Taltirelin Powder CAS 103300-74-9 | GMP Peptide Manufacturer China | Long-Acting TRH Analog Research Peptide

Core Selling Points

✅ ≥98% HPLC Purity Taltirelin Powder with Batch‑Specific COA Available

✅ Verified by HPLC, LC‑MS and Amino Acid Composition Analysis for TRH‑analog peptide identity confirmation

✅ China Peptide Manufacturer with Fmoc‑SPPS Production & GMP‑Aligned Quality System

✅ Specialized in DKP diketopiperazine by‑product & histidine‑related side‑reaction control

✅ Complete Documentation Package: COA, HPLC Chromatogram, LC‑MS Report & MSDS

✅ Flexible Supply from Research Samples to Bulk Peptide Orders Worldwide

What Is Taltirelin Powder?

Taltirelin powder, also known as TA‑0910, is an orally bioavailable thyrotropin‑releasing hormone (TRH) superagonist peptide analog, molecular formula C₁₇H₂₃N₇O₅, molecular weight 405.41 Da. It can cross the blood‑brain barrier, exhibits enhanced CNS neuroprotective activity and reduced endocrine side‑effects compared with native TRH, widely used for spinocerebellar degeneration, Parkinson‑related neuroprotection and neuronal injury pre‑clinical model research.

Manufactured via optimized Fmoc solid‑phase peptide synthesis under our GMP‑aligned quality system, our Taltirelin powder strictly controls diketopiperazine (DKP) cyclization impurities, histidine racemization and deletion fragment by‑products, securing stable receptor‑binding bioactivity and consistent batch‑to‑batch reproducibility. HDM BIO serves global biochemistry laboratories, pharmaceutical R&D institutions and biological‑reagent manufacturers, covering milligram‑level research samples up to kilogram‑scale worldwide bulk procurement. This peptide raw material is restricted exclusively to laboratory research use and must not be directly used for human clinical administration.

What Are the Official Quality Specifications of Taltirelin Powder?

Every production batch of Taltirelin undergoes multi‑level QC testing including HPLC, LC‑MS and amino acid composition analysis within HDM BIO in‑house analytical laboratory. Batch‑specific COA will be issued for all purchase orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.93%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Taltirelin vs Related TRH‑Family Peptides

For buyers sourcing TRH‑analog bioactive peptide raw materials for neuro‑pharmacology pre‑clinical research, the comparison table clarifies core differences for targeted raw‑material selection：

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Taltirelin	TRH‑R superagonist, neuroprotective, BBB‑permeable, oral‑active	Modified TRH analog, non‑native tripeptide derivative	Neurodegeneration, spinocerebellar ataxia, neuro‑protection assay	103300‑74‑9
Protirelin (TRH)	Endogenous thyrotropin‑releasing hormone	Native tripeptide, rapid metabolic degradation	Endocrine & neurotransmitter basic research	24305‑27‑9

This section covers long‑tail keywords: Taltirelin TA‑0910 raw material, BBB‑permeable TRH superagonist research peptide, neuroprotective peptide API.

How to Buy Taltirelin Powder from a Trustworthy Supplier?

When sourcing Taltirelin powder for central nervous system pre‑clinical research, R&D teams and international purchasers need to assess five core criteria to avoid supply‑quality risks:

HPLC purity validation: Confirm ≥98% HPLC purity with batch‑specific COA and full impurity chromatogram; pay special attention to DKP cyclization by‑products and histidine racemization impurities which will interfere with TRH‑receptor binding and neuronal cell assay results
Multi‑method structural confirmation: Peptide identity validated by HPLC, LC‑MS and amino‑acid composition analysis to confirm intact target molecule
Complete batch documentation package: Guarantee each order obtains batch‑specific COA, HPLC chromatogram, LC‑MS report and MSDS to satisfy global import customs clearance and lab audit requirements
Qualified manufacturing system: Select China peptide manufacturer with mature Fmoc‑SPPS workflow and GMP‑aligned quality system, proven track record on DKP cyclization‑suppression and histidine‑containing peptide synthesis technology
Global flexible supply: Confirm vendor can deliver both small‑scale research samples and large‑volume worldwide bulk peptide orders

Taltirelin Powder Price & Bulk Ordering Guide 2026

If you are searching for Taltirelin powder price, bulk quotation and delivery terms, please refer to key procurement information as follows:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑scale research samples available; kilogram‑level worldwide bulk supply for sustained research projects
Sample Access: Trial research samples for lab evaluation; contact sales team to get formal sample quotation
Bulk Kilogram Pricing: Tiered pricing structure; larger bulk volume brings competitive unit price
Production Lead Time: Complex modified TRH‑analog peptide with strict side‑reaction control; sales will confirm exact production schedule upon formal inquiry
Shipping Options: Sealed cold‑recommended shipping worldwide; avoid prolonged room‑temperature exposure; we supply complete documentation package (batch‑specific COA, HPLC chromatogram, LC‑MS report, MSDS, commercial invoice, packing list) for global customs clearance

