Icatibant Acetate API CAS 30308-48-4 | High Purity Bradykinin Antagonist Peptide Supplier China

Core Selling Points

✅ ≥98% HPLC Purity Research-Grade Peptide Material

✅ LC-MS Full Modified Decapeptide Sequence Verification

✅ Batch-Specific COA, HPLC & MS Test Reports Available

✅ Fmoc SPPS Production, In-house QC Laboratory

✅ Global Export Documentation & Cross-border Logistics Support

✅ Custom Modified Peptide Synthesis & Lyophilization Service

What Is Icatibant Acetate API Powder?

Icatibant Acetate powder is a synthetic selective bradykinin B2 receptor antagonist decapeptide, incorporated with five non-proteinogenic amino acid modifications to enhance metabolic stability and receptor binding affinity. As a specialized inflammatory research peptide, it is widely used in bradykinin pathway mechanism studies, hereditary angioedema related drug R&D and anti-inflammatory peptide therapeutic pipeline development.

Produced with optimized Fmoc solid-phase peptide synthesis, controlled non-natural amino acid stepwise coupling and multi-stage gradient HPLC purification, our Icatibant Acetate API delivers intact modified peptide structure, stable biological characteristics and consistent batch quality. HDM BIO serves global biotech research teams and pharmaceutical R&D enterprises with one-stop bulk supply, custom peptide modification and professional technical support. This product is for research and raw material manufacturing use only, not for direct clinical administration.

What Are the Official Quality Specifications of Icatibant Acetate API Powder?

Every production batch of Icatibant undergoes rigorous dual QC testing (HPLC + LC-MS) in HDM BIO's in-house laboratory, with an exclusive batch COA issued for all bulk procurement orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.66%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Icatibant Acetate vs Other Bradykinin Pathway Peptides

If you are sourcing raw materials for hereditary angioedema and inflammatory pathway research, this comparison helps you select suitable peptide reagents:

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Icatibant Acetate	Bradykinin B2 receptor competitive antagonist	Modified synthetic decapeptide	HAE mechanism research, anti-edema preclinical study	30308-48-4
Bradykinin	B2 receptor endogenous agonist	Natural linear peptide	Baseline bradykinin signal pathway testing	58-82-2
Ecallantide	Plasma kallikrein inhibitor	Recombinant protein inhibitor	HAE therapeutic candidate evaluation	265124-44-1

This comparison covers common long-tail search queries: icatibant vs ecallantide, bradykinin antagonist peptide raw material.

How to Buy Icatibant Acetate API Powder from a Reliable Supplier?

When sourcing Icatibant Acetate powder for inflammatory pharmacology research and rare disease drug development, pharmaceutical R&D teams and peptide buyers should evaluate five core factors to ensure product quality and supply stability:

HPLC purity verification: Confirm ≥98% purity with official chromatogram and full impurity profile data
LC-MS structure confirmation: Verify full-length modified peptide structure to avoid truncated or epimer impurities
Batch-specific COA availability: Ensure every production batch comes with complete quality documentation
Stable modified peptide manufacturing capacity: Verify mature non-natural amino acid coupling technology to avoid delivery delays
Export documentation and technical support: Confirm full regulatory document support and application guidance

HDM BIO provides research-grade Icatibant Acetate with complete quality documentation, flexible MOQ and global shipping support for lab research batches and large-scale bulk orders.

Icatibant Acetate API Price & Bulk Ordering Guide 2026

Buyers searching for Icatibant acetate price, bulk API quotation and delivery terms can refer to key procurement information below:

Minimum Order Quantity: Flexible MOQ, milligram & gram-level trial samples available; kilogram bulk supply for continuous research projects
Sample Pricing: Trial samples for lab evaluation, contact sales team to get sample quotation
Bulk Kilogram Quotation: Volume tiered pricing, larger orders obtain competitive unit cost
Production Lead Time: Standard lead time depends on order volume, sales will confirm production schedule upon inquiry
Shipping Options: Cold chain transportation for peptide stability; we provide commercial invoice, packing list, MSDS for customs clearance worldwide

Multiple conditions will affect the final quotation: purity grade, customized testing requirements, special packaging and cold-chain logistics. Contact our sales team to receive the latest quotation.

Icatibant Acetate API Procurement Guide for Global Buyers

HDM BIO has over 10 years of experience focused on Fmoc solid-phase peptide synthesis and modified peptide raw material production.

Dedicated SPPS production lines for complex modified peptides containing non-natural amino acids
Independent analytical laboratory equipped with HPLC, LC-MS, moisture tester and heavy metal testing instruments
Products exported to more than 70 countries, serving university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research-grade peptide raw materials, supporting long-term framework cooperation
Professional technical team with deep expertise in modified peptide synthesis, purification and peptide stability research

Our peptide manufacturing facility operates dedicated Fmoc SPPS production lines with in-house HPLC purification and LC-MS analytical capability.

What Makes Icatibant a Challenging Modified Peptide API?

As a 10-residue modified peptide containing multiple non-proteinogenic amino acids (D-Arg, Thi, D-Tic, Oic), Icatibant has high technical barriers in industrial synthesis and purification, which is the core threshold separating professional peptide manufacturers from low-quality suppliers.

