Sermorelin Acetate Powder CAS 114466‑38‑5 | High Purity 29‑Mer GHRH (1‑29) Peptide Supplier China

Core Selling Points

✅ ≥98% HPLC Purity Salmon Calcitonin Powder with Batch‑Specific COA Available

✅ Verified by HPLC, LC‑MS and Structural Analysis for Peptide Identity Confirmation

✅ China Peptide Manufacturer with Fmoc‑SPPS Production & GMP‑Compliant Quality System

✅ Specialized in Complex 32‑Mer Disulfide‑Bonded Salmon Calcitonin Peptide Synthesis and Purification

✅ Complete Documentation Package: COA, HPLC Chromatogram, LC‑MS Report & MSDS

✅ Flexible Supply from Research Samples to Bulk Peptide Orders Worldwide

What Is Sermorelin Acetate Powder?

Sermorelin Acetate powder is synthetic 29‑amino‑acid C‑terminal amidated peptide, corresponding to the biologically active 1‑29 fragment of human growth hormone‑releasing hormone (GHRH). It acts as a GHRH‑receptor agonist, triggering pituitary growth‑hormone secretion, widely deployed in endocrine mechanism research, pituitary function assays, GH‑axis pharmacology, metabolic research and peptide structure‑activity‑relationship investigation.

Manufactured via optimized Fmoc solid‑phase peptide synthesis under our GMP‑compliant quality system, controlled C‑terminal amidation and multi‑stage gradient HPLC purification, our Sermorelin Acetate powder strictly controls methionine oxidation, amino‑acid deletion impurities and truncated fragments, securing stable biological activity and consistent batch‑to‑batch performance.HDM BIO serves global biochemistry laboratories, pharmaceutical R&D institutions and biological‑reagent manufacturers, covering milligram‑level research samples up to kilogram‑scale worldwide bulk procurement. This peptide raw material is restricted exclusively to laboratory research use and must not be directly used for human clinical administration.

What Are the Official Quality Specifications of Sermorelin Acetate Powder?

Every production batch of Sermorelin Acetate undergoes multi‑level QC testing including HPLC, LC‑MS and structural analysis within HDM BIO in‑house analytical laboratory. Batch‑specific COA will be issued for all purchase orders.

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.66%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Sermorelin Acetate vs Other GHRH‑Related Regulatory Peptides

For buyers sourcing GH‑axis peptide raw materials for endocrine pharmacology research, the comparison table clarifies core differences for targeted raw‑material selection：

Product	Target Mechanism	Structural Feature	Primary Research Application	CAS Number
Sermorelin Acetate	GHRH receptor agonist, trigger pulsatile GH release	29‑mer peptide, C‑terminal Arg‑NH₂ amidation, Met‑containing sequence	Pituitary endocrine research, GH‑IGF‑1 axis assay, pulsatile hormone physiology	114466‑38‑5
Tesamorelin Acetate	GHRH agonist with lipid‑modified N‑terminus	44‑mer lipidated peptide	Lipid metabolism & visceral fat research	218949‑48‑5
GHRP‑2	Ghrelin receptor agonist, stimulate GH secretion	6‑mer short peptide	Growth‑hormone secretagogue screening	158861‑67‑7

This section covers long‑tail keywords: sermorelin acetate raw peptide, GHRH 1‑29 research peptide, 29‑mer C‑terminal amidated endocrine peptide.

How to Buy Sermorelin Acetate Powder from a Trustworthy Supplier?

When sourcing Sermorelin Acetate powder for endocrine physiology and pituitary‑function pre‑clinical research, R&D teams and international purchasers need to assess five core criteria to avoid supply‑quality risks:

HPLC purity validation: Confirm ≥98% HPLC purity with batch‑specific COA and full impurity chromatogram; pay special attention to methionine oxidation products, deletion‑sequence fragments and de‑amidated variants that impair biological potency
Multi‑method structural confirmation: Peptide identity validated by HPLC, LC‑MS and structural analysis to confirm full‑length 29‑mer complete amino‑acid sequence and intact C‑terminal amidation
Complete batch documentation package: Guarantee each order obtains batch‑specific COA, HPLC chromatogram, LC‑MS report and MSDS to satisfy global import customs clearance and lab audit requirements
Qualified manufacturing system: Select China peptide manufacturer with mature Fmoc‑SPPS workflow and GMP‑compliant quality system, proven track record on methionine‑containing long‑sequence amidated peptide synthesis
Global flexible supply: Confirm vendor can deliver both small‑scale research samples and large‑volume worldwide bulk peptide orders

HDM BIO provides research‑grade Sermorelin Acetate with full traceable quality records, flexible MOQ for lab trial batches and long‑term worldwide bulk procurement.

