Sulfamonomethoxine Sodium Raw Material Supplier China | ≥98% Long-Acting Veterinary Sulfonamide Manufacturer CAS 38006-08-5

Key Selling Points

✓ Long-Acting Sulfonamide with Sustained Therapeutic Levels

✓ Strongest Antibacterial Activity Among Sulfonamide Drugs

✓ Highly Water-Soluble Sodium Salt for Injection & Drinking Water

✓ Broad-Spectrum: Bacteria + Protozoa (Eimeria, Toxoplasma)

✓ Livestock, Poultry & Aquaculture Formulation Research

✓ Trimethoprim-Compatible (5:1) for Potentiated Sulfonamide

What Is Sulfamonomethoxine Sodium?

Sulfamonomethoxine Sodium Powder is a long-acting sulfonamide antibacterial and the water-soluble sodium salt of sulfamonomethoxine. It is recognized for having the strongest antibacterial activity among sulfonamide drugs, with a broad spectrum against gram-positive and gram-negative bacteria. It is widely used in veterinary medicine for the treatment and control of bacterial and protozoal infections in livestock, poultry and aquaculture.

As the sodium salt form, it is highly water-soluble, making it suitable for drinking-water solutions, injectable formulations and soluble powder preparations. The free base form (CAS 1220-83-3) has lower water solubility and is typically used in feed premixes.

How Does Sulfamonomethoxine Sodium Work?

Sulfamonomethoxine Sodium acts as a competitive inhibitor of dihydropteroate synthase (DHPS), an enzyme essential for converting para-aminobenzoic acid (PABA) into dihydrofolic acid. By blocking this folic acid synthesis pathway, it halts the production of purines, pyrimidines and amino acids required for bacterial DNA, RNA and protein synthesis, effectively stopping bacterial growth and replication.

Its long-acting pharmacokinetic profile allows sustained therapeutic concentrations, making Sulfamonomethoxine Sodium Powder valuable reference compound for veterinary antimicrobial and coccidiosis research.

What Are the Applications of Sulfamonomethoxine Sodium?

Livestock Bacterial Infections: Used in formulation research for respiratory, digestive and urinary tract infections in cattle, sheep, goats and pigs.
Poultry Health: Evaluated for bacterial infection control, coccidiosis and leucocytozoonosis research in chickens and turkeys.
Protozoal Research: Studied for activity against Eimeria species, Toxoplasma gondii and Eperythrozoon in veterinary research models.
Aquaculture: Used in aquatic animal antibacterial research and formulation development.
Potentiated Sulfonamide Research: Commonly studied in combination with trimethoprim (typically 5:1 ratio) for synergistic bactericidal activity.

What Is the Difference Between Sulfamonomethoxine and Sulfamonomethoxine Sodium?

Feature	Sulfamonomethoxine	Sulfamonomethoxine Sodium
CAS	1220-83-3	38006-08-5
Form	Free base	Sodium salt
Solubility	Lower water solubility	Highly water-soluble
Typical Use	Feed premix / oral powder	Drinking-water solution / injectable

How Does Sulfamonomethoxine Sodium Compare With Other Veterinary Sulfonamides?

Feature	Sulfamonomethoxine Sodium	Sulfadiazine	Sulfadimidine
CAS	38006-08-5	68-35-9	57-68-1
Acting Duration	Long-acting	Short to medium-acting	Medium-acting
Pyrimidine Ring	6-Methoxy	Unsubstituted	4,6-Dimethyl
Antibacterial Activity	Strongest among sulfonamides	Broad-spectrum	Broad-spectrum
Primary Use	Livestock/poultry/aquaculture infections	Human + veterinary broad-spectrum	Livestock enteric/respiratory
Combination	Trimethoprim (5:1)	Pyrimethamine / Trimethoprim	Trimethoprim

How Is Sulfamonomethoxine Sodium Manufactured?

Sulfamonomethoxine Sodium is manufactured by first synthesizing the free base sulfamonomethoxine through condensation of sulfanilamide with 4,6-dimethoxypyrimidine (or 4-chloro-6-methoxypyrimidine), followed by purification and treatment with sodium hydroxide to form the water-soluble sodium salt.

Raw Material QC → Pyrimidine Intermediate Preparation → Sulfonamide Condensation → Purification → Sodium Salt Formation → Crystallization → Drying → Final QC → Packaging

HDM BIO controls key condensation, purification and salt-formation parameters to maintain consistent purity and batch quality.