Taltirelin Powder Procurement Guide for Global Buyers

Before placing purchase orders for TRH‑superagonist neuro‑active peptide raw materials, international procurement teams should finish these verification steps to mitigate potential risks:

Supplier qualification check: Confirm the manufacturer owns independent peptide‑synthesis workshop and QC lab with GMP‑aligned quality system, hands‑on experience on histidine‑containing peptide synthesis and DKP cyclization impurity control
Document inspection: Request pre‑shipment complete documentation package including batch‑specific COA, HPLC chromatogram, LC‑MS report and MSDS; require multi‑method peptide identity confirmation and impurity profile covering DKP cyclization by‑products and histidine racemization impurities
Product confirmation: Confirm purity standard, endotoxin level and cold‑storage requirement match your experimental design
MOQ & lead‑time confirmation: Verify research sample / bulk peptide worldwide availability, peptide production cycle and order‑adjustment policy
Shipping‑document confirmation: Make sure supplier can provide complete paperwork set to satisfy import requirements of your target region

About HDM BIO Taltirelin Manufacturing Capability

HDM BIO possesses more than 10‑year expertise in Fmoc‑SPPS peptide synthesis under GMP‑aligned quality system, specialized in modified TRH‑analog peptide manufacturing with cyclization side‑reaction risk control.

Dedicated Fmoc‑SPPS production lines; adopt optimized coupling reagent and short coupling cycle strategy to suppress DKP diketopiperazine intramolecular cyclization during synthesis
Independent analytical laboratory equipped with HPLC, LC‑MS and amino‑acid composition analysis instruments; specialized RP‑HPLC gradient workflow for separation of cyclized DKP impurities, racemized histidine variants and deletion fragments
Peptide products exported worldwide to over 70 countries, supporting university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team experienced in TRH‑family peptide‑series synthesis and related analog custom modification

What Technical Challenges Exist in Taltirelin Synthesis & Production?

Taltirelin is a modified TRH‑analog peptide containing histidine residue. Controlling intramolecular diketopiperazine (DKP) cyclization side‑reaction, removing deletion fragments and suppressing histidine racemization constitute core technical bottlenecks separating qualified peptide manufacturers from low‑grade suppliers.

Key production challenges:

‑ Histidine‑proline‑adjacent structural motif is prone to intramolecular DKP cyclization during coupling and cleavage, generating cyclized impurities difficult for chromatographic removal

‑ Imidazole side‑chain of histidine easily triggers racemization under basic de‑protection condition, producing diastereomer impurities affecting receptor‑binding activity

‑ Multiple polar functional groups bring complex solubility fluctuation during preparative‑HPLC purification

‑ Single HPLC test is insufficient for full quality judgement; multi‑validation via HPLC, LC‑MS plus amino‑acid composition analysis is mandatory to guarantee intact target molecule for neuro‑pharmacology functional biology assays

How Does Taltirelin Powder Work in Laboratory Research?

As synthetic BBB‑permeable TRH receptor superagonist peptide, Taltirelin powder activates TRH‑R downstream intracellular signaling pathways, modulates neurotransmitter release, exerts neuro‑protective, anti‑oxidative and anti‑apoptosis effects on neuronal cells, widely applied for spinocerebellar degeneration, Parkinson‑related neuron‑protection and central nervous system drug‑discovery pre‑clinical research. All mechanism descriptions are limited to in‑vitro and pre‑clinical animal‑research scenarios only.

How Is Taltirelin Powder Manufactured at HDM BIO?

Taltirelin requires strict full‑process control for DKP cyclization suppression, histidine racemization control, deletion‑fragment removal and lyophilization, operated within our GMP‑aligned quality system.

Read related guide: Disulfide‑Containing Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Taltirelin Powder Manufacturing Workflow

Raw‑material QC of Fmoc‑amino‑acid building blocks → Step‑wise peptide assembly with short‑cycle low‑cyclization coupling protocol on solid resin → Resin cleavage & global deprotection with optimized scavenger combination → Crude peptide pretreatment → Multi‑stage preparative‑HPLC purification (remove DKP cyclization impurities, histidine‑racemization diastereomers & deletion‑fragment impurities) → Buffer‑exchange → Vacuum lyophilization → Full multi‑method QC testing (HPLC, LC‑MS, amino‑acid composition analysis for identity verification, impurity profiling & endotoxin test) → Batch‑specific COA issuance → Light‑proof, low‑moisture sealed packaging

QC Inspection Workflow

Incoming raw‑material QC → In‑process DKP cyclization risk monitoring → HPLC purity testing (diastereomer & cyclized‑impurity resolving gradient method) → LC‑MS molecular‑weight verification → Supplementary amino‑acid composition analysis for peptide identity confirmation → DKP‑impurity & histidine‑racemization quantitative analysis → Moisture & heavy‑metal testing → Residual‑solvent & endotoxin detection → Final batch‑release approval under GMP‑aligned quality system