Sermorelin Acetate Powder Price & Bulk Ordering Guide 2026

If you are searching for Sermorelin Acetate powder price, bulk quotation and delivery terms, please refer to key procurement information as follows:

Minimum Order Quantity: Flexible MOQ, milligram & gram‑scale research samples available; kilogram‑level worldwide bulk supply for sustained research projects
Sample Access: Trial research samples for lab evaluation; contact sales team to get formal sample quotation
Bulk Kilogram Pricing: Tiered pricing structure; larger bulk volume brings competitive unit price
Production Lead Time: Special handling required for complex 29‑mer methionine‑containing amidated peptide with oxidation‑prone residue; sales will confirm exact production schedule upon formal inquiry
Shipping Options: Sealed cold‑recommended shipping worldwide; avoid prolonged room‑temperature exposure; we supply complete documentation package (batch‑specific COA, HPLC chromatogram, LC‑MS report, MSDS, commercial invoice, packing list) for global customs clearance

Final quotation is affected by purity grade, structural analysis testing items, special packaging and cold‑chain‑logistics fees. Please contact our sales team for up‑to‑date formal quotation.

Sermorelin Acetate Powder Procurement Guide for Global Buyers

Before placing purchase orders for 29‑mer amidated GHRH‑fragment peptide raw materials, international procurement teams should finish these verification steps to mitigate potential risks:

Supplier qualification check: Confirm the manufacturer owns independent peptide‑synthesis workshop and QC lab with GMP‑compliant quality system, hands‑on experience on complex 29‑mer sermorelin peptide synthesis, methionine oxidation control and C‑terminal amidation process
Document inspection: Request pre‑shipment complete documentation package including batch‑specific COA, HPLC chromatogram, LC‑MS report and MSDS; require multi‑method peptide identity confirmation, amidation‑completeness verification and related‑substance impurity profile including oxidation impurities
Product confirmation: Confirm purity standard, impurity profile and cold‑storage requirement match your experimental design; aqueous reconstituted solution is prone to methionine oxidative degradation
MOQ & lead‑time confirmation: Verify research sample / bulk peptide worldwide availability, special long‑sequence peptide production cycle and order‑adjustment policy
Shipping‑document confirmation: Make sure supplier can provide complete paperwork set to satisfy import requirements of your target region

About HDM BIO Sermorelin Acetate Manufacturing Capability

HDM BIO possesses more than 10‑year expertise in Fmoc‑SPPS peptide synthesis under GMP‑compliant quality system, specialized in complex methionine‑containing C‑terminal‑amidated endocrine‑hormone peptide manufacturing.

Dedicated Fmoc‑SPPS production lines; optimized double‑coupling protocol for complex 29‑mer sermorelin sequence to minimize deletion impurities; antioxidant protection strategy to suppress Met oxidation; controlled C‑terminal amidation setup for high amidation yield
Independent analytical laboratory equipped with HPLC, LC‑MS and structural analysis instruments; specialized workflow for peptide identity confirmation, amidation completeness validation and oxidative‑impurity quantification
Peptide products exported worldwide to over 70 countries, supporting university labs, biotech startups and pharmaceutical R&D institutes
Stable annual production capacity for research‑grade peptide raw materials, supporting long‑term framework cooperation
Professional technical team experienced in GHRH‑family peptide‑series synthesis, oxidation‑control process optimization and related analog custom modification

Our peptide manufacturing site runs dedicated Fmoc‑SPPS production lines, in‑house preparative‑HPLC purification and complete multi‑test analytical workflow for complex amidated long‑chain peptides.

What Technical Challenges Exist in Sermorelin Acetate Synthesis & Production?

Sermorelin Acetate is a complex 29‑mer GHRH‑fragment peptide with C‑terminal argininamide and oxidation‑sensitive methionine residue. Controlling on‑resin aggregation, methionine oxidative by‑products, amino‑acid deletion impurities and high‑yield C‑terminal amidation constitute core technical bottlenecks separating qualified peptide manufacturers from low‑grade suppliers.

