Ziconotide Powder CAS 107452-89-1 | GMP Peptide Manufacturer China | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: Every batch of Ziconotide powder includes a detailed chromatogram.

✅ Precise Folding Control: Expertise in forming the specific 1-16, 8-20, 15-25 disulfide bridge pattern essential for biological activity.

✅ China Peptide Manufacturer: GMP-aligned production facility specializing in complex conotoxin synthesis.

✅ Identity Verification: Structural integrity confirmed by LC-MS and amino acid analysis (AAA).

✅ Complete Documentation: Full support for lab audits, including MSDS and export clearance documents.

✅ Scalable Supply: Flexible options from 1mg research vials to multi-gram bulk supply.

What Is Ziconotide Powder?

Ziconotide powder is the synthetic form of ωω-conotoxin MVIIA, a 25-amino acid peptide originally discovered in the venom of the marine snail Conus magus. As a potent and selective N-type voltage-gated calcium channel (VGCC) blocker, it is a primary research tool for investigating non-opioid pathways in chronic pain and neuroprotection.

The synthesis of Ziconotide is significantly more complex than standard linear peptides due to its three internal disulfide bonds. At HDM BIO, we utilize optimized oxidative folding buffers and thermodynamic control to ensure the correct "native" conformation. Our process minimizes misfolded isomers and truncated sequences, providing researchers with highly consistent and bioactive peptide raw materials.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications of Ziconotide powder?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.96%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Ziconotide vs Other Conotoxins: What Are The Differences?

Peptide	Selectivity	Research Focus	CAS Number
Ziconotide	N-type (Caᵥ2.2) selective	Severe chronic pain research	107452-89-1
ωω-Conotoxin GVIA	N-type (irreversible)	Calcium channel mapping	106362-34-9
μμ-Conotoxin GIIIA	Muscle-type Na⁺ channels	Neuromuscular signaling	93605-62-4

How Is Ziconotide Manufactured?

Our Ziconotide powder manufacturing process emphasizes structural precision:

Chain Assembly: Linear 25-mer sequence elongation via standardized Fmoc-SPPS.
Selective Cleavage: Gentle resin cleavage to preserve the six cysteine side-chains in a reduced state.
Oxidative Folding: The critical step-using air-oxidation or redox-buffer systems to drive the formation of the three specific disulfide bridges.
Isomer Purification: Utilizing high-resolution RP-HPLC to separate the bioactive Ziconotide from misfolded isomers.
Quality Release: Final verification via LC-MS to confirm the exact mass and HPLC to ensure purity.

Folding Integrity & Impurity Control

Ziconotide research requires the removal of "scrambled" peptides (isomers with incorrect disulfide pairings). HDM BIO employs targeted analytical methods to ensure the thermodynamic stability and structural homogeneity of each batch.

What Is The Difference Between Research Grade And Pharmaceutical Grade Ziconotide?

Category	Research Grade	Pharmaceutical Grade (API)
Primary Purpose	Preclinical lab research	Clinical drug production
Documentation	COA / HPLC / LC-MS / MSDS	DMF / GMP Compliance Dossier
Application	In-vitro / Animal models	Human intrathecal injection
Supplier Type	Research Peptide Supplier	Licensed API Manufacturer

HDM BIO supplies research-grade Ziconotide powder for laboratory use and formulation R&D only.

Why Is Supplier Qualification Important Before Purchasing Ziconotide?

Ziconotide's efficacy depends entirely on its 3D structure. Evaluate these points:

Folding Expertise: Does the supplier have data proving correct disulfide bridge formation?
HPLC Resolution: Can their analytical method distinguish Ziconotide from its isomers?
Batch Traceability: Full production logs from amino acid coupling to final lyophilization.
Technical Support: Availability of specialists to discuss solubility and stability in research buffers.

Ziconotide Powder Price & Bulk Order Guide 2026

MOQ: Flexible; milligram samples and bulk gram-scale orders supported.
Samples: Verified test samples available with full QC reports.
Pricing: Tiered structure based on volume. Competitive quotes for university labs and biotech institutes.
Lead time: Typically 1-2 weeks for stock items; 3-4 weeks for larger custom synthesis.
Quotation: Contact our sales team for a formal quote based on your specific purity and quantity needs.

Why Choose HDM BIO As Your Supplier?

Conotoxin Specialists: Extensive experience in multi-cysteine peptide synthesis and folding.
Superior Purity Control: Advanced HPLC methods to ensure ≥98% purity, free from misfolded contaminants.
Structural Certainty: Every batch is verified for identity (LC-MS) and purity (HPLC).
GMP-Aligned Quality: Strict internal QC standards adapted from pharmaceutical manufacturing.
Secure Global Delivery: Expertise in shipping peptides with required customs and safety documentation.

What Are The Main Research Applications?

N-type Calcium Channel Blocking: Studies on neurotransmitter release at the presynaptic terminal.
Non-Opioid Analgesic R&D: Investigating pathways that avoid opioid-related side effects.
Neuropathic Pain Models: Evaluation in diabetic neuropathy or post-herpetic neuralgia models.
Drug Delivery Systems: Research into sustained-release pumps or hydrogel carriers.
Neuroprotection Research: Exploring VGCC inhibition in ischemic injury models.

Common Questions About Ziconotide Powder

Q: What is the CAS number of Ziconotide?
A: The CAS number is 107452-89-1.

Q: Does your Ziconotide have the correct disulfide bridges?
A: Yes. We use directed folding and MS verification to ensure the 1-16, 8-20, and 15-25 bridge pattern.

Q: Where can I buy Ziconotide powder from China?
A: HDM BIO is a leading Chinese manufacturer providing high-purity Ziconotide for global research markets.

Q: What is the recommended storage?
A: Store the lyophilized powder at -20°C. Once reconstituted, aliquot and store at -80°C to maintain stability.

Q: Can I order Ziconotide in bulk?
A: Yes, we support orders ranging from milligrams for pilot studies to kilograms for larger R&D projects.