Core Process Highlights

‑ Optimized coupling cycle to suppress intramolecular DKP diketopiperazine cyclization side‑reaction

‑ Process parameter tuning to reduce histidine racemization diastereomer formation

‑ Optimized RP‑HPLC gradient for baseline separation of cyclized DKP impurities and deletion truncated fragments

‑ Multi‑level identity confirmation: HPLC, LC‑MS plus amino‑acid composition analysis verifying intact full‑structure Taltirelin peptide

‑ Lyophilized solid stable stored at −20 °C sealed condition; avoid repeated freeze‑thaw cycles, reconstituted peptide solution shall be aliquoted and stored at −80 °C.

What Are the Main Application Scenarios of Taltirelin Powder?

TRH receptor pharmacology research: TRH‑R agonist activity assay, intracellular calcium signaling pathway study
Neuro‑protection pre‑clinical research: Spinocerebellar degeneration, Parkinson‑disease‑related neuronal injury animal model evaluationPMC
CNS drug‑discovery research: Blood‑brain‑barrier permeability study, neurotransmitter modulation mechanism research
Peptide formulation development: Oral‑active peptide stability screening, pre‑formulation research
Biomedical reagent preparation: Laboratory reference standards for TRH‑family peptide research
Histidine‑containing peptide‑process‑development research: DKP cyclization side‑reaction control benchmark compound

Why Choose HDM BIO As Your Taltirelin Powder Supplier?

‑ 10+‑year China‑based peptide‑manufacturing experience with Fmoc‑SPPS production and GMP‑aligned quality system

‑ Specialized capability for complex Taltirelin peptide synthesis and purification, effectively reduce DKP diketopiperazine cyclization impurities and histidine racemization by‑products

‑ Every batch supported by multi‑validation: HPLC, LC‑MS and amino‑acid composition analysis, delivered with batch‑specific complete documentation package

‑ Complete batch‑wise production‑traceability documents for Taltirelin Powder

‑ Flexible worldwide supply capacity: research samples to kilogram‑scale bulk peptide orders

‑ Global‑export service covering more than 70 countries worldwide ‑ Professional technical team supporting TRH‑family peptide research and custom‑analog synthesis consulting

FAQs About Taltirelin Powder

Q: Where can I buy Taltirelin powder from China?

A: HDM BIO is a Chinese peptide manufacturer with Fmoc‑SPPS production and GMP‑aligned quality system, specialized in modified TRH‑analog neuro‑active research peptide. We deliver high‑purity Taltirelin powder for global pharmaceutical R&D teams and bioreagent laboratories, flexible worldwide supply from research samples to bulk peptide orders.

Q: What documents should a qualified Taltirelin supplier provide?

A: Reliable supplier shall supply complete documentation package: batch‑specific COA, HPLC chromatogram, LC‑MS report & MSDS. Peptide identity is verified by HPLC, LC‑MS and amino‑acid composition analysis; DKP cyclization impurity‑testing data are available upon request.

Q: What is the CAS number of Taltirelin Powder?

A: The CAS registry number of Taltirelin Powder is 103300‑74‑9.

Q: What purity grade of Taltirelin powder can you deliver?

A: Standard research‑grade ≥98% HPLC purity. Every batch comes with batch‑specific COA and multi‑method identity validation including amino‑acid composition check. Higher‑purity specifications and TRH‑series custom‑peptide‑analog synthesis are available for special experimental requirements.

Q: How should lyophilized Taltirelin powder be stored?

A: Store sealed at −20 °C, keep away from light and moisture. Strictly avoid repeated freeze‑thaw cycles. Aqueous reconstituted solution should be prepared into single‑use aliquots and stored at −80 °C.

Q: Can I get Taltirelin research samples before bulk purchase?

A: Yes. We provide milligram‑to‑gram‑level research samples attached with complete documentation package for laboratory assessment.

Q: What is the MOQ for bulk Taltirelin powder worldwide orders?

A: MOQ is flexible depending on purity grade and packaging specifications. We support small‑scale research samples and large‑volume worldwide bulk peptide orders for different‑project requirements.

Q: What is the molecular weight of Taltirelin Powder?

A: Theoretical molecular weight: 405.41 Da, molecular formula C₁₇H₂₃N₇O₅.

Scientific Review

Reviewed by:

HDM BIO Peptide Technical Team

Expertise:

Fmoc‑SPPS peptide synthesis Disulfide‑bond‑containing cyclic hormone peptide manufacturing Multi‑method peptide characterization: HPLC, LC‑MS and disulfide‑bond verification

Last Updated: August 2026

Disclaimer: All product content serves academic research and laboratory raw‑material reference only. Not for human clinical use, diagnosis or treatment.