Key production challenges:

‑ Methionine residue is highly susceptible to oxidation during cleavage, purification and lyophilization; oxidized‑Met impurity closely resembles main peak and is difficult to fully separate by conventional HPLC

‑ Long‑chain 29‑mer sequence brings cumulative incomplete‑coupling risk, generating multiple deletion‑sequence impurities which degrade biological activity

‑ Demanding C‑terminal arginine amidation; incomplete amidation generates inactive acid‑form impurity‑ Multiple positively‑charged arginine & lysine residues change peptide solubility, increasing difficulty in preparative‑HPLC gradient optimization

‑ Single HPLC test is insufficient for quality judgement; multi‑validation via HPLC, LC‑MS and structural analysis is mandatory to guarantee full‑length intact sequence, complete C‑terminal amidation and low oxidation level for functional endocrine biology assays

How Does Sermorelin Acetate Powder Work in Laboratory Research?

As synthetic GHRH‑(1‑29) peptide hormone, Sermorelin Acetate powder binds to GHRH receptors on pituitary somatotroph cells, induces pulsatile growth‑hormone release and downstream IGF‑1 elevation. It serves as core experimental reagent for GHRH‑receptor signaling profiling, pituitary endocrine cell assays, GH‑axis animal‑model studies and sermorelin‑ligand structure‑activity‑relationship exploration.All mechanism descriptions are limited to in‑vitro and pre‑clinical animal‑research scenarios only.

How Is Sermorelin Acetate Powder Manufactured at HDM BIO?

Sermorelin Acetate requires strict full‑process control for complex 29‑mer peptide coupling, methionine anti‑oxidation protection, C‑terminal arginine amidation and buffer‑exchange across synthesis, cleavage, purification and lyophilization, operated within our GMP‑compliant quality system.

Read related guide: Disulfide‑Containing Peptide API Manufacturing Guide | Fmoc SPPS Technology Explained

Complete Sermorelin Acetate Powder Manufacturing Workflow

Raw‑material QC of Fmoc‑amino‑acid building blocks → 29‑mer SPPS step‑wise coupling with double‑coupling & anti‑oxidation optimized protocol on Rink‑amide resin → Resin cleavage & global deprotection with antioxidant scavenger additive → Crude peptide pretreatment under inert atmosphere → Multi‑stage preparative‑HPLC purification (remove deletion‑peptide, Met‑oxidized by‑products & de‑amidated impurities) → Buffer‑exchange for acetate‑salt formation → Vacuum lyophilization under low‑oxygen environment → Full multi‑method QC testing (HPLC, LC‑MS, structural analysis for identity & amidation completeness verification, oxidation‑impurity profiling) → Batch‑specific COA issuance → Light‑proof, low‑moisture sealed packaging

QC Inspection Workflow

Incoming raw‑material QC → In‑process coupling, aggregation & methionine oxidation risk monitoring → HPLC purity testing → LC‑MS molecular‑weight, full‑sequence & amidation completeness verification → Supplementary structural analysis for peptide identity confirmation → Methionine‑oxidized & de‑amidated impurity quantitative analysis → Moisture & heavy‑metal testing → Residual‑solvent detection → Final batch‑release approval under GMP‑compliant quality system

Core Process Highlights

‑ Specialized double‑coupling parameter set for complex 29‑mer sermorelin acetate peptide to suppress multi‑site deletion impurities ‑ Full‑workflow inert‑atmosphere & scavenger protection to minimize methionine oxidative degradation ‑ Controlled C‑terminal arginine amidation to secure high ratio of active amidated target peptide ‑ Multi‑step high‑resolution HPLC to separate structurally‑similar oxidized‑Met by‑products, de‑amidated variants and deletion‑sequence peptide impurities ‑ Multi‑level identity confirmation: HPLC, LC‑MS plus structural analysis verifying full‑length intact peptide and complete C‑terminal amidation ‑ Lyophilized solid stable stored at −20 °C; aqueous solution highly susceptible to Met oxidation, aliquot and store at −80 °C immediately after reconstitution, avoid repeated freeze‑thaw cycles.

What Are the Main Application Scenarios of Sermorelin Acetate Powder?