Quality Specifications

Test Item	Standard	Typical Result
Appearance	White to off-white powder	Consistent
Assay (HPLC)	≥98%	99.3%
Identity (IR)	Conforms to reference standard	Confirmed
Related Substances	Within specification	Pass
Loss on Drying	≤1.0%	0.3%
Residue on Ignition	Within specification	Compliant
Heavy Metals	≤10 ppm	Compliant

What Quality Control Tests Are Performed for Sulfamonomethoxine Sodium?

Each batch undergoes multi-step quality control before release to verify identity, purity, concentration and physical properties.

Raw Material QC → In-Process Control → HPLC Assay → IR Identity Verification → Related Substances Testing → Loss on Drying → Heavy Metals → Residue on Ignition → Final Batch Release

Key evaluations include identification via infrared (IR) absorption spectrophotometry, HPLC active content assay, related substances analysis, loss on drying, heavy metal limits and residue on ignition. Every commercial batch is supported by a batch-specific COA and relevant analytical documentation for incoming QC and supplier qualification.

What Factors Affect Sulfamonomethoxine Sodium Bulk Price?

Sulfamonomethoxine Sodium bulk pricing is driven by several key factors:

Raw Material & Synthesis Costs: Fluctuations in sulfanilamide, methoxypyrimidine intermediate and sodium hydroxide prices directly dictate baseline manufacturing expenses.
Purity & Grade Quality: Higher assay percentages, strict impurity control and specific particle size distribution for specialized formulations cost more to produce.
Regulatory Compliance & Certification: GMP-standard API batches with consistent COA and complete export documentation demand a higher price than non-certified alternatives.
Order Volume: Large-scale industrial or wholesale contracts receive steeper per-kilogram discounts than small-batch specialty orders.
Logistics & Geography: Shipping distance, moisture-barrier packaging requirements and customs compliance add to the landed cost.

Contact HDM BIO for a current quotation and volume-based pricing.

Why Choose HDM BIO as Your Sulfamonomethoxine Sodium Supplier?

High-purity (≥98% / typical 99%+) long-acting veterinary sulfonamide with minimal impurities
Strongest antibacterial activity among sulfonamides for reliable formulation research
GMP-aligned production, ISO & HACCP certified quality system
Full batch traceability and complete documentation (COA, MSDS, HPLC)
Flexible supply: gram samples to ton-level bulk orders
Global export to 70+ countries with full customs support

Bulk Packaging, Shipping & Storage

Packaging: Foil bags for samples and moisture-proof fiber drums for bulk orders.
Custom Packaging: OEM labeling available.
Shipping Documents: COA, MSDS/SDS, commercial invoice, packing list and customs documentation available according to order requirements.
Storage: Store tightly sealed in a cool, dry, light-protected environment. Shelf life: 24 months.
Handling: For veterinary raw material use only; not for direct clinical administration.

Frequently Asked Questions About Sulfamonomethoxine Sodium

Q1: What is Sulfamonomethoxine Sodium?

A: A long-acting sulfonamide antibacterial with the strongest activity among sulfonamide drugs, supplied as the water-soluble sodium salt for veterinary raw material use.

Q2: What is the CAS number?

A: 38006-08-5 (sodium salt); free base is 1220-83-3.

Q3: Is Sulfamonomethoxine Sodium a long-acting sulfonamide?

A: Yes. It is classified as a long-acting sulfonamide with sustained therapeutic concentrations, suitable for less frequent dosing in veterinary formulation research.

Q4: How does it work?

A:Sulfamonomethoxine Sodium Powder competitively inhibits DHPS by mimicking PABA, blocking folic acid synthesis and halting bacterial DNA/RNA and protein production.

Q5: Is it water soluble?

A: Yes. As a sodium salt, it is highly water-soluble, suitable for drinking-water solutions and injectable formulations.

Q6: Where can I buy it from China?

A: HDM BIO supplies bulk Sulfamonomethoxine Sodium raw material with batch COA and global export support.

Q7: How much does Sulfamonomethoxine Sodium cost?

A: Bulk pricing depends on raw material costs, purity grade, regulatory compliance, order volume and logistics. Contact HDM BIO for a current quotation.

Q8: Is this product for human clinical use?

A: It is supplied as veterinary raw material and is not intended for direct clinical administration. Finished products manufactured from the material must comply with applicable local regulatory requirements.