Key production challenges include:

Precise control of non-natural amino acid coupling efficiency to reduce deletion and racemization by-products
High risk of incomplete coupling and truncated sequence impurities during long-chain assembly
Difficulty in separating target modified peptide from structural analog and epimer impurities
Strict full-structure verification and stereochemical configuration confirmation standards
High requirements for batch stability and activity consistency

HDM BIO applies optimized stepwise coupling technology, multi-stage gradient HPLC purification and full-process LC-MS confirmation for every batch, effectively reducing by-products and ensuring verified full-length modified peptide sequence consistency and stable batch quality.

How Does Icatibant Work in Pharmacological Research?

As a selective competitive bradykinin B2 receptor antagonist, Icatibant binds to B2 receptors on vascular endothelial cells, blocking bradykinin-mediated intracellular signaling cascades, vascular permeability increase and edema formation in laboratory research models. It provides a well-established experimental tool for studying inflammatory edema mechanisms and anti-angioedema drug efficacy evaluation.

This peptide is widely studied as a reference compound for inflammatory pharmacology and hereditary angioedema mechanism investigation. It serves as a core control material for anti-edema drug development and vascular biology research worldwide, supporting academic exploration and new drug precursor development. All mechanism descriptions are limited to in vitro and preclinical animal research scenarios only.

How Is Icatibant Acetate API Manufactured at HDM BIO?

Icatibant is produced through Fmoc solid-phase peptide synthesis, with specialized non-natural amino acid stepwise coupling and multi-stage purification processes. Precise control of coupling efficiency and stereochemical integrity is the core technical barrier to ensure high-purity modified peptide.

Read related guide: Modified Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Icatibant Manufacturing Workflow

Raw Material Inspection → Linear Modified Peptide SPPS Stepwise Coupling → Resin Cleavage & Global Deprotection → Multi-stage HPLC Purification → Acetate Salt Exchange → Vacuum Lyophilization → Full QC Testing → Batch COA Issuance → Sealed Light-Proof Packaging

QC Inspection Workflow

Incoming Raw Material QC → In-process Coupling & Stereochemistry Monitoring → HPLC Purity Testing → Mass Spectrometry Identity & Structure Verification → Moisture & Heavy Metal Testing → Residual Solvent Detection → Final Batch Release Approval

Core Process Highlights

Optimized non-natural amino acid coupling technology effectively reduces deletion and racemization by-products

Multi-stage high-precision HPLC purification thoroughly removes linear and structural analog impurities

Full-structure LC-MS verification ensures intact modified peptide chain and correct stereoconfiguration

Vacuum lyophilization and light-proof sealed packaging effectively maintain peptide stability during transportation and low-temperature storage

What Are the Main Application Scenarios of Icatibant API?

Inflammatory pharmacology research: Bradykinin B2 receptor pathway and vascular permeability regulation experiments
Rare disease drug R&D intermediate: Raw material for novel anti-hereditary angioedema drug preliminary development
Biomedical reagent preparation: Laboratory reference standards and experimental control reagents
Peptide formulation research: Injectable peptide formulation and delivery system development
Vascular biology mechanism research: Edema formation and inflammatory vascular response regulation pathway studies

Why Choose HDM BIO As Your Icatibant Acetate Supplier?

10+ years of professional modified peptide raw material manufacturing experience in China
Mature optimized Fmoc SPPS production line with controlled non-natural amino acid coupling technology
Strict full-structure verification and batch stability control for every batch
Full production traceability for every Icatibant production lot
Flexible supply: gram-level lab samples to kilogram-level bulk API orders
Global export service covering 70+ countries and regions
Professional technical team supporting inflammatory pharmacology research consulting

FAQs About Icatibant Acetate

Q: Where can I buy Icatibant API powder from China?

A: HDM BIO is a China-based modified peptide supplier supplying high-purity Icatibant Acetate powder to global pharmaceutical R&D teams and biotech companies. We support small research samples to large bulk orders, with complete export documentation and worldwide shipping.

Q: What documents should an Icatibant supplier provide?

A: A qualified supplier should provide batch-specific COA, HPLC purity chromatogram, LC-MS identity verification report, MSDS, and full production traceability records to support global customs clearance and quality audit.

Q: What is the CAS number of Icatibant Acetate?

A: The CAS registry number of Icatibant Acetate is 30308-48-4.

Q: What purity grades of Icatibant powder do you offer?

A: Standard research grade is ≥98% HPLC purity. Higher purity specifications (≥98%) can be customized for special research needs.

Q: How should Icatibant lyophilized powder be stored?

A: Store sealed at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles to maintain peptide stability and structural integrity.

Q: Can I get Icatibant samples before placing a bulk order?

A: Yes. We provide milligram to gram-level trial samples with complete COA and test documents for research evaluation before bulk cooperation.

Q: What is the MOQ for Icatibant bulk powder?

A: MOQ is flexible based on purity grade and packaging requirements. We support small research batches and large bulk orders to meet different project needs.

Scientific Review

Reviewed by: HDM BIO Peptide Technical Team Expertise: Peptide synthesis Modified peptide raw material manufacturing Analytical chemistry & HPLC/LC-MS testing

Last Updated: August 2026

Disclaimer: All product content is provided for academic research and laboratory raw material reference only. Not intended for human clinical use, diagnosis or treatment.