Acetyl Dipeptide-1 powder (CAS 196604-48-5) | Soothing & Anti-Irritation Peptide Specialist | ≥98% HPLC

Core Selling Points

✅ ≥98% HPLC Purity: Certified high-purity for consistent neuro-cosmetic research.

✅ Pro-Enkephalin Stimulation: Effectively studied for its ability to release "feel-good" messengers.

✅ Validated Soothing Efficacy: Primary tool for investigating the reduction of skin sensitivity and irritation.

✅ China Peptide Manufacturer: Specialized production facility for high-stability neuro-peptides.

✅ Structural Identity Verification: Every batch confirmed by high-resolution LC-MS and purity chromatograms.

✅ Complete Documentation: Full support for lab audits, including COA, MSDS, and export clearance.

What Is Acetyl Dipeptide-1 Powder?

Acetyl Dipeptide-1 (specifically Acetyl Dipeptide-1 Cetyl Ester) is a lipopeptide designed to mimic the action of pro-enkephalins, which are natural calming messengers in the skin. In laboratory research, it is recognized for its unique ability to modulate the perception of unpleasant sensations, such as heat, chemical stings, or mechanical stress. Acetyl Dipeptide-1 powder functions by binding to specific nerve receptors in the skin, providing a fundamental research tool for investigating the treatment of hypersensitive skin and the prevention of neurogenic inflammation.

The production of this high-stability lipopeptide requires precise control over the esterification process at the C-terminus to ensure superior skin-model penetration. HDM BIO utilizes advanced solid-phase peptide synthesis (SPPS) and preparative RP-HPLC to isolate the pure monomeric fraction. We supply this high-stability powder to global cosmetic R&D centers and pharmaceutical research institutes focusing on neuro-dermatology and soothing biotechnology.

Research-only disclaimer: For pre-clinical laboratory investigation only. Not for human clinical use, diagnosis, or medication.

What Are The Quality Specifications?

Item	Specification	Result
Appearance	White to off-white powder	Consistent
Purity (HPLC)	≥98%	99.68%
MS Identity	Consistent with reference standard	Confirmed
Conclusion	Cosmetic raw material requirement	Passed

Acetyl Dipeptide-1 vs. Palmitoyl Tripeptide-8: What Are The Differences?

Feature	Acetyl Dipeptide-1	Palmitoyl Tripeptide-8
Mechanism	Pro-Enkephalin Mimetic	Melanocortin Receptor Agonist
Primary Target	Nerve Receptors (Sensation)	Inflammatory Cytokines (Redness)
Research Focus	Sensitivity / Soothing / Stinging	Redness / Irritation / UV Damage
Stability	High Cetyl Ester Stability	High Palmitoyl Stability
CAS Number	196604-48-5	936544-53-1

How Is Acetyl Dipeptide-1 Manufactured?

Our production follows a standardized cosmetic peptide synthesis protocol:

Chain Assembly: Stepwise synthesis of the Dipeptide-1 backbone on a Rink Amide resin via Fmoc-SPPS.
N-Terminal Acetylation & C-Terminal Esterification: Precision modification to enhance protease resistance and lipophilicity.
RP-HPLC Purification: Preparative reverse-phase HPLC isolation of the ≥98% pure monomeric fraction.
Quality Release: Final confirmation via high-resolution LC-MS to verify the identity of the Acetyl Dipeptide-1 powder.

Structural Stability Control:

The efficacy of the peptide depends on the integrity of the cetyl ester modification. HDM BIO monitors every synthesis step to ensure our products meet the highest analytical standards for research reproducibility.

What Is The Difference Between Research Grade And Cosmetic Grade?

Category	Research Grade	Cosmetic Grade
Primary Purpose	Pre-clinical / Lab research	Cosmetic formulation
Documentation	COA / HPLC / LC-MS / AAA	MSDS / COA / TDS
Purity Standard	Typically ≥98%	Typically ≥95%
Supply Channel	Specialized R&D Suppliers	Cosmetic Raw Material Suppliers

Why Is Supplier Qualification Important Before Purchasing?

Choosing a reliable Acetyl Dipeptide-1 powder supplier is critical to ensure the absence of residual coupling agents and unreacted cetyl alcohol. For researchers, it is essential that the manufacturer validates the monomeric purity through HPLC, as impurities can skew data in nerve-response assays. Reliable suppliers provide batch-specific chromatograms and ensure the removal of trifluoroacetic acid (TFA) to protect the viability of sensitive neuro-dermal cellular models.

Price & Bulk Order Guide 2026

MOQ: Flexible; from 1g research samples to 5kg+ industrial bulk orders.
Samples: Paid test samples available with full QC documentation.
Bulk pricing: Tiered pricing structure; larger volumes deliver highly competitive unit costs.
Lead time: Standard batches are usually in stock; bulk custom orders take 2 weeks.
Quotation: Contact our sales team for the latest formal quotation based on your specific requirements.

Why Choose HDM BIO As Your Supplier?

Antioxidant Experts: Over 10 years of experience in the synthesis of glutathione and its derivatives.
High-Purity Guarantee: Advanced purification ensuring ≥99% purity and zero oxidized GSSG.
Rigorous Analytical QC: Every batch confirmed by HPLC, LC-MS, and NMR.
Global Shipping Support: Fast, secure export to 70+ countries with customs-ready documentation.
Technical Support: Direct assistance with solubility, redox stability, and formulation compatibility.

Main Research Applications

Neurogenic Inflammation Assays: Investigating the reduction of nerve-mediated inflammatory markers.
Skin Sensitivity Research: Measuring the modulation of sensory receptors in skin-equivalent models.
Anti-Stinging Efficacy: Evaluating the attenuation of unpleasant sensations from chemical irritants.
Lipopeptide Penetration Studies: Studying the transport efficiency of cetyl-ester modified peptides.

FAQs

Q: What is the benefit of Acetyl Dipeptide-1 Cetyl Ester for skin?

A: In research, it is primarily used for its soothing and calming effects. It helps study the reduction of skin sensitivity by mimicking natural endorphins, which helps the skin "relax" and feel less reactive to environmental stressors.

Q: Is Acetyl Dipeptide-1 Cetyl Ester safe for sensitive skin research?

A: Yes, it is specifically designed for research into sensitive and reactive skin types. It has an excellent safety profile in laboratory skin-model assays and is highly regarded for its non-irritating, neuro-cosmetic properties.

Q: How does this peptide work in "anti-aging" models?

A: While it is not a direct collagen stimulant, researchers study its ability to reduce "tension-induced" aging. By relaxing the micro-contractions in the skin, it provides a model for preventing the formation of expression lines.

Q: How should I store Acetyl Dipeptide-1 powder?

A: Lyophilized powder should be stored sealed at -20°C, protected from light and moisture. The cetyl ester bond is stable, but maintaining a dry, cold environment is essential for a shelf life of up to 24 months.