Endocrine & pituitary‑physiology research: GHRH‑receptor binding assay, pituitary GH‑secretion test, growth‑hormone secretagogue ligand screening, sermorelin analog structure‑activity‑relationship exploration
GH‑IGF‑1 axis pre‑clinical research: Pituitary function evaluation, growth‑hormone‑deficiency animal model intervention, endocrine metabolic phenotype assessment
Neuroendocrine research: Hypothalamus‑pituitary axis signaling, neuro‑endocrine regulation mechanism investigation
Peptide formulation development: Lyophilized‑formulation feasibility research, sermorelin peptide delivery‑system development
Biomedical reagent preparation: Laboratory reference standards and experimental‑control reagents for GHRH‑family peptide research
Complex long‑chain amidated methionine‑containing‑peptide‑process‑development research: 29‑mer endocrine peptide synthesis & oxidation‑impurity‑control benchmark compound

Why Choose HDM BIO As Your Sermorelin Acetate Powder Supplier?

10+‑year China‑based peptide‑manufacturing experience with Fmoc‑SPPS production and GMP‑compliant quality system
Specialized capability for complex 29‑mer C‑terminal‑amidated sermorelin acetate peptide synthesis and purification, effectively reduce sequence‑deletion, methionine‑oxidized by‑products and de‑amidated impurities
Every batch supported by multi‑validation: HPLC, LC‑MS and structural analysis, delivered with batch‑specific complete documentation package ‑ Complete batch‑wise production‑traceability documents for Sermorelin Acetate Powder
Flexible worldwide supply capacity: research samples to kilogram‑scale bulk peptide orders ‑ Global‑export service covering more than 70 countries worldwide
Professional technical team supporting GHRH‑family peptide research and custom‑analog synthesis consulting

FAQs About Sermorelin Acetate Powder

Q: Where can I buy Sermorelin Acetate powder from China?

A: HDM BIO is a Chinese peptide manufacturer with Fmoc‑SPPS production and GMP‑compliant quality system, specialized in complex 29‑mer C‑terminal‑amidated GHRH‑fragment peptide. We deliver high‑purity Sermorelin Acetate powder for global pharmaceutical R&D teams and bioreagent laboratories, flexible worldwide supply from research samples to bulk peptide orders.

Q: What documents should a qualified Sermorelin Acetate supplier provide?

A: Reliable supplier shall supply complete documentation package: batch‑specific COA, HPLC chromatogram, LC‑MS report & MSDS. Peptide identity is verified by HPLC, LC‑MS and structural analysis; methionine‑oxidized, de‑amidated and peptide‑deletion impurity‑testing data are available upon request.

Q: What is the CAS number of Sermorelin Acetate Powder?

A: The CAS registry number of Sermorelin Acetate Powder is 114466‑38‑5.

Q: What purity grade of Sermorelin Acetate powder can you deliver?

A: Standard research‑grade ≥98% HPLC purity. Every batch comes with batch‑specific COA and multi‑method identity validation. Higher‑purity specifications and GHRH‑series custom‑peptide‑analog synthesis are available for special experimental requirements.

Q: How should lyophilized Sermorelin Acetate powder be stored?

A: Store sealed at −20 °C, keep away from light and moisture. Strictly avoid repeated freeze‑thaw cycles. Aqueous reconstituted solution is highly susceptible to methionine oxidation; prepare single‑use aliquots and store at −80 °C, long‑term storage under 2‑8 °C is not recommended.

Q: Can I get Sermorelin Acetate research samples before bulk purchase?

A: Yes. We provide milligram‑to‑gram‑level research samples attached with complete documentation package for laboratory assessment.

Q: What is the MOQ for bulk Sermorelin Acetate powder worldwide orders?

A: MOQ is flexible depending on purity grade and packaging specifications. We support small‑scale research samples and large‑volume worldwide bulk peptide orders for different‑project requirements.

Q: What is the amino‑acid sequence of Sermorelin Acetate Powder?

A: H‑Tyr‑Ala‑Asp‑Ala‑Ile‑Phe‑Thr‑Asn‑Ser‑Tyr‑Arg‑Lys‑Val‑Leu‑Gly‑Gln‑Leu‑Ser‑Ala‑Arg‑Lys‑Leu‑Leu‑Gln‑Asp‑Ile‑Met‑Ser‑Arg‑NH₂,C‑terminal amidated.

Scientific Review

Reviewed by:

HDM BIO Peptide Technical Team

Expertise:

Fmoc‑SPPS peptide synthesis Complex long‑chain aggregation‑prone disulfide‑bonded amylin‑family peptide manufacturing Multi‑method peptide characterization: HPLC, LC‑MS and structural analysis

Last Updated: August 2026

Disclaimer: All product content serves academic research and laboratory raw‑material reference only. Not for human clinical use, diagnosis or treatment.