocrinology research
Sustained-release peptide formulation and polymer implant prototype development
GnRH analog structure-activity relationship (SAR) comparative research
Hormone-dependent oncology pre-clinical in-vitro and animal model investigations

Common Questions About Histrelin Acetate powder

Q: What is the CAS number of Histrelin Acetate powder?

A: The CAS registry number is 220810-26-4.

Q: Where can I buy Histrelin Acetate powder from China?

A: HDM BIO is a professional Chinese peptide manufacturer supplying high-purity research-grade Histrelin Acetate to global customers.

Q: Do you support large bulk orders?

A: Yes. We support both small research samples and kilogram-scale bulk orders for long-term research projects.

Q: Is Histrelin Acetate the same as Histrelin?

A: Histrelin Acetate Powder is the active peptide molecule, while Histrelin Acetate refers to the acetate salt form commonly supplied for research and formulation studies.

Q: How do I verify Histrelin Acetate purity?

A: Purity verification typically includes HPLC analysis, LC-MS molecular weight confirmation and batch-specific quality documentation.